Best TWAS P=7.18e-17 · Best GWAS P=2.38e-33 conditioned to 8.93e-25
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 9 | ROSMAP | Brain Pre-frontal Cortex | TWIST1 | 0.09 | 0.02 | blup | 618 | 0.02 | 8.5e-04 | -4.9 | -8.3 | 7.2e-17 | -0.05 | 0.36 | 0.03 | TRUE |
| 5 | GTEx | Nerve Tibial | TWISTNB | 0.20 | 0.01 | enet | 13 | 0.07 | 9.4e-06 | 4.7 | 6.8 | 7.9e-12 | 0.00 | 0.28 | 0.26 | TRUE |
| 3 | GTEx | Brain Nucleus accumbens basal ganglia | CTA-293F17.1 | 0.32 | 0.26 | lasso | 5 | 0.27 | 7.4e-08 | 5.8 | -6.2 | 7.2e-10 | -0.26 | 0.12 | 0.51 | TRUE |
| 10 | The Cancer Genome Atlas | Colon Adenocarcinoma | SNX13 | 0.15 | 0.16 | lasso | 3 | 0.18 | 1.7e-10 | 5.4 | -5.5 | 2.8e-08 | -0.02 | 0.03 | 0.97 | TRUE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | CTA-293F17.1 | 0.21 | 0.13 | lasso | 9 | 0.12 | 6.5e-07 | 5.8 | -6.1 | 1.0e-09 | -0.24 | 0.74 | 0.03 | FALSE |
| 1 | CommonMind | Brain Pre-frontal Cortex | TMEM196 | 0.08 | 0.01 | bslmm | 554 | 0.02 | 1.5e-03 | 4.4 | 5.5 | 3.7e-08 | 0.05 | 0.15 | 0.36 | FALSE |
| 7 | GTEx | Testis | SNX13 | 0.21 | 0.14 | enet | 15 | 0.13 | 2.0e-06 | -5.0 | 5.4 | 5.9e-08 | -0.02 | 0.18 | 0.82 | FALSE |
| 4 | GTEx | Colon Transverse | SNX13 | 0.14 | 0.07 | lasso | 5 | 0.07 | 3.8e-04 | -4.3 | -5.2 | 2.1e-07 | 0.00 | 0.06 | 0.85 | FALSE |
| 8 | METSIM | Adipose | SNX13 | 0.07 | 0.09 | lasso | 2 | 0.09 | 1.0e-13 | 4.9 | 5.2 | 2.2e-07 | -0.03 | 0.58 | 0.42 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | SNX13 | 0.19 | 0.16 | lasso | 2 | 0.13 | 1.5e-10 | 4.9 | 5.2 | 2.5e-07 | -0.01 | 0.57 | 0.43 | FALSE |