Best TWAS P=7.47e-22 · Best GWAS P=1.38e-33 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | LIN7C | 0.08 | 0.06 | lasso | 1 | 0.04 | 4.1e-04 | 9.61 | 9.6 | 7.5e-22 | 0.63 | 0.73 | 0.15 | TRUE |
2 | GTEx | Brain Putamen basal ganglia | BDNF-AS | 0.22 | 0.17 | lasso | 4 | 0.13 | 5.5e-04 | -6.47 | 7.7 | 1.9e-14 | 0.33 | 0.23 | 0.05 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | LIN7C | 0.26 | 0.22 | lasso | 6 | 0.25 | 1.4e-18 | 9.61 | 7.9 | 2.5e-15 | 0.62 | 1.00 | 0.00 | FALSE |
4 | GTEx | Esophagus Muscularis | LIN7C | 0.14 | 0.08 | enet | 11 | 0.07 | 5.4e-05 | 3.10 | 6.8 | 9.3e-12 | 0.60 | 0.70 | 0.14 | FALSE |
5 | GTEx | Liver | METTL15 | 0.18 | 0.05 | lasso | 3 | 0.09 | 1.9e-03 | -0.91 | -7.2 | 5.7e-13 | -0.68 | 0.02 | 0.82 | TRUE |
6 | GTEx | Nerve Tibial | LIN7C | 0.18 | 0.08 | enet | 27 | 0.12 | 4.2e-09 | 9.61 | 6.1 | 1.2e-09 | 0.56 | 0.59 | 0.38 | TRUE |
7 | GTEx | Thyroid | LIN7C | 0.08 | 0.04 | lasso | 4 | 0.04 | 6.0e-04 | 9.61 | 9.2 | 2.9e-20 | 0.69 | 0.54 | 0.34 | FALSE |
8 | NTR | Blood | LIN7C | 0.01 | 0.00 | lasso | 3 | 0.01 | 2.2e-03 | 9.83 | -9.5 | 1.7e-21 | -0.72 | 0.10 | 0.80 | FALSE |
9 | ROSMAP | Brain Pre-frontal Cortex | METTL15 | 0.04 | 0.03 | blup | 364 | 0.03 | 4.6e-05 | -2.82 | -5.3 | 9.5e-08 | -0.19 | 0.72 | 0.01 | TRUE |
10 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | LIN7C | 0.04 | 0.01 | lasso | 3 | 0.02 | 1.0e-02 | -0.86 | 5.2 | 2.4e-07 | 0.46 | 0.02 | 0.84 | FALSE |
11 | The Cancer Genome Atlas | Colon Adenocarcinoma | LIN7C | 0.10 | 0.03 | blup | 32 | 0.08 | 2.8e-05 | 9.81 | 7.1 | 9.6e-13 | 0.57 | 0.02 | 0.88 | FALSE |
12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LIN7C | 0.05 | 0.02 | lasso | 3 | 0.03 | 2.9e-04 | 9.82 | 8.7 | 2.2e-18 | 0.63 | 0.02 | 0.94 | FALSE |
13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LIN7C | 0.09 | 0.12 | lasso | 2 | 0.12 | 2.6e-13 | 3.12 | 5.3 | 1.3e-07 | 0.52 | 0.97 | 0.03 | TRUE |
14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | BDNFOS | 0.03 | 0.01 | blup | 83 | 0.02 | 1.4e-03 | 1.21 | 5.2 | 2.4e-07 | -0.13 | 0.34 | 0.02 | TRUE |