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chr6:154,878,398-156,330,580

Best TWAS P=9.44e-15 · Best GWAS P=4.35e-14 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
5	GTEx	Brain Cerebellar Hemisphere	RP11-477D19.2	0.56	0.48	lasso	7	0.50	8.6e-15	-7.5	-7.8	9.4e-15	0.96	0.01	0.99	TRUE
4	GTEx	Adrenal Gland	RP11-477D19.2	0.36	0.34	lasso	6	0.35	2.5e-13	-7.3	-7.6	3.1e-14	0.84	0.02	0.98	FALSE
28	GTEx	Stomach	RP11-477D19.2	0.21	0.17	lasso	5	0.16	7.2e-08	-7.3	-7.6	3.1e-14	0.89	0.02	0.98	FALSE
14	GTEx	Colon Transverse	RP11-477D19.2	0.21	0.24	lasso	11	0.21	2.3e-10	-7.3	-7.6	3.5e-14	0.84	0.02	0.98	FALSE
20	GTEx	Heart Left Ventricle	RP11-477D19.2	0.19	0.13	lasso	2	0.12	1.0e-06	-7.5	-7.6	3.9e-14	1.00	0.01	0.99	FALSE
41	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TFB1M	0.05	0.03	blup	96	0.02	7.9e-04	-6.9	-7.5	5.3e-14	0.79	0.02	0.97	FALSE
8	GTEx	Brain Hypothalamus	RP11-477D19.2	0.52	0.26	lasso	6	0.31	6.0e-08	-7.4	-7.4	1.1e-13	0.88	0.02	0.98	FALSE
17	GTEx	Esophagus Mucosa	RP11-477D19.2	0.15	0.11	enet	10	0.09	6.9e-07	-7.3	-7.4	1.2e-13	0.88	0.02	0.98	FALSE
23	GTEx	Pituitary	RP11-477D19.2	0.45	0.29	lasso	8	0.20	8.4e-06	-7.3	-7.4	1.5e-13	0.91	0.02	0.98	FALSE
12	GTEx	Cells Transformed fibroblasts	RP11-477D19.2	0.13	0.07	lasso	2	0.07	1.2e-05	-7.3	-7.4	1.8e-13	0.90	0.02	0.98	FALSE
25	GTEx	Skin Sun Exposed Lower leg	RP11-477D19.2	0.23	0.25	lasso	4	0.25	1.2e-20	-7.3	-7.3	2.2e-13	0.87	0.02	0.98	FALSE
2	GTEx	Adipose Subcutaneous	RP11-477D19.2	0.10	0.07	lasso	2	0.05	3.0e-05	-7.3	-7.3	2.6e-13	0.91	0.02	0.98	FALSE
31	GTEx	Thyroid	RP11-477D19.2	0.29	0.28	lasso	7	0.27	1.1e-20	-7.3	-7.3	2.6e-13	0.81	0.02	0.98	FALSE
6	GTEx	Brain Cerebellum	RP11-477D19.2	0.60	0.52	lasso	5	0.53	3.0e-18	-7.3	-7.3	2.8e-13	0.91	0.02	0.98	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	RP11-477D19.2	0.24	0.21	enet	21	0.19	7.1e-11	-6.9	-7.2	4.1e-13	0.79	0.02	0.98	FALSE
11	GTEx	Cells Transformed fibroblasts	TFB1M	0.17	0.07	enet	21	0.10	6.3e-08	-7.4	-7.1	9.2e-13	0.87	0.02	0.98	FALSE
9	GTEx	Breast Mammary Tissue	RP11-477D19.2	0.19	0.15	lasso	7	0.12	1.3e-06	-7.3	-7.1	1.7e-12	0.87	0.02	0.98	FALSE
19	GTEx	Heart Left Ventricle	TFB1M	0.27	0.22	lasso	10	0.23	1.4e-12	-5.5	-7.0	2.2e-12	0.83	0.17	0.83	FALSE
58	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TFB1M	0.11	0.00	blup	93	0.06	1.1e-02	-5.5	-7.0	3.4e-12	0.88	0.02	0.64	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	RP11-477D19.2	0.26	0.35	lasso	6	0.37	4.7e-50	-7.3	-6.9	4.0e-12	0.87	0.01	0.99	FALSE
22	GTEx	Nerve Tibial	RP11-477D19.2	0.28	0.17	lasso	6	0.16	1.2e-11	-7.3	-6.8	8.3e-12	0.88	0.02	0.98	FALSE
18	GTEx	Heart Atrial Appendage	RP11-477D19.2	0.15	0.12	lasso	1	0.10	2.1e-05	-6.7	-6.8	1.5e-11	0.77	0.03	0.94	FALSE
37	The Cancer Genome Atlas	Colon Adenocarcinoma	TFB1M	0.22	0.24	enet	19	0.23	1.6e-13	-5.5	-6.7	2.2e-11	0.83	0.90	0.10	FALSE
56	The Cancer Genome Atlas	Stomach Adenocarcinoma	TFB1M	0.16	0.20	enet	9	0.20	1.5e-14	-5.5	-6.7	2.5e-11	0.82	0.90	0.10	FALSE
30	GTEx	Thyroid	TFB1M	0.24	0.09	lasso	6	0.09	2.7e-07	-6.7	-6.7	3.0e-11	0.79	0.29	0.71	FALSE
13	GTEx	Colon Transverse	TFB1M	0.21	0.11	enet	14	0.17	1.6e-08	-6.7	-6.6	4.4e-11	0.74	0.05	0.95	FALSE
44	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TIAM2	0.13	0.08	blup	261	0.07	8.5e-05	-7.2	-6.5	5.8e-11	0.76	0.01	0.98	FALSE
36	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TFB1M	0.14	0.10	enet	8	0.09	5.1e-05	-5.5	-6.4	1.8e-10	0.75	0.42	0.42	FALSE
3	GTEx	Adrenal Gland	TFB1M	0.42	0.23	lasso	7	0.28	8.4e-11	-6.7	-6.4	1.9e-10	0.76	0.41	0.59	FALSE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	TFB1M	0.21	0.23	enet	11	0.26	1.8e-26	-5.5	-6.4	2.0e-10	0.74	1.00	0.00	FALSE
46	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TFB1M	0.06	0.07	lasso	3	0.06	5.8e-04	-5.6	-6.3	2.5e-10	0.69	0.09	0.78	FALSE
40	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TFB1M	0.16	0.17	lasso	6	0.19	1.3e-20	-5.5	-6.3	2.7e-10	0.76	1.00	0.00	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	TFB1M	0.27	0.33	enet	11	0.34	9.0e-34	-5.5	-6.3	3.1e-10	0.78	1.00	0.00	FALSE
43	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TFB1M	0.11	0.15	lasso	4	0.16	2.3e-09	-5.5	-6.2	5.6e-10	0.81	0.40	0.60	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	TFB1M	0.20	0.05	lasso	3	0.08	1.1e-03	-6.3	-6.2	5.7e-10	0.64	0.04	0.77	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	TFB1M	0.27	0.19	lasso	2	0.17	3.1e-06	5.7	-6.2	6.4e-10	0.68	0.12	0.79	FALSE
39	The Cancer Genome Atlas	Glioblastoma Multiforme	TFB1M	0.25	0.21	lasso	8	0.17	8.8e-06	-5.5	-6.1	8.9e-10	0.76	0.08	0.89	FALSE
50	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TFB1M	0.15	0.11	blup	94	0.08	3.2e-04	-6.9	-6.1	1.1e-09	0.68	0.17	0.64	FALSE
29	GTEx	Testis	RP11-477D19.2	0.23	0.08	enet	17	0.13	2.5e-06	5.5	-6.0	1.8e-09	0.71	0.03	0.97	FALSE
54	The Cancer Genome Atlas	Rectum Adenocarcinoma	TFB1M	0.28	0.22	lasso	8	0.18	4.1e-05	-5.5	-6.0	1.8e-09	0.75	0.05	0.76	FALSE
55	The Cancer Genome Atlas	Skin Cutaneous Melanoma	TFB1M	0.14	0.04	blup	96	0.05	1.6e-02	-5.5	-6.0	2.0e-09	0.87	0.02	0.33	FALSE
45	The Cancer Genome Atlas	Brain Lower Grade Glioma	TFB1M	0.39	0.30	enet	22	0.34	4.6e-40	-5.5	-5.9	3.3e-09	0.73	1.00	0.00	FALSE
49	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TFB1M	0.18	0.18	blup	96	0.19	4.0e-13	-5.5	-5.9	3.7e-09	0.70	0.98	0.02	FALSE
48	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TFB1M	0.13	0.13	lasso	8	0.11	8.6e-13	-5.5	-5.9	3.8e-09	0.75	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	TFB1M	0.29	0.36	lasso	4	0.37	9.1e-47	-5.5	-5.9	4.4e-09	0.76	1.00	0.00	FALSE
47	The Cancer Genome Atlas	Lung Adenocarcinoma	TFB1M	0.18	0.19	lasso	9	0.19	1.9e-21	-5.6	-5.8	5.3e-09	0.66	1.00	0.00	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	TFB1M	0.12	0.16	enet	12	0.16	1.4e-31	-5.5	-5.8	6.0e-09	0.73	1.00	0.00	FALSE
16	GTEx	Esophagus Mucosa	TFB1M	0.18	0.17	lasso	6	0.14	8.8e-10	-5.5	-5.8	6.6e-09	0.74	0.96	0.04	FALSE
26	GTEx	Spleen	RP11-477D19.2	0.53	0.09	lasso	8	0.17	3.0e-05	-6.7	-5.8	6.9e-09	0.71	0.02	0.86	FALSE
52	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TIAM2	0.13	0.01	blup	266	0.03	3.4e-02	-7.3	-5.8	8.9e-09	0.66	0.02	0.79	FALSE
27	GTEx	Stomach	TFB1M	0.19	0.09	enet	14	0.09	2.8e-05	-5.6	-5.7	1.1e-08	0.59	0.29	0.68	FALSE
42	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TIAM2	0.05	0.01	blup	265	0.01	7.3e-03	-6.9	-5.7	1.2e-08	0.61	0.02	0.78	FALSE
21	GTEx	Lung	RP11-477D19.2	0.15	0.01	enet	33	0.01	5.8e-02	-2.6	-5.5	2.8e-08	0.50	0.02	0.89	FALSE
51	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TFB1M	0.29	0.23	lasso	4	0.27	3.8e-11	-5.5	-5.5	4.1e-08	0.71	0.87	0.13	FALSE
32	ROSMAP	Brain Pre-frontal Cortex	TFB1M	0.16	0.18	lasso	5	0.17	2.1e-21	-5.5	-5.5	4.4e-08	0.73	1.00	0.00	FALSE
7	GTEx	Brain Frontal Cortex BA9	TFB1M	0.34	0.23	lasso	8	0.15	7.8e-05	-5.5	-5.5	4.9e-08	0.80	0.13	0.62	FALSE
38	The Cancer Genome Atlas	Esophageal Carcinoma	TFB1M	0.36	0.21	blup	98	0.26	7.6e-09	-5.5	-5.4	6.1e-08	0.76	0.52	0.33	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	CLDN20	0.02	0.00	blup	79	0.01	8.0e-03	2.3	5.3	1.2e-07	-0.80	0.02	0.44	FALSE