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chr6:79,927,081-85,117,025

Best TWAS P=1.47e-49 · Best GWAS P=1.02e-42 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
35	GTEx	Heart Atrial Appendage	RP11-250B2.6	0.20	0.00	enet	17	0.03	2.6e-02	-7.8	-14.8	1.5e-49	0.26	0.08	0.21	TRUE
53	GTEx	Testis	RP11-250B2.5	0.13	0.17	lasso	3	0.14	7.0e-07	-10.8	-10.5	1.1e-25	0.06	0.74	0.10	TRUE
29	GTEx	Colon Transverse	RP11-250B2.5	0.13	0.02	enet	3	0.01	6.3e-02	-4.8	-8.9	4.0e-19	0.02	0.11	0.08	TRUE
22	GTEx	Cells EBV-transformed lymphocytes	RP11-250B2.6	0.21	0.03	enet	37	0.13	4.7e-05	7.7	-8.6	6.5e-18	0.16	0.14	0.05	TRUE
66	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BCKDHB	0.12	0.06	lasso	4	0.06	4.2e-07	10.2	-8.1	4.3e-16	0.02	0.97	0.00	TRUE
70	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	DOPEY1	0.06	0.08	lasso	2	0.04	3.9e-03	7.6	-7.7	1.7e-14	-0.04	0.00	0.94	TRUE
62	ROSMAP	Brain Pre-frontal Cortex	FAM46A	0.08	0.01	blup	495	0.03	2.7e-04	5.2	7.3	3.8e-13	0.04	0.65	0.01	TRUE
26	GTEx	Cells Transformed fibroblasts	RP11-250B2.6	0.11	0.01	lasso	7	0.00	1.4e-01	-10.8	-7.1	1.0e-12	0.04	0.38	0.02	TRUE
25	GTEx	Cells Transformed fibroblasts	RP11-250B2.5	0.16	0.07	lasso	10	0.05	5.8e-05	12.3	6.9	4.1e-12	-0.05	0.10	0.84	TRUE
20	GTEx	Breast Mammary Tissue (Female)	RP11-250B2.3	0.16	0.06	enet	11	0.04	2.4e-02	10.5	-6.7	2.6e-11	0.01	0.12	0.06	TRUE
52	GTEx	Testis	ELOVL4	0.31	0.19	lasso	7	0.18	1.9e-08	-6.7	-6.4	1.2e-10	0.09	0.96	0.00	TRUE
63	ROSMAP	Brain Pre-frontal Cortex	RP11-250B2.3	0.08	0.02	blup	402	0.04	5.8e-06	7.5	-6.1	8.1e-10	0.15	0.79	0.02	TRUE
5	GTEx	Adipose Visceral Omentum	RP11-250B2.3	0.13	0.00	enet	13	0.01	8.2e-02	-4.8	-5.9	3.5e-09	0.14	0.06	0.05	TRUE
2	CommonMind	Brain Pre-frontal Cortex	SNAP91	0.09	0.05	lasso	3	0.08	1.6e-09	6.1	5.6	2.4e-08	0.00	0.65	0.35	TRUE
42	GTEx	Muscle Skeletal	RP11-250B2.6	0.07	0.04	lasso	5	0.04	4.2e-05	11.9	-12.5	1.1e-35	0.09	0.81	0.15	FALSE
24	GTEx	Cells Transformed fibroblasts	BCKDHB	0.16	0.02	enet	42	0.04	3.7e-04	8.0	12.3	8.4e-35	-0.09	0.51	0.27	FALSE
40	GTEx	Lung	RP11-250B2.6	0.09	0.05	enet	16	0.07	5.3e-06	8.1	-12.3	1.3e-34	0.01	0.71	0.17	FALSE
6	GTEx	Adipose Visceral Omentum	RP11-250B2.6	0.16	0.05	lasso	6	0.06	7.8e-04	11.0	-11.6	4.3e-31	0.00	0.36	0.08	FALSE
14	GTEx	Brain Cerebellum	RP11-250B2.5	0.43	0.11	lasso	5	0.14	4.7e-05	-11.6	-11.6	4.7e-31	0.17	0.42	0.06	FALSE
32	GTEx	Esophagus Mucosa	RP11-250B2.6	0.20	0.16	lasso	7	0.23	3.3e-15	-10.8	-11.6	4.7e-31	0.02	1.00	0.00	FALSE
36	GTEx	Heart Left Ventricle	RP11-250B2.6	0.09	0.00	enet	6	0.02	2.0e-02	10.9	-10.7	6.2e-27	0.07	0.16	0.09	FALSE
55	GTEx	Thyroid	BCKDHB	0.17	0.06	lasso	8	0.10	3.4e-08	8.1	10.1	5.9e-24	-0.05	1.00	0.00	FALSE
59	METSIM	Adipose	RP11-250B2.6	0.04	0.04	lasso	12	0.02	1.7e-04	11.5	-9.8	1.8e-22	-0.01	0.74	0.01	FALSE
56	GTEx	Thyroid	RP11-250B2.6	0.11	0.10	lasso	2	0.07	3.2e-06	8.0	-8.0	1.2e-15	0.01	1.00	0.00	FALSE
44	GTEx	Nerve Tibial	BCKDHB	0.18	0.11	lasso	9	0.10	2.4e-07	7.7	7.9	2.3e-15	-0.04	1.00	0.00	FALSE
38	GTEx	Lung	BCKDHB	0.09	0.06	enet	10	0.05	1.8e-04	7.6	7.6	2.3e-14	-0.03	0.91	0.01	FALSE
8	GTEx	Artery Aorta	BCKDHB	0.14	0.14	lasso	1	0.13	9.8e-08	7.6	7.6	3.0e-14	-0.03	1.00	0.00	FALSE
68	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DOPEY1	0.08	0.08	blup	47	0.09	2.3e-10	6.9	-7.6	3.8e-14	-0.04	0.03	0.97	FALSE
45	GTEx	Ovary	DOPEY1	0.33	0.19	enet	18	0.23	2.9e-06	6.9	-7.5	4.7e-14	-0.02	0.01	0.98	FALSE
58	METSIM	Adipose	DOPEY1	0.08	0.08	lasso	10	0.07	2.4e-10	6.9	-7.5	5.1e-14	-0.03	0.09	0.91	FALSE
23	GTEx	Cells Transformed fibroblasts	DOPEY1	0.17	0.14	enet	16	0.17	1.8e-12	6.9	-7.5	5.8e-14	-0.01	0.01	0.99	FALSE
11	GTEx	Artery Tibial	DOPEY1	0.33	0.28	lasso	7	0.30	2.0e-23	6.9	-7.4	9.8e-14	-0.03	0.01	0.99	FALSE
48	GTEx	Skin Sun Exposed Lower leg	DOPEY1	0.16	0.17	lasso	5	0.16	4.0e-13	7.0	-7.4	1.2e-13	-0.04	0.00	1.00	FALSE
64	YFS	Blood	DOPEY1	0.18	0.21	lasso	9	0.21	1.4e-67	6.9	-7.4	1.3e-13	-0.02	0.13	0.87	FALSE
54	GTEx	Testis	RP11-250B2.6	0.09	0.05	lasso	6	0.04	6.9e-03	8.1	-7.4	1.5e-13	0.01	0.42	0.03	FALSE
3	GTEx	Adipose Subcutaneous	DOPEY1	0.29	0.27	lasso	6	0.28	4.2e-23	6.9	-7.3	2.0e-13	-0.03	0.01	0.99	FALSE
4	GTEx	Adipose Visceral Omentum	DOPEY1	0.20	0.18	enet	11	0.20	1.1e-10	6.9	-7.3	2.8e-13	0.00	0.01	0.99	FALSE
27	GTEx	Colon Sigmoid	DOPEY1	0.19	0.21	lasso	6	0.21	5.6e-08	7.0	-7.2	4.2e-13	-0.04	0.00	1.00	FALSE
65	The Cancer Genome Atlas	Breast Invasive Carcinoma	DOPEY1	0.05	0.06	lasso	2	0.06	2.6e-12	6.9	-7.2	4.7e-13	-0.02	0.04	0.96	FALSE
28	GTEx	Colon Transverse	DOPEY1	0.14	0.13	enet	7	0.12	2.3e-06	6.9	-7.2	4.8e-13	-0.01	0.01	0.98	FALSE
50	GTEx	Stomach	RP11-250B2.6	0.13	0.15	lasso	6	0.12	2.5e-06	8.0	-7.2	5.9e-13	0.00	0.94	0.00	FALSE
30	GTEx	Colon Transverse	RP11-250B2.6	0.15	0.16	lasso	2	0.13	9.8e-07	8.0	-7.2	7.3e-13	0.01	0.95	0.00	FALSE
41	GTEx	Muscle Skeletal	DOPEY1	0.13	0.11	lasso	5	0.10	4.2e-10	6.9	-7.2	7.9e-13	-0.02	0.01	0.99	FALSE
43	GTEx	Nerve Tibial	DOPEY1	0.23	0.28	lasso	3	0.28	3.7e-20	6.9	-7.2	8.8e-13	-0.02	0.01	0.99	FALSE
31	GTEx	Esophagus Gastroesophageal Junction	DOPEY1	0.19	0.11	lasso	5	0.08	6.0e-04	6.9	-7.1	1.0e-12	-0.02	0.01	0.97	FALSE
12	GTEx	Artery Tibial	BCKDHB	0.16	0.16	lasso	11	0.15	4.9e-12	7.6	7.1	1.2e-12	-0.03	1.00	0.00	FALSE
71	The Cancer Genome Atlas	Lung Adenocarcinoma	DOPEY1	0.03	0.02	lasso	2	0.02	2.1e-03	6.9	-7.1	1.2e-12	-0.02	0.02	0.78	FALSE
78	The Cancer Genome Atlas	Stomach Adenocarcinoma	DOPEY1	0.11	0.06	lasso	3	0.06	4.1e-05	6.9	-7.1	1.6e-12	-0.02	0.03	0.95	FALSE
34	GTEx	Esophagus Muscularis	BCKDHB	0.18	0.07	enet	25	0.06	2.4e-04	7.6	7.0	3.6e-12	-0.04	0.94	0.00	FALSE
76	The Cancer Genome Atlas	Soft Tissue Sarcoma	DOPEY1	0.04	0.02	blup	47	0.02	1.4e-02	6.0	-6.9	4.0e-12	-0.04	0.01	0.84	FALSE
37	GTEx	Lung	DOPEY1	0.11	0.13	lasso	3	0.12	2.9e-09	6.9	-6.9	6.8e-12	-0.01	0.01	0.99	FALSE
72	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DOPEY1	0.07	0.05	lasso	3	0.04	8.7e-06	6.9	-6.9	6.8e-12	-0.01	0.10	0.85	FALSE
74	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	DOPEY1	0.17	0.16	lasso	3	0.14	1.6e-06	6.9	-6.9	6.8e-12	-0.01	0.05	0.93	FALSE
47	GTEx	Skin Not Sun Exposed Suprapubic	RP11-250B2.6	0.08	0.05	lasso	4	0.01	8.1e-02	8.1	-6.8	7.3e-12	-0.09	0.22	0.04	FALSE
13	GTEx	Brain Caudate basal ganglia	UBE3D	0.29	0.28	lasso	2	0.26	5.9e-08	6.8	6.8	9.6e-12	0.05	0.01	0.99	FALSE
19	GTEx	Breast Mammary Tissue (Female)	DOPEY1	0.31	0.14	lasso	5	0.07	4.5e-03	6.9	-6.7	1.7e-11	-0.02	0.02	0.86	FALSE
15	GTEx	Brain Putamen basal ganglia	UBE3D	0.40	0.21	lasso	5	0.21	9.5e-06	6.8	6.7	1.8e-11	0.04	0.01	0.96	FALSE
16	GTEx	Breast Mammary Tissue	DOPEY1	0.32	0.18	enet	29	0.16	1.2e-08	6.9	-6.7	2.2e-11	-0.03	0.01	0.99	FALSE
75	The Cancer Genome Atlas	Prostate Adenocarcinoma	DOPEY1	0.07	0.11	blup	47	0.11	1.7e-11	6.2	-6.7	2.9e-11	-0.04	0.90	0.10	FALSE
57	METSIM	Adipose	BCKDHB	0.05	0.03	blup	558	0.05	1.1e-07	-10.8	6.6	4.3e-11	0.00	1.00	0.00	FALSE
49	GTEx	Spleen	DOPEY1	0.21	0.12	lasso	4	0.12	7.1e-04	6.2	-6.6	5.4e-11	-0.04	0.14	0.38	FALSE
46	GTEx	Skin Not Sun Exposed Suprapubic	RP11-250B2.5	0.13	0.16	lasso	4	0.17	1.1e-09	10.5	-6.5	1.1e-10	-0.01	0.98	0.00	FALSE
73	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	DOPEY1	0.08	0.05	blup	47	0.04	1.4e-03	6.9	-6.4	1.3e-10	-0.03	0.02	0.88	FALSE
51	GTEx	Testis	DOPEY1	0.19	0.00	lasso	9	0.03	2.4e-02	6.2	-6.4	1.4e-10	-0.03	0.06	0.66	FALSE
18	GTEx	Breast Mammary Tissue (Male)	RP11-250B2.6	0.12	0.00	enet	10	0.00	3.9e-01	9.5	6.4	1.9e-10	-0.15	0.06	0.06	FALSE
33	GTEx	Esophagus Muscularis	DOPEY1	0.25	0.15	enet	10	0.14	1.4e-08	6.9	-6.3	2.7e-10	-0.02	0.01	0.99	FALSE
79	The Cancer Genome Atlas	Testicular Germ Cell Tumors	BCKDHB	0.19	0.02	blup	137	0.06	2.6e-03	7.6	6.2	5.6e-10	-0.04	0.03	0.08	FALSE
61	ROSMAP	Brain Pre-frontal Cortex	BCKDHB	0.18	0.13	lasso	6	0.14	2.9e-17	7.7	6.1	1.1e-09	-0.05	1.00	0.00	FALSE
7	GTEx	Artery Aorta	DOPEY1	0.36	0.20	enet	34	0.25	5.4e-14	6.9	-6.0	1.6e-09	-0.03	0.01	0.99	FALSE
67	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DOPEY1	0.09	0.02	enet	3	0.04	2.4e-05	6.9	-5.9	4.2e-09	-0.01	0.02	0.97	FALSE
9	GTEx	Artery Aorta	ELOVL4	0.11	0.13	lasso	2	0.11	1.7e-06	5.8	5.8	9.2e-09	0.03	0.95	0.00	FALSE
10	GTEx	Artery Coronary	BCKDHB	0.29	0.05	lasso	27	0.11	1.7e-04	7.7	5.5	3.0e-08	0.15	0.41	0.04	FALSE
69	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ELOVL4	0.09	0.04	enet	4	0.02	1.9e-03	5.5	5.5	3.2e-08	0.00	0.24	0.10	FALSE
1	CommonMind	Brain Pre-frontal Cortex	BCKDHB	0.11	0.09	bslmm	563	0.09	1.1e-10	7.7	5.5	3.6e-08	-0.11	1.00	0.00	FALSE
77	The Cancer Genome Atlas	Soft Tissue Sarcoma	UBE2CBP	0.09	0.00	blup	85	0.03	6.4e-03	-4.1	5.4	8.5e-08	0.03	0.05	0.28	FALSE
17	GTEx	Breast Mammary Tissue	RP11-250B2.3	0.13	0.06	lasso	4	0.04	2.6e-03	-4.8	-5.3	1.2e-07	0.02	0.16	0.06	FALSE
21	GTEx	Breast Mammary Tissue (Female)	RP11-250B2.5	0.08	-0.01	lasso	4	-0.01	7.0e-01	-10.3	-5.3	1.4e-07	0.07	0.06	0.08	FALSE
60	ROSMAP	Brain Pre-frontal Cortex	DOPEY1	0.11	0.08	enet	45	0.09	2.9e-11	5.6	-5.3	1.4e-07	-0.07	0.91	0.09	FALSE
39	GTEx	Lung	UBE3D	0.07	0.01	enet	16	0.02	9.8e-03	6.3	5.2	1.9e-07	0.02	0.06	0.51	FALSE