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chr6:124,741,508-127,355,237

Best TWAS P=9.76e-94 · Best GWAS P=6.52e-93 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CENPW	0.04	0.06	lasso	10	0.06	2.4e-07	20.31	-20.5	9.8e-94	-0.99	0.02	0.98	TRUE
11	GTEx	Vagina	CENPW	0.24	-0.01	lasso	8	-0.01	7.9e-01	6.63	8.2	3.1e-16	0.40	0.04	0.06	TRUE
2	CommonMind	Brain Pre-frontal Cortex	HEY2	0.15	0.20	lasso	10	0.21	6.7e-25	-7.31	-7.2	4.0e-13	-0.07	0.00	1.00	TRUE
8	GTEx	Skin Sun Exposed Lower leg	HINT3	0.08	0.01	lasso	4	0.03	2.0e-03	-5.46	-6.8	1.1e-11	-0.19	0.22	0.14	TRUE
3	GTEx	Artery Coronary	TPD52L1	0.31	-0.01	enet	19	0.05	7.0e-03	-0.38	-6.1	9.7e-10	-0.15	0.03	0.55	TRUE
7	GTEx	Pancreas	HEY2	0.28	0.11	lasso	3	0.10	3.5e-05	-5.51	-6.0	1.5e-09	-0.06	0.14	0.86	TRUE
20	The Cancer Genome Atlas	Thyroid Carcinoma	HEY2	0.03	0.04	lasso	3	0.02	3.8e-03	5.66	-6.0	2.5e-09	-0.07	0.01	0.98	TRUE
16	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRMT11	0.03	0.03	lasso	1	0.03	3.3e-07	-5.47	5.5	4.4e-08	0.23	0.01	0.99	TRUE
4	GTEx	Breast Mammary Tissue (Female)	HINT3	0.39	-0.01	enet	16	0.08	2.2e-03	-2.72	-5.2	2.5e-07	-0.14	0.13	0.06	TRUE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	CENPW	0.04	0.06	blup	35	0.05	9.2e-07	20.09	-19.3	7.7e-83	-0.98	0.03	0.97	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CENPW	0.04	0.05	lasso	5	0.05	2.6e-06	20.17	-19.3	1.1e-82	-0.98	0.02	0.98	FALSE
12	METSIM	Adipose	CENPW	0.02	0.02	blup	189	0.01	8.3e-03	20.19	-14.5	9.9e-48	-0.74	0.03	0.69	FALSE
6	GTEx	Heart Atrial Appendage	CENPW	0.17	0.01	enet	15	0.06	1.8e-03	20.19	-12.0	2.0e-33	-0.70	0.03	0.48	FALSE
14	METSIM	Adipose	NCOA7	0.05	0.05	enet	5	0.05	1.9e-07	5.81	9.2	4.0e-20	0.24	0.95	0.03	FALSE
10	GTEx	Thyroid	HEY2	0.22	0.24	lasso	6	0.23	1.0e-17	-6.93	-7.2	8.2e-13	-0.08	0.02	0.98	FALSE
9	GTEx	Testis	HEY2	0.31	0.17	lasso	5	0.19	7.4e-09	-6.93	-6.9	5.4e-12	-0.08	0.02	0.98	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	HEY2	0.10	0.12	enet	15	0.13	9.8e-17	6.56	-6.6	3.6e-11	-0.06	0.02	0.98	FALSE
5	GTEx	Esophagus Muscularis	HINT3	0.08	0.00	enet	14	0.00	2.9e-01	6.88	-6.2	4.6e-10	-0.11	0.07	0.04	FALSE
19	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HEY2	0.09	0.06	lasso	8	0.06	2.3e-03	-5.51	-5.5	4.0e-08	-0.04	0.03	0.78	FALSE
13	METSIM	Adipose	HEY2	0.02	0.04	lasso	1	0.02	1.6e-04	-5.43	-5.4	5.5e-08	-0.06	0.03	0.97	FALSE