Best TWAS P=1.47e-49 · Best GWAS P=1.02e-42 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | BCKDHB | 0.11 | 0.09 | bslmm | 563 | 0.09 | 1.1e-10 | 7.7 | 5.5 | 3.6e-08 | -0.11 | 1.00 | 0.00 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | SNAP91 | 0.09 | 0.05 | lasso | 3 | 0.08 | 1.6e-09 | 6.1 | 5.6 | 2.4e-08 | 0.00 | 0.65 | 0.35 | TRUE |
3 | GTEx | Adipose Subcutaneous | DOPEY1 | 0.29 | 0.27 | lasso | 6 | 0.28 | 4.2e-23 | 6.9 | -7.3 | 2.0e-13 | -0.03 | 0.01 | 0.99 | FALSE |
4 | GTEx | Adipose Visceral Omentum | DOPEY1 | 0.20 | 0.18 | enet | 11 | 0.20 | 1.1e-10 | 6.9 | -7.3 | 2.8e-13 | 0.00 | 0.01 | 0.99 | FALSE |
5 | GTEx | Adipose Visceral Omentum | RP11-250B2.3 | 0.13 | 0.00 | enet | 13 | 0.01 | 8.2e-02 | -4.8 | -5.9 | 3.5e-09 | 0.14 | 0.06 | 0.05 | TRUE |
6 | GTEx | Adipose Visceral Omentum | RP11-250B2.6 | 0.16 | 0.05 | lasso | 6 | 0.06 | 7.8e-04 | 11.0 | -11.6 | 4.3e-31 | 0.00 | 0.36 | 0.08 | FALSE |
7 | GTEx | Artery Aorta | DOPEY1 | 0.36 | 0.20 | enet | 34 | 0.25 | 5.4e-14 | 6.9 | -6.0 | 1.6e-09 | -0.03 | 0.01 | 0.99 | FALSE |
8 | GTEx | Artery Aorta | BCKDHB | 0.14 | 0.14 | lasso | 1 | 0.13 | 9.8e-08 | 7.6 | 7.6 | 3.0e-14 | -0.03 | 1.00 | 0.00 | FALSE |
9 | GTEx | Artery Aorta | ELOVL4 | 0.11 | 0.13 | lasso | 2 | 0.11 | 1.7e-06 | 5.8 | 5.8 | 9.2e-09 | 0.03 | 0.95 | 0.00 | FALSE |
10 | GTEx | Artery Coronary | BCKDHB | 0.29 | 0.05 | lasso | 27 | 0.11 | 1.7e-04 | 7.7 | 5.5 | 3.0e-08 | 0.15 | 0.41 | 0.04 | FALSE |
11 | GTEx | Artery Tibial | DOPEY1 | 0.33 | 0.28 | lasso | 7 | 0.30 | 2.0e-23 | 6.9 | -7.4 | 9.8e-14 | -0.03 | 0.01 | 0.99 | FALSE |
12 | GTEx | Artery Tibial | BCKDHB | 0.16 | 0.16 | lasso | 11 | 0.15 | 4.9e-12 | 7.6 | 7.1 | 1.2e-12 | -0.03 | 1.00 | 0.00 | FALSE |
13 | GTEx | Brain Caudate basal ganglia | UBE3D | 0.29 | 0.28 | lasso | 2 | 0.26 | 5.9e-08 | 6.8 | 6.8 | 9.6e-12 | 0.05 | 0.01 | 0.99 | FALSE |
14 | GTEx | Brain Cerebellum | RP11-250B2.5 | 0.43 | 0.11 | lasso | 5 | 0.14 | 4.7e-05 | -11.6 | -11.6 | 4.7e-31 | 0.17 | 0.42 | 0.06 | FALSE |
15 | GTEx | Brain Putamen basal ganglia | UBE3D | 0.40 | 0.21 | lasso | 5 | 0.21 | 9.5e-06 | 6.8 | 6.7 | 1.8e-11 | 0.04 | 0.01 | 0.96 | FALSE |
16 | GTEx | Breast Mammary Tissue | DOPEY1 | 0.32 | 0.18 | enet | 29 | 0.16 | 1.2e-08 | 6.9 | -6.7 | 2.2e-11 | -0.03 | 0.01 | 0.99 | FALSE |
17 | GTEx | Breast Mammary Tissue | RP11-250B2.3 | 0.13 | 0.06 | lasso | 4 | 0.04 | 2.6e-03 | -4.8 | -5.3 | 1.2e-07 | 0.02 | 0.16 | 0.06 | FALSE |
18 | GTEx | Breast Mammary Tissue (Male) | RP11-250B2.6 | 0.12 | 0.00 | enet | 10 | 0.00 | 3.9e-01 | 9.5 | 6.4 | 1.9e-10 | -0.15 | 0.06 | 0.06 | FALSE |
19 | GTEx | Breast Mammary Tissue (Female) | DOPEY1 | 0.31 | 0.14 | lasso | 5 | 0.07 | 4.5e-03 | 6.9 | -6.7 | 1.7e-11 | -0.02 | 0.02 | 0.86 | FALSE |
20 | GTEx | Breast Mammary Tissue (Female) | RP11-250B2.3 | 0.16 | 0.06 | enet | 11 | 0.04 | 2.4e-02 | 10.5 | -6.7 | 2.6e-11 | 0.01 | 0.12 | 0.06 | TRUE |
21 | GTEx | Breast Mammary Tissue (Female) | RP11-250B2.5 | 0.08 | -0.01 | lasso | 4 | -0.01 | 7.0e-01 | -10.3 | -5.3 | 1.4e-07 | 0.07 | 0.06 | 0.08 | FALSE |
22 | GTEx | Cells EBV-transformed lymphocytes | RP11-250B2.6 | 0.21 | 0.03 | enet | 37 | 0.13 | 4.7e-05 | 7.7 | -8.6 | 6.5e-18 | 0.16 | 0.14 | 0.05 | TRUE |
23 | GTEx | Cells Transformed fibroblasts | DOPEY1 | 0.17 | 0.14 | enet | 16 | 0.17 | 1.8e-12 | 6.9 | -7.5 | 5.8e-14 | -0.01 | 0.01 | 0.99 | FALSE |
24 | GTEx | Cells Transformed fibroblasts | BCKDHB | 0.16 | 0.02 | enet | 42 | 0.04 | 3.7e-04 | 8.0 | 12.3 | 8.4e-35 | -0.09 | 0.51 | 0.27 | FALSE |
25 | GTEx | Cells Transformed fibroblasts | RP11-250B2.5 | 0.16 | 0.07 | lasso | 10 | 0.05 | 5.8e-05 | 12.3 | 6.9 | 4.1e-12 | -0.05 | 0.10 | 0.84 | TRUE |
26 | GTEx | Cells Transformed fibroblasts | RP11-250B2.6 | 0.11 | 0.01 | lasso | 7 | 0.00 | 1.4e-01 | -10.8 | -7.1 | 1.0e-12 | 0.04 | 0.38 | 0.02 | TRUE |
27 | GTEx | Colon Sigmoid | DOPEY1 | 0.19 | 0.21 | lasso | 6 | 0.21 | 5.6e-08 | 7.0 | -7.2 | 4.2e-13 | -0.04 | 0.00 | 1.00 | FALSE |
28 | GTEx | Colon Transverse | DOPEY1 | 0.14 | 0.13 | enet | 7 | 0.12 | 2.3e-06 | 6.9 | -7.2 | 4.8e-13 | -0.01 | 0.01 | 0.98 | FALSE |
29 | GTEx | Colon Transverse | RP11-250B2.5 | 0.13 | 0.02 | enet | 3 | 0.01 | 6.3e-02 | -4.8 | -8.9 | 4.0e-19 | 0.02 | 0.11 | 0.08 | TRUE |
30 | GTEx | Colon Transverse | RP11-250B2.6 | 0.15 | 0.16 | lasso | 2 | 0.13 | 9.8e-07 | 8.0 | -7.2 | 7.3e-13 | 0.01 | 0.95 | 0.00 | FALSE |
31 | GTEx | Esophagus Gastroesophageal Junction | DOPEY1 | 0.19 | 0.11 | lasso | 5 | 0.08 | 6.0e-04 | 6.9 | -7.1 | 1.0e-12 | -0.02 | 0.01 | 0.97 | FALSE |
32 | GTEx | Esophagus Mucosa | RP11-250B2.6 | 0.20 | 0.16 | lasso | 7 | 0.23 | 3.3e-15 | -10.8 | -11.6 | 4.7e-31 | 0.02 | 1.00 | 0.00 | FALSE |
33 | GTEx | Esophagus Muscularis | DOPEY1 | 0.25 | 0.15 | enet | 10 | 0.14 | 1.4e-08 | 6.9 | -6.3 | 2.7e-10 | -0.02 | 0.01 | 0.99 | FALSE |
34 | GTEx | Esophagus Muscularis | BCKDHB | 0.18 | 0.07 | enet | 25 | 0.06 | 2.4e-04 | 7.6 | 7.0 | 3.6e-12 | -0.04 | 0.94 | 0.00 | FALSE |
35 | GTEx | Heart Atrial Appendage | RP11-250B2.6 | 0.20 | 0.00 | enet | 17 | 0.03 | 2.6e-02 | -7.8 | -14.8 | 1.5e-49 | 0.26 | 0.08 | 0.21 | TRUE |
36 | GTEx | Heart Left Ventricle | RP11-250B2.6 | 0.09 | 0.00 | enet | 6 | 0.02 | 2.0e-02 | 10.9 | -10.7 | 6.2e-27 | 0.07 | 0.16 | 0.09 | FALSE |
37 | GTEx | Lung | DOPEY1 | 0.11 | 0.13 | lasso | 3 | 0.12 | 2.9e-09 | 6.9 | -6.9 | 6.8e-12 | -0.01 | 0.01 | 0.99 | FALSE |
38 | GTEx | Lung | BCKDHB | 0.09 | 0.06 | enet | 10 | 0.05 | 1.8e-04 | 7.6 | 7.6 | 2.3e-14 | -0.03 | 0.91 | 0.01 | FALSE |
39 | GTEx | Lung | UBE3D | 0.07 | 0.01 | enet | 16 | 0.02 | 9.8e-03 | 6.3 | 5.2 | 1.9e-07 | 0.02 | 0.06 | 0.51 | FALSE |
40 | GTEx | Lung | RP11-250B2.6 | 0.09 | 0.05 | enet | 16 | 0.07 | 5.3e-06 | 8.1 | -12.3 | 1.3e-34 | 0.01 | 0.71 | 0.17 | FALSE |
41 | GTEx | Muscle Skeletal | DOPEY1 | 0.13 | 0.11 | lasso | 5 | 0.10 | 4.2e-10 | 6.9 | -7.2 | 7.9e-13 | -0.02 | 0.01 | 0.99 | FALSE |
42 | GTEx | Muscle Skeletal | RP11-250B2.6 | 0.07 | 0.04 | lasso | 5 | 0.04 | 4.2e-05 | 11.9 | -12.5 | 1.1e-35 | 0.09 | 0.81 | 0.15 | FALSE |
43 | GTEx | Nerve Tibial | DOPEY1 | 0.23 | 0.28 | lasso | 3 | 0.28 | 3.7e-20 | 6.9 | -7.2 | 8.8e-13 | -0.02 | 0.01 | 0.99 | FALSE |
44 | GTEx | Nerve Tibial | BCKDHB | 0.18 | 0.11 | lasso | 9 | 0.10 | 2.4e-07 | 7.7 | 7.9 | 2.3e-15 | -0.04 | 1.00 | 0.00 | FALSE |
45 | GTEx | Ovary | DOPEY1 | 0.33 | 0.19 | enet | 18 | 0.23 | 2.9e-06 | 6.9 | -7.5 | 4.7e-14 | -0.02 | 0.01 | 0.98 | FALSE |
46 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-250B2.5 | 0.13 | 0.16 | lasso | 4 | 0.17 | 1.1e-09 | 10.5 | -6.5 | 1.1e-10 | -0.01 | 0.98 | 0.00 | FALSE |
47 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-250B2.6 | 0.08 | 0.05 | lasso | 4 | 0.01 | 8.1e-02 | 8.1 | -6.8 | 7.3e-12 | -0.09 | 0.22 | 0.04 | FALSE |
48 | GTEx | Skin Sun Exposed Lower leg | DOPEY1 | 0.16 | 0.17 | lasso | 5 | 0.16 | 4.0e-13 | 7.0 | -7.4 | 1.2e-13 | -0.04 | 0.00 | 1.00 | FALSE |
49 | GTEx | Spleen | DOPEY1 | 0.21 | 0.12 | lasso | 4 | 0.12 | 7.1e-04 | 6.2 | -6.6 | 5.4e-11 | -0.04 | 0.14 | 0.38 | FALSE |
50 | GTEx | Stomach | RP11-250B2.6 | 0.13 | 0.15 | lasso | 6 | 0.12 | 2.5e-06 | 8.0 | -7.2 | 5.9e-13 | 0.00 | 0.94 | 0.00 | FALSE |
51 | GTEx | Testis | DOPEY1 | 0.19 | 0.00 | lasso | 9 | 0.03 | 2.4e-02 | 6.2 | -6.4 | 1.4e-10 | -0.03 | 0.06 | 0.66 | FALSE |
52 | GTEx | Testis | ELOVL4 | 0.31 | 0.19 | lasso | 7 | 0.18 | 1.9e-08 | -6.7 | -6.4 | 1.2e-10 | 0.09 | 0.96 | 0.00 | TRUE |
53 | GTEx | Testis | RP11-250B2.5 | 0.13 | 0.17 | lasso | 3 | 0.14 | 7.0e-07 | -10.8 | -10.5 | 1.1e-25 | 0.06 | 0.74 | 0.10 | TRUE |
54 | GTEx | Testis | RP11-250B2.6 | 0.09 | 0.05 | lasso | 6 | 0.04 | 6.9e-03 | 8.1 | -7.4 | 1.5e-13 | 0.01 | 0.42 | 0.03 | FALSE |
55 | GTEx | Thyroid | BCKDHB | 0.17 | 0.06 | lasso | 8 | 0.10 | 3.4e-08 | 8.1 | 10.1 | 5.9e-24 | -0.05 | 1.00 | 0.00 | FALSE |
56 | GTEx | Thyroid | RP11-250B2.6 | 0.11 | 0.10 | lasso | 2 | 0.07 | 3.2e-06 | 8.0 | -8.0 | 1.2e-15 | 0.01 | 1.00 | 0.00 | FALSE |
57 | METSIM | Adipose | BCKDHB | 0.05 | 0.03 | blup | 558 | 0.05 | 1.1e-07 | -10.8 | 6.6 | 4.3e-11 | 0.00 | 1.00 | 0.00 | FALSE |
58 | METSIM | Adipose | DOPEY1 | 0.08 | 0.08 | lasso | 10 | 0.07 | 2.4e-10 | 6.9 | -7.5 | 5.1e-14 | -0.03 | 0.09 | 0.91 | FALSE |
59 | METSIM | Adipose | RP11-250B2.6 | 0.04 | 0.04 | lasso | 12 | 0.02 | 1.7e-04 | 11.5 | -9.8 | 1.8e-22 | -0.01 | 0.74 | 0.01 | FALSE |
60 | ROSMAP | Brain Pre-frontal Cortex | DOPEY1 | 0.11 | 0.08 | enet | 45 | 0.09 | 2.9e-11 | 5.6 | -5.3 | 1.4e-07 | -0.07 | 0.91 | 0.09 | FALSE |
61 | ROSMAP | Brain Pre-frontal Cortex | BCKDHB | 0.18 | 0.13 | lasso | 6 | 0.14 | 2.9e-17 | 7.7 | 6.1 | 1.1e-09 | -0.05 | 1.00 | 0.00 | FALSE |
62 | ROSMAP | Brain Pre-frontal Cortex | FAM46A | 0.08 | 0.01 | blup | 495 | 0.03 | 2.7e-04 | 5.2 | 7.3 | 3.8e-13 | 0.04 | 0.65 | 0.01 | TRUE |
63 | ROSMAP | Brain Pre-frontal Cortex | RP11-250B2.3 | 0.08 | 0.02 | blup | 402 | 0.04 | 5.8e-06 | 7.5 | -6.1 | 8.1e-10 | 0.15 | 0.79 | 0.02 | TRUE |
64 | YFS | Blood | DOPEY1 | 0.18 | 0.21 | lasso | 9 | 0.21 | 1.4e-67 | 6.9 | -7.4 | 1.3e-13 | -0.02 | 0.13 | 0.87 | FALSE |
65 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DOPEY1 | 0.05 | 0.06 | lasso | 2 | 0.06 | 2.6e-12 | 6.9 | -7.2 | 4.7e-13 | -0.02 | 0.04 | 0.96 | FALSE |
66 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | BCKDHB | 0.12 | 0.06 | lasso | 4 | 0.06 | 4.2e-07 | 10.2 | -8.1 | 4.3e-16 | 0.02 | 0.97 | 0.00 | TRUE |
67 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DOPEY1 | 0.09 | 0.02 | enet | 3 | 0.04 | 2.4e-05 | 6.9 | -5.9 | 4.2e-09 | -0.01 | 0.02 | 0.97 | FALSE |
68 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DOPEY1 | 0.08 | 0.08 | blup | 47 | 0.09 | 2.3e-10 | 6.9 | -7.6 | 3.8e-14 | -0.04 | 0.03 | 0.97 | FALSE |
69 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ELOVL4 | 0.09 | 0.04 | enet | 4 | 0.02 | 1.9e-03 | 5.5 | 5.5 | 3.2e-08 | 0.00 | 0.24 | 0.10 | FALSE |
70 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | DOPEY1 | 0.06 | 0.08 | lasso | 2 | 0.04 | 3.9e-03 | 7.6 | -7.7 | 1.7e-14 | -0.04 | 0.00 | 0.94 | TRUE |
71 | The Cancer Genome Atlas | Lung Adenocarcinoma | DOPEY1 | 0.03 | 0.02 | lasso | 2 | 0.02 | 2.1e-03 | 6.9 | -7.1 | 1.2e-12 | -0.02 | 0.02 | 0.78 | FALSE |
72 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | DOPEY1 | 0.07 | 0.05 | lasso | 3 | 0.04 | 8.7e-06 | 6.9 | -6.9 | 6.8e-12 | -0.01 | 0.10 | 0.85 | FALSE |
73 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | DOPEY1 | 0.08 | 0.05 | blup | 47 | 0.04 | 1.4e-03 | 6.9 | -6.4 | 1.3e-10 | -0.03 | 0.02 | 0.88 | FALSE |
74 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | DOPEY1 | 0.17 | 0.16 | lasso | 3 | 0.14 | 1.6e-06 | 6.9 | -6.9 | 6.8e-12 | -0.01 | 0.05 | 0.93 | FALSE |
75 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DOPEY1 | 0.07 | 0.11 | blup | 47 | 0.11 | 1.7e-11 | 6.2 | -6.7 | 2.9e-11 | -0.04 | 0.90 | 0.10 | FALSE |
76 | The Cancer Genome Atlas | Soft Tissue Sarcoma | DOPEY1 | 0.04 | 0.02 | blup | 47 | 0.02 | 1.4e-02 | 6.0 | -6.9 | 4.0e-12 | -0.04 | 0.01 | 0.84 | FALSE |
77 | The Cancer Genome Atlas | Soft Tissue Sarcoma | UBE2CBP | 0.09 | 0.00 | blup | 85 | 0.03 | 6.4e-03 | -4.1 | 5.4 | 8.5e-08 | 0.03 | 0.05 | 0.28 | FALSE |
78 | The Cancer Genome Atlas | Stomach Adenocarcinoma | DOPEY1 | 0.11 | 0.06 | lasso | 3 | 0.06 | 4.1e-05 | 6.9 | -7.1 | 1.6e-12 | -0.02 | 0.03 | 0.95 | FALSE |
79 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | BCKDHB | 0.19 | 0.02 | blup | 137 | 0.06 | 2.6e-03 | 7.6 | 6.2 | 5.6e-10 | -0.04 | 0.03 | 0.08 | FALSE |