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chr6:157,713,662-161,786,694

Best TWAS P=3.65e-17 · Best GWAS P=2.8e-21 conditioned to 0.000821

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
10	GTEx	Esophagus Mucosa	SLC22A3	0.19	0.08	enet	47	0.12	1.7e-08	5.7	-8.4	3.7e-17	-0.58	0.68	0.32	TRUE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TULP4	0.09	0.05	blup	148	0.04	2.0e-05	5.5	-8.2	3.1e-16	0.05	0.76	0.03	TRUE
9	GTEx	Cells EBV-transformed lymphocytes	SERAC1	0.24	0.31	lasso	8	0.30	1.4e-10	-5.2	-5.6	2.1e-08	-0.02	0.93	0.01	TRUE
1	CommonMind	Brain Pre-frontal Cortex	LPA	0.10	0.02	lasso	5	0.04	3.2e-06	2.2	-5.6	2.3e-08	-0.62	0.04	0.92	TRUE
7	GTEx	Brain Cortex	TMEM181	0.32	-0.01	enet	72	0.04	2.8e-02	-1.0	5.3	1.4e-07	-0.06	0.07	0.09	TRUE
6	GTEx	Brain Caudate basal ganglia	SLC22A3	0.15	0.10	enet	39	0.11	5.6e-04	-8.7	-8.4	4.6e-17	-0.71	0.04	0.89	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	SLC22A3	0.14	0.20	lasso	10	0.19	2.4e-24	-7.1	-7.3	2.6e-13	-0.67	1.00	0.00	FALSE
21	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LPAL2	0.07	0.00	blup	74	0.04	1.1e-03	-3.8	7.2	5.9e-13	0.75	0.04	0.53	FALSE
4	GTEx	Adipose Visceral Omentum	SLC22A3	0.13	0.06	enet	7	0.09	1.3e-05	-7.1	-7.2	7.2e-13	-0.63	0.52	0.47	FALSE
8	GTEx	Brain Frontal Cortex BA9	SLC22A3	0.26	0.08	lasso	6	0.05	1.5e-02	-4.4	-6.6	3.4e-11	-0.62	0.16	0.57	FALSE
11	GTEx	Nerve Tibial	SLC22A3	0.20	0.10	lasso	7	0.13	3.2e-09	-7.1	-6.5	1.0e-10	-0.56	0.99	0.00	FALSE
16	GTEx	Testis	SLC22A3	0.19	0.01	lasso	14	0.05	2.6e-03	-9.0	-6.1	1.0e-09	-0.66	0.32	0.64	FALSE
13	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A3	0.15	0.05	lasso	9	0.05	9.9e-04	-2.8	-6.0	1.8e-09	-0.65	0.20	0.74	FALSE
12	GTEx	Ovary	SLC22A3	0.33	0.29	lasso	6	0.23	2.8e-06	-5.6	-6.0	2.6e-09	-0.65	0.11	0.80	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SLC22A3	0.10	0.02	blup	582	0.05	4.4e-07	-7.2	-5.7	1.3e-08	-0.63	0.61	0.38	FALSE
17	GTEx	Thyroid	TULP4	0.09	0.02	lasso	4	0.03	1.4e-03	7.9	5.7	1.4e-08	0.08	0.11	0.35	FALSE
3	CommonMind	Brain Pre-frontal Cortex	TULP4	0.16	0.08	bslmm	596	0.12	2.9e-14	-6.0	-5.7	1.6e-08	-0.04	0.85	0.15	FALSE
15	GTEx	Stomach	IGF2R	0.25	0.00	enet	41	0.00	6.6e-01	2.9	-5.7	1.6e-08	-0.28	0.10	0.05	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	TULP4	0.03	0.03	lasso	3	0.02	5.1e-03	5.2	-5.4	6.7e-08	0.01	0.10	0.59	FALSE
14	GTEx	Skin Sun Exposed Lower leg	SLC22A3	0.29	0.14	lasso	10	0.20	3.7e-16	3.5	-5.3	1.0e-07	-0.48	1.00	0.00	FALSE
5	GTEx	Artery Aorta	SNX9	0.14	0.00	lasso	3	0.00	1.9e-01	7.9	5.1	3.0e-07	0.00	0.01	0.97	FALSE