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chr6:129,638,583-132,302,295

Best TWAS P=7.96e-83 · Best GWAS P=2.81e-73 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
30	GTEx	Thyroid	L3MBTL3	0.40	0.39	enet	9	0.43	2.8e-35	18.1	19.3	8.0e-83	0.95	0.00	1.00	TRUE
22	GTEx	Skin Not Sun Exposed Suprapubic	L3MBTL3	0.26	0.12	lasso	4	0.12	4.0e-07	15.2	18.3	9.5e-75	0.92	0.00	1.00	TRUE
18	GTEx	Pituitary	L3MBTL3	0.45	0.31	lasso	8	0.29	5.1e-08	13.7	16.4	3.4e-60	0.85	0.00	0.99	TRUE
36	ROSMAP	Brain Pre-frontal Cortex	L3MBTL3	0.14	0.07	blup	609	0.08	3.8e-10	18.1	16.0	6.8e-58	0.72	0.00	1.00	TRUE
34	METSIM	Adipose	L3MBTL3	0.13	0.12	enet	22	0.12	4.8e-18	16.0	14.7	7.1e-49	0.72	0.99	0.01	TRUE
35	ROSMAP	Brain Pre-frontal Cortex	EPB41L2	0.12	0.12	blup	522	0.10	6.5e-13	4.2	6.8	1.3e-11	0.00	1.00	0.00	TRUE
1	CommonMind	Brain Pre-frontal Cortex	TMEM200A	0.04	0.03	lasso	3	0.03	9.4e-05	4.8	-5.2	2.3e-07	-0.24	0.81	0.01	TRUE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	L3MBTL3	0.05	0.00	blup	114	0.01	1.0e-02	11.0	5.1	2.9e-07	0.33	0.03	0.22	TRUE
14	GTEx	Lung	L3MBTL3	0.37	0.34	lasso	4	0.38	4.1e-30	18.1	19.0	1.6e-80	0.96	0.00	1.00	FALSE
3	GTEx	Adipose Visceral Omentum	L3MBTL3	0.14	0.12	lasso	2	0.15	2.8e-08	18.1	18.9	7.2e-80	0.94	0.00	1.00	FALSE
17	GTEx	Pancreas	L3MBTL3	0.32	0.17	lasso	4	0.23	4.4e-10	18.1	18.9	1.9e-79	0.98	0.00	1.00	FALSE
15	GTEx	Lung	RP11-73O6.3	0.15	0.08	lasso	5	0.12	2.2e-09	18.1	18.9	2.0e-79	0.93	0.00	1.00	FALSE
31	GTEx	Thyroid	RP11-73O6.3	0.18	0.15	lasso	3	0.20	2.3e-15	16.5	18.8	5.2e-79	0.91	0.00	1.00	FALSE
16	GTEx	Nerve Tibial	L3MBTL3	0.30	0.23	lasso	4	0.22	2.3e-15	18.1	18.8	7.7e-79	0.99	0.00	1.00	FALSE
24	GTEx	Small Intestine Terminal Ileum	L3MBTL3	0.37	0.20	lasso	4	0.17	1.3e-04	18.1	18.7	2.2e-78	0.98	0.00	0.98	FALSE
32	GTEx	Whole Blood	L3MBTL3	0.22	0.20	lasso	9	0.20	5.1e-18	18.1	18.7	3.1e-78	0.98	0.00	1.00	FALSE
4	GTEx	Breast Mammary Tissue	L3MBTL3	0.31	0.25	lasso	7	0.23	2.8e-12	18.1	18.7	4.5e-78	0.97	0.00	1.00	FALSE
25	GTEx	Spleen	L3MBTL3	0.64	0.34	enet	14	0.48	6.4e-14	16.0	18.7	1.0e-77	0.87	0.02	0.98	FALSE
5	GTEx	Breast Mammary Tissue	RP11-73O6.3	0.27	0.22	lasso	9	0.22	1.5e-11	18.1	18.6	2.2e-77	0.97	0.00	1.00	FALSE
33	GTEx	Whole Blood	RP11-73O6.3	0.15	0.06	lasso	8	0.04	1.1e-04	18.1	18.6	3.0e-77	0.97	0.00	1.00	FALSE
6	GTEx	Breast Mammary Tissue (Male)	L3MBTL3	0.31	0.24	lasso	6	0.23	5.5e-06	18.1	18.6	3.2e-77	0.94	0.00	0.98	FALSE
9	GTEx	Breast Mammary Tissue (Female)	RP11-73O6.3	0.29	0.08	lasso	5	0.10	5.7e-04	16.0	18.6	6.6e-77	0.90	0.01	0.97	FALSE
12	GTEx	Colon Transverse	RP11-73O6.3	0.19	0.09	lasso	2	0.06	1.2e-03	18.1	18.5	1.3e-76	0.99	0.00	1.00	FALSE
11	GTEx	Colon Transverse	L3MBTL3	0.27	0.13	lasso	8	0.20	8.0e-10	18.1	18.5	2.2e-76	0.88	0.00	1.00	FALSE
2	GTEx	Adipose Subcutaneous	L3MBTL3	0.20	0.08	lasso	4	0.09	1.1e-07	18.1	18.4	8.0e-76	0.94	0.00	1.00	FALSE
8	GTEx	Breast Mammary Tissue (Female)	L3MBTL3	0.30	0.13	lasso	5	0.14	4.5e-05	13.7	18.4	8.0e-76	0.93	0.01	0.98	FALSE
20	GTEx	Prostate	L3MBTL3	0.35	0.27	lasso	5	0.17	5.9e-05	18.1	18.4	1.3e-75	0.97	0.00	0.99	FALSE
13	GTEx	Esophagus Mucosa	L3MBTL3	0.26	0.18	lasso	2	0.23	2.7e-15	16.0	18.4	2.0e-75	0.93	0.00	1.00	FALSE
23	GTEx	Skin Sun Exposed Lower leg	L3MBTL3	0.25	0.25	lasso	9	0.24	1.4e-19	18.1	18.2	1.2e-73	0.97	0.00	1.00	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	L3MBTL3	0.28	0.08	lasso	10	0.03	4.4e-02	18.1	18.1	2.1e-73	0.85	0.01	0.97	FALSE
7	GTEx	Breast Mammary Tissue (Male)	RP11-73O6.3	0.33	0.17	lasso	4	0.12	1.3e-03	18.1	17.9	1.2e-71	0.94	0.01	0.96	FALSE
27	GTEx	Stomach	L3MBTL3	0.36	0.18	enet	27	0.20	1.1e-09	17.7	17.8	1.5e-70	0.77	0.02	0.98	FALSE
26	GTEx	Spleen	RP11-73O6.3	0.45	0.43	enet	21	0.42	7.7e-12	16.0	17.6	1.3e-69	0.82	0.05	0.95	FALSE
29	GTEx	Testis	L3MBTL3	0.41	0.22	lasso	8	0.30	9.2e-14	18.1	17.5	2.8e-68	0.90	0.00	1.00	FALSE
28	GTEx	Stomach	RP11-73O6.3	0.21	0.12	lasso	6	0.06	5.9e-04	17.7	16.7	2.1e-62	0.73	0.12	0.55	FALSE
37	YFS	Blood	L3MBTL3	0.28	0.22	blup	614	0.27	1.2e-88	16.0	15.1	3.0e-51	0.74	1.00	0.00	FALSE
39	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	L3MBTL3	0.06	0.01	blup	114	0.04	4.0e-03	16.0	14.4	8.8e-47	0.77	0.02	0.87	FALSE
19	GTEx	Pituitary	RP11-73O6.3	0.48	0.07	lasso	7	0.16	8.2e-05	13.7	13.9	5.2e-44	0.78	0.01	0.98	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	AKAP7	0.24	0.07	lasso	5	0.17	8.7e-10	-6.1	5.8	5.9e-09	-0.04	0.71	0.07	FALSE
40	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LOC285733	0.22	0.19	enet	9	0.19	3.9e-11	4.7	5.2	2.4e-07	0.00	1.00	0.00	FALSE