TWAS
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Usage
Models
Genes
Traits
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Traits
:
Hip circumference
:
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chr19:9,810,038-11,438,022
Best TWAS P=8.86e-10 · Best GWAS P=1.1e-11 conditioned to 0.206
9.8M
10M
10.2M
10.4M
10.6M
10.8M
11M
11.2M
11.4M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Brain Lower Grade Glioma
LOC147727
0.07
0.02
lasso
2
0.02
5.4e-03
5.9
-6.1
8.9e-10
-0.93
0.06
0.23
TRUE
2
GTEx
Pituitary
CDC37
0.23
0.11
lasso
5
0.05
2.3e-02
4.4
5.3
1.0e-07
0.26
0.07
0.39
TRUE
1
GTEx
Muscle Skeletal
SLC44A2
0.19
0.18
lasso
5
0.19
5.1e-18
5.5
5.9
4.0e-09
0.76
0.92
0.08
FALSE
4
The Cancer Genome Atlas
Thyroid Carcinoma
SLC44A2
0.32
0.22
enet
14
0.25
3.8e-24
6.8
5.4
5.7e-08
0.93
0.01
0.99
FALSE