Best TWAS P=2.3e-09 · Best GWAS P=7.6e-10 conditioned to 0.491
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | KLHL24 | 0.42 | 0.60 | bslmm | 493 | 0.66 | 4.5e-107 | -5.5 | -5.9 | 4.7e-09 | -0.12 | 0.03 | 0.97 | FALSE |
2 | GTEx | Adipose Subcutaneous | KLHL24 | 0.15 | 0.10 | lasso | 6 | 0.10 | 1.4e-08 | -5.6 | 5.9 | 3.0e-09 | 0.15 | 0.03 | 0.97 | TRUE |
3 | GTEx | Brain Caudate basal ganglia | KLHL24 | 0.22 | 0.21 | lasso | 3 | 0.19 | 3.5e-06 | -5.6 | 5.6 | 2.3e-08 | 0.13 | 0.03 | 0.95 | FALSE |
4 | GTEx | Brain Cerebellum | KLHL24 | 0.52 | 0.14 | enet | 26 | 0.16 | 1.9e-05 | -5.6 | 5.4 | 6.7e-08 | 0.13 | 0.03 | 0.96 | TRUE |
5 | GTEx | Brain Cortex | KLHL24 | 0.21 | 0.15 | lasso | 3 | 0.07 | 6.1e-03 | -5.6 | 5.9 | 3.5e-09 | 0.17 | 0.03 | 0.90 | FALSE |
6 | GTEx | Brain Hypothalamus | KLHL24 | 0.22 | 0.24 | lasso | 2 | 0.19 | 3.3e-05 | -5.6 | 5.6 | 2.4e-08 | 0.10 | 0.04 | 0.74 | FALSE |
7 | GTEx | Breast Mammary Tissue | KLHL24 | 0.25 | 0.13 | lasso | 5 | 0.11 | 3.4e-06 | -5.6 | 5.8 | 8.2e-09 | 0.14 | 0.03 | 0.97 | FALSE |
8 | GTEx | Esophagus Muscularis | KLHL24 | 0.10 | 0.12 | lasso | 1 | 0.09 | 4.4e-06 | -5.6 | 5.6 | 2.0e-08 | 0.14 | 0.03 | 0.97 | FALSE |
9 | GTEx | Nerve Tibial | KLHL24 | 0.08 | 0.06 | lasso | 3 | 0.05 | 1.5e-04 | -5.5 | 5.5 | 3.9e-08 | 0.13 | 0.04 | 0.94 | FALSE |
10 | GTEx | Skin Sun Exposed Lower leg | KLHL24 | 0.09 | 0.06 | lasso | 10 | 0.05 | 9.5e-05 | -5.6 | 5.6 | 2.2e-08 | 0.14 | 0.03 | 0.96 | FALSE |
11 | GTEx | Testis | KLHL24 | 0.17 | 0.10 | lasso | 4 | 0.10 | 4.0e-05 | -5.6 | 5.6 | 1.9e-08 | 0.14 | 0.03 | 0.97 | FALSE |
12 | METSIM | Adipose | MAP6D1 | 0.06 | 0.05 | bslmm | 473 | 0.06 | 2.3e-09 | 4.9 | 5.2 | 2.1e-07 | 0.27 | 0.96 | 0.04 | TRUE |
13 | YFS | Blood | KLHL24 | 0.02 | 0.01 | lasso | 2 | 0.01 | 1.4e-03 | -4.9 | 5.3 | 1.4e-07 | 0.12 | 0.04 | 0.95 | TRUE |
14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ECE2 | 0.04 | 0.02 | blup | 61 | 0.03 | 3.5e-04 | 4.7 | 5.7 | 1.2e-08 | 0.70 | 0.03 | 0.94 | TRUE |
15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | KLHL24 | 0.05 | 0.05 | blup | 53 | 0.05 | 1.1e-06 | -5.5 | 5.8 | 5.5e-09 | 0.14 | 0.04 | 0.96 | TRUE |
16 | The Cancer Genome Atlas | Lung Adenocarcinoma | PSMD2 | 0.09 | 0.02 | blup | 50 | 0.05 | 1.2e-06 | -3.6 | 6.0 | 2.3e-09 | 0.46 | 0.15 | 0.28 | TRUE |
17 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | KLHL24 | 0.16 | 0.16 | blup | 53 | 0.21 | 4.3e-08 | -5.6 | 5.6 | 1.9e-08 | 0.13 | 0.03 | 0.97 | FALSE |