Best TWAS P=3.2e-13 · Best GWAS P=1.41e-12 conditioned to 0.108
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | PEPD | 0.30 | 0.25 | lasso | 6 | 0.26 | 2.5e-21 | 5.8 | 5.8 | 8.4e-09 | 0.73 | 0.91 | 0.09 | FALSE |
2 | GTEx | Adipose Visceral Omentum | PEPD | 0.15 | 0.05 | enet | 10 | 0.03 | 1.3e-02 | 5.6 | 6.3 | 2.5e-10 | 0.62 | 0.05 | 0.69 | FALSE |
3 | GTEx | Breast Mammary Tissue | PEPD | 0.16 | 0.06 | lasso | 4 | 0.04 | 3.5e-03 | 5.8 | 5.9 | 3.3e-09 | 0.78 | 0.36 | 0.60 | FALSE |
4 | GTEx | Colon Transverse | PEPD | 0.14 | 0.16 | lasso | 2 | 0.13 | 1.2e-06 | 5.8 | 5.7 | 1.1e-08 | 0.71 | 0.52 | 0.36 | FALSE |
5 | GTEx | Esophagus Mucosa | PEPD | 0.37 | 0.32 | enet | 20 | 0.39 | 9.5e-28 | 5.9 | 6.7 | 2.5e-11 | 0.87 | 0.02 | 0.98 | FALSE |
6 | METSIM | Adipose | CHST8 | 0.22 | 0.17 | lasso | 4 | 0.17 | 3.7e-25 | 5.9 | 6.2 | 7.8e-10 | 0.73 | 0.90 | 0.10 | FALSE |
7 | METSIM | Adipose | PEPD | 0.19 | 0.18 | lasso | 5 | 0.17 | 2.3e-24 | 5.9 | 6.0 | 2.7e-09 | 0.73 | 0.90 | 0.10 | FALSE |
8 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PEPD | 0.06 | 0.01 | blup | 114 | 0.04 | 2.6e-04 | 6.9 | 7.2 | 7.1e-13 | 0.84 | 0.01 | 0.96 | FALSE |
9 | The Cancer Genome Atlas | Colon Adenocarcinoma | PEPD | 0.13 | 0.06 | blup | 113 | 0.10 | 1.2e-06 | 5.4 | 7.3 | 3.2e-13 | 0.86 | 0.01 | 0.99 | TRUE |
10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PEPD | 0.07 | 0.00 | blup | 113 | 0.04 | 1.5e-05 | 3.4 | 5.2 | 2.4e-07 | 0.59 | 0.08 | 0.78 | FALSE |
11 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PEPD | 0.17 | 0.05 | blup | 114 | 0.12 | 4.1e-07 | -2.9 | 5.5 | 3.2e-08 | 0.57 | 0.16 | 0.75 | FALSE |
12 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PEPD | 0.16 | 0.07 | lasso | 3 | 0.05 | 3.1e-03 | 7.0 | 7.0 | 2.3e-12 | 0.95 | 0.01 | 0.97 | FALSE |
13 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PEPD | 0.08 | 0.02 | blup | 113 | 0.02 | 7.0e-03 | -4.0 | 5.7 | 1.3e-08 | 0.60 | 0.06 | 0.29 | FALSE |