Best TWAS P=1.52e-10 · Best GWAS P=5.31e-12 conditioned to 0.00208
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | BMP8A | 0.05 | 0.03 | lasso | 3 | 0.02 | 8.8e-04 | 5.4 | 5.6 | 2.2e-08 | 0.71 | 0.07 | 0.88 | FALSE |
2 | GTEx | Adrenal Gland | PABPC4 | 0.20 | 0.09 | lasso | 8 | 0.06 | 3.0e-03 | 5.4 | -6.4 | 1.5e-10 | -0.77 | 0.06 | 0.78 | TRUE |
3 | GTEx | Artery Tibial | PABPC4 | 0.10 | 0.10 | lasso | 4 | 0.10 | 3.4e-08 | 5.4 | -5.3 | 1.1e-07 | -0.72 | 0.46 | 0.54 | FALSE |
4 | GTEx | Breast Mammary Tissue | PABPC4 | 0.13 | 0.02 | enet | 14 | 0.04 | 3.4e-03 | 5.4 | -5.4 | 7.8e-08 | -0.70 | 0.08 | 0.81 | FALSE |
5 | GTEx | Breast Mammary Tissue (Female) | PABPC4 | 0.10 | 0.00 | enet | 9 | 0.01 | 1.5e-01 | 6.3 | -6.3 | 3.2e-10 | -0.83 | 0.03 | 0.47 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | PABPC4 | 0.07 | 0.09 | lasso | 1 | 0.06 | 2.7e-05 | 5.4 | -5.4 | 6.4e-08 | -0.68 | 0.22 | 0.72 | FALSE |
7 | GTEx | Esophagus Mucosa | PABPC4 | 0.06 | 0.06 | lasso | 3 | 0.08 | 7.3e-06 | 5.4 | -5.5 | 4.8e-08 | -0.73 | 0.38 | 0.56 | FALSE |
8 | GTEx | Lung | PABPC4 | 0.05 | 0.03 | lasso | 3 | 0.02 | 1.3e-02 | 5.4 | -5.1 | 3.0e-07 | -0.64 | 0.12 | 0.72 | FALSE |
9 | GTEx | Nerve Tibial | PABPC4 | 0.17 | 0.08 | enet | 12 | 0.05 | 2.7e-04 | 5.4 | -5.1 | 2.8e-07 | -0.73 | 0.07 | 0.93 | FALSE |
10 | GTEx | Nerve Tibial | RP11-69E11.8 | 0.05 | 0.00 | lasso | 3 | 0.01 | 6.9e-02 | 5.4 | -5.7 | 1.1e-08 | -0.75 | 0.03 | 0.87 | FALSE |
11 | GTEx | Ovary | RP11-69E11.4 | 0.25 | 0.05 | enet | 11 | 0.03 | 6.7e-02 | 4.9 | 5.3 | 1.1e-07 | 0.68 | 0.05 | 0.43 | FALSE |
12 | GTEx | Skin Not Sun Exposed Suprapubic | PABPC4 | 0.12 | 0.10 | lasso | 3 | 0.05 | 1.0e-03 | 5.4 | -5.5 | 3.0e-08 | -0.71 | 0.28 | 0.41 | FALSE |
13 | GTEx | Skin Sun Exposed Lower leg | RP11-69E11.4 | 0.13 | 0.12 | lasso | 6 | 0.15 | 1.3e-12 | 5.5 | 5.3 | 9.2e-08 | 0.72 | 0.92 | 0.08 | FALSE |
14 | GTEx | Spleen | RP11-69E11.4 | 0.25 | 0.12 | lasso | 4 | 0.15 | 9.3e-05 | 4.5 | 5.5 | 5.0e-08 | 0.70 | 0.21 | 0.53 | FALSE |
15 | GTEx | Spleen | BMP8A | 0.16 | 0.08 | lasso | 3 | 0.05 | 1.6e-02 | 5.5 | 5.2 | 2.1e-07 | 0.75 | 0.07 | 0.30 | FALSE |
16 | NTR | Blood | KIAA0754 | 0.03 | 0.00 | bslmm | 366 | 0.01 | 1.6e-03 | -1.7 | 5.9 | 3.5e-09 | 0.62 | 0.10 | 0.75 | FALSE |
17 | NTR | Blood | PABPC4 | 0.01 | 0.00 | blup | 383 | 0.00 | 2.8e-02 | 5.4 | -6.2 | 4.2e-10 | -0.68 | 0.05 | 0.48 | FALSE |
18 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PABPC4 | 0.03 | 0.03 | lasso | 2 | 0.04 | 1.3e-08 | 5.4 | -5.6 | 2.4e-08 | -0.62 | 0.00 | 1.00 | FALSE |
19 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | BMP8A | 0.04 | 0.03 | blup | 48 | 0.04 | 3.5e-05 | 4.5 | 5.8 | 6.2e-09 | 0.68 | 0.02 | 0.97 | FALSE |
20 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PABPC4 | 0.03 | 0.01 | enet | 4 | 0.02 | 4.3e-03 | 5.4 | -5.2 | 2.1e-07 | -0.68 | 0.00 | 0.98 | FALSE |
21 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PABPC4 | 0.04 | 0.05 | blup | 31 | 0.04 | 1.2e-05 | 4.9 | -5.2 | 2.0e-07 | -0.57 | 0.02 | 0.97 | FALSE |
22 | The Cancer Genome Atlas | Brain Lower Grade Glioma | BMP8A | 0.05 | 0.01 | blup | 48 | 0.04 | 6.8e-05 | 6.0 | 5.6 | 2.6e-08 | 0.68 | 0.00 | 0.98 | FALSE |
23 | The Cancer Genome Atlas | Lung Adenocarcinoma | PABPC4 | 0.04 | 0.03 | enet | 8 | 0.04 | 4.5e-05 | 5.4 | -5.5 | 3.8e-08 | -0.62 | 0.00 | 1.00 | FALSE |
24 | The Cancer Genome Atlas | Thyroid Carcinoma | PABPC4 | 0.09 | 0.07 | enet | 5 | 0.08 | 4.1e-08 | 5.4 | -5.7 | 1.2e-08 | -0.62 | 0.00 | 1.00 | FALSE |