[Hub]/) : Traits : Waist circumference : ← →

chr11:26,818,083-29,054,545

Best TWAS P=1.16e-23 · Best GWAS P=1.38e-31 conditioned to 1.22e-07

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous LIN7C 0.08 0.06 lasso 1 0.04 4.1e-04 10.0 10.0 1.2e-23 0.65 0.76 0.11 TRUE
2 GTEx Brain Putamen basal ganglia BDNF-AS 0.22 0.17 lasso 4 0.13 5.5e-04 -6.6 7.9 3.2e-15 0.33 0.23 0.05 TRUE
3 GTEx Cells Transformed fibroblasts LIN7C 0.26 0.22 lasso 6 0.25 1.4e-18 10.0 8.3 8.4e-17 0.64 1.00 0.00 FALSE
4 GTEx Esophagus Muscularis LIN7C 0.14 0.08 enet 11 0.07 5.4e-05 3.3 7.0 2.3e-12 0.62 0.70 0.14 FALSE
5 GTEx Liver METTL15 0.18 0.05 lasso 3 0.09 1.9e-03 -0.9 -7.0 2.8e-12 -0.69 0.02 0.83 FALSE
6 GTEx Nerve Tibial LIN7C 0.18 0.08 enet 27 0.12 4.2e-09 10.0 6.5 6.2e-11 0.56 0.74 0.22 FALSE
7 GTEx Thyroid LIN7C 0.08 0.04 lasso 4 0.04 6.0e-04 10.0 9.6 5.1e-22 0.71 0.43 0.47 FALSE
8 NTR Blood LIN7C 0.01 0.00 lasso 3 0.01 2.2e-03 10.1 -9.9 4.3e-23 -0.74 0.10 0.80 FALSE
9 ROSMAP Brain Pre-frontal Cortex METTL15 0.04 0.03 blup 364 0.03 4.6e-05 -3.0 -5.3 1.4e-07 -0.19 0.72 0.01 TRUE
10 The Cancer Genome Atlas Bladder Urothelial Carcinoma LIN7C 0.04 0.01 lasso 3 0.02 1.0e-02 -1.9 6.0 1.5e-09 0.48 0.02 0.85 FALSE
11 The Cancer Genome Atlas Colon Adenocarcinoma LIN7C 0.10 0.03 blup 32 0.08 2.8e-05 10.0 7.5 7.6e-14 0.56 0.02 0.92 FALSE
12 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma LIN7C 0.05 0.02 lasso 3 0.03 2.9e-04 10.2 9.2 5.3e-20 0.65 0.01 0.98 FALSE
13 The Cancer Genome Atlas Brain Lower Grade Glioma LIN7C 0.09 0.12 lasso 2 0.12 2.6e-13 3.3 5.5 3.7e-08 0.53 0.96 0.04 FALSE