Best TWAS P=2.59e-15 · Best GWAS P=4.74e-16 conditioned to 0.249
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | RER1 | 0.06 | 0.00 | blup | 359 | 0.01 | 8.1e-03 | 1.3 | -6.4 | 1.3e-10 | -0.48 | 0.04 | 0.20 | TRUE |
2 | CommonMind | Brain Pre-frontal Cortex | TNFRSF14 | 0.05 | 0.00 | blup | 372 | 0.02 | 1.5e-03 | 7.4 | 5.2 | 2.6e-07 | 0.57 | 0.04 | 0.45 | FALSE |
3 | GTEx | Adipose Subcutaneous | RP11-181G12.2 | 0.09 | 0.07 | lasso | 1 | 0.05 | 1.3e-04 | -5.5 | 5.5 | 4.3e-08 | 0.50 | 0.75 | 0.02 | FALSE |
4 | GTEx | Esophagus Gastroesophageal Junction | RP11-181G12.2 | 0.16 | 0.02 | enet | 18 | 0.01 | 1.1e-01 | 7.7 | 7.9 | 2.6e-15 | 0.79 | 0.03 | 0.70 | TRUE |
5 | GTEx | Esophagus Muscularis | RP11-181G12.2 | 0.23 | 0.14 | lasso | 4 | 0.19 | 1.0e-11 | 6.9 | 7.1 | 1.0e-12 | 0.71 | 0.63 | 0.37 | FALSE |
6 | GTEx | Lung | AL590822.2 | 0.09 | 0.00 | lasso | 3 | 0.00 | 2.0e-01 | 6.3 | 7.1 | 1.2e-12 | 0.82 | 0.03 | 0.72 | FALSE |
7 | GTEx | Muscle Skeletal | C1orf86 | 0.20 | 0.16 | lasso | 4 | 0.15 | 8.0e-15 | -5.5 | -5.5 | 4.2e-08 | -0.51 | 1.00 | 0.00 | FALSE |
8 | GTEx | Muscle Skeletal | RP11-181G12.2 | 0.12 | 0.13 | enet | 8 | 0.14 | 7.6e-14 | -5.5 | 5.9 | 2.9e-09 | 0.53 | 1.00 | 0.00 | FALSE |
9 | GTEx | Nerve Tibial | RP11-181G12.2 | 0.24 | 0.22 | lasso | 5 | 0.21 | 3.7e-15 | -5.5 | 5.8 | 5.5e-09 | 0.51 | 1.00 | 0.00 | FALSE |
10 | GTEx | Thyroid | PRKCZ | 0.16 | 0.03 | lasso | 4 | 0.08 | 1.9e-06 | -4.7 | -5.7 | 1.4e-08 | -0.65 | 0.27 | 0.07 | FALSE |
11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C1orf86 | 0.03 | 0.02 | blup | 49 | 0.01 | 1.3e-02 | 7.7 | 6.8 | 7.7e-12 | 0.62 | 0.06 | 0.42 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C1orf86 | 0.04 | 0.02 | lasso | 5 | 0.02 | 1.5e-03 | 7.8 | 6.2 | 4.3e-10 | 0.55 | 0.05 | 0.25 | FALSE |