Hub : Genes

TMEM200A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0430 0.0190 0.00180 0.034 0.019 0.025 0.024 0.031 4.7e-05 2.0e-03 4.6e-04 0.00063 9.4e-05
2 METSIM Adipose 0.0401 0.0155 0.00073 0.003 0.017 0.009 0.015 0.006 1.1e-01 1.0e-03 1.2e-02 0.00190 3.4e-02
3 TCGA Thyroid Carcinoma 0.0980 0.0400 0.00068 0.052 0.039 0.055 NA 0.052 8.5e-06 9.2e-05 4.5e-06 NA 8.4e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 2.2 3.4 7.3 2.7 -1.5 0.9
Bipolar Disorder or Schizophrenia 3.1 7.5 13.2 2.5 -3.6 1.7
Depressed Affect (Nagel 2018) 3.1 6.5 9.8 3.0 -3.1 0.8
Depression (Nagel 2018) 3.7 5.6 11.0 3.3 -2.2 -0.9
Intelligence (Savage-Jansen 2018) 0.7 2.2 4.5 2.1 0.6 1.3
Neuroticism (Nagel 2018) 3.8 8.8 16.6 4.1 -3.0 0.9
Schizophrenia (2018) 2.5 5.2 12.2 1.0 -3.5 1.5
Schizophrenia vs Biploar Disorder 0.9 1.2 2.4 -1.0 -1.6 0.5
Worry (Nagel 2018) 1.4 2.9 7.3 1.1 -2.7 0.5
Alzheimer’s Disease (in mother) 2.1 2.5 7.4 0.0 -0.3 2.7
Alzheimer’s Disease (in father) 0.1 0.1 0.2 0.3 0.4 -0.0
Alzheimer’s Disease (including proxy) 0.8 1.2 3.5 0.4 0.0 1.9
Crohns Disease (2017) 0.5 1.1 2.0 1.4 -0.7 -0.9
Irritable Bowel Disease (IBD) 0.2 0.4 0.6 0.4 0.8 0.6
Ulcerative Colitis (UC) 1.0 1.8 2.6 -0.9 1.5 1.6
Major Depression (MDD) 4.6 5.6 8.0 2.8 -2.8 1.1
Reaction Time 2.8 5.4 8.8 3.0 -2.7 0.1
Verbal and Numeric Reasoning (VNR) 0.9 2.2 3.9 1.1 1.3 2.0
Breast Cancer 0.4 0.9 2.7 -1.6 -0.0 -0.2
Ovarian Cancer 0.2 0.3 0.4 0.4 -0.6 -0.6
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 2.4 3.5 8.2 -0.9 1.2 -2.9
Bipolar Disorder (2011) 1.6 1.5 4.1 2.0 0.8 0.0
Body Mass Index (BMI) (2010) 1.0 1.4 3.4 0.7 1.8 0.4
Coronary Artery Disease (CAD) 0.8 0.9 2.2 -0.3 -0.6 -1.5
Crohns Disease (2012) 1.1 1.8 3.0 1.7 -0.7 -1.4
Mean Putamen Volume 1.0 1.2 2.2 -1.5 -1.1 0.1
Fasting Glucose 0.4 0.5 0.9 -0.6 0.9 -0.4
HbA1C 1.6 1.8 3.1 -1.8 0.3 -1.5
HDL Cholesterol 0.4 0.7 1.0 -1.0 -0.4 0.8
LDL Cholesterol 0.5 0.8 2.0 0.2 1.4 0.5
Lupus 0.2 0.2 0.4 0.7 -0.5 -0.2
Neuroticism (2016) 2.7 3.9 6.7 2.6 -1.8 -1.4
Primary Biliary Cirrhosis 0.0 0.0 0.0 0.1 0.1 -0.0
Rheumatoid Arthritis 0.7 0.9 1.6 -0.5 -1.3 -1.0
Schizophrenia (2014) 3.3 7.2 17.2 1.5 -4.2 1.5
Triglycerides 0.3 0.5 0.9 1.0 0.0 0.8
Type 2 Diabetes (T2D) (2012) 0.7 0.8 0.9 1.0 0.8 0.8
Ulcerative Colitis 0.5 0.8 1.4 -0.7 1.2 0.6
Blood Eosinophil Count 0.2 1.5 4.3 -0.4 -0.3 -2.1
Blood Platelet Count 0.5 5.6 16.6 0.1 -4.1 0.1
Blood Red Count 0.0 0.4 1.0 0.3 -0.4 1.0
Blood White Count 0.3 2.0 4.1 1.3 0.0 -2.0
Heel T-Score 2.4 19.4 53.9 1.5 7.3 -1.4
BMI 0.6 3.5 4.5 -1.2 2.1 -2.1
Height 0.5 9.3 26.5 -5.2 1.1 0.4
Waist Hip Ratio (WHR) 0.5 2.4 4.1 2.0 -1.1 1.3
Systolic Blood Pressure 2.0 10.2 19.1 2.5 -4.4 2.3
Smoking Status 1.9 4.6 7.1 1.5 2.1 -2.7
Allergy or Eczema 0.3 0.8 1.3 -1.1 -0.8 0.6
Cardiovascular Disease 1.0 3.2 9.2 -0.2 -3.0 0.7
Hypothyroidism (self reported) 0.1 0.3 0.6 0.6 -0.2 -0.8
Respiratory disease 1.2 2.7 7.6 -0.6 0.1 -2.8
Type 2 Diabetes (T2D) (2018) 0.2 0.3 0.6 0.8 0.4 -0.4
Lung FEV1/FVC ratio 0.1 0.4 1.0 -0.2 -0.4 -1.0
Lung FVC 0.5 2.5 3.2 1.3 1.5 1.8
Neuroticism 2.6 6.3 10.1 2.9 -3.2 0.7
Chronotype (morning person) 1.8 4.1 11.9 0.1 0.7 3.4
Hair Pigment 0.1 2.8 8.0 2.8 0.6 -0.2
Tanning 0.0 0.4 1.3 0.2 -0.0 -1.1
Hand grip strength (left) 0.3 0.8 1.7 -1.3 0.3 0.7
Number of treatments/medications taken 2.2 4.0 8.6 0.3 -1.8 -2.9
Average weekly spirits intake 0.4 0.5 0.9 1.0 -0.2 -0.7
Sensitivity / hurt feelings 2.0 3.4 8.0 2.8 -1.5 0.2
Frequency of depressed mood in last 2 weeks 3.7 5.1 6.8 2.5 -2.6 -1.4
Hearing difficulty/problems: Yes 0.0 0.0 0.0 0.0 -0.1 -0.2
Relative age of first facial hair 0.1 0.2 0.4 -0.3 -0.7 -0.1
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.7 -0.1 -0.9 -0.7
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.2 1.1 -0.7 -0.2
Ever had hysterectomy (womb removed) 0.2 0.3 0.5 -0.2 0.6 0.7
Systolic blood pressure, automated reading 1.9 5.5 13.1 1.3 -3.6 1.2
Eye problems/disorders: Diabetes related eye disease 1.7 1.9 4.1 0.2 -2.0 1.2
Angina 3.2 4.2 9.0 1.7 -3.0 -0.7
Medication for hormone replacement therapy 2.4 2.7 5.1 1.1 -2.3 1.3
Vitamin and mineral supplements 0.2 0.2 0.4 0.3 0.4 0.6
Supplements: Zinc 0.9 0.9 1.6 -0.0 -1.3 1.1
Medication: Co-codamol 1.3 1.5 4.2 -0.6 0.2 -2.0
Medication: Metformin 1.0 1.5 2.3 1.5 -1.1 1.0
Diabetes (father) 1.7 2.1 6.0 -0.3 2.5 -0.2
Diabetes (mother) 0.4 0.6 1.1 -1.0 -0.7 0.3
Severe depression (siblings) 4.6 5.2 11.0 2.1 -3.3 0.4
Pack years adult smoking proportion 1.6 2.4 4.2 1.8 -2.1 -0.0
Impedance of leg (right) 1.1 5.2 8.4 2.5 -1.1 2.9
Leg fat-free mass (left) 1.5 7.7 15.5 -3.9 2.2 -1.7
Trunk fat percentage 1.0 4.0 6.8 -0.9 2.6 -2.1
Hand grip strength (right) 0.4 1.0 2.0 -1.4 0.7 0.8
Townsend deprivation index at recruitment 1.7 2.3 4.5 2.1 -0.6 1.5
Current tobacco smoking 1.2 2.0 2.9 0.9 -1.5 -1.7
Average weekly fortified wine intake 0.8 0.9 2.2 -0.6 1.5 0.3
Maternal smoking around birth 0.7 1.0 1.5 1.2 -1.1 0.6
Fed-up feelings 4.7 8.5 14.1 3.8 -3.3 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 2.2 3.0 5.7 2.4 -1.6 -0.8
Relative age voice broke 0.2 0.2 0.3 -0.6 0.5 -0.4
Taking other prescription medications 1.5 2.3 5.6 1.2 0.2 -2.4
Age when periods started (menarche) 0.1 0.2 0.5 -0.1 0.4 0.7
Bilateral oophorectomy (both ovaries removed) 1.5 1.8 3.5 1.2 -1.9 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 2.3 0.5 1.5 0.1
Tinnitus: Yes, but not now, but have in the past 2.7 2.9 7.4 0.5 -2.7 1.0
Qualifications: CSEs or equivalent 1.5 2.0 4.8 -0.5 -2.2 1.0
Serious illness, injury or assault to yourself 1.8 2.2 4.8 2.2 -1.3 0.4
High blood pressure 1.1 3.1 9.2 -0.2 -3.0 -0.2
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.3 -0.8 -0.3 1.1
Multivitamins +/- minerals 0.6 0.8 1.7 0.6 -0.6 1.3
Stomach or abdominal pain in last month 2.3 2.8 4.3 -0.4 -2.1 -2.0
Supplements: Glucosamine 1.3 1.7 4.3 0.1 2.1 0.9
Diverticular disease/diverticulitis (self-reported) 1.2 1.4 3.2 -0.0 1.1 -1.8
Medication: Atenolol 2.0 2.6 5.3 1.5 -2.3 0.5
Medication: Levothyroxine sodium 0.1 0.2 0.5 -0.0 0.7 -0.5
Sitting height 0.5 3.6 7.8 -2.8 0.8 1.6
Chronic bronchitis/emphysema (father) 0.3 0.4 0.6 -0.8 0.7 0.3
High blood pressure (mother) 0.1 0.2 0.2 -0.4 0.5 0.4
Body mass index (BMI) 0.9 3.7 5.5 -1.1 2.1 -2.4
Impedance of leg (left) 0.6 3.1 4.5 1.9 -1.1 2.1
Leg predicted mass (left) 1.4 7.6 14.8 -3.9 2.3 -1.6
Trunk fat mass 1.3 5.6 8.1 -2.1 2.9 -2.1
Waist circumference 1.0 3.7 5.5 -1.7 2.3 -1.6
Number of incorrect matches in round 0.2 0.4 0.8 -0.1 0.6 -0.9
Past tobacco smoking 4.0 7.4 15.1 -0.2 -3.9 2.6
Alcohol usually taken with meals 0.5 0.8 1.3 -0.6 0.8 -1.1
Nervous feelings 1.2 2.2 6.5 0.0 -2.6 -0.1
Frequency of tenseness / restlessness in last 2 weeks 3.0 4.7 4.9 2.2 -2.2 -2.1
Hearing difficulty/problems with background noise 0.2 0.3 0.7 0.9 0.2 -0.0
Hair/balding pattern: Pattern 2 0.6 0.8 1.9 -0.2 1.4 0.7
Had menopause 0.7 0.9 1.2 0.6 1.1 -1.1
Had other major operations 1.0 1.2 3.4 -0.3 -0.1 -1.8
Forced vital capacity (FVC) 1.2 4.6 7.5 -2.1 1.4 2.7
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 3.3 0.2 1.8 -0.2
Ever unenthusiastic/disinterested for a whole week 4.9 6.0 13.3 1.5 -3.7 1.5
Qualifications: None of the above 0.7 1.4 2.2 -1.2 -1.5 -0.9
Financial difficulties in last 2 years 3.1 4.2 7.9 2.8 -2.1 -0.7
Mouth/teeth dental problems 2.8 4.2 9.9 -3.1 0.4 1.6
Heart attack 2.4 3.1 5.1 1.0 -2.3 1.8
Allergy 0.1 0.2 0.7 -0.0 0.8 0.1
Pain all over the body in last month 2.3 2.4 2.9 1.7 -1.6 1.4
Diabetes (self-reported) 0.1 0.2 0.5 0.7 -0.2 -0.0
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 0.8 -0.8 -0.9 0.6
Medication: Ramipril 0.6 0.8 1.8 0.5 -1.3 -0.5
Medication: Simvastatin 0.6 0.9 1.5 -0.8 -1.2 -0.8
Fluid intelligence score 2.7 5.7 8.6 1.5 2.5 2.9
Illnesses of siblings 0.2 0.4 0.7 0.5 0.8 0.4
Neuroticism score 4.2 8.7 15.9 3.2 -4.0 0.5
Weight 1.5 7.3 11.2 -3.4 2.6 -1.9
Impedance of arm (right) 0.4 2.0 4.5 2.1 0.2 1.2
Arm fat percentage (right) 1.0 4.0 5.8 -0.8 2.4 -2.4
Trunk fat-free mass 1.2 6.7 18.1 -4.3 1.3 -0.5
Hip circumference 1.6 7.1 10.8 -3.3 2.5 -2.1
Time employed in main current job 0.7 0.8 1.5 -1.2 -0.3 -1.0
Alcohol intake versus 10 years previously 1.2 1.8 3.2 -1.8 -1.2 -0.8
Father’s age at death 0.6 0.8 1.1 -1.0 0.6 -1.0
Worrier / anxious feelings 2.8 5.2 6.8 1.8 -2.4 2.6
Frequency of tiredness / lethargy in last 2 weeks 2.3 3.8 9.0 3.0 -1.5 -0.1
Falls in the last year 0.2 0.3 0.7 0.3 -0.0 0.9
Hair/balding pattern: Pattern 3 0.7 1.0 2.8 -1.7 -0.2 -0.4
Number of live births 0.2 0.3 0.4 0.3 0.6 -0.7
Forced expiratory volume in 1-second (FEV1) 1.3 4.4 8.5 -1.9 1.0 2.9
Pulse rate 1.1 1.9 4.8 -0.8 -2.2 0.5
Happiness 3.2 3.8 6.7 2.6 -2.1 -0.6
Noisy workplace 1.4 1.7 3.5 1.2 -1.9 0.6
Qualifications: A levels/AS levels or equivalent 0.7 1.6 2.2 -1.5 1.5 0.6
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.4 2.5 1.6 1.2 0.5
Mouth/teeth dental problems: Dentures 1.1 1.8 2.8 1.7 0.2 -1.6
Asthma 0.6 1.3 3.0 -0.1 -0.8 -1.7
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 2.4 -0.8 1.0 -1.5
Medication: Cholesterol lowering 0.5 0.9 2.3 0.1 -1.5 0.5
Depression (self-reported) 2.5 2.9 5.0 1.9 -2.2 0.5
Medication: Lansoprazole 3.2 3.7 10.9 -0.0 0.5 -3.3
Prospective memory result 1.2 1.4 2.8 -1.7 -0.9 -0.9
Lung cancer (father) 1.0 1.2 2.0 -1.2 0.3 1.4
Illnesses of mother 0.2 0.3 0.8 0.2 -0.0 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 1.3 4.2 5.2 -2.3 2.0 1.9
Pulse wave Arterial Stiffness index 1.3 1.5 2.2 1.5 -1.5 0.3
Impedance of arm (left) 0.3 1.5 2.9 1.7 -0.3 1.2
Arm fat mass (right) 1.1 4.7 6.0 -1.6 2.3 -2.5
Trunk predicted mass 1.1 6.5 17.8 -4.2 1.3 -0.5
Standing height 1.0 9.8 26.7 -5.2 1.3 0.9
Length of working week for main job 1.3 1.5 3.0 1.1 -1.7 0.6
Exposure to tobacco smoke at home 0.4 0.5 0.8 0.6 -0.9 -0.6
Breastfed as a baby 1.6 2.0 5.5 -0.3 0.7 -2.3
Tense / ‘highly strung’ 3.7 6.1 12.9 2.2 -3.6 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 5.5 8.4 15.3 3.9 -2.8 1.5
Hair/balding pattern: Pattern 4 2.5 6.1 13.2 3.6 -2.1 0.8
Birth weight of first child 0.9 1.6 4.4 0.4 -0.3 2.1
Peak expiratory flow (PEF) 1.1 2.6 3.3 -1.8 1.6 1.4
Pulse wave reflection index 1.2 1.4 2.7 1.7 -1.2 0.1
Ever highly irritable/argumentative for 2 days 3.2 3.9 8.1 2.8 -1.7 -0.8
Loud music exposure frequency 0.9 1.0 1.2 0.8 1.0 1.1
Qualifications: O levels/GCSEs or equivalent 1.6 2.5 6.2 -0.8 2.5 0.8
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.5 0.5 -0.3 -1.2
Blood clot in the leg (DVT) 3.2 4.1 9.1 3.0 -0.1 -1.8
Medication: Paracetamol 0.6 1.0 1.6 -0.8 0.8 -1.3
Headache pain in last month 0.7 1.1 3.2 -0.2 -1.8 0.4
Medication for cholesterol, blood pressure or diabetes 1.2 2.1 3.7 1.4 1.9 0.7
Glaucoma (self-reported) 0.9 1.0 1.5 1.1 -1.2 0.7
Gout (self-reported) 1.0 1.3 3.5 1.9 0.5 0.5
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.6 0.5 0.1 -0.8
Medication: Amlodipine 0.2 0.3 0.4 -0.3 0.6 -0.6
Medication: Ventolin 100micrograms inhaler 1.2 1.5 4.2 -0.6 -0.1 -2.0
Birth weight 0.8 1.7 2.3 -1.4 1.5 -1.0
Chronic bronchitis/emphysema (mother) 0.6 0.8 2.2 1.5 0.1 -0.3
High blood pressure (siblings) 0.9 1.3 3.1 -0.3 -1.8 0.8
Forced vital capacity (FVC), Best measure 1.6 5.8 7.6 -2.8 2.3 2.1
Body fat percentage 0.9 3.7 5.8 -0.5 2.4 -2.2
Leg fat percentage (right) 0.8 2.8 4.5 0.0 2.1 -2.0
Arm fat-free mass (right) 1.5 7.6 19.5 -4.4 1.3 -1.2
Exposure to tobacco smoke outside home 1.8 2.4 6.3 2.5 -0.6 -0.7
Comparative body size at age 10 1.3 3.6 9.0 -0.0 3.0 -1.4
Number of full brothers 1.3 1.6 4.5 2.1 -0.5 -0.4
Worry too long after embarrassment 1.4 2.4 3.0 1.1 -1.7 1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 2.6 3.3 5.7 2.0 -2.4 0.3
Wheeze or whistling in the chest in last year 2.0 3.6 5.5 2.4 -1.6 -1.7
Number of children fathered 0.0 0.0 0.0 0.1 0.0 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.7 -0.1 0.5 -0.8
Age at first live birth 1.5 2.6 6.1 -2.5 0.9 -0.9
Pulse wave peak to peak time 1.5 1.7 2.6 -1.6 1.6 -0.0
Health satisfaction 0.2 0.3 0.8 -0.2 -0.1 -0.9
Shortness of breath walking on level ground 0.1 0.1 0.2 -0.1 0.1 0.5
Qualifications: College or University degree 0.4 1.2 3.0 0.5 0.6 1.7
Eye problems/disorders: None of the above 0.9 1.1 2.5 -0.6 1.6 0.6
Mouth/teeth dental problems: Loose teeth 1.2 1.4 4.1 2.0 0.1 -0.2
Emphysema/chronic bronchitis 2.3 2.6 4.2 1.8 -2.0 0.6
Medication for pain relief, constipation, heartburn 0.4 0.7 1.6 -0.7 0.1 1.3
Neck or shoulder pain in last month 1.5 2.1 4.7 2.2 0.2 -1.2
Medication: Blood pressure 0.2 0.3 0.5 -0.1 -0.7 -0.6
Angina (self-reported) 4.0 5.3 10.6 2.2 -3.3 -0.6
Migraine (self-reported) 1.1 1.3 1.9 -1.0 1.4 -1.0
Medication: Ibuprofen 1.7 2.0 2.8 -1.1 1.5 -1.7
Medication: Allopurinol 1.4 1.9 4.9 2.2 -0.4 0.7
Medication: Omeprazole 0.3 0.4 0.6 0.8 0.4 -0.6
Medication: Seretide 50 evohaler 1.3 1.5 2.1 1.0 -1.5 -1.1
Mean time to correctly identify matches 3.2 6.0 10.4 2.7 -3.2 -0.8
Heart disease (mother) 1.6 1.9 3.5 1.9 0.7 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.5 0.3 0.7 -0.1
Whole body fat mass 1.0 4.3 6.1 -1.7 2.5 -2.0
Leg fat mass (right) 1.1 4.4 6.9 -1.6 2.6 -1.9
Arm predicted mass (right) 1.4 7.3 17.8 -4.2 1.5 -1.3
Pulse rate, automated reading 0.1 0.5 0.8 -0.3 -0.9 0.7
Alcohol intake frequency. 0.9 2.1 5.2 -2.3 -0.9 -0.4
Comparative height size at age 10 1.2 6.3 18.3 -4.3 0.8 -0.3
Number of full sisters 0.1 0.1 0.3 -0.3 -0.0 -0.5
Suffer from ‘nerves’ 2.7 4.2 8.8 1.6 -3.0 1.1
Overall health rating 1.0 2.2 5.2 2.3 -0.9 -0.7
Chest pain or discomfort 1.0 1.4 2.6 1.6 -0.9 -0.9
Had major operations 1.4 1.7 2.0 -1.0 1.4 1.4
Age at last live birth 0.5 0.7 1.6 -0.7 0.1 -1.3
Family relationship satisfaction 2.2 2.7 6.7 2.6 -0.5 -1.1
Leg pain on walking 0.2 0.2 0.4 -0.3 0.6 -0.4
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.5 3.4 1.8 -0.9 0.7
Commuting to job workplace: Car/motor vehicle 3.1 3.6 6.0 -2.1 2.5 -0.7
Illness, injury, bereavement, stress in last 2 years 1.1 1.3 3.1 -1.8 0.9 0.1
Medication: Aspirin 0.7 0.9 1.5 0.7 -1.2 0.8
Supplements: Vitamin C 1.7 2.0 5.5 -2.3 -0.4 -0.7
Knee pain experienced in last month 1.2 1.8 3.0 1.5 0.5 -1.7
Hypertension (Self-reported) 1.0 2.8 8.1 -0.3 -2.9 -0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 2.7 0.6 1.6 -0.2
Illnesses of father: Heart disease 1.5 2.1 5.4 -0.8 0.3 2.3
Illnesses of siblings: Diabetes 0.2 0.3 0.7 -0.9 -0.1 0.1
Smoking status: Previous 2.8 4.1 10.8 0.0 3.3 -1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 4.8 -2.2 -0.0 0.5
Whole body fat-free mass 1.4 7.9 19.4 -4.4 1.8 -1.1
Leg fat-free mass (right) 1.6 8.7 17.3 -4.2 2.2 -2.0
Arm fat percentage (left) 1.0 3.8 5.7 -0.8 2.2 -2.4
Average weekly red wine intake 0.2 0.2 0.5 -0.4 0.7 0.2
Handedness (chirality/laterality): Left-handed 1.6 1.9 4.9 -2.2 -0.9 -0.2
Mood swings 2.7 4.9 8.4 2.4 -2.9 0.8
Loneliness, isolation 6.2 8.6 15.5 2.7 -3.9 1.8
Long-standing illness, disability or infirmity 1.3 1.9 4.2 2.1 -1.2 0.3
Ever had bowel cancer screening 1.0 1.1 1.6 0.9 -1.0 -1.3
Diabetes diagnosed by doctor 0.6 0.9 2.1 1.4 -0.8 0.2
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 2.3 1.5 -0.8 -0.8
Friendships satisfaction 2.1 2.6 6.2 1.0 -2.5 0.8
Qualifications: nursing, teaching 0.2 0.3 0.7 -0.5 0.8 -0.2
Commuting to job workplace: Walk 1.1 1.2 1.9 0.5 -1.2 1.4
Eye problems/disorders: Cataract 2.2 2.5 6.8 0.4 -0.7 -2.6
Mouth/teeth dental problems: Mouth ulcers 1.1 1.8 5.3 2.3 -0.2 -0.3
Medication for cholesterol 1.2 1.8 4.3 -1.0 2.1 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 0.7 -0.8 -0.0 -0.9
Back pain experienced in last month 0.8 1.1 2.0 -0.3 1.2 -1.4
Mineral and other dietary supplements 0.7 1.0 3.0 -0.1 -1.7 0.1
Breast cancer (self-reported) 0.7 0.9 1.6 0.9 1.3 0.4
Asthma (self-reported) 1.0 2.0 5.3 -0.4 -0.8 -2.3
Osteoporosis (self-reported) 0.9 1.1 3.0 -0.5 -0.1 -1.7
Osteoarthritis (self-reported) 1.1 1.5 4.0 -0.6 2.0 0.4
Medication: Aspirin 1.0 1.3 2.1 1.2 -1.4 0.7
Medication: Gliclazide 1.9 2.1 5.0 0.9 -2.2 0.7
Illnesses of father: None of the above (group 1) 0.5 0.7 1.6 0.5 -0.4 -1.3
Smoking status: Current 1.3 2.0 4.6 0.6 -1.0 -2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.6 0.4 0.2 1.3
Whole body water mass 1.5 8.3 20.3 -4.5 1.8 -1.2
Leg predicted mass (right) 1.7 8.9 18.1 -4.2 2.2 -2.0
Arm fat mass (left) 1.3 5.2 5.9 -2.0 2.4 -2.4
Number of self-reported non-cancer illnesses 0.5 0.8 1.2 0.7 -0.8 -1.1
Average weekly champagne plus white wine intake 1.4 1.9 4.6 2.1 1.0 0.1
Miserableness 2.2 3.8 5.9 2.4 -2.3 0.6
Guilty feelings 4.6 6.9 13.3 3.6 -2.7 -0.3
Wears glasses or contact lenses 0.5 0.6 1.3 -0.6 0.3 -1.2
Ever taken oral contraceptive pill 1.1 1.3 3.0 0.7 0.6 1.7
Hearing aid user 1.6 1.9 3.5 1.9 -0.9 -1.1
Mother’s age at death 1.2 1.5 4.0 -2.0 0.8 0.1
Financial situation satisfaction 3.1 3.9 6.8 2.6 -1.5 -1.6
Tinnitus: Yes, now most or all of the time 0.3 0.4 0.9 -0.4 0.1 1.0
Commuting to job workplace: Public transport 0.5 0.6 1.3 0.5 1.1 0.3
Eye problems/disorders: Glaucoma 1.2 1.4 2.9 1.1 -1.7 0.4
Medication: Blood pressure 0.8 1.5 2.8 0.2 -1.7 -1.3
Pain type(s) experienced in last month: Hip pain 1.3 1.7 2.3 1.5 1.5 -0.7
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.1 0.2 1.0 -0.3
High cholesterol (Self-reported) 0.8 1.4 3.5 -0.0 -1.9 -0.9
Medication: Bendroflumethiazide 1.0 1.6 3.4 -0.0 -1.8 -1.2
Medication: Paracetamol 0.4 0.5 1.0 -0.7 0.3 -1.0
Medication: Lisinopril 1.0 1.3 3.0 -0.1 -1.0 -1.7
Medication: Atorvastatin 1.5 1.9 4.6 2.1 -1.0 0.0
Illnesses of father: High blood pressure 0.0 0.0 0.1 -0.2 0.3 -0.1
Alcohol drinker status: Never 0.5 0.5 0.7 -0.6 -0.9 0.8
Ever smoked 4.0 7.0 10.7 -0.3 3.2 -3.3
Basal metabolic rate 1.3 7.4 16.4 -4.0 2.0 -1.4
Leg fat percentage (left) 1.2 4.3 7.6 -0.5 2.2 -2.8
Arm fat-free mass (left) 1.5 7.5 16.9 -4.1 2.0 -1.2
Number of operations (self-reported) 0.5 0.7 2.0 -1.4 0.3 -0.1
Average weekly beer plus cider intake 0.4 0.6 1.2 0.8 1.1 0.3
Irritability 2.7 4.6 13.6 3.7 0.3 -0.4
Risk taking 0.4 0.6 1.6 -1.3 0.3 -0.3
Ever had prostate specific antigen (PSA) test 1.1 1.3 1.9 1.4 -0.5 -1.3
Fractured/broken bones in last 5 years 1.1 1.5 2.4 -0.9 1.1 -1.6
Age started oral contraceptive pill 0.3 0.4 1.1 -0.2 1.0 -0.0
Diastolic blood pressure, automated reading 0.8 2.4 7.0 0.6 -2.6 0.1
Ever depressed for a whole week 3.2 3.9 6.2 1.6 -2.5 1.7
Unable to work because of sickness or disability 0.3 0.4 0.9 0.1 -1.0 -0.5
Commuting to job workplace: Cycle 0.0 0.0 0.1 -0.2 -0.2 -0.3
Myopia 0.1 0.2 0.4 0.6 0.2 0.3
Vascular/heart problems diagnosed by doctor 1.5 4.0 11.7 0.0 3.4 0.4
Cholesterol lowering medication 0.2 0.3 0.8 0.1 -0.4 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 1.4 1.2 1.2 -0.7
Pain experienced in last month 0.2 0.4 0.8 -0.9 0.2 0.5
Supplements: Calcium 0.1 0.1 0.3 -0.2 0.2 0.5
Basal cell carcinoma (self-reported) 0.9 1.1 2.2 -0.0 1.0 -1.5
Heart attack/myocardial infarction (self-reported) 2.1 2.7 4.3 0.7 -2.1 1.8
Deep venous thrombosis (DVT) (self-reported) 2.8 3.7 8.8 3.0 -0.4 -1.4
Heart disease (siblings) 0.8 1.0 2.2 0.4 -0.8 -1.5
Alcohol drinker status: Previous 0.2 0.2 0.4 0.0 0.6 -0.5
Pack years of smoking 1.5 2.3 5.1 1.3 -2.3 -0.1
Impedance of whole body 0.6 3.1 4.7 2.2 -0.7 2.1
Leg fat mass (left) 1.3 4.9 6.2 -1.8 2.5 -2.3
Arm predicted mass (left) 1.2 6.1 13.8 -3.7 1.8 -1.1