Hub : Genes

TMEM200A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0430	0.0190	0.00180	0.034	0.019	0.025	0.024	0.031	4.7e-05	2.0e-03	4.6e-04	0.00063	9.4e-05
2	METSIM	Adipose	0.0401	0.0155	0.00073	0.003	0.017	0.009	0.015	0.006	1.1e-01	1.0e-03	1.2e-02	0.00190	3.4e-02
3	TCGA	Thyroid Carcinoma	0.0980	0.0400	0.00068	0.052	0.039	0.055	NA	0.052	8.5e-06	9.2e-05	4.5e-06	NA	8.4e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	2.2	3.4	7.3	2.7	-1.5	0.9
Bipolar Disorder or Schizophrenia	3.1	7.5	13.2	2.5	-3.6	1.7
Depressed Affect (Nagel 2018)	3.1	6.5	9.8	3.0	-3.1	0.8
Depression (Nagel 2018)	3.7	5.6	11.0	3.3	-2.2	-0.9
Intelligence (Savage-Jansen 2018)	0.7	2.2	4.5	2.1	0.6	1.3
Neuroticism (Nagel 2018)	3.8	8.8	16.6	4.1	-3.0	0.9
Schizophrenia (2018)	2.5	5.2	12.2	1.0	-3.5	1.5
Schizophrenia vs Biploar Disorder	0.9	1.2	2.4	-1.0	-1.6	0.5
Worry (Nagel 2018)	1.4	2.9	7.3	1.1	-2.7	0.5
Alzheimer’s Disease (in mother)	2.1	2.5	7.4	0.0	-0.3	2.7
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.3	0.4	-0.0
Alzheimer’s Disease (including proxy)	0.8	1.2	3.5	0.4	0.0	1.9
Crohns Disease (2017)	0.5	1.1	2.0	1.4	-0.7	-0.9
Irritable Bowel Disease (IBD)	0.2	0.4	0.6	0.4	0.8	0.6
Ulcerative Colitis (UC)	1.0	1.8	2.6	-0.9	1.5	1.6
Major Depression (MDD)	4.6	5.6	8.0	2.8	-2.8	1.1
Reaction Time	2.8	5.4	8.8	3.0	-2.7	0.1
Verbal and Numeric Reasoning (VNR)	0.9	2.2	3.9	1.1	1.3	2.0
Breast Cancer	0.4	0.9	2.7	-1.6	-0.0	-0.2
Ovarian Cancer	0.2	0.3	0.4	0.4	-0.6	-0.6
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	2.4	3.5	8.2	-0.9	1.2	-2.9
Bipolar Disorder (2011)	1.6	1.5	4.1	2.0	0.8	0.0
Body Mass Index (BMI) (2010)	1.0	1.4	3.4	0.7	1.8	0.4
Coronary Artery Disease (CAD)	0.8	0.9	2.2	-0.3	-0.6	-1.5
Crohns Disease (2012)	1.1	1.8	3.0	1.7	-0.7	-1.4
Mean Putamen Volume	1.0	1.2	2.2	-1.5	-1.1	0.1
Fasting Glucose	0.4	0.5	0.9	-0.6	0.9	-0.4
HbA1C	1.6	1.8	3.1	-1.8	0.3	-1.5
HDL Cholesterol	0.4	0.7	1.0	-1.0	-0.4	0.8
LDL Cholesterol	0.5	0.8	2.0	0.2	1.4	0.5
Lupus	0.2	0.2	0.4	0.7	-0.5	-0.2
Neuroticism (2016)	2.7	3.9	6.7	2.6	-1.8	-1.4
Primary Biliary Cirrhosis	0.0	0.0	0.0	0.1	0.1	-0.0
Rheumatoid Arthritis	0.7	0.9	1.6	-0.5	-1.3	-1.0
Schizophrenia (2014)	3.3	7.2	17.2	1.5	-4.2	1.5
Triglycerides	0.3	0.5	0.9	1.0	0.0	0.8
Type 2 Diabetes (T2D) (2012)	0.7	0.8	0.9	1.0	0.8	0.8
Ulcerative Colitis	0.5	0.8	1.4	-0.7	1.2	0.6
Blood Eosinophil Count	0.2	1.5	4.3	-0.4	-0.3	-2.1
Blood Platelet Count	0.5	5.6	16.6	0.1	-4.1	0.1
Blood Red Count	0.0	0.4	1.0	0.3	-0.4	1.0
Blood White Count	0.3	2.0	4.1	1.3	0.0	-2.0
Heel T-Score	2.4	19.4	53.9	1.5	7.3	-1.4
BMI	0.6	3.5	4.5	-1.2	2.1	-2.1
Height	0.5	9.3	26.5	-5.2	1.1	0.4
Waist Hip Ratio (WHR)	0.5	2.4	4.1	2.0	-1.1	1.3
Systolic Blood Pressure	2.0	10.2	19.1	2.5	-4.4	2.3
Smoking Status	1.9	4.6	7.1	1.5	2.1	-2.7
Allergy or Eczema	0.3	0.8	1.3	-1.1	-0.8	0.6
Cardiovascular Disease	1.0	3.2	9.2	-0.2	-3.0	0.7
Hypothyroidism (self reported)	0.1	0.3	0.6	0.6	-0.2	-0.8
Respiratory disease	1.2	2.7	7.6	-0.6	0.1	-2.8
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.6	0.8	0.4	-0.4
Lung FEV1/FVC ratio	0.1	0.4	1.0	-0.2	-0.4	-1.0
Lung FVC	0.5	2.5	3.2	1.3	1.5	1.8
Neuroticism	2.6	6.3	10.1	2.9	-3.2	0.7
Chronotype (morning person)	1.8	4.1	11.9	0.1	0.7	3.4
Hair Pigment	0.1	2.8	8.0	2.8	0.6	-0.2
Tanning	0.0	0.4	1.3	0.2	-0.0	-1.1
Hand grip strength (left)	0.3	0.8	1.7	-1.3	0.3	0.7
Number of treatments/medications taken	2.2	4.0	8.6	0.3	-1.8	-2.9
Average weekly spirits intake	0.4	0.5	0.9	1.0	-0.2	-0.7
Sensitivity / hurt feelings	2.0	3.4	8.0	2.8	-1.5	0.2
Frequency of depressed mood in last 2 weeks	3.7	5.1	6.8	2.5	-2.6	-1.4
Hearing difficulty/problems: Yes	0.0	0.0	0.0	0.0	-0.1	-0.2
Relative age of first facial hair	0.1	0.2	0.4	-0.3	-0.7	-0.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.7	-0.1	-0.9	-0.7
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.2	1.1	-0.7	-0.2
Ever had hysterectomy (womb removed)	0.2	0.3	0.5	-0.2	0.6	0.7
Systolic blood pressure, automated reading	1.9	5.5	13.1	1.3	-3.6	1.2
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	4.1	0.2	-2.0	1.2
Angina	3.2	4.2	9.0	1.7	-3.0	-0.7
Medication for hormone replacement therapy	2.4	2.7	5.1	1.1	-2.3	1.3
Vitamin and mineral supplements	0.2	0.2	0.4	0.3	0.4	0.6
Supplements: Zinc	0.9	0.9	1.6	-0.0	-1.3	1.1
Medication: Co-codamol	1.3	1.5	4.2	-0.6	0.2	-2.0
Medication: Metformin	1.0	1.5	2.3	1.5	-1.1	1.0
Diabetes (father)	1.7	2.1	6.0	-0.3	2.5	-0.2
Diabetes (mother)	0.4	0.6	1.1	-1.0	-0.7	0.3
Severe depression (siblings)	4.6	5.2	11.0	2.1	-3.3	0.4
Pack years adult smoking proportion	1.6	2.4	4.2	1.8	-2.1	-0.0
Impedance of leg (right)	1.1	5.2	8.4	2.5	-1.1	2.9
Leg fat-free mass (left)	1.5	7.7	15.5	-3.9	2.2	-1.7
Trunk fat percentage	1.0	4.0	6.8	-0.9	2.6	-2.1
Hand grip strength (right)	0.4	1.0	2.0	-1.4	0.7	0.8
Townsend deprivation index at recruitment	1.7	2.3	4.5	2.1	-0.6	1.5
Current tobacco smoking	1.2	2.0	2.9	0.9	-1.5	-1.7
Average weekly fortified wine intake	0.8	0.9	2.2	-0.6	1.5	0.3
Maternal smoking around birth	0.7	1.0	1.5	1.2	-1.1	0.6
Fed-up feelings	4.7	8.5	14.1	3.8	-3.3	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.2	3.0	5.7	2.4	-1.6	-0.8
Relative age voice broke	0.2	0.2	0.3	-0.6	0.5	-0.4
Taking other prescription medications	1.5	2.3	5.6	1.2	0.2	-2.4
Age when periods started (menarche)	0.1	0.2	0.5	-0.1	0.4	0.7
Bilateral oophorectomy (both ovaries removed)	1.5	1.8	3.5	1.2	-1.9	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.3	0.5	1.5	0.1
Tinnitus: Yes, but not now, but have in the past	2.7	2.9	7.4	0.5	-2.7	1.0
Qualifications: CSEs or equivalent	1.5	2.0	4.8	-0.5	-2.2	1.0
Serious illness, injury or assault to yourself	1.8	2.2	4.8	2.2	-1.3	0.4
High blood pressure	1.1	3.1	9.2	-0.2	-3.0	-0.2
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.3	-0.8	-0.3	1.1
Multivitamins +/- minerals	0.6	0.8	1.7	0.6	-0.6	1.3
Stomach or abdominal pain in last month	2.3	2.8	4.3	-0.4	-2.1	-2.0
Supplements: Glucosamine	1.3	1.7	4.3	0.1	2.1	0.9
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	3.2	-0.0	1.1	-1.8
Medication: Atenolol	2.0	2.6	5.3	1.5	-2.3	0.5
Medication: Levothyroxine sodium	0.1	0.2	0.5	-0.0	0.7	-0.5
Sitting height	0.5	3.6	7.8	-2.8	0.8	1.6
Chronic bronchitis/emphysema (father)	0.3	0.4	0.6	-0.8	0.7	0.3
High blood pressure (mother)	0.1	0.2	0.2	-0.4	0.5	0.4
Body mass index (BMI)	0.9	3.7	5.5	-1.1	2.1	-2.4
Impedance of leg (left)	0.6	3.1	4.5	1.9	-1.1	2.1
Leg predicted mass (left)	1.4	7.6	14.8	-3.9	2.3	-1.6
Trunk fat mass	1.3	5.6	8.1	-2.1	2.9	-2.1
Waist circumference	1.0	3.7	5.5	-1.7	2.3	-1.6
Number of incorrect matches in round	0.2	0.4	0.8	-0.1	0.6	-0.9
Past tobacco smoking	4.0	7.4	15.1	-0.2	-3.9	2.6
Alcohol usually taken with meals	0.5	0.8	1.3	-0.6	0.8	-1.1
Nervous feelings	1.2	2.2	6.5	0.0	-2.6	-0.1
Frequency of tenseness / restlessness in last 2 weeks	3.0	4.7	4.9	2.2	-2.2	-2.1
Hearing difficulty/problems with background noise	0.2	0.3	0.7	0.9	0.2	-0.0
Hair/balding pattern: Pattern 2	0.6	0.8	1.9	-0.2	1.4	0.7
Had menopause	0.7	0.9	1.2	0.6	1.1	-1.1
Had other major operations	1.0	1.2	3.4	-0.3	-0.1	-1.8
Forced vital capacity (FVC)	1.2	4.6	7.5	-2.1	1.4	2.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	3.3	0.2	1.8	-0.2
Ever unenthusiastic/disinterested for a whole week	4.9	6.0	13.3	1.5	-3.7	1.5
Qualifications: None of the above	0.7	1.4	2.2	-1.2	-1.5	-0.9
Financial difficulties in last 2 years	3.1	4.2	7.9	2.8	-2.1	-0.7
Mouth/teeth dental problems	2.8	4.2	9.9	-3.1	0.4	1.6
Heart attack	2.4	3.1	5.1	1.0	-2.3	1.8
Allergy	0.1	0.2	0.7	-0.0	0.8	0.1
Pain all over the body in last month	2.3	2.4	2.9	1.7	-1.6	1.4
Diabetes (self-reported)	0.1	0.2	0.5	0.7	-0.2	-0.0
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	0.8	-0.8	-0.9	0.6
Medication: Ramipril	0.6	0.8	1.8	0.5	-1.3	-0.5
Medication: Simvastatin	0.6	0.9	1.5	-0.8	-1.2	-0.8
Fluid intelligence score	2.7	5.7	8.6	1.5	2.5	2.9
Illnesses of siblings	0.2	0.4	0.7	0.5	0.8	0.4
Neuroticism score	4.2	8.7	15.9	3.2	-4.0	0.5
Weight	1.5	7.3	11.2	-3.4	2.6	-1.9
Impedance of arm (right)	0.4	2.0	4.5	2.1	0.2	1.2
Arm fat percentage (right)	1.0	4.0	5.8	-0.8	2.4	-2.4
Trunk fat-free mass	1.2	6.7	18.1	-4.3	1.3	-0.5
Hip circumference	1.6	7.1	10.8	-3.3	2.5	-2.1
Time employed in main current job	0.7	0.8	1.5	-1.2	-0.3	-1.0
Alcohol intake versus 10 years previously	1.2	1.8	3.2	-1.8	-1.2	-0.8
Father’s age at death	0.6	0.8	1.1	-1.0	0.6	-1.0
Worrier / anxious feelings	2.8	5.2	6.8	1.8	-2.4	2.6
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.8	9.0	3.0	-1.5	-0.1
Falls in the last year	0.2	0.3	0.7	0.3	-0.0	0.9
Hair/balding pattern: Pattern 3	0.7	1.0	2.8	-1.7	-0.2	-0.4
Number of live births	0.2	0.3	0.4	0.3	0.6	-0.7
Forced expiratory volume in 1-second (FEV1)	1.3	4.4	8.5	-1.9	1.0	2.9
Pulse rate	1.1	1.9	4.8	-0.8	-2.2	0.5
Happiness	3.2	3.8	6.7	2.6	-2.1	-0.6
Noisy workplace	1.4	1.7	3.5	1.2	-1.9	0.6
Qualifications: A levels/AS levels or equivalent	0.7	1.6	2.2	-1.5	1.5	0.6
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	2.5	1.6	1.2	0.5
Mouth/teeth dental problems: Dentures	1.1	1.8	2.8	1.7	0.2	-1.6
Asthma	0.6	1.3	3.0	-0.1	-0.8	-1.7
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	2.4	-0.8	1.0	-1.5
Medication: Cholesterol lowering	0.5	0.9	2.3	0.1	-1.5	0.5
Depression (self-reported)	2.5	2.9	5.0	1.9	-2.2	0.5
Medication: Lansoprazole	3.2	3.7	10.9	-0.0	0.5	-3.3
Prospective memory result	1.2	1.4	2.8	-1.7	-0.9	-0.9
Lung cancer (father)	1.0	1.2	2.0	-1.2	0.3	1.4
Illnesses of mother	0.2	0.3	0.8	0.2	-0.0	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.2	5.2	-2.3	2.0	1.9
Pulse wave Arterial Stiffness index	1.3	1.5	2.2	1.5	-1.5	0.3
Impedance of arm (left)	0.3	1.5	2.9	1.7	-0.3	1.2
Arm fat mass (right)	1.1	4.7	6.0	-1.6	2.3	-2.5
Trunk predicted mass	1.1	6.5	17.8	-4.2	1.3	-0.5
Standing height	1.0	9.8	26.7	-5.2	1.3	0.9
Length of working week for main job	1.3	1.5	3.0	1.1	-1.7	0.6
Exposure to tobacco smoke at home	0.4	0.5	0.8	0.6	-0.9	-0.6
Breastfed as a baby	1.6	2.0	5.5	-0.3	0.7	-2.3
Tense / ‘highly strung’	3.7	6.1	12.9	2.2	-3.6	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	5.5	8.4	15.3	3.9	-2.8	1.5
Hair/balding pattern: Pattern 4	2.5	6.1	13.2	3.6	-2.1	0.8
Birth weight of first child	0.9	1.6	4.4	0.4	-0.3	2.1
Peak expiratory flow (PEF)	1.1	2.6	3.3	-1.8	1.6	1.4
Pulse wave reflection index	1.2	1.4	2.7	1.7	-1.2	0.1
Ever highly irritable/argumentative for 2 days	3.2	3.9	8.1	2.8	-1.7	-0.8
Loud music exposure frequency	0.9	1.0	1.2	0.8	1.0	1.1
Qualifications: O levels/GCSEs or equivalent	1.6	2.5	6.2	-0.8	2.5	0.8
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.5	0.5	-0.3	-1.2
Blood clot in the leg (DVT)	3.2	4.1	9.1	3.0	-0.1	-1.8
Medication: Paracetamol	0.6	1.0	1.6	-0.8	0.8	-1.3
Headache pain in last month	0.7	1.1	3.2	-0.2	-1.8	0.4
Medication for cholesterol, blood pressure or diabetes	1.2	2.1	3.7	1.4	1.9	0.7
Glaucoma (self-reported)	0.9	1.0	1.5	1.1	-1.2	0.7
Gout (self-reported)	1.0	1.3	3.5	1.9	0.5	0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.6	0.5	0.1	-0.8
Medication: Amlodipine	0.2	0.3	0.4	-0.3	0.6	-0.6
Medication: Ventolin 100micrograms inhaler	1.2	1.5	4.2	-0.6	-0.1	-2.0
Birth weight	0.8	1.7	2.3	-1.4	1.5	-1.0
Chronic bronchitis/emphysema (mother)	0.6	0.8	2.2	1.5	0.1	-0.3
High blood pressure (siblings)	0.9	1.3	3.1	-0.3	-1.8	0.8
Forced vital capacity (FVC), Best measure	1.6	5.8	7.6	-2.8	2.3	2.1
Body fat percentage	0.9	3.7	5.8	-0.5	2.4	-2.2
Leg fat percentage (right)	0.8	2.8	4.5	0.0	2.1	-2.0
Arm fat-free mass (right)	1.5	7.6	19.5	-4.4	1.3	-1.2
Exposure to tobacco smoke outside home	1.8	2.4	6.3	2.5	-0.6	-0.7
Comparative body size at age 10	1.3	3.6	9.0	-0.0	3.0	-1.4
Number of full brothers	1.3	1.6	4.5	2.1	-0.5	-0.4
Worry too long after embarrassment	1.4	2.4	3.0	1.1	-1.7	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.3	5.7	2.0	-2.4	0.3
Wheeze or whistling in the chest in last year	2.0	3.6	5.5	2.4	-1.6	-1.7
Number of children fathered	0.0	0.0	0.0	0.1	0.0	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.7	-0.1	0.5	-0.8
Age at first live birth	1.5	2.6	6.1	-2.5	0.9	-0.9
Pulse wave peak to peak time	1.5	1.7	2.6	-1.6	1.6	-0.0
Health satisfaction	0.2	0.3	0.8	-0.2	-0.1	-0.9
Shortness of breath walking on level ground	0.1	0.1	0.2	-0.1	0.1	0.5
Qualifications: College or University degree	0.4	1.2	3.0	0.5	0.6	1.7
Eye problems/disorders: None of the above	0.9	1.1	2.5	-0.6	1.6	0.6
Mouth/teeth dental problems: Loose teeth	1.2	1.4	4.1	2.0	0.1	-0.2
Emphysema/chronic bronchitis	2.3	2.6	4.2	1.8	-2.0	0.6
Medication for pain relief, constipation, heartburn	0.4	0.7	1.6	-0.7	0.1	1.3
Neck or shoulder pain in last month	1.5	2.1	4.7	2.2	0.2	-1.2
Medication: Blood pressure	0.2	0.3	0.5	-0.1	-0.7	-0.6
Angina (self-reported)	4.0	5.3	10.6	2.2	-3.3	-0.6
Migraine (self-reported)	1.1	1.3	1.9	-1.0	1.4	-1.0
Medication: Ibuprofen	1.7	2.0	2.8	-1.1	1.5	-1.7
Medication: Allopurinol	1.4	1.9	4.9	2.2	-0.4	0.7
Medication: Omeprazole	0.3	0.4	0.6	0.8	0.4	-0.6
Medication: Seretide 50 evohaler	1.3	1.5	2.1	1.0	-1.5	-1.1
Mean time to correctly identify matches	3.2	6.0	10.4	2.7	-3.2	-0.8
Heart disease (mother)	1.6	1.9	3.5	1.9	0.7	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	0.3	0.7	-0.1
Whole body fat mass	1.0	4.3	6.1	-1.7	2.5	-2.0
Leg fat mass (right)	1.1	4.4	6.9	-1.6	2.6	-1.9
Arm predicted mass (right)	1.4	7.3	17.8	-4.2	1.5	-1.3
Pulse rate, automated reading	0.1	0.5	0.8	-0.3	-0.9	0.7
Alcohol intake frequency.	0.9	2.1	5.2	-2.3	-0.9	-0.4
Comparative height size at age 10	1.2	6.3	18.3	-4.3	0.8	-0.3
Number of full sisters	0.1	0.1	0.3	-0.3	-0.0	-0.5
Suffer from ‘nerves’	2.7	4.2	8.8	1.6	-3.0	1.1
Overall health rating	1.0	2.2	5.2	2.3	-0.9	-0.7
Chest pain or discomfort	1.0	1.4	2.6	1.6	-0.9	-0.9
Had major operations	1.4	1.7	2.0	-1.0	1.4	1.4
Age at last live birth	0.5	0.7	1.6	-0.7	0.1	-1.3
Family relationship satisfaction	2.2	2.7	6.7	2.6	-0.5	-1.1
Leg pain on walking	0.2	0.2	0.4	-0.3	0.6	-0.4
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	3.4	1.8	-0.9	0.7
Commuting to job workplace: Car/motor vehicle	3.1	3.6	6.0	-2.1	2.5	-0.7
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	3.1	-1.8	0.9	0.1
Medication: Aspirin	0.7	0.9	1.5	0.7	-1.2	0.8
Supplements: Vitamin C	1.7	2.0	5.5	-2.3	-0.4	-0.7
Knee pain experienced in last month	1.2	1.8	3.0	1.5	0.5	-1.7
Hypertension (Self-reported)	1.0	2.8	8.1	-0.3	-2.9	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.7	0.6	1.6	-0.2
Illnesses of father: Heart disease	1.5	2.1	5.4	-0.8	0.3	2.3
Illnesses of siblings: Diabetes	0.2	0.3	0.7	-0.9	-0.1	0.1
Smoking status: Previous	2.8	4.1	10.8	0.0	3.3	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	4.8	-2.2	-0.0	0.5
Whole body fat-free mass	1.4	7.9	19.4	-4.4	1.8	-1.1
Leg fat-free mass (right)	1.6	8.7	17.3	-4.2	2.2	-2.0
Arm fat percentage (left)	1.0	3.8	5.7	-0.8	2.2	-2.4
Average weekly red wine intake	0.2	0.2	0.5	-0.4	0.7	0.2
Handedness (chirality/laterality): Left-handed	1.6	1.9	4.9	-2.2	-0.9	-0.2
Mood swings	2.7	4.9	8.4	2.4	-2.9	0.8
Loneliness, isolation	6.2	8.6	15.5	2.7	-3.9	1.8
Long-standing illness, disability or infirmity	1.3	1.9	4.2	2.1	-1.2	0.3
Ever had bowel cancer screening	1.0	1.1	1.6	0.9	-1.0	-1.3
Diabetes diagnosed by doctor	0.6	0.9	2.1	1.4	-0.8	0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.3	1.5	-0.8	-0.8
Friendships satisfaction	2.1	2.6	6.2	1.0	-2.5	0.8
Qualifications: nursing, teaching	0.2	0.3	0.7	-0.5	0.8	-0.2
Commuting to job workplace: Walk	1.1	1.2	1.9	0.5	-1.2	1.4
Eye problems/disorders: Cataract	2.2	2.5	6.8	0.4	-0.7	-2.6
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	5.3	2.3	-0.2	-0.3
Medication for cholesterol	1.2	1.8	4.3	-1.0	2.1	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.7	-0.8	-0.0	-0.9
Back pain experienced in last month	0.8	1.1	2.0	-0.3	1.2	-1.4
Mineral and other dietary supplements	0.7	1.0	3.0	-0.1	-1.7	0.1
Breast cancer (self-reported)	0.7	0.9	1.6	0.9	1.3	0.4
Asthma (self-reported)	1.0	2.0	5.3	-0.4	-0.8	-2.3
Osteoporosis (self-reported)	0.9	1.1	3.0	-0.5	-0.1	-1.7
Osteoarthritis (self-reported)	1.1	1.5	4.0	-0.6	2.0	0.4
Medication: Aspirin	1.0	1.3	2.1	1.2	-1.4	0.7
Medication: Gliclazide	1.9	2.1	5.0	0.9	-2.2	0.7
Illnesses of father: None of the above (group 1)	0.5	0.7	1.6	0.5	-0.4	-1.3
Smoking status: Current	1.3	2.0	4.6	0.6	-1.0	-2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.6	0.4	0.2	1.3
Whole body water mass	1.5	8.3	20.3	-4.5	1.8	-1.2
Leg predicted mass (right)	1.7	8.9	18.1	-4.2	2.2	-2.0
Arm fat mass (left)	1.3	5.2	5.9	-2.0	2.4	-2.4
Number of self-reported non-cancer illnesses	0.5	0.8	1.2	0.7	-0.8	-1.1
Average weekly champagne plus white wine intake	1.4	1.9	4.6	2.1	1.0	0.1
Miserableness	2.2	3.8	5.9	2.4	-2.3	0.6
Guilty feelings	4.6	6.9	13.3	3.6	-2.7	-0.3
Wears glasses or contact lenses	0.5	0.6	1.3	-0.6	0.3	-1.2
Ever taken oral contraceptive pill	1.1	1.3	3.0	0.7	0.6	1.7
Hearing aid user	1.6	1.9	3.5	1.9	-0.9	-1.1
Mother’s age at death	1.2	1.5	4.0	-2.0	0.8	0.1
Financial situation satisfaction	3.1	3.9	6.8	2.6	-1.5	-1.6
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.9	-0.4	0.1	1.0
Commuting to job workplace: Public transport	0.5	0.6	1.3	0.5	1.1	0.3
Eye problems/disorders: Glaucoma	1.2	1.4	2.9	1.1	-1.7	0.4
Medication: Blood pressure	0.8	1.5	2.8	0.2	-1.7	-1.3
Pain type(s) experienced in last month: Hip pain	1.3	1.7	2.3	1.5	1.5	-0.7
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.1	0.2	1.0	-0.3
High cholesterol (Self-reported)	0.8	1.4	3.5	-0.0	-1.9	-0.9
Medication: Bendroflumethiazide	1.0	1.6	3.4	-0.0	-1.8	-1.2
Medication: Paracetamol	0.4	0.5	1.0	-0.7	0.3	-1.0
Medication: Lisinopril	1.0	1.3	3.0	-0.1	-1.0	-1.7
Medication: Atorvastatin	1.5	1.9	4.6	2.1	-1.0	0.0
Illnesses of father: High blood pressure	0.0	0.0	0.1	-0.2	0.3	-0.1
Alcohol drinker status: Never	0.5	0.5	0.7	-0.6	-0.9	0.8
Ever smoked	4.0	7.0	10.7	-0.3	3.2	-3.3
Basal metabolic rate	1.3	7.4	16.4	-4.0	2.0	-1.4
Leg fat percentage (left)	1.2	4.3	7.6	-0.5	2.2	-2.8
Arm fat-free mass (left)	1.5	7.5	16.9	-4.1	2.0	-1.2
Number of operations (self-reported)	0.5	0.7	2.0	-1.4	0.3	-0.1
Average weekly beer plus cider intake	0.4	0.6	1.2	0.8	1.1	0.3
Irritability	2.7	4.6	13.6	3.7	0.3	-0.4
Risk taking	0.4	0.6	1.6	-1.3	0.3	-0.3
Ever had prostate specific antigen (PSA) test	1.1	1.3	1.9	1.4	-0.5	-1.3
Fractured/broken bones in last 5 years	1.1	1.5	2.4	-0.9	1.1	-1.6
Age started oral contraceptive pill	0.3	0.4	1.1	-0.2	1.0	-0.0
Diastolic blood pressure, automated reading	0.8	2.4	7.0	0.6	-2.6	0.1
Ever depressed for a whole week	3.2	3.9	6.2	1.6	-2.5	1.7
Unable to work because of sickness or disability	0.3	0.4	0.9	0.1	-1.0	-0.5
Commuting to job workplace: Cycle	0.0	0.0	0.1	-0.2	-0.2	-0.3
Myopia	0.1	0.2	0.4	0.6	0.2	0.3
Vascular/heart problems diagnosed by doctor	1.5	4.0	11.7	0.0	3.4	0.4
Cholesterol lowering medication	0.2	0.3	0.8	0.1	-0.4	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	1.4	1.2	1.2	-0.7
Pain experienced in last month	0.2	0.4	0.8	-0.9	0.2	0.5
Supplements: Calcium	0.1	0.1	0.3	-0.2	0.2	0.5
Basal cell carcinoma (self-reported)	0.9	1.1	2.2	-0.0	1.0	-1.5
Heart attack/myocardial infarction (self-reported)	2.1	2.7	4.3	0.7	-2.1	1.8
Deep venous thrombosis (DVT) (self-reported)	2.8	3.7	8.8	3.0	-0.4	-1.4
Heart disease (siblings)	0.8	1.0	2.2	0.4	-0.8	-1.5
Alcohol drinker status: Previous	0.2	0.2	0.4	0.0	0.6	-0.5
Pack years of smoking	1.5	2.3	5.1	1.3	-2.3	-0.1
Impedance of whole body	0.6	3.1	4.7	2.2	-0.7	2.1
Leg fat mass (left)	1.3	4.9	6.2	-1.8	2.5	-2.3
Arm predicted mass (left)	1.2	6.1	13.8	-3.7	1.8	-1.1