Best TWAS P=6.53e-14 · Best GWAS P=6.07e-12 conditioned to 0.897
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DHX36 | 0.05 | 0.06 | blup | 357 | 0.05 | 1.3e-06 | -6.9 | -7.0 | 1.8e-12 | 0.87 | 0.01 | 0.99 | FALSE |
2 | GTEx | Adipose Subcutaneous | ARHGEF26 | 0.10 | 0.06 | enet | 8 | 0.07 | 2.2e-06 | -6.9 | 7.0 | 1.9e-12 | -0.95 | 0.01 | 0.99 | FALSE |
3 | GTEx | Artery Tibial | ARHGEF26 | 0.11 | 0.12 | enet | 12 | 0.12 | 5.9e-10 | -6.8 | 6.3 | 3.7e-10 | -0.96 | 0.02 | 0.98 | FALSE |
4 | GTEx | Ovary | ARHGEF26 | 0.14 | 0.03 | enet | 15 | 0.06 | 1.4e-02 | 6.2 | 7.1 | 1.4e-12 | -0.59 | 0.07 | 0.51 | FALSE |
5 | GTEx | Pancreas | ARHGEF26 | 0.26 | 0.26 | lasso | 5 | 0.28 | 3.2e-12 | -6.4 | 7.4 | 1.0e-13 | -0.94 | 0.02 | 0.98 | FALSE |
6 | GTEx | Skin Not Sun Exposed Suprapubic | ARHGEF26 | 0.13 | 0.11 | lasso | 4 | 0.07 | 6.8e-05 | -6.4 | 7.5 | 6.5e-14 | -0.92 | 0.02 | 0.98 | TRUE |
7 | GTEx | Skin Sun Exposed Lower leg | ARHGEF26 | 0.10 | 0.08 | enet | 12 | 0.11 | 2.9e-09 | -6.9 | 6.6 | 3.9e-11 | -0.90 | 0.02 | 0.98 | FALSE |
8 | GTEx | Spleen | DHX36 | 0.39 | 0.09 | enet | 21 | 0.34 | 2.1e-09 | -3.3 | -5.4 | 6.1e-08 | 0.47 | 0.82 | 0.09 | FALSE |
9 | GTEx | Thyroid | ARHGEF26 | 0.09 | 0.07 | enet | 17 | 0.08 | 1.9e-06 | -6.6 | 6.8 | 1.2e-11 | -0.81 | 0.02 | 0.98 | FALSE |
10 | GTEx | Thyroid | DHX36 | 0.06 | 0.01 | lasso | 4 | 0.02 | 1.7e-02 | -5.3 | -5.2 | 2.2e-07 | 0.84 | 0.06 | 0.85 | FALSE |
11 | METSIM | Adipose | ARHGEF26 | 0.07 | 0.08 | lasso | 6 | 0.07 | 3.5e-11 | -6.9 | 6.8 | 1.2e-11 | -0.98 | 0.01 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SGEF | 0.04 | 0.04 | enet | 12 | 0.04 | 1.1e-05 | -6.7 | 7.4 | 1.8e-13 | -0.91 | 0.01 | 0.98 | FALSE |
13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DHX36 | 0.11 | 0.09 | enet | 11 | 0.10 | 6.4e-12 | -5.4 | -5.8 | 6.4e-09 | 0.75 | 0.39 | 0.61 | FALSE |