Best TWAS P=1.33e-111 · Best GWAS P=5.7e-118 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | GPR126 | 0.06 | 0.04 | lasso | 4 | 0.04 | 6.1e-04 | -22.1 | 22.4 | 1.3e-111 | -0.97 | 0.02 | 0.95 | TRUE |
2 | GTEx | Colon Transverse | GPR126 | 0.13 | -0.01 | lasso | 7 | 0.00 | 4.2e-01 | -9.5 | -8.0 | 1.5e-15 | 0.32 | 0.07 | 0.37 | TRUE |
3 | METSIM | Adipose | GPR126 | 0.05 | 0.01 | blup | 429 | 0.02 | 1.9e-04 | -11.2 | 18.5 | 2.2e-76 | -0.74 | 0.12 | 0.87 | TRUE |
4 | METSIM | Adipose | VTA1 | 0.03 | 0.03 | lasso | 5 | 0.02 | 9.8e-04 | -7.5 | -5.8 | 6.0e-09 | 0.04 | 0.62 | 0.01 | TRUE |
5 | NTR | Blood | HIVEP2 | 0.02 | 0.01 | blup | 424 | 0.01 | 2.6e-03 | -8.3 | -13.3 | 1.6e-40 | 0.40 | 0.34 | 0.05 | TRUE |
6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | GPR126 | 0.06 | 0.00 | blup | 69 | 0.01 | 4.6e-02 | -2.7 | -7.5 | 4.5e-14 | 0.42 | 0.02 | 0.07 | FALSE |
7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NMBR | 0.03 | 0.03 | blup | 46 | 0.02 | 3.6e-05 | 8.7 | -9.6 | 6.7e-22 | 0.13 | 0.84 | 0.08 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NMBR | 0.04 | 0.04 | enet | 9 | 0.03 | 1.7e-04 | 8.1 | -7.8 | 5.5e-15 | 0.11 | 0.37 | 0.07 | TRUE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | VTA1 | 0.03 | 0.02 | blup | 66 | 0.02 | 1.7e-03 | 10.2 | -9.5 | 3.1e-21 | 0.08 | 0.22 | 0.11 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NMBR | 0.07 | 0.05 | blup | 46 | 0.05 | 1.4e-06 | 9.0 | -7.0 | 3.3e-12 | 0.10 | 0.98 | 0.00 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | VTA1 | 0.03 | 0.00 | enet | 8 | 0.00 | 1.1e-01 | 10.2 | -5.5 | 3.6e-08 | 0.15 | 0.09 | 0.13 | TRUE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | NMBR | 0.06 | 0.04 | blup | 46 | 0.05 | 1.1e-05 | 9.0 | -5.3 | 1.5e-07 | 0.08 | 0.91 | 0.00 | TRUE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | VTA1 | 0.03 | 0.04 | enet | 3 | 0.01 | 1.2e-02 | 8.1 | -7.7 | 1.3e-14 | 0.07 | 0.19 | 0.08 | FALSE |
14 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | NMBR | 0.09 | 0.01 | blup | 46 | 0.04 | 3.4e-02 | 8.5 | -10.5 | 1.4e-25 | 0.11 | 0.01 | 0.67 | TRUE |