Best TWAS P=2.51e-12 · Best GWAS P=7.61e-13 conditioned to 0.0249
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | HECTD4 | 0.06 | 0.00 | enet | 15 | 0.02 | 1.0e-02 | 4.3 | -6.1 | 1.3e-09 | 0.66 | 0.06 | 0.84 | FALSE |
2 | GTEx | Adrenal Gland | PPTC7 | 0.13 | -0.01 | lasso | 6 | 0.00 | 3.4e-01 | 5.5 | 5.8 | 6.9e-09 | -0.19 | 0.03 | 0.17 | FALSE |
3 | GTEx | Artery Tibial | VPS29 | 0.05 | 0.03 | lasso | 3 | 0.02 | 5.9e-03 | 6.1 | 5.7 | 9.6e-09 | -0.07 | 0.01 | 0.96 | FALSE |
4 | GTEx | Artery Tibial | HECTD4 | 0.05 | 0.02 | lasso | 3 | 0.01 | 3.1e-02 | -6.6 | -7.0 | 2.5e-12 | 0.85 | 0.02 | 0.92 | TRUE |
5 | GTEx | Breast Mammary Tissue (Female) | VPS29 | 0.10 | -0.01 | lasso | 2 | 0.02 | 1.0e-01 | -3.6 | 5.4 | 5.4e-08 | -0.24 | 0.02 | 0.32 | FALSE |
6 | GTEx | Cells EBV-transformed lymphocytes | ARPC3 | 0.13 | 0.09 | lasso | 4 | 0.04 | 2.0e-02 | 5.5 | -5.4 | 5.4e-08 | 0.00 | 0.06 | 0.60 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | VPS29 | 0.09 | 0.13 | lasso | 3 | 0.13 | 9.8e-10 | 6.1 | 5.8 | 5.3e-09 | -0.03 | 0.00 | 1.00 | FALSE |
8 | GTEx | Colon Transverse | VPS29 | 0.13 | 0.01 | enet | 41 | 0.10 | 2.0e-05 | 5.2 | 5.2 | 2.1e-07 | -0.05 | 0.04 | 0.60 | FALSE |
9 | GTEx | Esophagus Mucosa | VPS29 | 0.14 | 0.13 | lasso | 6 | 0.13 | 3.0e-09 | 5.1 | 5.7 | 1.1e-08 | -0.01 | 0.02 | 0.98 | FALSE |
10 | GTEx | Esophagus Muscularis | VPS29 | 0.08 | 0.04 | lasso | 4 | 0.03 | 9.0e-03 | 5.1 | 5.3 | 1.2e-07 | -0.01 | 0.02 | 0.92 | FALSE |
11 | GTEx | Lung | GPN3 | 0.08 | 0.08 | enet | 8 | 0.07 | 1.0e-05 | 5.2 | -5.4 | 5.2e-08 | 0.00 | 0.21 | 0.78 | FALSE |
12 | GTEx | Muscle Skeletal | ARPC3 | 0.14 | 0.11 | enet | 23 | 0.10 | 2.2e-10 | 5.4 | -5.3 | 9.3e-08 | -0.04 | 0.09 | 0.91 | FALSE |
13 | GTEx | Muscle Skeletal | VPS29 | 0.06 | 0.06 | lasso | 3 | 0.05 | 4.3e-06 | 6.1 | 5.9 | 4.2e-09 | -0.04 | 0.00 | 0.99 | FALSE |
14 | GTEx | Muscle Skeletal | IFT81 | 0.08 | 0.08 | lasso | 5 | 0.07 | 1.7e-07 | 5.5 | 5.7 | 1.1e-08 | 0.01 | 0.07 | 0.93 | FALSE |
15 | GTEx | Muscle Skeletal | ANAPC7 | 0.08 | 0.01 | lasso | 3 | 0.00 | 1.1e-01 | 5.1 | 5.7 | 1.2e-08 | -0.01 | 0.03 | 0.77 | FALSE |
16 | GTEx | Nerve Tibial | VPS29 | 0.05 | 0.01 | lasso | 4 | 0.00 | 2.5e-01 | 5.3 | 5.2 | 2.6e-07 | 0.02 | 0.02 | 0.76 | FALSE |
17 | GTEx | Nerve Tibial | HECTD4 | 0.05 | 0.01 | enet | 6 | 0.01 | 3.6e-02 | 6.0 | -6.6 | 4.9e-11 | 0.48 | 0.21 | 0.49 | FALSE |
18 | GTEx | Skin Not Sun Exposed Suprapubic | VPS29 | 0.06 | 0.01 | lasso | 3 | 0.01 | 6.9e-02 | 5.5 | 6.0 | 2.1e-09 | -0.01 | 0.04 | 0.67 | TRUE |
19 | GTEx | Skin Not Sun Exposed Suprapubic | MAPKAPK5-AS1 | 0.04 | 0.00 | enet | 30 | 0.00 | 7.0e-01 | 4.3 | 5.2 | 1.8e-07 | -0.52 | 0.20 | 0.18 | FALSE |
20 | GTEx | Skin Sun Exposed Lower leg | ARPC3 | 0.13 | 0.15 | lasso | 3 | 0.15 | 1.9e-12 | 5.3 | -5.3 | 9.2e-08 | 0.00 | 0.11 | 0.89 | FALSE |
21 | GTEx | Skin Sun Exposed Lower leg | VPS29 | 0.05 | 0.04 | lasso | 6 | 0.03 | 1.0e-03 | 5.1 | 5.3 | 9.9e-08 | -0.03 | 0.02 | 0.94 | FALSE |
22 | GTEx | Skin Sun Exposed Lower leg | ALDH2 | 0.10 | 0.09 | enet | 13 | 0.13 | 6.7e-11 | 4.1 | -6.2 | 7.0e-10 | 0.67 | 0.49 | 0.51 | FALSE |
23 | GTEx | Spleen | VPS29 | 0.24 | 0.01 | enet | 14 | 0.04 | 2.9e-02 | 5.2 | 5.6 | 2.4e-08 | 0.04 | 0.05 | 0.48 | FALSE |
24 | GTEx | Testis | MAPKAPK5 | 0.23 | 0.12 | lasso | 5 | 0.15 | 3.1e-07 | 4.1 | -5.1 | 2.7e-07 | 0.40 | 0.66 | 0.28 | FALSE |
25 | GTEx | Testis | ARPC3 | 0.16 | 0.16 | lasso | 3 | 0.14 | 7.5e-07 | 5.3 | -5.3 | 1.0e-07 | 0.00 | 0.10 | 0.90 | FALSE |
26 | NTR | Blood | GPN3 | 0.03 | 0.01 | blup | 236 | 0.02 | 2.7e-06 | 5.1 | -5.9 | 3.3e-09 | 0.06 | 0.06 | 0.94 | FALSE |
27 | YFS | Blood | ARPC3 | 0.06 | 0.04 | lasso | 4 | 0.05 | 7.9e-16 | 5.3 | -5.4 | 6.5e-08 | -0.04 | 0.13 | 0.87 | FALSE |
28 | The Cancer Genome Atlas | Breast Invasive Carcinoma | VPS29 | 0.02 | 0.02 | lasso | 5 | 0.03 | 4.6e-06 | 5.3 | 5.7 | 1.2e-08 | -0.01 | 0.01 | 0.99 | FALSE |
29 | The Cancer Genome Atlas | Colon Adenocarcinoma | ALDH2 | 0.07 | 0.03 | lasso | 4 | 0.06 | 3.9e-04 | 3.7 | -5.2 | 2.2e-07 | 0.48 | 0.05 | 0.67 | FALSE |
30 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RAD9B | 0.04 | 0.02 | blup | 29 | 0.03 | 4.9e-04 | 5.5 | 5.7 | 1.4e-08 | 0.00 | 0.01 | 0.89 | FALSE |
31 | The Cancer Genome Atlas | Brain Lower Grade Glioma | VPS29 | 0.06 | 0.06 | enet | 7 | 0.06 | 2.1e-07 | 5.4 | 5.8 | 6.8e-09 | 0.00 | 0.01 | 0.99 | FALSE |
32 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ERP29 | 0.11 | 0.03 | blup | 25 | 0.05 | 5.0e-03 | 4.3 | 5.3 | 1.4e-07 | -0.59 | 0.01 | 0.75 | FALSE |
33 | The Cancer Genome Atlas | Thyroid Carcinoma | C12orf24 | 0.08 | 0.08 | lasso | 3 | 0.10 | 1.6e-09 | 5.3 | -5.1 | 2.8e-07 | 0.02 | 0.01 | 0.99 | FALSE |
34 | The Cancer Genome Atlas | Thyroid Carcinoma | IFT81 | 0.06 | 0.09 | lasso | 1 | 0.09 | 3.8e-09 | 5.2 | -5.2 | 1.8e-07 | 0.00 | 0.02 | 0.98 | FALSE |
35 | The Cancer Genome Atlas | Thyroid Carcinoma | RAD9B | 0.10 | 0.06 | enet | 5 | 0.06 | 1.2e-06 | 5.3 | 5.3 | 9.5e-08 | 0.00 | 0.05 | 0.94 | FALSE |