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chr1:7,135,268-12,013,869

Best TWAS P=2.28e-21 · Best GWAS P=4.55e-16 conditioned to 0.000559

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
54	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	H6PD	0.31	0.06	blup	64	0.14	3.8e-06	4.66	-9.5	2.3e-21	-0.05	0.01	0.88	TRUE
35	ROSMAP	Brain Pre-frontal Cortex	MTOR	0.07	0.05	bslmm	423	0.04	2.0e-06	7.94	8.3	7.3e-17	0.02	0.01	0.99	TRUE
15	GTEx	Cells EBV-transformed lymphocytes	PGD	0.17	0.14	lasso	6	0.08	1.7e-03	6.45	8.0	9.8e-16	0.54	0.23	0.41	TRUE
41	YFS	Blood	UBE4B	0.03	0.01	bslmm	373	0.02	3.1e-06	4.89	-7.2	8.7e-13	0.00	0.13	0.87	TRUE
46	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PARK7	0.03	0.03	enet	3	0.02	1.3e-03	5.97	6.2	5.9e-10	-0.03	0.00	0.94	TRUE
14	GTEx	Breast Mammary Tissue (Male)	RP5-1115A15.1	0.18	0.07	lasso	3	0.06	1.7e-02	6.25	-5.9	3.2e-09	0.00	0.05	0.10	TRUE
33	ROSMAP	Brain Pre-frontal Cortex	RBP7	0.08	0.00	bslmm	301	0.01	4.9e-03	2.70	5.1	2.9e-07	0.11	0.05	0.06	TRUE
13	GTEx	Brain Cortex	RP4-635E18.7	0.17	0.05	lasso	4	0.07	6.4e-03	7.95	8.0	1.7e-15	0.02	0.02	0.90	FALSE
1	CommonMind	Brain Pre-frontal Cortex	EXOSC10	0.06	0.08	lasso	2	0.07	6.8e-09	7.75	7.9	2.1e-15	0.03	0.02	0.98	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MTOR	0.13	0.15	lasso	4	0.15	5.6e-18	7.94	7.7	1.2e-14	0.02	0.00	1.00	FALSE
4	GTEx	Adipose Subcutaneous	EXOSC10	0.17	0.00	lasso	3	0.00	1.8e-01	7.45	7.7	1.7e-14	0.09	0.04	0.22	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	EXOSC10	0.06	0.06	lasso	2	0.06	4.9e-08	7.75	7.7	1.7e-14	0.03	0.06	0.94	FALSE
11	GTEx	Brain Cerebellum	EXOSC10	0.33	0.16	lasso	6	0.18	3.8e-06	7.44	7.7	1.9e-14	0.02	0.06	0.92	FALSE
47	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MTOR	0.02	0.02	blup	54	0.02	5.4e-03	7.36	7.6	3.3e-14	0.05	0.06	0.69	FALSE
6	GTEx	Adipose Visceral Omentum	RP4-635E18.7	0.19	0.08	lasso	6	0.05	9.0e-04	7.74	7.5	7.7e-14	0.03	0.02	0.96	FALSE
24	GTEx	Skin Sun Exposed Lower leg	PGD	0.08	0.06	lasso	5	0.06	1.3e-05	-7.31	7.5	9.6e-14	0.28	0.49	0.39	FALSE
29	METSIM	Adipose	MTOR	0.04	0.02	bslmm	434	0.02	1.5e-04	7.94	7.3	2.2e-13	0.04	0.02	0.98	FALSE
22	GTEx	Lung	EXOSC10	0.11	0.07	lasso	4	0.05	1.2e-04	7.42	7.3	2.8e-13	0.02	0.12	0.86	FALSE
48	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTOR	0.03	0.01	blup	54	0.02	5.9e-03	7.35	7.2	4.1e-13	0.05	0.03	0.73	FALSE
26	GTEx	Thyroid	RP4-635E18.7	0.07	0.02	lasso	2	0.01	5.5e-02	7.42	7.1	1.1e-12	0.00	0.04	0.80	FALSE
12	GTEx	Brain Cerebellum	RP4-635E18.7	0.17	0.17	lasso	5	0.09	1.3e-03	7.44	7.1	1.3e-12	0.03	0.05	0.87	FALSE
9	GTEx	Brain Cerebellar Hemisphere	EXOSC10	0.23	0.10	lasso	3	0.12	6.4e-04	7.49	7.0	2.1e-12	0.06	0.06	0.68	FALSE
31	NTR	Blood	KIF1B	0.11	0.08	enet	11	0.09	3.7e-28	8.12	6.7	2.7e-11	0.95	0.00	1.00	FALSE
55	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PGD	0.09	0.02	blup	52	0.05	6.0e-03	4.68	6.5	9.9e-11	0.34	0.03	0.13	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	PGD	0.06	0.05	enet	10	0.03	7.7e-04	6.15	6.4	1.2e-10	0.28	0.74	0.04	FALSE
21	GTEx	Lung	KIF1B	0.09	0.11	lasso	2	0.10	7.8e-08	6.44	6.4	1.3e-10	0.32	0.99	0.01	FALSE
17	GTEx	Colon Transverse	DFFA	0.13	0.01	enet	7	0.01	9.0e-02	5.98	-6.4	1.8e-10	-0.56	0.07	0.48	FALSE
16	GTEx	Cells Transformed fibroblasts	PGD	0.47	0.56	enet	15	0.55	7.5e-49	6.16	6.3	3.7e-10	0.31	1.00	0.00	FALSE
23	GTEx	Muscle Skeletal	PGD	0.14	0.15	enet	9	0.16	2.1e-15	6.15	6.2	4.5e-10	0.30	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	APITD1	0.07	0.01	enet	12	0.04	4.6e-04	-0.68	6.2	7.1e-10	0.38	0.02	0.11	FALSE
7	GTEx	Adrenal Gland	PGD	0.15	0.10	lasso	2	0.02	4.3e-02	6.15	6.2	7.7e-10	0.30	0.20	0.10	FALSE
27	GTEx	Whole Blood	MTOR	0.16	0.06	enet	18	0.07	5.1e-07	7.30	6.2	7.8e-10	0.04	0.27	0.73	FALSE
52	The Cancer Genome Atlas	Lung Adenocarcinoma	PGD	0.04	0.06	lasso	9	0.06	3.9e-07	6.03	6.1	9.6e-10	0.30	0.98	0.01	FALSE
25	GTEx	Thyroid	DFFA	0.06	0.07	enet	5	0.04	8.1e-04	-5.07	-6.1	1.4e-09	-0.30	0.21	0.41	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	ERRFI1	0.01	0.01	blup	27	0.00	4.3e-02	5.49	-6.0	1.8e-09	0.02	0.01	0.83	FALSE
49	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MASP2	0.05	0.03	blup	30	0.04	6.0e-03	1.86	-6.0	2.0e-09	-0.05	0.02	0.58	FALSE
3	GTEx	Adipose Subcutaneous	DFFA	0.11	0.08	enet	8	0.06	1.3e-05	5.07	-6.0	2.6e-09	-0.21	0.83	0.02	FALSE
38	YFS	Blood	KIF1B	0.30	0.26	enet	49	0.29	7.8e-97	8.12	5.8	5.0e-09	0.91	0.00	1.00	FALSE
18	GTEx	Esophagus Mucosa	DFFA	0.11	0.00	lasso	2	0.00	1.6e-01	5.21	-5.8	6.3e-09	-0.16	0.12	0.14	FALSE
32	NTR	Blood	PARK7	0.02	0.01	lasso	3	0.01	1.4e-05	5.49	5.8	6.4e-09	-0.02	0.80	0.19	FALSE
56	The Cancer Genome Atlas	Stomach Adenocarcinoma	PGD	0.05	0.04	blup	51	0.03	2.8e-03	6.15	5.8	6.6e-09	0.34	0.16	0.19	FALSE
20	GTEx	Liver	PEX14	0.31	0.02	enet	10	-0.01	6.2e-01	4.78	-5.7	1.3e-08	-0.22	0.06	0.27	FALSE
50	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PEX14	0.08	0.01	enet	8	0.05	3.1e-03	-5.38	-5.6	1.9e-08	-0.29	0.03	0.51	FALSE
28	METSIM	Adipose	EXOSC10	0.05	0.06	lasso	1	0.05	3.5e-08	5.61	5.6	2.1e-08	0.00	0.07	0.93	FALSE
39	YFS	Blood	PARK7	0.08	0.11	lasso	6	0.11	4.4e-34	5.49	5.5	2.9e-08	-0.01	0.99	0.01	FALSE
40	YFS	Blood	SPSB1	0.03	0.03	bslmm	425	0.03	1.5e-09	5.06	5.5	2.9e-08	0.04	1.00	0.00	FALSE
53	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PGD	0.07	0.00	enet	5	0.04	1.0e-02	4.63	5.5	3.3e-08	0.22	0.04	0.04	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	RP4-635E18.7	0.23	0.09	enet	24	0.24	3.8e-30	6.98	5.5	3.5e-08	0.03	0.10	0.90	FALSE
51	The Cancer Genome Atlas	Lung Adenocarcinoma	PARK7	0.03	0.03	lasso	1	0.02	5.0e-03	5.49	5.5	4.0e-08	-0.01	0.01	0.76	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	KIF1B	0.05	0.01	blup	108	0.01	9.4e-04	6.06	5.5	4.6e-08	0.35	0.31	0.11	FALSE
30	NTR	Blood	H6PD	0.10	0.08	bslmm	435	0.08	3.1e-23	4.65	-5.4	6.6e-08	0.00	1.00	0.00	FALSE
37	ROSMAP	Brain Pre-frontal Cortex	RP11-431K24.1	0.16	0.16	bslmm	384	0.17	3.1e-21	-5.12	-5.2	1.7e-07	0.05	1.00	0.00	FALSE
8	GTEx	Artery Tibial	VAMP3	0.20	0.05	enet	22	0.11	5.8e-09	-4.50	-5.2	1.8e-07	0.03	0.90	0.03	FALSE
43	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PGD	0.04	0.02	blup	52	0.03	2.6e-03	6.06	5.2	2.2e-07	0.32	0.10	0.08	FALSE
19	GTEx	Esophagus Muscularis	DFFA	0.12	0.00	enet	27	0.01	6.3e-02	4.60	-5.2	2.3e-07	-0.40	0.17	0.19	FALSE
5	GTEx	Adipose Visceral Omentum	PEX14	0.11	0.08	lasso	2	0.07	2.2e-04	-5.10	-5.2	2.7e-07	-0.16	0.81	0.01	FALSE
10	GTEx	Brain Cerebellum	H6PD	0.69	0.40	lasso	9	0.42	6.8e-14	4.65	-5.1	3.0e-07	-0.01	0.95	0.04	FALSE