Best TWAS P=6.07e-13 · Best GWAS P=7.13e-13 conditioned to 0.00208
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Caudate basal ganglia | CCDC171 | 0.30 | 0.18 | lasso | 4 | 0.23 | 2.4e-07 | 6.0 | -6.4 | 1.2e-10 | 0.71 | 0.34 | 0.65 | FALSE |
2 | GTEx | Brain Cerebellar Hemisphere | CCDC171 | 0.46 | 0.19 | lasso | 7 | 0.23 | 1.3e-06 | -6.4 | -7.2 | 6.1e-13 | 0.69 | 0.20 | 0.76 | TRUE |
3 | GTEx | Brain Cerebellum | CCDC171 | 0.46 | 0.22 | lasso | 7 | 0.15 | 3.4e-05 | -6.2 | -6.6 | 4.5e-11 | 0.73 | 0.08 | 0.92 | FALSE |
4 | GTEx | Brain Cortex | CCDC171 | 0.26 | 0.15 | lasso | 2 | 0.16 | 2.8e-05 | -4.8 | -5.7 | 1.3e-08 | 0.66 | 0.20 | 0.69 | FALSE |
5 | GTEx | Brain Frontal Cortex BA9 | CCDC171 | 0.27 | 0.18 | enet | 10 | 0.19 | 8.3e-06 | 6.0 | -6.1 | 9.3e-10 | 0.62 | 0.16 | 0.71 | FALSE |
6 | GTEx | Brain Hypothalamus | CCDC171 | 0.32 | 0.17 | enet | 6 | 0.09 | 4.0e-03 | -6.4 | -5.5 | 4.5e-08 | 0.66 | 0.12 | 0.60 | FALSE |
7 | GTEx | Nerve Tibial | CCDC171 | 0.25 | 0.16 | lasso | 6 | 0.14 | 2.1e-10 | -6.1 | -6.1 | 9.0e-10 | 0.73 | 0.58 | 0.42 | FALSE |
8 | GTEx | Ovary | CCDC171 | 0.21 | 0.19 | lasso | 4 | 0.16 | 7.7e-05 | 5.7 | 5.4 | 5.7e-08 | -0.62 | 0.18 | 0.46 | FALSE |
9 | GTEx | Pituitary | CCDC171 | 0.28 | 0.16 | enet | 29 | 0.12 | 5.2e-04 | 5.9 | -6.0 | 2.3e-09 | 0.68 | 0.20 | 0.73 | FALSE |
10 | METSIM | Adipose | CCDC171 | 0.03 | 0.00 | blup | 828 | 0.01 | 4.0e-02 | 6.0 | -5.4 | 7.2e-08 | 0.59 | 0.33 | 0.31 | FALSE |
11 | ROSMAP | Brain Pre-frontal Cortex | CCDC171 | 0.14 | 0.11 | enet | 21 | 0.11 | 8.3e-14 | 6.1 | -5.9 | 4.5e-09 | 0.64 | 0.67 | 0.33 | FALSE |
12 | The Cancer Genome Atlas | Soft Tissue Sarcoma | C9orf93 | 0.06 | 0.05 | lasso | 3 | 0.03 | 5.3e-03 | 5.8 | -5.2 | 1.9e-07 | 0.61 | 0.11 | 0.38 | FALSE |