Best TWAS P=4.2e-11 · Best GWAS P=6.98e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | HTR1D | 0.24 | 0.12 | lasso | 4 | 0.12 | 1.2e-05 | -6.5 | 6.6 | 4.2e-11 | -0.97 | 0.00 | 1.00 | TRUE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | WNT4 | 0.03 | 0.01 | blup | 72 | 0.02 | 3.8e-05 | 5.0 | 6.1 | 9.4e-10 | 0.05 | 0.00 | 0.99 | TRUE |
| 4 | GTEx | Testis | LUZP1 | 0.17 | 0.09 | lasso | 4 | 0.08 | 2.6e-04 | -6.5 | -5.8 | 8.2e-09 | 0.94 | 0.01 | 0.98 | FALSE |
| 2 | GTEx | Brain Cortex | LUZP1 | 0.23 | 0.14 | lasso | 5 | 0.10 | 7.8e-04 | -5.5 | 5.6 | 2.3e-08 | -0.63 | 0.05 | 0.44 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | LUZP1 | 0.09 | 0.09 | lasso | 4 | 0.08 | 2.8e-06 | -5.5 | 5.5 | 2.8e-08 | -0.63 | 0.53 | 0.43 | FALSE |
| 1 | GTEx | Brain Cerebellar Hemisphere | ZNF436 | 0.19 | -0.01 | enet | 12 | 0.00 | 4.1e-01 | -5.3 | -5.2 | 1.7e-07 | 0.72 | 0.03 | 0.54 | FALSE |