Best TWAS P=4.09e-55 · Best GWAS P=7.68e-91 conditioned to 0.282
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HACE1 | 0.14 | 0.10 | enet | 28 | 0.11 | 8.9e-14 | 5.8 | -8.4 | 6.0e-17 | -0.42 | 1.00 | 0.00 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | LIN28B | 0.04 | 0.04 | lasso | 9 | 0.03 | 3.9e-05 | 16.5 | 15.6 | 4.1e-55 | 0.74 | 0.18 | 0.82 | TRUE |
| 3 | CommonMind | Brain Pre-frontal Cortex | POPDC3 | 0.06 | 0.03 | bslmm | 386 | 0.02 | 1.0e-03 | 5.7 | -9.2 | 2.8e-20 | -0.31 | 0.19 | 0.10 | TRUE |
| 4 | GTEx | Brain Cerebellar Hemisphere | HACE1 | 0.36 | 0.43 | enet | 19 | 0.39 | 5.8e-11 | 5.7 | -6.4 | 1.4e-10 | -0.30 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Brain Cerebellum | HACE1 | 0.28 | 0.28 | enet | 16 | 0.26 | 3.6e-08 | 5.7 | -6.5 | 5.8e-11 | -0.31 | 0.98 | 0.00 | FALSE |
| 6 | GTEx | Brain Frontal Cortex BA9 | HACE1 | 0.25 | 0.21 | enet | 22 | 0.18 | 1.7e-05 | 5.7 | -5.9 | 3.7e-09 | -0.31 | 0.52 | 0.08 | TRUE |
| 7 | GTEx | Cells EBV-transformed lymphocytes | HACE1 | 0.40 | 0.15 | lasso | 8 | 0.22 | 1.1e-07 | 7.3 | -8.9 | 5.7e-19 | -0.43 | 0.75 | 0.16 | TRUE |
| 8 | GTEx | Cells Transformed fibroblasts | HACE1 | 0.07 | 0.02 | lasso | 3 | 0.01 | 3.0e-02 | 3.5 | -7.2 | 8.9e-13 | -0.34 | 0.09 | 0.45 | FALSE |
| 9 | GTEx | Esophagus Mucosa | HACE1 | 0.17 | 0.03 | lasso | 6 | 0.04 | 9.6e-04 | -1.3 | -5.4 | 5.4e-08 | -0.28 | 0.64 | 0.08 | TRUE |
| 10 | GTEx | Lung | HACE1 | 0.09 | 0.00 | lasso | 4 | 0.00 | 6.2e-01 | -1.1 | -11.3 | 1.2e-29 | -0.56 | 0.05 | 0.25 | TRUE |
| 11 | GTEx | Thyroid | HACE1 | 0.08 | 0.06 | lasso | 4 | 0.04 | 8.9e-04 | 7.3 | -8.2 | 2.2e-16 | -0.35 | 0.26 | 0.04 | FALSE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | HACE1 | 0.16 | 0.16 | lasso | 5 | 0.16 | 1.4e-20 | 7.3 | -7.2 | 4.2e-13 | -0.36 | 1.00 | 0.00 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | BVES | 0.08 | 0.00 | enet | 26 | 0.05 | 7.3e-07 | 1.7 | 5.3 | 1.4e-07 | 0.26 | 0.15 | 0.10 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HACE1 | 0.05 | 0.01 | blup | 72 | 0.02 | 1.6e-03 | 5.8 | -5.8 | 7.5e-09 | -0.25 | 0.50 | 0.31 | TRUE |
| 15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HACE1 | 0.08 | 0.04 | blup | 72 | 0.05 | 1.1e-06 | 3.5 | -5.3 | 1.3e-07 | -0.26 | 0.62 | 0.30 | TRUE |
| 16 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | HACE1 | 0.17 | 0.03 | enet | 21 | 0.11 | 3.2e-05 | -1.3 | -5.4 | 8.2e-08 | -0.17 | 0.09 | 0.20 | FALSE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HACE1 | 0.04 | 0.03 | lasso | 7 | 0.03 | 3.8e-04 | 5.8 | -5.5 | 3.3e-08 | -0.26 | 0.43 | 0.04 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | HACE1 | 0.09 | 0.03 | enet | 18 | 0.06 | 1.9e-06 | 5.8 | -6.3 | 3.5e-10 | -0.28 | 0.52 | 0.35 | FALSE |