Best TWAS P=9.76e-10 · Best GWAS P=4.27e-10 conditioned to 0.0504
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | SPAG8 | 0.11 | 0.10 | lasso | 7 | 0.06 | 2.0e-04 | 6.0 | -6.1 | 9.8e-10 | -0.86 | 0.01 | 0.98 | TRUE |
2 | GTEx | Breast Mammary Tissue (Female) | OR13E1P | 0.06 | 0.05 | lasso | 2 | 0.01 | 1.4e-01 | 5.4 | -5.4 | 5.7e-08 | -0.84 | 0.04 | 0.39 | FALSE |
3 | GTEx | Liver | NPR2 | 0.18 | 0.04 | lasso | 3 | 0.02 | 1.1e-01 | 5.9 | -6.0 | 2.4e-09 | -0.88 | 0.03 | 0.84 | FALSE |
4 | ROSMAP | Brain Pre-frontal Cortex | RP11-112J3.16 | 0.11 | 0.12 | bslmm | 410 | 0.11 | 1.5e-13 | 5.7 | -5.4 | 7.3e-08 | -0.89 | 0.05 | 0.95 | FALSE |
5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C9orf128 | 0.14 | 0.15 | blup | 50 | 0.16 | 1.4e-32 | 5.5 | -5.5 | 4.5e-08 | -0.84 | 0.06 | 0.94 | FALSE |
6 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | GBA2 | 0.07 | 0.03 | blup | 44 | 0.03 | 1.1e-02 | -2.4 | -5.7 | 1.0e-08 | -0.70 | 0.02 | 0.43 | FALSE |
7 | The Cancer Genome Atlas | Lung Adenocarcinoma | C9orf128 | 0.07 | 0.07 | lasso | 2 | 0.07 | 1.6e-08 | 5.5 | -5.4 | 6.5e-08 | -0.82 | 0.06 | 0.94 | FALSE |
8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C9orf128 | 0.02 | 0.01 | blup | 50 | 0.01 | 2.3e-02 | 5.5 | -5.4 | 8.8e-08 | -0.86 | 0.04 | 0.78 | FALSE |
9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C9orf128 | 0.11 | 0.18 | lasso | 2 | 0.16 | 3.7e-16 | 5.5 | -5.5 | 4.6e-08 | -0.83 | 0.05 | 0.95 | FALSE |
10 | The Cancer Genome Atlas | Stomach Adenocarcinoma | C9orf128 | 0.04 | 0.06 | lasso | 2 | 0.05 | 2.8e-04 | 5.6 | -5.6 | 2.5e-08 | -0.85 | 0.01 | 0.85 | FALSE |
11 | The Cancer Genome Atlas | Stomach Adenocarcinoma | GBA2 | 0.04 | 0.03 | blup | 44 | 0.02 | 1.0e-02 | -4.5 | -5.2 | 1.6e-07 | -0.68 | 0.06 | 0.20 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | C9orf128 | 0.12 | 0.19 | lasso | 1 | 0.20 | 8.5e-19 | 5.5 | -5.5 | 4.6e-08 | -0.83 | 0.06 | 0.94 | FALSE |