Best TWAS P=1.15e-08 · Best GWAS P=2.03e-08 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PRDM4 | 0.07 | 0.08 | lasso | 2 | 0.07 | 5.0e-09 | 5.5 | 5.3 | 1.1e-07 | 0.97 | 0.01 | 0.99 | FALSE |
2 | GTEx | Adipose Subcutaneous | C12orf23 | 0.07 | 0.02 | lasso | 4 | 0.02 | 5.5e-03 | -5.2 | 5.2 | 2.0e-07 | 0.02 | 0.04 | 0.87 | FALSE |
3 | GTEx | Adipose Subcutaneous | RP11-412D9.4 | 0.22 | 0.13 | lasso | 5 | 0.13 | 5.1e-11 | -4.9 | 5.6 | 2.2e-08 | 0.00 | 0.04 | 0.96 | FALSE |
4 | GTEx | Artery Tibial | RP11-412D9.4 | 0.06 | 0.05 | lasso | 3 | 0.06 | 2.9e-05 | -5.2 | 5.7 | 1.2e-08 | 0.00 | 0.01 | 0.98 | TRUE |
5 | GTEx | Breast Mammary Tissue | RP11-412D9.4 | 0.23 | 0.26 | lasso | 4 | 0.26 | 9.7e-14 | -5.2 | 5.2 | 2.2e-07 | 0.02 | 0.02 | 0.98 | FALSE |
6 | GTEx | Lung | C12orf23 | 0.04 | 0.03 | lasso | 2 | 0.02 | 9.9e-03 | -5.2 | 5.3 | 9.3e-08 | 0.01 | 0.02 | 0.92 | FALSE |
7 | GTEx | Nerve Tibial | C12orf23 | 0.09 | 0.12 | enet | 10 | 0.12 | 1.1e-08 | -5.0 | 5.3 | 1.3e-07 | 0.01 | 0.03 | 0.96 | FALSE |
8 | GTEx | Nerve Tibial | RP11-412D9.4 | 0.18 | 0.18 | enet | 11 | 0.20 | 5.6e-14 | -4.9 | 5.3 | 9.0e-08 | 0.01 | 0.04 | 0.96 | FALSE |
9 | GTEx | Skin Sun Exposed Lower leg | C12orf23 | 0.06 | 0.04 | lasso | 3 | 0.03 | 8.0e-04 | -5.2 | 5.3 | 1.3e-07 | 0.02 | 0.03 | 0.95 | FALSE |
10 | GTEx | Thyroid | RP11-412D9.4 | 0.10 | 0.10 | enet | 7 | 0.12 | 9.3e-10 | 4.9 | 5.3 | 1.2e-07 | 0.02 | 0.05 | 0.95 | FALSE |
11 | GTEx | Whole Blood | PRDM4 | 0.10 | 0.08 | lasso | 5 | 0.05 | 1.8e-05 | 5.5 | -5.6 | 2.4e-08 | -0.99 | 0.01 | 0.99 | TRUE |
12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MTERFD3 | 0.02 | 0.01 | lasso | 4 | 0.01 | 1.3e-03 | -5.0 | 5.2 | 2.0e-07 | 0.04 | 0.01 | 0.91 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ASCL4 | 0.03 | 0.03 | blup | 49 | 0.03 | 2.9e-04 | 5.5 | 5.4 | 7.3e-08 | 0.88 | 0.01 | 0.94 | FALSE |