TWAS hub - RER1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.057	0.0230	0.0050	-0.002	0.013	0.001	0.012	-0.002	0.9800	0.0081	0.2100	0.010	0.6200
2	GTEx	Testis	0.243	0.0780	0.0037	0.051	NA	0.041	NA	0.060	0.0026	NA	0.0064	NA	0.0012
3	YFS	Blood	0.014	0.0074	0.0160	-0.001	0.003	-0.001	0.004	-0.001	0.8400	0.0200	0.9600	0.017	0.9400

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Alcohol drinker status: Never	4.1	5.0	8.2	-1.6	-2.9	2.0
Hearing aid user	4.0	4.6	11.8	1.1	3.4	-0.9
Supplements: Fish oil (including cod liver oil)	3.7	4.8	9.4	0.9	2.1	-3.1
Glaucoma (self-reported)	3.4	3.9	8.1	2.8	1.6	-1.1
Length of working week for main job	3.3	3.7	10.0	3.2	0.3	-0.9
Age started oral contraceptive pill	3.3	4.1	10.6	3.2	0.4	-1.2
Sensitivity / hurt feelings	3.0	5.2	15.4	-3.9	0.2	0.3
Exposure to tobacco smoke outside home	3.0	4.0	5.5	1.6	2.0	-2.3
Bipolar Disorder or Schizophrenia	2.9	7.2	11.1	1.4	-2.9	-3.3
Hearing difficulty/problems: Yes	2.9	4.5	6.7	2.1	1.6	-2.6
Prospective memory result	2.9	3.6	8.2	-2.9	-1.5	-0.6
Schizophrenia (2018)	2.8	5.8	11.2	1.9	-1.6	-3.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.8	3.3	5.2	2.2	-2.3	-0.1
Serious illness, injury or assault of a close relative in last 2 years	2.7	3.1	7.7	-1.3	0.1	2.8
Average weekly fortified wine intake	2.6	3.1	4.5	2.1	1.8	-1.2
Eye problems/disorders: Glaucoma	2.5	3.0	6.3	2.5	1.5	-0.5
Pain all over the body in last month	2.4	2.5	5.0	-0.5	-1.5	-2.2
Pulse wave reflection index	2.4	3.0	7.4	0.4	2.7	-1.2
Health satisfaction	2.4	3.1	5.4	0.9	-2.3	-1.7
Had major operations	2.4	2.8	6.8	-2.6	0.6	-1.2
Average weekly spirits intake	2.2	2.7	7.2	1.0	2.7	0.1
Trunk predicted mass	2.2	12.3	31.7	-5.6	-0.2	2.3
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.5	11.6	-3.4	-1.3	0.4
Mineral and other dietary supplements	2.2	2.9	5.3	-0.4	-1.8	2.3
Trunk fat-free mass	2.1	12.3	31.6	-5.6	-0.2	2.3
Standing height	2.1	20.7	41.2	-6.4	-3.1	3.4
Medication: Allopurinol	2.1	2.8	6.4	-2.5	1.1	0.9
Whole body fat-free mass	2.1	11.9	31.4	-5.6	-0.3	2.0
Whole body water mass	2.1	11.9	31.1	-5.6	-0.2	2.1
Fractured/broken bones in last 5 years	2.1	2.8	5.8	2.4	-0.3	-1.6
Ever used hormone-replacement therapy (HRT)	2.0	2.5	4.7	2.2	1.1	-1.2
Breast cancer (self-reported)	2.0	2.4	5.8	-0.5	-2.4	1.1
Rheumatoid Arthritis	1.9	2.7	4.8	1.8	0.1	2.2
Height	1.9	36.5	77.8	-8.8	-4.0	4.0
Diabetes (mother)	1.9	2.5	5.9	1.2	2.4	0.0
Pulse rate	1.9	3.2	5.7	-1.4	-2.4	1.4
Chronic bronchitis/emphysema (mother)	1.9	2.2	6.5	-0.2	0.1	-2.5
Alcohol intake frequency.	1.9	4.4	7.4	-2.7	-2.3	0.8
Leg fat-free mass (right)	1.9	10.4	26.6	-5.2	-0.9	1.9
Leg predicted mass (right)	1.9	10.1	26.1	-5.1	-0.9	1.9
Supplements: Calcium	1.9	2.1	5.9	0.5	2.4	0.5
Schizophrenia (2014)	1.8	4.0	7.6	1.8	-1.0	-2.8
Hearing difficulty/problems with background noise	1.8	2.8	4.4	2.1	0.9	-1.8
Arm fat-free mass (right)	1.8	9.4	26.4	-5.1	-0.2	1.4
Mouth/teeth dental problems: Loose teeth	1.8	2.2	5.6	-0.8	-2.4	0.6
Illnesses of father: Heart disease	1.8	2.5	4.2	2.1	0.2	-1.8
Ever had prostate specific antigen (PSA) test	1.8	2.1	3.0	-1.5	-1.7	1.0
Bipolar Disorder (2018)	1.7	2.7	7.0	-0.2	-2.6	-1.1
Angina	1.7	2.2	3.6	1.7	0.4	-1.9
Leg fat-free mass (left)	1.7	8.9	22.8	-4.8	-0.4	1.9
Fed-up feelings	1.7	3.1	3.4	-1.7	1.7	1.9
Father’s age at death	1.7	2.3	4.4	1.4	2.1	-0.9
Worrier / anxious feelings	1.7	3.1	6.5	-1.6	2.5	0.7
Basal metabolic rate	1.7	9.6	26.3	-5.1	-0.4	1.5
Arm predicted mass (left)	1.7	8.4	24.4	-4.9	-0.2	0.9
Ulcerative Colitis (UC)	1.6	2.9	5.3	2.3	1.1	1.5
Age at First Birth	1.6	2.3	5.2	2.3	1.3	0.3
Ulcerative Colitis	1.6	2.4	6.6	-0.1	0.7	2.6
Leg predicted mass (left)	1.6	8.7	21.9	-4.7	-0.4	2.0
Falls in the last year	1.6	2.2	4.0	1.3	0.9	-2.0
Angina (self-reported)	1.6	2.1	4.1	1.5	0.2	-2.0
Arm predicted mass (right)	1.6	8.2	23.6	-4.9	-0.2	1.0
Arm fat-free mass (left)	1.6	8.0	22.9	-4.8	-0.1	1.1
Irritability	1.6	2.7	5.8	-2.4	1.3	0.8
Irritable Bowel Disease (IBD)	1.5	3.5	4.2	2.0	1.6	1.9
Bilateral oophorectomy (both ovaries removed)	1.5	1.8	3.6	-1.3	1.9	0.2
Time employed in main current job	1.5	1.7	5.0	0.0	-0.0	2.2
Systolic Blood Pressure	1.4	6.8	17.6	4.2	-1.7	0.3
Frequency of depressed mood in last 2 weeks	1.4	2.0	5.3	-2.3	-0.1	0.9
Medication: Metformin	1.4	2.0	4.3	-0.3	2.1	1.3
Pack years adult smoking proportion	1.4	2.2	2.9	1.2	1.7	-1.5
Neuroticism score	1.4	3.0	6.6	-2.6	1.0	1.2
Number of children fathered	1.4	1.5	2.9	1.3	-0.1	-1.7
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	4.4	0.8	0.0	-2.1
Pack years of smoking	1.4	2.0	2.3	1.3	1.5	-1.4
Schizophrenia vs Biploar Disorder	1.3	1.8	2.3	0.9	1.5	-1.5
Systolic blood pressure, automated reading	1.3	3.8	10.8	3.3	0.5	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	2.9	-1.4	1.7	0.7
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	1.7	1.3	1.3	-0.8
Pulse wave peak to peak time	1.3	1.5	4.2	0.3	-2.0	0.3
Comparative height size at age 10	1.3	7.4	12.6	-3.5	-1.8	2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	2.0	1.4	1.2	1.0
Diabetes diagnosed by doctor	1.3	2.2	4.2	1.3	2.0	0.8
Back pain experienced in last month	1.3	2.0	4.8	2.2	1.0	-0.4
Medication: Blood pressure	1.3	2.5	5.3	2.3	0.2	-1.4
Sitting height	1.2	8.8	12.2	-3.2	-1.9	3.5
Number of incorrect matches in round	1.2	2.0	4.9	-2.2	0.9	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	2.9	-1.3	-1.7	0.0
Wears glasses or contact lenses	1.2	1.4	2.8	-1.7	0.5	-1.1
Cholesterol lowering medication	1.2	1.8	2.5	1.6	0.6	-1.6
Crohns Disease (2012)	1.1	1.7	3.7	1.1	0.4	1.9
Lung FEV1/FVC ratio	1.1	5.5	8.9	2.4	1.4	-3.0
Had menopause	1.1	1.4	3.1	1.8	0.9	-0.6
Forced vital capacity (FVC)	1.1	4.2	6.1	-2.0	-2.5	1.6
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	2.9	-1.7	-0.9	0.6
Noisy workplace	1.1	1.3	2.9	1.0	-0.2	-1.7
Illnesses of mother	1.1	1.4	3.9	-0.3	0.5	2.0
Pulse wave Arterial Stiffness index	1.1	1.2	3.4	-0.5	1.8	-0.2
Birth weight of first child	1.1	2.1	3.7	-1.4	-0.8	-1.9
Migraine (self-reported)	1.1	1.4	4.1	-0.2	2.0	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.1	-0.9	0.2	1.8
Ever had bowel cancer screening	1.1	1.3	3.4	0.3	0.7	-1.9
Medication: Gliclazide	1.1	1.3	2.9	0.9	1.7	-0.4
Guilty feelings	1.1	1.6	1.6	-1.3	-1.3	1.2
Myopia	1.1	1.6	3.8	-1.9	0.4	-0.9
Neuroticism (Nagel 2018)	1.0	2.5	6.8	-2.6	0.7	0.1
Reaction Time	1.0	1.9	5.4	0.5	2.3	0.4
Heel T-Score	1.0	8.2	23.6	1.0	4.9	-0.0
Smoking Status	1.0	2.3	3.0	1.7	1.0	-1.7
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.6	0.7	-0.1	1.9
Relative age voice broke	1.0	1.5	4.1	-0.3	0.6	-2.0
Exposure to tobacco smoke at home	1.0	1.1	2.0	0.5	-1.0	1.4
Tense / ‘highly strung’	1.0	1.6	3.3	-1.8	-0.5	1.1
Hair/balding pattern: Pattern 4	1.0	2.3	4.0	-2.0	-1.3	-1.1
Gout (self-reported)	1.0	1.3	2.5	-1.6	1.1	0.5
Chest pain or discomfort	1.0	1.5	3.5	0.6	1.9	0.7
Friendships satisfaction	1.0	1.3	2.6	0.9	0.6	-1.6
Smoking status: Current	1.0	1.6	2.1	1.4	1.2	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.0	4.2	1.1	-0.8	-2.1
HDL Cholesterol	0.9	1.4	2.6	1.3	0.3	-1.6
Supplements: Glucosamine	0.9	1.2	3.5	-0.4	0.1	-1.9
Medication: Simvastatin	0.9	1.4	3.7	-0.1	-1.9	-0.7
Fluid intelligence score	0.9	1.9	5.5	2.4	0.5	-0.2
Hair/balding pattern: Pattern 3	0.9	1.3	2.9	0.7	1.7	0.7
Medication: Amlodipine	0.9	1.3	3.4	-0.2	-1.8	0.7
Number of full brothers	0.9	1.1	2.9	-1.7	0.2	0.5
Mean time to correctly identify matches	0.9	1.8	5.1	-0.2	2.2	0.5
Average weekly red wine intake	0.9	1.3	2.4	1.6	-0.9	-0.7
High cholesterol (Self-reported)	0.9	1.5	3.4	0.6	-0.9	-1.8
Number of operations (self-reported)	0.9	1.3	3.8	-2.0	-0.2	-0.2
Crohns Disease (2017)	0.8	1.8	3.8	0.9	2.0	0.9
Blood Platelet Count	0.8	9.5	22.6	4.8	-1.7	-1.7
Waist Hip Ratio (WHR)	0.8	3.6	5.4	1.6	2.3	-1.7
Relative age of first facial hair	0.8	1.7	4.8	0.4	-0.3	-2.2
Age when periods started (menarche)	0.8	1.9	3.5	-1.9	1.3	0.8
Weight	0.8	3.8	11.3	-3.4	-0.3	-0.0
Alcohol intake versus 10 years previously	0.8	1.2	2.6	-0.9	-1.6	-0.5
Forced vital capacity (FVC), Best measure	0.8	2.8	4.5	-1.7	-2.1	1.0
Neck or shoulder pain in last month	0.8	1.2	1.9	1.4	1.2	-0.3
Mood swings	0.8	1.4	2.0	-1.4	1.4	0.3
Commuting to job workplace: Walk	0.8	0.8	1.4	1.0	0.4	-1.2
Osteoporosis (self-reported)	0.8	1.1	1.9	1.0	1.4	-0.6
Illnesses of father: None of the above (group 1)	0.8	1.0	2.4	-0.2	0.7	1.5
Leg fat percentage (left)	0.8	2.9	8.7	0.3	0.2	-2.9
Worry (Nagel 2018)	0.7	1.4	3.0	-1.7	1.0	-0.4
Prostate Cancer	0.7	1.0	1.6	0.4	-1.1	1.3
HbA1C	0.7	0.7	2.1	-0.0	-1.5	0.3
LDL Cholesterol	0.7	1.1	1.6	1.3	-1.3	-0.1
Lupus	0.7	1.0	2.1	0.2	-0.9	1.5
Allergy or Eczema	0.7	1.8	3.9	2.0	-0.8	0.9
Neuroticism	0.7	1.6	4.7	-2.2	0.5	-0.1
Current tobacco smoking	0.7	1.2	2.1	1.0	0.7	-1.4
Chronic bronchitis/emphysema (father)	0.7	0.8	2.1	0.0	0.6	-1.5
High blood pressure (mother)	0.7	1.0	2.2	1.5	0.4	-0.7
Impedance of leg (left)	0.7	3.2	4.0	1.9	-1.4	-2.0
Number of live births	0.7	1.1	2.4	0.7	1.5	0.5
Blood clot in the leg (DVT)	0.7	0.9	2.1	0.6	1.4	0.3
Leg fat percentage (right)	0.7	2.6	7.0	0.7	0.5	-2.6
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.1	-0.6	-1.0	-1.0
Emphysema/chronic bronchitis	0.7	0.7	1.5	0.2	-0.8	-1.2
Medication: Omeprazole	0.7	0.8	1.5	1.0	1.2	-0.0
Number of full sisters	0.7	0.9	1.8	0.7	0.5	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.4	-1.2	0.5	0.9
Knee pain experienced in last month	0.7	1.0	2.1	-0.7	1.4	-0.7
Illnesses of siblings: Diabetes	0.7	0.8	1.1	1.0	-1.0	0.7
Commuting to job workplace: Public transport	0.7	0.8	1.4	0.9	1.2	-0.6
Diastolic blood pressure, automated reading	0.7	2.3	4.3	2.1	0.3	-1.6
Commuting to job workplace: Cycle	0.7	0.9	2.0	-0.1	1.4	-0.8
Impedance of whole body	0.7	3.7	7.8	2.8	-1.5	-1.0
Depression (Nagel 2018)	0.6	0.8	2.4	-1.6	0.2	0.1
Intelligence (Savage-Jansen 2018)	0.6	1.8	4.3	2.1	1.0	0.3
Blood Eosinophil Count	0.6	4.6	9.4	-3.1	0.1	2.1
Lung FVC	0.6	2.8	7.8	2.8	-0.8	0.2
Number of treatments/medications taken	0.6	1.1	2.2	0.1	-1.1	1.5
Supplements: Zinc	0.6	0.6	1.1	-0.4	1.0	0.8
Diabetes (father)	0.6	0.7	0.8	0.7	0.8	-0.9
Impedance of leg (right)	0.6	2.9	6.0	2.5	-0.6	-1.5
Hand grip strength (right)	0.6	1.6	4.4	-2.1	0.2	0.7
Maternal smoking around birth	0.6	0.8	2.2	-0.1	0.4	-1.5
Medication: Levothyroxine sodium	0.6	1.0	2.9	0.5	0.2	1.7
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.7	-1.3	0.9	0.4
Mouth/teeth dental problems: Dentures	0.6	1.1	2.7	1.6	-0.6	-0.2
Headache pain in last month	0.6	1.1	2.3	-0.0	1.5	0.9
Medication for cholesterol, blood pressure or diabetes	0.6	1.1	3.1	0.2	1.8	-0.2
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	1.9	1.0	0.7	1.4
Birth weight	0.6	1.4	3.5	-0.6	-1.9	0.4
Worry too long after embarrassment	0.6	1.1	2.9	-1.7	0.5	-0.2
Medication: Seretide 50 evohaler	0.6	0.7	1.4	0.6	0.4	1.2
Heart disease (mother)	0.6	0.8	1.8	-0.3	-1.3	-0.7
Loneliness, isolation	0.6	0.8	1.6	-0.2	1.3	0.9
Miserableness	0.6	1.1	1.9	-0.9	0.7	1.4
Medication: Bendroflumethiazide	0.6	1.0	2.5	-0.5	-1.6	-0.3
Average weekly beer plus cider intake	0.6	0.9	1.7	0.7	1.3	-0.8
Heart attack/myocardial infarction (self-reported)	0.6	0.7	1.1	1.1	-0.4	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.4	0.6	1.2	0.6
Depressed Affect (Nagel 2018)	0.5	1.1	1.4	-1.2	1.0	0.8
Mean Putamen Volume	0.5	0.6	1.0	-0.6	0.7	1.0
Fasting Glucose	0.5	0.6	0.9	1.0	0.4	0.8
Triglycerides	0.5	0.8	1.6	1.3	0.9	0.2
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.5	1.2	1.1	-0.3
Chronotype (morning person)	0.5	1.1	1.7	0.1	-1.2	-1.3
Townsend deprivation index at recruitment	0.5	0.7	1.5	-1.2	-0.6	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	1.7	1.2	1.3	0.3
Hayfever, allergic rhinitis or eczema	0.5	1.0	2.7	1.6	-0.5	0.1
Waist circumference	0.5	1.8	2.5	-1.0	1.4	-1.6
Hair/balding pattern: Pattern 2	0.5	0.7	1.4	-1.2	0.8	0.2
Financial difficulties in last 2 years	0.5	0.6	1.0	-0.9	0.1	1.0
Heart attack	0.5	0.7	0.9	1.0	-0.8	-0.7
Diabetes (self-reported)	0.5	0.8	1.0	1.0	0.8	0.9
Hip circumference	0.5	2.2	6.4	-2.5	-0.3	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.9	0.0	0.6	-1.4
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.3	-0.2	-1.0	-1.5
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.8	-0.2	1.4	0.3
Medication: Cholesterol lowering	0.5	0.7	2.2	-0.1	-1.5	0.1
High blood pressure (siblings)	0.5	0.7	1.3	0.8	-1.1	-0.6
Qualifications: College or University degree	0.5	1.6	2.9	0.2	-1.7	-1.4
Medication: Blood pressure	0.5	0.8	1.7	-0.8	-1.3	0.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	1.9	-0.6	-1.4	0.6
Average weekly champagne plus white wine intake	0.5	0.6	0.9	-0.9	1.0	0.4
Ever smoked	0.5	0.8	1.4	-1.2	0.7	0.8
Risk taking	0.5	0.8	1.2	-1.1	-1.1	-0.1
Alcohol drinker status: Previous	0.5	0.5	0.7	0.8	-0.5	-0.8
Alzheimer’s Disease (in mother)	0.4	0.5	1.0	0.4	0.6	-1.0
Alzheimer’s Disease (in father)	0.4	0.4	0.5	-0.5	-0.7	0.6
Body Mass Index (BMI) (2010)	0.4	0.6	1.4	0.6	0.2	-1.2
Blood White Count	0.4	2.7	7.6	0.6	-0.4	-2.8
BMI	0.4	2.5	3.8	-0.4	1.9	-2.0
Hypothyroidism (self reported)	0.4	0.9	1.3	1.2	0.8	0.9
Respiratory disease	0.4	0.9	1.9	0.7	-0.5	1.4
Ever had hysterectomy (womb removed)	0.4	0.5	0.7	-0.9	0.1	-0.8
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	0.7	0.6	0.6	0.9
Medication: Co-codamol	0.4	0.4	1.1	-1.1	0.0	-0.3
Taking other prescription medications	0.4	0.7	1.1	-0.3	0.9	1.0
Body mass index (BMI)	0.4	1.7	3.1	-0.6	1.3	-1.8
Had other major operations	0.4	0.5	1.3	-0.3	1.1	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	2.4	0.2	1.6	0.1
Mouth/teeth dental problems	0.4	0.7	1.5	-0.5	1.2	0.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	2.7	-1.1	-1.6	0.7
Lung cancer (father)	0.4	0.5	0.7	-0.8	-0.2	-0.8
Impedance of arm (left)	0.4	2.0	3.2	1.8	-1.6	0.4
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.9	0.2	-1.0	-0.7
Wheeze or whistling in the chest in last year	0.4	0.6	0.9	-0.9	0.9	0.5
Medication: Ibuprofen	0.4	0.5	1.4	0.4	1.2	0.2
Family relationship satisfaction	0.4	0.5	1.2	-0.5	-1.1	-0.2
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.3	1.1	-0.3	-0.3
Long-standing illness, disability or infirmity	0.4	0.6	1.3	0.6	1.1	0.5
Qualifications: nursing, teaching	0.4	0.7	0.9	1.0	-0.5	-0.9
Medication for cholesterol	0.4	0.6	1.5	-1.2	-0.3	0.5
Osteoarthritis (self-reported)	0.4	0.6	0.9	0.5	0.9	-0.8
Medication: Aspirin	0.4	0.5	0.7	0.7	-0.8	-0.6
Mother’s age at death	0.4	0.5	0.8	-0.6	-0.4	0.9
Financial situation satisfaction	0.4	0.5	1.4	-0.2	-0.1	-1.2
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.5	0.7	0.7	-0.7
Leg fat mass (left)	0.4	1.4	2.3	-1.3	0.2	-1.5
Breast Cancer	0.3	0.7	2.0	-0.5	1.4	0.1
Ovarian Cancer	0.3	0.4	0.7	-0.0	0.8	-0.7
Neuroticism (2016)	0.3	0.5	1.2	-0.4	0.0	1.1
Primary Biliary Cirrhosis	0.3	0.4	0.9	0.1	-0.9	-0.6
Cardiovascular Disease	0.3	1.0	2.7	0.5	-1.6	-0.0
Hand grip strength (left)	0.3	0.9	1.3	-1.1	0.8	0.9
Qualifications: CSEs or equivalent	0.3	0.4	0.8	-0.9	0.4	0.4
Multivitamins +/- minerals	0.3	0.3	0.7	0.5	0.8	0.3
Medication: Atenolol	0.3	0.4	0.7	0.4	0.6	-0.9
Past tobacco smoking	0.3	0.5	1.2	-0.6	-1.1	-0.3
Allergy	0.3	0.8	1.4	-1.2	0.8	-0.5
Impedance of arm (right)	0.3	1.4	3.2	1.8	-1.0	0.3
Arm fat percentage (right)	0.3	1.0	2.3	0.4	0.7	-1.5
Arm fat mass (right)	0.3	1.1	1.9	-1.4	0.4	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.0	-1.0	-0.4	-0.4
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.1	-0.2	0.4	1.1
Body fat percentage	0.3	1.4	3.8	0.5	0.2	-2.0
Eye problems/disorders: None of the above	0.3	0.3	0.5	-0.4	-0.7	-0.4
Suffer from ‘nerves’	0.3	0.4	0.9	-0.9	-0.1	0.7
Age at last live birth	0.3	0.4	1.0	1.0	0.1	-0.4
Leg pain on walking	0.3	0.3	0.4	0.4	0.7	-0.6
Supplements: Vitamin C	0.3	0.4	0.6	-0.8	0.8	0.0
Eye problems/disorders: Cataract	0.3	0.3	0.3	-0.5	-0.6	-0.5
Medication: Lisinopril	0.3	0.4	0.9	-0.5	0.1	-1.0
Medication: Atorvastatin	0.3	0.3	0.6	-0.0	-0.6	0.8
Illnesses of father: High blood pressure	0.3	0.3	1.0	0.1	-0.0	1.0
Unable to work because of sickness or disability	0.3	0.4	0.8	0.1	-0.9	0.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.0	0.5	1.0	0.1
Pain experienced in last month	0.3	0.6	0.8	0.9	0.9	0.3
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.9	1.0	0.5	0.6
Blood Red Count	0.2	2.0	2.6	-1.6	0.9	1.6
Medication for hormone replacement therapy	0.2	0.2	0.6	-0.3	0.8	0.1
Trunk fat percentage	0.2	1.0	2.8	0.1	-0.3	-1.7
Serious illness, injury or assault to yourself	0.2	0.3	0.5	0.5	-0.2	0.7
Trunk fat mass	0.2	0.8	1.8	-1.3	-0.2	-0.6
Alcohol usually taken with meals	0.2	0.3	0.4	0.4	-0.5	-0.6
Nervous feelings	0.2	0.3	0.5	-0.7	-0.1	0.7
Qualifications: None of the above	0.2	0.5	0.9	-0.3	0.9	0.6
Illnesses of siblings	0.2	0.2	0.4	-0.6	-0.3	0.4
Asthma	0.2	0.5	0.9	0.2	-0.7	0.9
Medication: Lansoprazole	0.2	0.2	0.3	-0.1	0.6	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.6	-0.7	-1.3	-0.0
Peak expiratory flow (PEF)	0.2	0.4	0.8	-0.9	0.7	-0.3
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	0.5	-0.2	-0.6
Loud music exposure frequency	0.2	0.2	0.5	0.7	-0.1	-0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.6	-0.0	-0.6	-0.8
Medication: Paracetamol	0.2	0.3	0.6	-0.5	-0.8	0.4
Comparative body size at age 10	0.2	0.6	1.2	-1.1	-0.2	-0.7
Age at first live birth	0.2	0.4	0.5	-0.4	-0.7	0.7
Shortness of breath walking on level ground	0.2	0.3	0.7	0.8	-0.0	-0.3
Whole body fat mass	0.2	0.9	1.7	-1.3	0.3	-0.9
Leg fat mass (right)	0.2	1.0	1.8	-1.0	0.3	-1.3
Pulse rate, automated reading	0.2	0.5	1.2	1.1	0.6	0.0
Medication: Aspirin	0.2	0.3	0.6	0.7	-0.4	-0.5
Arm fat percentage (left)	0.2	0.7	1.7	0.3	0.7	-1.3
Asthma (self-reported)	0.2	0.5	0.9	0.5	-0.5	0.9
Arm fat mass (left)	0.2	0.9	1.7	-1.3	0.5	-0.9
Number of self-reported non-cancer illnesses	0.2	0.4	0.8	0.9	0.2	0.7
Ever taken oral contraceptive pill	0.2	0.3	0.7	0.8	0.1	0.3
Ever depressed for a whole week	0.2	0.3	0.5	-0.7	-0.0	0.6
Basal cell carcinoma (self-reported)	0.2	0.3	0.6	-0.4	0.2	0.8
Heart disease (siblings)	0.2	0.3	0.6	-0.3	0.8	-0.3
Alzheimer’s Disease (including proxy)	0.1	0.2	0.6	-0.1	-0.1	-0.8
Hair Pigment	0.1	1.8	4.0	-0.7	-0.9	2.0
Tanning	0.1	1.0	2.6	0.6	1.6	-0.2
Vitamin and mineral supplements	0.1	0.1	0.2	0.2	-0.5	-0.2
Severe depression (siblings)	0.1	0.1	0.3	0.2	0.5	-0.0
High blood pressure	0.1	0.2	0.3	0.6	-0.6	-0.1
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.0	0.5	0.1
Medication: Ramipril	0.1	0.2	0.5	0.1	-0.7	0.1
Happiness	0.1	0.1	0.2	-0.5	0.0	-0.2
Depression (self-reported)	0.1	0.1	0.4	-0.0	-0.1	-0.7
Breastfed as a baby	0.1	0.2	0.4	-0.3	-0.1	-0.6
Medication for pain relief, constipation, heartburn	0.1	0.1	0.2	-0.1	0.4	-0.5
Overall health rating	0.1	0.2	0.4	-0.2	0.1	-0.6
Hypertension (Self-reported)	0.1	0.4	0.7	0.7	-0.8	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.1	-0.2	-0.4
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.3	-0.6	0.3	-0.3
Medication: Paracetamol	0.1	0.1	0.2	0.3	-0.5	-0.1
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.4	-0.6	0.4	0.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	0.0	0.2	0.2
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.0	-0.0	-0.0	0.0
Smoking status: Previous	0.0	0.1	0.1	0.2	0.2	0.3
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.0	-0.2	-0.0	-0.1

Hub : Genes

RER1

Models

Trait associations