Best TWAS P=3.87e-18 · Best GWAS P=1.88e-18 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | RPS6KA5 | 0.08 | 0.07 | lasso | 2 | 0.06 | 5.3e-05 | -8.4 | 8.7 | 3.9e-18 | -0.95 | 0.01 | 0.99 | TRUE |
| 2 | GTEx | Colon Sigmoid | RPS6KA5 | 0.16 | 0.09 | lasso | 5 | 0.08 | 7.1e-04 | -6.8 | -6.9 | 6.5e-12 | 0.79 | 0.09 | 0.77 | FALSE |
| 3 | GTEx | Heart Atrial Appendage | C14orf159 | 0.18 | 0.10 | lasso | 4 | 0.06 | 1.6e-03 | -5.5 | -6.2 | 6.7e-10 | 0.50 | 0.11 | 0.68 | FALSE |
| 4 | GTEx | Heart Left Ventricle | RPS6KA5 | 0.13 | 0.00 | enet | 38 | 0.02 | 2.2e-02 | -6.4 | -5.6 | 1.8e-08 | 0.55 | 0.02 | 0.80 | FALSE |
| 5 | GTEx | Spleen | C14orf159 | 0.30 | 0.21 | lasso | 5 | 0.21 | 3.6e-06 | -7.4 | 8.2 | 3.1e-16 | -0.79 | 0.10 | 0.27 | FALSE |
| 6 | METSIM | Adipose | C14orf159 | 0.04 | 0.00 | blup | 464 | 0.01 | 4.0e-03 | -6.2 | 7.0 | 2.4e-12 | -0.70 | 0.08 | 0.74 | FALSE |