TWAS hub - PRKCZ

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Ovary	0.363	0.116	0.00035	-0.007	NA	-0.003	NA	0.004	0.50000	NA	3.9e-01	NA	2.5e-01
2	GTEx	Thyroid	0.163	0.070	0.00420	0.035	NA	0.068	NA	0.076	0.00100	NA	6.2e-06	NA	1.9e-06
3	TCGA	Thyroid Carcinoma	0.118	0.048	0.00017	0.035	0.016	0.016	NA	0.003	0.00024	0.0093	9.0e-03	NA	1.5e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Illnesses of mother	9.4	11.7	15.8	-3.2	-4.0	-3.0
Heart disease (mother)	6.4	7.8	12.6	2.2	3.5	2.5
Alcohol drinker status: Never	6.1	7.3	12.2	-1.9	2.4	3.5
Commuting to job workplace: Car/motor vehicle	5.8	6.7	10.6	1.3	2.8	3.3
Illnesses of father: Heart disease	4.5	6.3	10.6	1.7	3.3	2.3
Gout (self-reported)	4.4	6.0	9.1	0.8	-3.0	-2.9
High blood pressure (siblings)	3.7	5.3	10.2	0.2	3.2	2.4
High blood pressure (mother)	3.6	5.1	9.7	3.1	2.0	1.3
Father’s age at death	3.5	4.8	8.0	-1.8	-2.8	-1.7
Supplements: Vitamin C	3.5	4.1	11.8	-3.4	0.3	0.7
Illnesses of father: None of the above (group 1)	3.5	4.3	5.9	-1.2	-2.4	-2.4
Forced expiratory volume in 1-second (FEV1), predicted	3.2	6.6	9.4	-3.1	-2.8	-1.6
Illnesses of siblings	3.0	4.2	6.8	-0.7	-2.6	-2.3
Peak expiratory flow (PEF)	3.0	7.0	10.6	0.8	-3.3	-3.1
Leg fat-free mass (right)	3.0	15.9	27.6	-2.8	-5.2	-3.5
Leg predicted mass (right)	3.0	16.2	28.1	-2.8	-5.3	-3.6
Height	2.9	55.0	95.3	-3.1	-9.8	-7.7
Length of working week for main job	2.9	3.2	9.5	3.1	-0.1	0.0
Angina (self-reported)	2.9	3.8	6.3	2.5	1.9	1.2
Eye problems/disorders: Diabetes related eye disease	2.8	3.1	5.2	-0.2	2.0	2.3
Angina	2.8	3.7	6.0	2.4	1.9	1.2
Blood Platelet Count	2.7	31.5	73.3	3.3	8.6	3.3
Leg fat-free mass (left)	2.7	14.3	26.5	-2.4	-5.2	-3.2
Leg predicted mass (left)	2.7	14.3	26.6	-2.4	-5.2	-3.2
Whole body water mass	2.7	15.2	26.9	-3.1	-5.2	-3.0
Bilateral oophorectomy (both ovaries removed)	2.6	3.0	5.2	-1.1	-1.6	-2.3
Prospective memory result	2.6	3.2	4.1	-2.0	-1.9	-1.4
Whole body fat-free mass	2.6	14.9	26.2	-3.1	-5.1	-3.0
Cardiovascular Disease	2.5	8.1	16.7	4.1	2.0	1.9
Number of children fathered	2.5	2.8	8.1	2.9	0.6	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.5	3.0	4.0	1.2	-2.0	-1.8
Systolic Blood Pressure	2.4	12.2	28.3	5.3	2.2	1.8
Trunk fat-free mass	2.4	13.8	24.1	-3.3	-4.9	-2.6
Trunk predicted mass	2.4	13.7	23.8	-3.3	-4.9	-2.6
Reaction Time	2.3	4.3	7.8	-1.0	-2.0	-2.8
Ulcerative Colitis	2.3	3.4	4.1	-2.0	-1.6	-1.9
Impedance of leg (left)	2.3	11.2	17.9	2.7	4.2	2.9
Health satisfaction	2.3	2.9	6.8	-0.2	2.6	1.4
Impedance of leg (right)	2.2	10.6	15.1	2.7	3.9	3.1
Medication: Allopurinol	2.2	3.0	4.7	-0.4	-2.0	-2.2
Basal metabolic rate	2.2	12.0	22.5	-2.5	-4.7	-2.7
Vascular/heart problems diagnosed by doctor	2.2	6.0	12.4	-3.5	-1.8	-1.6
Hypertension (Self-reported)	2.1	5.8	12.2	3.5	1.9	1.3
Crohns Disease (2012)	2.0	3.3	6.1	0.1	-1.9	-2.5
High blood pressure	2.0	5.7	11.9	3.5	1.8	1.4
Medication: Blood pressure	2.0	3.5	6.0	1.0	2.5	1.9
Medication: Blood pressure	2.0	3.9	9.8	3.1	0.8	1.1
Risk taking	2.0	3.0	4.2	-1.8	-1.3	-2.0
Age started oral contraceptive pill	2.0	2.4	6.2	2.5	0.8	0.7
Commuting to job workplace: Cycle	2.0	2.4	4.1	-0.3	-1.8	-2.0
Serious illness, injury or assault to yourself	1.9	2.3	3.3	1.2	1.8	1.5
Exposure to tobacco smoke outside home	1.9	2.6	3.8	1.1	1.9	1.7
Had major operations	1.9	2.2	3.7	-1.9	-1.5	-0.7
Systolic blood pressure, automated reading	1.8	5.2	13.5	3.7	1.3	0.7
Worrier / anxious feelings	1.8	3.4	8.4	-2.9	-1.0	1.0
Forced expiratory volume in 1-second (FEV1)	1.8	6.0	11.5	0.5	-3.4	-2.5
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	4.6	2.1	0.7	0.8
Osteoporosis (self-reported)	1.8	2.3	6.1	2.5	0.1	-0.9
Arm fat-free mass (left)	1.8	9.1	17.1	-2.4	-4.1	-2.1
Fractured/broken bones in last 5 years	1.8	2.3	3.8	1.9	1.5	0.9
Sitting height	1.7	12.0	24.9	-0.9	-5.0	-3.2
Standing height	1.7	17.0	32.1	-2.2	-5.7	-3.8
Arm fat-free mass (right)	1.7	8.7	16.7	-2.1	-4.1	-2.2
Alcohol intake frequency.	1.7	4.0	5.8	-1.9	1.6	2.4
Loneliness, isolation	1.7	2.4	3.0	-1.5	-1.4	-1.7
Arm predicted mass (left)	1.7	8.5	16.9	-2.1	-4.1	-2.0
Crohns Disease (2017)	1.6	3.6	6.8	1.1	-1.7	-2.6
Blood Eosinophil Count	1.6	12.6	34.3	-5.9	-1.7	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.0	10.2	-0.2	-3.2	-2.2
Exposure to tobacco smoke at home	1.6	1.8	3.1	1.8	1.3	0.7
Forced vital capacity (FVC), Best measure	1.6	5.9	11.8	-1.5	-3.4	-1.9
Comparative body size at age 10	1.6	4.5	6.4	-1.4	-2.5	-2.3
Arm predicted mass (right)	1.6	8.2	15.7	-2.0	-4.0	-2.2
Financial situation satisfaction	1.6	2.0	2.8	1.5	1.7	1.0
Smoking Status	1.5	3.5	6.6	0.3	2.0	2.6
Sensitivity / hurt feelings	1.5	2.5	3.7	-1.7	-1.9	-0.9
Diabetes (mother)	1.5	1.9	4.2	2.0	0.8	0.9
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	4.5	-0.6	-2.1	-1.6
Friendships satisfaction	1.5	1.8	2.7	0.7	1.5	1.6
Ever taken oral contraceptive pill	1.5	1.7	3.6	0.8	-0.9	-1.9
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	4.8	-0.7	1.1	2.2
Breastfed as a baby	1.4	1.7	2.2	-1.5	-1.3	-1.1
Birth weight of first child	1.4	2.6	7.0	-2.6	0.7	0.5
Illnesses of siblings: Diabetes	1.4	1.7	4.6	2.1	-0.5	-0.4
Medication for cholesterol	1.4	2.1	6.3	-2.5	-0.3	-0.2
Hearing aid user	1.4	1.6	4.3	2.1	0.6	0.4
Number of operations (self-reported)	1.4	2.0	4.5	-2.1	-0.8	-1.0
Stomach or abdominal pain in last month	1.3	1.6	3.8	-0.3	-2.0	-0.9
Forced vital capacity (FVC)	1.3	5.2	11.4	-0.2	-3.4	-2.0
Mean time to correctly identify matches	1.3	2.6	5.0	-0.5	-1.6	-2.2
Number of full sisters	1.3	1.6	4.6	2.1	0.3	0.2
Worry (Nagel 2018)	1.2	2.6	5.0	-1.7	-0.2	2.2
Ulcerative Colitis (UC)	1.2	2.2	3.6	-1.1	-1.4	-1.9
Lupus	1.2	1.8	3.2	1.8	1.1	1.0
Current tobacco smoking	1.2	1.9	3.4	-0.5	1.4	1.8
Comparative height size at age 10	1.2	6.5	13.2	-1.3	-3.6	-2.2
Knee pain experienced in last month	1.2	1.9	2.8	-1.3	-1.0	-1.7
Supplements: Fish oil (including cod liver oil)	1.2	1.5	2.1	-1.4	1.4	0.8
Cholesterol lowering medication	1.2	1.7	5.1	2.2	-0.0	-0.4
Irritable Bowel Disease (IBD)	1.1	2.7	5.6	0.3	-1.5	-2.4
Schizophrenia (2014)	1.1	2.5	2.9	-1.4	1.7	1.6
Townsend deprivation index at recruitment	1.1	1.5	2.9	-1.1	-1.7	-0.7
Number of live births	1.1	1.6	1.9	1.3	1.0	1.4
Glaucoma (self-reported)	1.1	1.3	3.0	1.7	0.8	0.6
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.0	-0.1	1.3	1.4
Leg fat percentage (right)	1.1	4.0	4.8	2.0	1.8	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.3	1.8	0.4	-0.5
Impedance of whole body	1.1	5.8	8.3	2.9	2.8	1.2
Mean Putamen Volume	1.0	1.1	2.4	0.8	0.6	1.6
Rheumatoid Arthritis	1.0	1.4	2.2	1.0	-1.0	-1.5
Blood Red Count	1.0	9.3	13.8	-2.1	-3.7	-3.1
Waist Hip Ratio (WHR)	1.0	4.5	13.2	3.6	0.5	-0.1
Average weekly spirits intake	1.0	1.2	2.4	0.2	1.1	1.6
Qualifications: CSEs or equivalent	1.0	1.3	3.8	1.9	0.1	0.2
Neuroticism score	1.0	2.2	3.7	-1.9	-1.7	0.1
Qualifications: College or University degree	1.0	3.1	4.5	-2.0	2.1	0.9
Chest pain or discomfort	1.0	1.4	2.7	1.2	-1.6	-0.2
Guilty feelings	1.0	1.5	2.3	-0.9	-1.5	-1.2
Mother’s age at death	1.0	1.3	1.6	-1.2	1.3	0.9
Leg fat percentage (left)	1.0	3.5	3.8	1.9	1.8	2.0
Myopia	1.0	1.4	2.3	-1.5	-1.1	-0.8
Heart disease (siblings)	1.0	1.2	1.8	0.8	1.1	1.4
Pack years of smoking	1.0	1.4	2.9	0.4	1.1	1.7
Alzheimer’s Disease (in mother)	0.9	1.0	3.0	1.7	-0.3	0.1
HbA1C	0.9	1.0	1.6	0.6	1.3	1.0
Hypothyroidism (self reported)	0.9	2.0	3.2	1.1	1.3	1.8
Vitamin and mineral supplements	0.9	1.2	2.4	1.5	-1.1	-0.3
Hand grip strength (right)	0.9	2.3	4.5	-1.6	-2.1	-0.3
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	1.6	-0.6	1.2	1.2
Number of incorrect matches in round	0.9	1.5	3.4	-1.8	-0.1	1.0
Weight	0.9	4.4	9.8	-0.7	-3.1	-1.7
Noisy workplace	0.9	1.2	3.2	1.8	0.5	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	2.0	-1.4	-0.9	-0.7
Tense / ‘highly strung’	0.9	1.5	2.3	-1.4	-0.2	1.5
Medication for pain relief, constipation, heartburn	0.9	1.5	2.2	-1.0	-1.1	-1.5
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.0	0.2	-1.2	-1.4
Average weekly champagne plus white wine intake	0.9	1.3	2.3	-0.2	-1.5	-1.2
Eye problems/disorders: Glaucoma	0.9	1.1	2.9	1.7	0.5	0.4
Irritability	0.9	1.5	2.7	-1.6	-0.9	1.0
Neuroticism (Nagel 2018)	0.8	1.8	3.1	-1.8	-0.7	1.4
Heart attack	0.8	1.0	2.9	1.7	0.4	-0.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	1.8	0.3	-1.1	-1.3
Falls in the last year	0.8	1.0	2.2	1.5	-0.0	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.9	-1.4	-0.9	-0.7
Loud music exposure frequency	0.8	0.9	1.3	1.0	-0.6	-1.1
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	2.9	1.7	0.5	0.3
Migraine (self-reported)	0.8	1.0	1.4	-0.5	1.2	1.2
Overall health rating	0.8	1.7	3.5	0.5	1.1	1.9
Medication: Atorvastatin	0.8	1.0	2.3	1.5	0.8	0.4
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.9	1.7	0.4	-0.2
Fasting Glucose	0.7	0.8	1.0	0.7	-1.0	-1.0
Hearing difficulty/problems: Yes	0.7	1.1	1.8	1.4	1.1	0.5
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.6	0.4	1.3	0.9
Diabetes (father)	0.7	0.9	1.5	0.7	0.8	1.2
Pack years adult smoking proportion	0.7	1.0	2.0	0.1	1.0	1.4
Maternal smoking around birth	0.7	1.0	1.5	1.2	1.2	-0.2
Supplements: Glucosamine	0.7	0.9	1.5	-1.2	-0.5	-0.9
Qualifications: None of the above	0.7	1.5	2.7	0.8	-1.6	-1.2
Mouth/teeth dental problems	0.7	1.0	1.7	-0.9	-0.7	-1.3
Mouth/teeth dental problems: Loose teeth	0.7	0.9	1.9	1.4	0.3	-0.8
Emphysema/chronic bronchitis	0.7	0.8	1.0	1.0	1.0	0.7
Commuting to job workplace: Walk	0.7	0.8	1.3	0.6	-1.1	-0.8
Mineral and other dietary supplements	0.7	0.9	2.4	1.6	-0.1	0.7
Medication: Lisinopril	0.7	0.9	1.0	-0.8	-1.0	-0.9
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.3	-0.8	-0.7	-1.1
Schizophrenia vs Biploar Disorder	0.6	0.8	1.9	1.4	0.8	0.0
Prostate Cancer	0.6	0.8	1.4	0.8	0.7	1.2
Chronotype (morning person)	0.6	1.5	2.5	0.2	1.4	1.6
Severe depression (siblings)	0.6	0.7	1.0	1.0	0.5	0.9
Medication: Levothyroxine sodium	0.6	1.1	2.1	0.8	0.7	1.4
Hearing difficulty/problems with background noise	0.6	1.0	1.2	1.1	0.9	1.1
Had menopause	0.6	0.7	1.4	-0.6	1.2	0.7
Mouth/teeth dental problems: Dentures	0.6	1.1	1.5	1.2	0.7	1.1
Pulse rate, automated reading	0.6	1.9	3.8	-2.0	1.2	0.7
Breast cancer (self-reported)	0.6	0.8	2.0	0.0	1.4	0.5
Smoking status: Current	0.6	1.0	2.1	-0.4	0.9	1.4
High cholesterol (Self-reported)	0.6	1.0	2.7	0.4	1.6	0.6
Medication: Bendroflumethiazide	0.6	0.9	1.2	1.1	0.7	1.0
Average weekly beer plus cider intake	0.6	0.9	1.7	1.3	-0.6	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	0.8	0.8	0.8	0.9
Schizophrenia (2018)	0.5	1.0	1.8	-0.6	1.4	0.9
Breast Cancer	0.5	1.1	2.8	-0.7	-1.7	-0.3
Neuroticism	0.5	1.3	2.5	-1.6	-0.8	0.9
Hand grip strength (left)	0.5	1.3	3.3	-0.8	-1.8	-0.1
Frequency of depressed mood in last 2 weeks	0.5	0.8	1.1	-1.0	-1.0	-0.5
Ever had hysterectomy (womb removed)	0.5	0.5	1.3	-0.5	1.1	0.2
Age when periods started (menarche)	0.5	1.2	2.5	0.9	-1.6	-0.5
Hair/balding pattern: Pattern 2	0.5	0.6	1.2	-1.1	-0.6	-0.5
Had other major operations	0.5	0.6	1.1	-1.0	-0.5	-0.8
Pain all over the body in last month	0.5	0.5	1.4	1.2	0.0	0.5
Medication: Ramipril	0.5	0.7	1.3	0.6	0.7	1.1
Hair/balding pattern: Pattern 3	0.5	0.8	1.7	0.6	-1.3	-0.5
Depression (self-reported)	0.5	0.5	1.1	0.0	0.7	1.0
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.4	0.2	0.7	1.2
Medication: Amlodipine	0.5	0.8	1.5	0.9	1.2	0.2
Age at last live birth	0.5	0.7	1.1	1.0	0.7	0.7
Leg pain on walking	0.5	0.6	1.7	-1.3	0.0	-0.2
Qualifications: nursing, teaching	0.5	0.7	1.9	0.2	1.4	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.5	0.5	-1.6	-0.6
Medication: Paracetamol	0.5	0.7	1.1	1.0	0.3	1.1
Alcohol drinker status: Previous	0.5	0.6	1.0	0.4	1.0	0.7
Bipolar Disorder or Schizophrenia	0.4	1.1	1.5	-1.2	1.2	0.6
Depressed Affect (Nagel 2018)	0.4	0.8	1.7	-1.3	-0.5	0.6
Ovarian Cancer	0.4	0.6	1.2	-0.4	-0.6	-1.1
Heel T-Score	0.4	3.3	4.4	-1.7	-2.1	-1.6
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.3	0.3	0.9	1.2
Fed-up feelings	0.4	0.7	1.6	0.1	-1.2	-0.7
Nervous feelings	0.4	0.7	1.8	0.6	-0.3	1.3
Medication: Simvastatin	0.4	0.6	1.3	0.0	1.1	0.7
Hip circumference	0.4	1.9	4.4	-0.9	-2.1	-0.5
Alcohol intake versus 10 years previously	0.4	0.6	1.7	1.3	0.3	-0.2
Pulse wave Arterial Stiffness index	0.4	0.4	0.7	0.5	-0.8	-0.6
Impedance of arm (left)	0.4	2.0	3.6	1.9	1.5	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.3	-1.1	-0.6	-0.1
Body fat percentage	0.4	1.5	4.3	2.1	0.4	0.4
Medication: Omeprazole	0.4	0.5	0.6	0.6	0.7	0.8
Suffer from ‘nerves’	0.4	0.7	1.9	0.1	-0.3	1.4
Medication: Aspirin	0.4	0.5	1.3	1.1	0.4	0.0
Average weekly red wine intake	0.4	0.7	1.0	0.3	1.0	0.9
Mood swings	0.4	0.8	1.9	-1.4	-0.7	0.4
Eye problems/disorders: Cataract	0.4	0.4	1.2	-1.1	-0.1	0.2
Pain experienced in last month	0.4	0.6	1.8	0.2	1.4	-0.0
Bipolar Disorder (2018)	0.3	0.5	1.3	-1.1	0.3	-0.2
Alzheimer’s Disease (in father)	0.3	0.3	0.5	0.2	0.6	0.7
Alzheimer’s Disease (including proxy)	0.3	0.4	1.1	1.0	-0.0	0.2
Lung FVC	0.3	1.4	2.6	1.1	0.4	1.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.6	-0.8	-0.6	0.4
Medication: Co-codamol	0.3	0.3	0.8	-0.9	-0.2	-0.3
Trunk fat percentage	0.3	1.3	3.8	1.9	-0.3	-0.3
Multivitamins +/- minerals	0.3	0.4	0.9	0.0	0.9	0.5
Chronic bronchitis/emphysema (father)	0.3	0.4	0.5	-0.6	-0.7	0.5
Trunk fat mass	0.3	1.4	2.5	1.0	-1.6	-0.9
Past tobacco smoking	0.3	0.5	0.8	-0.7	-0.6	-0.9
Diabetes (self-reported)	0.3	0.4	0.9	0.4	0.4	1.0
Impedance of arm (right)	0.3	1.3	2.3	1.5	1.2	0.4
Qualifications: A levels/AS levels or equivalent	0.3	0.8	1.5	-0.6	1.2	0.6
Medication: Cholesterol lowering	0.3	0.4	1.0	0.4	1.0	0.2
Medication: Lansoprazole	0.3	0.3	0.9	0.2	-0.9	-0.3
Lung cancer (father)	0.3	0.3	0.5	-0.7	0.3	0.6
Pulse wave reflection index	0.3	0.4	0.5	-0.4	-0.7	-0.7
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	0.9	-0.3	0.9	-0.5
Headache pain in last month	0.3	0.4	1.1	-0.3	0.3	1.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.1	0.6	0.2	1.0
Birth weight	0.3	0.6	1.2	-0.2	-0.7	-1.1
Number of full brothers	0.3	0.4	0.7	-0.7	-0.9	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.9	-0.4	0.4	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.7	-0.8	-0.6	-0.2
Pulse wave peak to peak time	0.3	0.3	0.6	-0.3	0.8	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.8	-0.4	0.9	0.3
Smoking status: Previous	0.3	0.5	0.8	0.4	0.9	0.7
Osteoarthritis (self-reported)	0.3	0.4	0.4	-0.7	-0.6	-0.6
Medication: Aspirin	0.3	0.4	1.1	1.1	0.3	-0.1
Wears glasses or contact lenses	0.3	0.3	0.5	-0.7	0.2	0.7
Illnesses of father: High blood pressure	0.3	0.4	0.5	-0.7	0.5	0.7
Ever smoked	0.3	0.6	1.5	-0.0	0.6	1.2
Diastolic blood pressure, automated reading	0.3	1.0	1.7	0.9	1.3	0.7
Unable to work because of sickness or disability	0.3	0.4	0.9	1.0	0.2	-0.4
Depression (Nagel 2018)	0.2	0.3	0.5	-0.7	-0.6	0.3
Age at First Birth	0.2	0.3	0.4	-0.6	0.6	0.4
Neuroticism (2016)	0.2	0.2	0.5	-0.3	0.1	0.7
Primary Biliary Cirrhosis	0.2	0.4	0.5	0.5	-0.7	-0.6
BMI	0.2	1.0	1.5	-1.1	-1.2	-0.4
Lung FEV1/FVC ratio	0.2	0.8	1.0	1.0	0.6	-1.0
Medication for hormone replacement therapy	0.2	0.2	0.3	-0.5	0.4	-0.5
Average weekly fortified wine intake	0.2	0.2	0.4	-0.2	-0.6	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.9	-0.2	-1.0	-0.7
Medication: Atenolol	0.2	0.3	0.3	-0.6	-0.5	0.5
Waist circumference	0.2	0.7	1.3	0.9	-1.1	-0.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.6	-0.8	-0.1	0.3
Fluid intelligence score	0.2	0.5	0.8	-0.9	0.6	0.5
Happiness	0.2	0.3	0.5	-0.7	0.4	0.5
Wheeze or whistling in the chest in last year	0.2	0.4	0.5	-0.7	-0.5	0.6
Shortness of breath walking on level ground	0.2	0.2	0.5	0.3	-0.7	0.1
Neck or shoulder pain in last month	0.2	0.3	0.7	0.4	0.4	0.8
Medication: Ibuprofen	0.2	0.2	0.6	-0.8	0.2	0.1
Whole body fat mass	0.2	0.8	1.5	0.9	-1.2	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.3	0.4	-0.4	0.5
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.7	-0.8	0.1	-0.0
Ever had bowel cancer screening	0.2	0.2	0.3	0.5	-0.4	-0.3
Back pain experienced in last month	0.2	0.3	0.7	0.8	-0.5	0.2
Medication: Gliclazide	0.2	0.3	0.5	-0.7	-0.4	0.4
Arm fat mass (left)	0.2	0.7	1.8	0.2	-1.4	-0.6
Miserableness	0.2	0.4	0.7	-0.2	-0.9	0.7
Ever depressed for a whole week	0.2	0.2	0.5	-0.4	0.3	0.7
Supplements: Calcium	0.2	0.2	0.5	-0.7	0.4	-0.0
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	-0.8	0.1	-0.2
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.8	0.4	-0.6	-0.9
Blood White Count	0.1	1.1	2.5	0.6	1.6	0.6
Allergy or Eczema	0.1	0.1	0.3	-0.2	0.3	0.6
Respiratory disease	0.1	0.2	0.4	-0.3	-0.6	-0.5
Tanning	0.1	0.8	2.4	1.5	-0.1	-0.1
Number of treatments/medications taken	0.1	0.1	0.2	-0.1	0.5	0.3
Relative age of first facial hair	0.1	0.1	0.2	0.5	0.2	-0.2
Supplements: Zinc	0.1	0.1	0.3	-0.6	-0.4	0.0
Medication: Metformin	0.1	0.1	0.1	-0.0	-0.3	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.3	-0.5	-0.4	0.2
Relative age voice broke	0.1	0.1	0.2	0.3	-0.3	0.4
Taking other prescription medications	0.1	0.2	0.3	-0.5	-0.5	-0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	-0.0	-0.2	-0.6
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.7	0.3	0.0	0.8
Body mass index (BMI)	0.1	0.2	0.7	0.2	-0.8	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.4	-0.3	-0.6	-0.4
Financial difficulties in last 2 years	0.1	0.1	0.2	-0.2	0.5	-0.2
Arm fat percentage (right)	0.1	0.5	1.1	1.1	0.2	0.5
Time employed in main current job	0.1	0.1	0.3	-0.1	-0.3	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.7	-0.2	0.4
Pulse rate	0.1	0.2	0.6	-0.8	0.2	-0.1
Asthma	0.1	0.1	0.2	-0.3	-0.4	-0.3
Arm fat mass (right)	0.1	0.6	1.5	-0.0	-1.2	-0.4
Hair/balding pattern: Pattern 4	0.1	0.2	0.4	0.2	0.6	0.5
Blood clot in the leg (DVT)	0.1	0.2	0.3	-0.4	-0.5	-0.2
Medication: Paracetamol	0.1	0.2	0.2	0.4	-0.3	0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.1	-0.1	-0.3	0.4
Worry too long after embarrassment	0.1	0.2	0.3	0.3	-0.5	-0.5
Age at first live birth	0.1	0.3	0.5	-0.1	-0.5	-0.7
Leg fat mass (right)	0.1	0.5	1.0	1.0	-0.4	0.5
Family relationship satisfaction	0.1	0.1	0.2	-0.5	-0.1	0.0
Arm fat percentage (left)	0.1	0.5	1.3	1.1	0.3	0.3
Long-standing illness, disability or infirmity	0.1	0.2	0.5	0.1	0.1	0.7
Diabetes diagnosed by doctor	0.1	0.2	0.5	-0.3	0.0	0.7
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.3	-0.5	-0.4	0.0
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	0.6	0.3	0.5
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	0.0	-0.0	-0.5
Commuting to job workplace: Public transport	0.1	0.1	0.2	0.4	0.2	-0.2
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.4	0.0	-0.7	0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.3	-0.4	-0.5	-0.3
Leg fat mass (left)	0.1	0.4	0.8	0.9	-0.4	0.4
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.2	-0.2	-0.4	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.5	1.3	1.1	-0.5	-0.4
Alcohol usually taken with meals	0.0	0.0	0.0	0.2	0.2	-0.1
Allergy	0.0	0.1	0.1	0.2	0.4	-0.2
Eye problems/disorders: None of the above	0.0	0.0	0.0	-0.0	-0.1	0.2
Medication: Seretide 50 evohaler	0.0	0.0	0.0	-0.0	-0.1	0.2
Asthma (self-reported)	0.0	0.1	0.1	-0.2	-0.3	-0.2

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Trait associations