Best TWAS P=1.01e-13 · Best GWAS P=6.17e-16 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6 | ROSMAP | Brain Pre-frontal Cortex | MPPED2 | 0.25 | 0.29 | lasso | 7 | 0.29 | 4.4e-37 | 7.4 | -7.4 | 1.0e-13 | -0.97 | 0.01 | 0.99 | TRUE |
| 5 | GTEx | Pituitary | ARL14EP | 0.30 | 0.28 | lasso | 4 | 0.22 | 3.0e-06 | 7.0 | -6.8 | 1.3e-11 | -0.84 | 0.08 | 0.85 | FALSE |
| 1 | GTEx | Brain Cerebellum | ARL14EP | 0.33 | 0.25 | lasso | 10 | 0.26 | 3.7e-08 | 6.4 | -6.4 | 1.4e-10 | -0.69 | 0.73 | 0.25 | FALSE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | ARL14EP | 0.15 | 0.14 | lasso | 3 | 0.11 | 1.2e-04 | 6.3 | -6.4 | 2.1e-10 | -0.71 | 0.45 | 0.24 | FALSE |
| 3 | GTEx | Esophagus Muscularis | ARL14EP | 0.18 | 0.20 | lasso | 8 | 0.19 | 9.5e-12 | 6.0 | -6.3 | 2.8e-10 | -0.63 | 0.95 | 0.05 | FALSE |
| 4 | GTEx | Pancreas | ARL14EP | 0.16 | 0.08 | lasso | 6 | 0.07 | 1.0e-03 | 5.2 | -6.0 | 2.0e-09 | -0.62 | 0.29 | 0.12 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | MPPED2 | 0.07 | 0.01 | blup | 149 | 0.03 | 7.0e-05 | 7.0 | -6.0 | 2.1e-09 | -0.75 | 0.02 | 0.96 | FALSE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | C11orf46 | 0.12 | 0.08 | blup | 34 | 0.07 | 5.7e-05 | 5.9 | 5.1 | 2.9e-07 | 0.67 | 0.05 | 0.56 | FALSE |