Hub : Genes

TWIST1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0710	0.0310	8.5e-03	0.001	0.006	-0.001	0.004	-0.001	2.4e-01	0.04900	5.3e-01	0.0890	4.1e-01
2	GTEx	Artery Coronary	0.6970	0.0900	1.9e-04	0.001	NA	0.002	NA	-0.005	2.8e-01	NA	2.6e-01	NA	5.3e-01
3	GTEx	Breast Mammary Tissue (Female)	0.0952	0.0990	2.3e-01	0.097	NA	0.010	NA	0.129	7.9e-04	NA	1.5e-01	NA	1.2e-04
4	GTEx	Nerve Tibial	0.1505	0.0428	2.7e-05	0.111	NA	0.165	NA	0.168	3.2e-08	NA	9.3e-12	NA	5.7e-12
5	ROSMAP	Brain Pre-frontal Cortex	0.0871	0.0280	3.0e-04	0.017	0.021	0.001	0.019	0.016	2.5e-03	0.00085	2.4e-01	0.0013	3.4e-03
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0560	0.0370	8.1e-03	0.002	0.006	0.002	NA	-0.001	1.6e-01	0.06200	2.0e-01	NA	5.0e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.5	0.8	2.6	-0.1	-0.7	-1.6	-0.5	-0.7	-1.1
Bipolar Disorder or Schizophrenia	0.7	1.7	7.2	-0.6	1.3	-2.7	0.2	-0.3	-0.9
Depressed Affect (Nagel 2018)	0.5	1.0	2.7	-0.7	1.2	-1.2	-1.6	-0.1	0.1
Depression (Nagel 2018)	1.1	1.6	3.5	0.4	1.0	-1.7	-1.1	1.9	0.9
Intelligence (Savage-Jansen 2018)	0.7	2.1	7.1	-0.8	0.2	0.9	-0.8	-2.7	-1.9
Neuroticism (Nagel 2018)	0.3	0.7	2.6	0.3	1.0	-1.6	0.4	0.6	-0.4
Schizophrenia (2018)	0.8	1.7	4.7	-0.8	2.1	-2.2	0.7	0.1	-0.4
Schizophrenia vs Biploar Disorder	0.8	1.1	3.6	-0.1	1.2	0.3	0.2	1.2	1.9
Worry (Nagel 2018)	0.5	1.1	2.3	0.6	1.0	-0.8	1.5	0.8	-1.3
Alzheimer’s Disease (in mother)	0.5	0.6	1.8	-1.3	-0.6	-1.2	-0.1	-0.1	-0.2
Alzheimer’s Disease (in father)	0.9	1.0	2.3	-1.3	1.2	-0.4	0.8	1.5	0.2
Alzheimer’s Disease (including proxy)	0.7	1.0	3.8	-2.0	0.5	-1.2	0.3	0.5	-0.1
Crohns Disease (2017)	0.5	1.1	1.8	0.9	1.0	1.3	1.4	0.6	-0.8
Irritable Bowel Disease (IBD)	0.2	0.5	1.3	-0.3	-0.3	1.2	0.8	-0.3	-0.7
Ulcerative Colitis (UC)	0.5	0.9	3.4	-1.2	-1.9	0.1	-0.1	-0.6	-0.5
Major Depression (MDD)	1.3	1.6	6.3	-0.1	1.3	-2.5	0.3	1.1	0.5
Reaction Time	2.1	4.0	13.3	2.1	-0.5	-0.9	-0.6	3.6	-2.3
Verbal and Numeric Reasoning (VNR)	1.0	2.5	5.0	-2.1	0.4	0.3	-1.5	-2.2	-1.7
Breast Cancer	1.0	2.4	10.0	-0.2	-0.3	-1.3	-3.2	0.3	1.6
Ovarian Cancer	1.0	1.3	3.3	0.4	-0.7	-0.8	1.7	0.5	1.8
Prostate Cancer	2.2	3.0	7.4	-0.6	1.6	2.1	2.7	-1.9	-0.3
Age at First Birth	0.2	0.3	0.8	-0.1	0.5	-0.7	0.9	0.3	-0.3
Bipolar Disorder (2011)	0.6	0.5	2.0	-0.3	0.3	-1.4	1.0	0.4	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	2.5	-0.6	1.0	-0.2	-1.6	0.1	0.0
Coronary Artery Disease (CAD)	1.2	1.4	2.5	1.5	-0.4	-1.1	-1.1	1.6	-0.9
Crohns Disease (2012)	1.1	1.8	4.3	2.1	0.8	1.9	1.3	0.5	0.5
Mean Putamen Volume	0.5	0.5	0.9	-0.6	-0.9	-0.6	0.9	-0.3	0.9
Fasting Glucose	1.0	1.2	2.7	0.0	-1.5	-0.0	-1.4	0.3	1.6
HbA1C	3.9	4.3	8.2	1.2	2.9	2.7	1.1	-0.3	2.7
HDL Cholesterol	0.5	0.8	2.5	-1.6	-0.0	-1.2	-0.5	-0.5	0.7
LDL Cholesterol	0.2	0.4	1.8	-0.2	-0.1	0.2	0.0	-0.5	1.3
Lupus	0.8	1.2	4.2	-0.7	-0.0	-0.7	0.7	-2.1	1.2
Neuroticism (2016)	0.8	1.2	3.2	1.8	0.8	0.7	0.8	1.0	1.1
Primary Biliary Cirrhosis	1.1	1.6	4.3	1.1	0.4	1.1	2.1	0.2	1.6
Rheumatoid Arthritis	0.9	1.2	2.7	-1.6	1.6	0.7	0.4	0.9	-0.7
Schizophrenia (2014)	0.6	1.4	4.6	-0.5	2.2	-1.8	0.4	-0.2	-0.3
Triglycerides	0.4	0.6	0.9	0.8	0.8	0.4	-0.6	-0.8	1.0
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	0.2	-0.4	-0.2	-0.4	-0.3	0.7
Ulcerative Colitis	0.2	0.3	1.4	-0.5	-1.2	0.5	-0.1	-0.2	-0.4
Blood Eosinophil Count	0.1	0.9	2.1	1.4	1.1	1.3	-0.1	0.4	0.6
Blood Platelet Count	0.1	1.0	2.7	1.1	-0.4	1.0	-0.6	1.6	0.7
Blood Red Count	0.2	1.6	4.5	1.5	-1.1	2.1	0.6	-0.4	1.2
Blood White Count	0.1	0.8	1.8	0.4	-0.8	0.9	0.1	1.0	1.4
Heel T-Score	1.1	8.5	41.6	1.4	1.1	-0.0	6.5	-1.8	-1.8
BMI	0.6	3.4	8.1	1.6	-1.1	-2.7	-0.7	2.9	1.0
Height	2.0	37.8	118.8	-4.5	2.5	7.4	-1.5	-10.9	4.9
Waist Hip Ratio (WHR)	0.6	2.7	8.2	-2.9	-1.8	-0.7	-0.2	-2.0	-0.2
Systolic Blood Pressure	0.9	4.3	11.1	2.1	-1.7	-1.5	-1.8	3.3	1.2
Smoking Status	0.5	1.1	3.0	-0.4	-1.1	-1.7	-0.1	0.7	1.4
Allergy or Eczema	0.3	0.8	2.6	-0.7	-1.1	0.0	-0.6	-1.6	0.1
Cardiovascular Disease	1.0	3.3	11.8	0.3	-0.9	-1.7	-1.8	3.4	-0.9
Hypothyroidism (self reported)	0.1	0.3	0.9	1.0	-0.1	0.6	0.2	-0.1	-0.6
Respiratory disease	0.2	0.4	1.3	0.3	-1.1	0.2	-0.7	0.6	0.4
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.9	-0.9	1.4	-1.1	-1.1	-0.1	-0.2
Lung FEV1/FVC ratio	0.6	3.1	7.5	2.2	-2.7	-1.9	1.0	1.2	-0.0
Lung FVC	1.7	8.4	33.3	0.3	0.2	1.1	-5.8	-2.5	-3.1
Neuroticism	0.3	0.8	2.8	0.0	1.7	-1.4	0.4	0.1	0.5
Chronotype (morning person)	0.9	2.1	5.0	2.2	-0.8	0.0	-1.7	1.8	0.8
Hair Pigment	0.3	8.7	41.7	0.4	0.5	-0.4	6.5	2.9	-1.4
Tanning	0.2	2.1	5.5	0.5	-1.2	-1.1	-1.6	1.3	2.3
Hand grip strength (left)	0.6	1.7	3.3	-1.7	-0.8	-0.9	1.8	-0.5	1.4
Number of treatments/medications taken	0.7	1.2	2.7	0.1	0.4	-1.2	-1.6	1.6	-0.8
Average weekly spirits intake	0.5	0.7	1.4	-1.2	-0.0	-0.7	-1.1	-0.6	0.6
Sensitivity / hurt feelings	0.5	0.9	1.6	1.3	0.8	1.2	1.1	0.3	0.4
Frequency of depressed mood in last 2 weeks	0.8	1.2	2.5	1.5	0.2	-1.3	0.2	1.6	0.8
Hearing difficulty/problems: Yes	1.4	2.2	8.2	1.3	0.3	-1.4	0.7	2.9	0.8
Relative age of first facial hair	3.4	7.1	21.4	-0.9	-2.4	0.0	-4.6	-3.5	-1.7
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	3.4	1.8	0.8	0.3	-0.8	1.4	-0.0
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.1	0.7	0.9	1.1	-1.4	-0.3	-0.1
Ever had hysterectomy (womb removed)	0.7	0.8	2.3	0.3	1.5	1.2	0.8	-0.4	0.0
Systolic blood pressure, automated reading	0.3	0.9	2.4	1.4	-0.4	-0.5	-0.4	1.5	0.9
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	2.0	-0.1	1.4	0.4	-1.1	0.6	0.2
Angina	1.2	1.5	4.3	2.1	0.2	0.1	-0.5	2.1	-0.5
Medication for hormone replacement therapy	0.7	0.8	3.1	-0.9	-0.1	0.5	-1.8	-0.6	0.5
Vitamin and mineral supplements	1.0	1.4	6.8	-0.1	-0.9	-0.9	0.0	2.6	-0.0
Supplements: Zinc	0.8	0.9	3.2	1.8	-0.4	0.8	-0.3	-0.4	1.0
Medication: Co-codamol	1.7	2.0	4.6	1.2	0.2	2.0	2.1	-0.0	1.3
Medication: Metformin	0.7	1.0	2.0	1.2	0.9	-0.2	-1.4	-1.2	-0.4
Diabetes (father)	0.2	0.2	0.7	-0.1	-0.0	-0.6	0.5	-0.8	0.4
Diabetes (mother)	0.7	0.9	1.9	0.7	-0.0	1.3	-1.0	-1.4	0.7
Severe depression (siblings)	0.6	0.7	1.4	1.2	-0.8	-0.8	1.1	0.7	-0.0
Pack years adult smoking proportion	0.6	1.0	2.9	1.7	-0.8	-0.7	0.2	1.3	-0.4
Impedance of leg (right)	0.2	0.7	2.3	-1.3	0.4	0.4	0.4	-1.5	0.1
Leg fat-free mass (left)	0.4	2.2	5.8	-0.7	-0.4	1.7	-0.8	-2.4	1.9
Trunk fat percentage	0.2	0.7	1.2	-0.1	0.7	-0.5	1.0	1.1	1.1
Hand grip strength (right)	0.3	0.9	2.5	-0.6	-1.0	-0.5	1.6	-0.9	0.8
Townsend deprivation index at recruitment	0.9	1.3	5.3	1.1	-0.9	-0.5	-0.4	2.3	0.1
Current tobacco smoking	0.5	0.9	2.9	-0.4	0.5	-1.1	-1.7	-0.4	0.8
Average weekly fortified wine intake	2.0	2.3	6.3	0.7	0.2	2.5	-2.3	-1.2	0.8
Maternal smoking around birth	1.3	1.9	6.4	1.1	-1.6	-0.9	-2.5	0.1	0.6
Fed-up feelings	0.5	1.0	4.2	0.0	0.8	-2.0	-0.7	0.6	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	2.7	3.6	13.8	2.2	0.2	-0.7	0.2	3.7	1.6
Relative age voice broke	0.8	1.2	2.3	-1.2	-0.8	1.3	-1.5	-0.9	0.0
Taking other prescription medications	1.4	2.1	5.4	0.4	1.4	-2.3	-0.1	-0.1	-2.3
Age when periods started (menarche)	0.5	1.1	2.3	-0.9	-0.8	-1.5	1.1	0.5	-1.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	-0.1	0.7	0.3	-0.7	0.4	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	11.2	0.9	0.2	-0.3	3.4	-1.4	-1.6
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.8	-0.3	0.5	-0.5	0.2	-0.9	0.6
Qualifications: CSEs or equivalent	2.1	2.7	10.6	1.9	-0.9	-1.0	0.0	3.3	0.7
Serious illness, injury or assault to yourself	0.6	0.7	2.6	-0.2	-0.1	-1.6	0.9	0.5	-0.7
High blood pressure	0.9	2.5	9.2	0.4	-0.4	-1.1	-1.8	3.0	-1.1
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.8	0.0	-0.6	0.3	-0.6	-1.4	0.7
Multivitamins +/- minerals	1.4	1.8	4.4	0.7	-0.3	0.3	-1.4	-2.1	2.0
Stomach or abdominal pain in last month	1.3	1.6	4.8	0.3	-0.4	1.1	-1.8	0.2	-2.2
Supplements: Glucosamine	0.5	0.7	1.3	-0.6	-0.1	1.2	0.9	-1.0	-0.7
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.3	-0.0	-0.7	-0.1	-0.1	0.6	1.1
Medication: Atenolol	1.3	1.6	5.4	0.7	-0.8	-0.9	-1.3	2.3	-0.8
Medication: Levothyroxine sodium	0.2	0.3	0.7	-0.4	0.8	0.4	0.2	0.4	-0.9
Sitting height	3.2	23.0	69.4	-3.6	2.2	5.0	-4.2	-8.3	2.8
Chronic bronchitis/emphysema (father)	0.8	0.9	2.0	0.3	0.0	1.3	1.2	0.5	1.4
High blood pressure (mother)	0.9	1.3	4.5	-1.1	0.4	-1.3	0.3	-0.3	-2.1
Body mass index (BMI)	0.3	1.5	4.8	1.1	-0.3	-1.6	-0.3	2.2	0.2
Impedance of leg (left)	0.1	0.7	2.2	-1.4	0.2	-0.1	0.3	-1.5	-0.1
Leg predicted mass (left)	0.4	2.4	5.9	-0.8	-0.3	1.8	-0.9	-2.4	1.9
Trunk fat mass	0.1	0.5	2.2	-0.4	0.5	-0.0	0.4	-0.1	1.5
Waist circumference	0.1	0.4	1.3	-0.6	-0.5	-0.4	-0.7	-0.3	1.1
Number of incorrect matches in round	0.4	0.7	3.1	0.4	-0.3	1.8	-0.1	-0.5	0.7
Past tobacco smoking	0.9	1.7	3.9	1.1	2.0	1.7	0.2	0.1	-1.6
Alcohol usually taken with meals	1.0	1.6	3.8	1.0	-1.0	1.4	1.9	-0.1	1.4
Nervous feelings	0.6	1.1	2.9	1.4	1.2	0.4	1.7	0.4	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.7	1.6	-0.2	-1.2	-0.0	1.5	1.4
Hearing difficulty/problems with background noise	1.4	2.3	7.3	1.3	-0.8	-1.0	0.6	2.7	1.6
Hair/balding pattern: Pattern 2	8.0	10.1	45.7	2.2	-0.9	0.4	-6.8	-2.9	0.7
Had menopause	0.1	0.2	0.6	0.7	0.4	0.4	0.4	0.2	-0.0
Had other major operations	0.5	0.6	1.2	-0.6	-1.1	-0.9	0.5	0.9	-0.4
Forced vital capacity (FVC)	1.4	5.5	16.0	-1.5	-0.8	1.0	-3.6	-4.0	0.0
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.6	10.5	1.5	-0.4	-0.3	3.2	-0.5	-1.5
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	6.3	0.2	2.5	1.4	-0.7	-0.4	1.1
Qualifications: None of the above	0.5	1.0	2.3	0.8	0.3	1.0	-1.5	1.2	-0.6
Financial difficulties in last 2 years	2.0	2.7	9.5	3.1	-1.1	0.1	-1.1	2.0	0.5
Mouth/teeth dental problems	0.1	0.1	0.3	0.1	0.4	0.6	-0.2	-0.2	-0.1
Heart attack	1.0	1.2	4.5	0.3	1.3	-0.4	-0.8	2.1	-0.5
Allergy	0.2	0.4	1.3	-0.1	0.1	-0.5	1.0	1.1	-0.0
Pain all over the body in last month	1.8	1.9	3.8	1.9	-1.0	-0.5	0.8	1.9	1.5
Diabetes (self-reported)	0.5	0.7	1.6	-0.6	0.7	-0.0	-1.3	-1.1	0.9
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	3.0	1.3	0.3	1.7	-0.6	-1.3	0.2
Medication: Ramipril	1.5	2.0	6.3	0.2	-0.8	-2.1	-0.7	2.5	-0.1
Medication: Simvastatin	1.4	2.1	5.0	2.0	0.9	-0.8	-1.4	2.2	-0.1
Fluid intelligence score	1.5	3.2	6.6	-2.3	-0.6	-0.1	-2.5	-2.6	-0.6
Illnesses of siblings	1.3	1.9	4.5	1.2	0.8	0.7	2.0	-2.1	0.3
Neuroticism score	0.3	0.7	1.6	0.3	1.1	-1.2	0.6	0.8	0.3
Weight	0.2	1.2	3.4	-0.6	-0.1	0.5	-0.6	-1.6	1.9
Impedance of arm (right)	0.3	1.4	4.0	-2.0	1.2	0.5	1.5	-0.7	-0.4
Arm fat percentage (right)	0.3	1.4	4.9	0.4	0.1	-1.6	0.6	2.2	0.3
Trunk fat-free mass	0.8	4.9	15.2	-1.2	-0.6	2.0	-1.9	-3.9	2.2
Hip circumference	0.2	1.1	5.5	-0.0	-0.1	0.5	-0.4	-0.6	2.4
Time employed in main current job	1.4	1.6	5.4	0.7	0.7	1.5	2.3	-0.5	-0.9
Alcohol intake versus 10 years previously	1.2	1.7	5.2	-1.7	0.1	-2.3	-0.4	-0.9	-1.2
Father’s age at death	2.9	3.9	18.1	-1.2	-0.3	1.7	0.5	-4.3	0.9
Worrier / anxious feelings	0.5	0.9	2.5	-0.1	0.9	-0.9	1.6	0.8	-0.9
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.4	7.7	2.4	0.6	-0.6	-2.5	2.8	0.1
Falls in the last year	0.9	1.2	4.8	0.6	0.9	-0.5	-2.2	0.6	0.8
Hair/balding pattern: Pattern 3	12.5	18.6	83.7	-1.2	1.3	0.3	9.1	4.8	-1.3
Number of live births	0.8	1.2	2.2	1.0	0.9	0.3	-1.5	-1.1	1.3
Forced expiratory volume in 1-second (FEV1)	1.4	4.6	13.8	-0.8	-0.7	0.8	-3.5	-3.7	-0.3
Pulse rate	0.7	1.2	2.3	1.3	-1.2	0.4	1.5	0.6	1.2
Happiness	0.6	0.7	1.1	-0.9	0.9	-1.0	1.0	-0.9	0.1
Noisy workplace	0.4	0.5	1.6	0.6	0.4	0.6	1.3	0.6	-0.3
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.8	-0.4	0.6	0.4	1.7	-1.4	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	2.8	-0.9	-1.3	-1.7	0.2	0.5	0.6
Mouth/teeth dental problems: Dentures	0.2	0.3	0.6	0.6	0.7	0.2	0.6	0.8	-0.2
Asthma	0.5	0.9	3.3	0.1	-1.8	0.8	-0.9	0.4	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	2.6	-1.6	-0.2	-1.6	-0.8	-0.3	0.5
Medication: Cholesterol lowering	1.8	2.7	11.0	0.5	-0.1	-2.0	-0.9	3.3	-0.6
Depression (self-reported)	0.6	0.7	2.1	0.4	0.8	-0.3	0.5	-1.1	-1.5
Medication: Lansoprazole	1.2	1.4	4.8	0.8	0.4	-0.7	-1.4	2.2	-0.7
Prospective memory result	0.1	0.1	0.4	0.4	0.3	-0.2	0.6	0.2	-0.3
Lung cancer (father)	0.7	0.9	2.5	1.6	-0.5	-0.2	0.3	0.1	1.5
Illnesses of mother	0.3	0.4	1.4	0.2	-0.8	0.3	-0.0	-0.6	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.3	14.1	-0.3	-0.9	0.8	-3.8	-3.8	-1.4
Pulse wave Arterial Stiffness index	0.2	0.3	0.6	0.4	0.2	0.8	0.6	-0.4	0.6
Impedance of arm (left)	0.3	1.4	3.8	-1.7	1.3	0.3	2.0	-0.5	0.1
Arm fat mass (right)	0.1	0.4	0.9	0.0	0.2	-0.9	0.2	0.9	0.8
Trunk predicted mass	0.9	5.0	15.4	-1.2	-0.6	2.0	-2.0	-3.9	2.2
Standing height	2.0	20.2	69.6	-4.2	0.3	4.5	-1.1	-8.3	3.5
Length of working week for main job	0.7	0.7	1.6	-0.7	0.6	0.9	0.7	1.3	0.8
Exposure to tobacco smoke at home	1.2	1.3	3.4	1.9	0.4	-0.1	0.2	1.1	1.7
Breastfed as a baby	0.4	0.4	0.9	1.0	-0.6	-0.3	0.9	0.3	0.6
Tense / ‘highly strung’	1.1	1.8	5.0	2.0	-0.5	0.2	2.2	1.1	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	5.4	-0.1	0.9	-2.3	-1.7	0.0	-1.9
Hair/balding pattern: Pattern 4	29.1	70.6	334.9	2.5	3.2	1.0	18.3	8.4	0.0
Birth weight of first child	0.6	1.0	2.1	1.0	0.8	1.0	-0.8	-1.5	0.9
Peak expiratory flow (PEF)	0.4	0.9	3.6	-0.2	-0.6	-0.8	-1.0	-1.9	0.1
Pulse wave reflection index	0.7	0.9	2.7	-0.9	0.6	0.2	-1.6	-1.0	-0.5
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.6	1.0	-1.6	0.9	0.2	1.3	1.3
Loud music exposure frequency	2.2	2.4	7.8	1.6	-1.6	0.5	0.9	0.8	2.8
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	4.0	-0.6	-0.0	0.1	0.0	-2.0	1.6
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	3.1	-0.2	0.6	0.7	1.2	-1.8	0.5
Blood clot in the leg (DVT)	1.0	1.3	4.5	0.6	2.1	1.3	-0.2	-0.9	-0.4
Medication: Paracetamol	0.4	0.7	2.8	-0.0	1.1	-0.1	-1.7	-0.1	-0.0
Headache pain in last month	0.1	0.2	0.6	-0.2	0.3	0.4	-0.8	0.2	-0.0
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	9.2	-0.7	0.7	1.0	1.4	-3.0	-0.6
Glaucoma (self-reported)	0.2	0.2	0.5	0.3	-0.4	-0.6	-0.2	0.3	-0.7
Gout (self-reported)	0.9	1.2	2.1	-1.1	1.4	-1.3	0.2	0.1	-1.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.2	0.8	0.2	1.1	0.2	-0.0	-0.4
Medication: Amlodipine	1.8	2.5	5.9	0.6	-2.4	-1.4	-0.4	2.1	1.5
Medication: Ventolin 100micrograms inhaler	0.8	1.0	1.9	1.4	-0.5	-0.2	-1.0	1.4	-1.0
Birth weight	0.3	0.7	3.4	-0.0	0.2	1.9	0.2	0.3	0.6
Chronic bronchitis/emphysema (mother)	1.0	1.1	4.1	1.5	0.3	-0.1	0.1	2.0	-0.7
High blood pressure (siblings)	0.6	0.9	1.9	-0.7	0.1	-0.1	-1.4	1.2	1.1
Forced vital capacity (FVC), Best measure	1.8	6.4	18.2	-0.9	-0.8	1.3	-4.3	-4.1	-0.8
Body fat percentage	0.2	0.8	2.0	0.4	0.4	-1.1	0.9	1.4	0.6
Leg fat percentage (right)	0.2	0.8	2.3	0.8	0.2	-1.4	0.3	1.5	0.1
Arm fat-free mass (right)	0.7	3.5	7.8	-0.1	-0.9	1.9	-1.7	-2.8	2.5
Exposure to tobacco smoke outside home	2.4	3.2	8.0	1.8	-0.9	-2.0	0.7	2.8	1.6
Comparative body size at age 10	0.8	2.1	6.0	-1.4	-0.1	-2.0	-2.4	0.7	0.4
Number of full brothers	0.1	0.2	0.4	0.6	0.2	0.5	-0.2	0.1	-0.3
Worry too long after embarrassment	0.7	1.1	5.6	0.8	-0.5	-0.1	2.4	0.1	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.1	0.7	-0.5	-1.5	1.0	0.0	-0.7
Wheeze or whistling in the chest in last year	0.6	1.1	2.2	0.9	-0.0	1.2	-1.5	0.5	1.4
Number of children fathered	1.4	1.6	4.2	-0.6	2.0	1.1	-0.7	-1.8	0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	6.1	1.0	0.5	0.6	2.5	0.2	0.0
Age at first live birth	0.2	0.3	1.4	-0.3	-1.2	-0.3	-0.4	-0.6	-0.1
Pulse wave peak to peak time	0.2	0.3	0.6	-0.7	-0.3	-0.5	-0.8	-0.1	-0.2
Health satisfaction	0.5	0.6	2.1	0.9	0.2	0.3	0.7	1.4	0.1
Shortness of breath walking on level ground	0.5	0.5	1.8	0.6	0.5	0.9	0.3	1.3	0.4
Qualifications: College or University degree	0.3	1.1	3.9	-0.4	-0.6	0.1	2.0	-1.4	-0.3
Eye problems/disorders: None of the above	0.6	0.7	1.8	0.9	-1.0	-1.3	-0.1	0.3	0.8
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.6	0.3	0.2	0.8	-0.8	0.1	0.4
Emphysema/chronic bronchitis	0.2	0.2	0.6	-0.1	-0.5	-0.7	-0.8	0.3	-0.1
Medication for pain relief, constipation, heartburn	1.0	1.7	4.9	0.4	-1.6	1.5	2.2	-0.1	0.7
Neck or shoulder pain in last month	0.8	1.1	4.2	-1.1	0.6	-0.2	-2.1	-0.2	-0.8
Medication: Blood pressure	1.0	1.8	7.3	0.5	-0.4	-1.4	-1.0	2.7	0.4
Angina (self-reported)	1.0	1.3	3.9	2.0	0.1	0.4	-0.7	1.7	-0.3
Migraine (self-reported)	0.6	0.8	2.1	0.3	-1.4	0.2	1.0	1.0	-0.8
Medication: Ibuprofen	0.8	1.0	2.8	-1.7	0.1	-1.7	-0.6	-0.2	0.1
Medication: Allopurinol	0.8	1.1	2.7	-1.4	1.6	-0.8	-0.6	0.5	-0.7
Medication: Omeprazole	0.5	0.6	2.7	-0.3	-0.5	-0.6	-1.7	0.3	-0.5
Medication: Seretide 50 evohaler	0.5	0.6	1.5	-0.8	0.5	0.2	-0.7	-0.8	1.2
Mean time to correctly identify matches	2.1	3.9	14.7	2.1	0.1	-0.3	0.4	3.8	-2.0
Heart disease (mother)	0.8	1.0	4.8	0.3	0.1	-0.5	-0.3	-0.9	-2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	2.1	-0.2	0.1	0.9	-1.5	-0.4	-0.1
Whole body fat mass	0.1	0.3	1.5	-0.1	0.3	-0.6	0.4	0.2	1.2
Leg fat mass (right)	0.1	0.3	0.7	0.4	0.2	-0.8	-0.3	0.4	0.7
Arm predicted mass (right)	0.6	3.2	7.3	-0.3	-1.1	1.9	-1.4	-2.7	2.3
Pulse rate, automated reading	0.5	1.8	3.3	1.8	-0.7	1.3	1.3	0.6	1.8
Alcohol intake frequency.	1.2	2.9	8.5	0.2	1.0	0.3	-2.7	-0.3	-2.9
Comparative height size at age 10	1.4	7.5	18.7	-2.4	-0.7	3.5	0.0	-4.3	2.8
Number of full sisters	0.3	0.4	1.6	0.4	0.2	1.3	-0.2	0.2	-0.6
Suffer from ‘nerves’	0.4	0.6	2.1	0.2	-0.7	-1.5	-0.5	0.5	-0.7
Overall health rating	0.8	1.7	4.9	1.1	-1.0	-1.0	-0.7	2.2	-1.2
Chest pain or discomfort	1.7	2.4	11.4	0.7	0.6	0.5	-3.4	0.4	1.3
Had major operations	0.7	0.8	2.8	1.7	0.2	-0.8	0.2	1.0	-0.6
Age at last live birth	0.2	0.3	0.9	0.6	-0.8	-0.2	0.0	-0.3	1.0
Family relationship satisfaction	0.3	0.4	1.1	-0.5	0.3	0.2	-0.9	-1.0	-0.2
Leg pain on walking	1.5	1.8	6.9	1.3	-0.0	2.6	1.0	-0.6	1.1
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	4.3	-0.8	0.6	0.4	0.1	-1.8	2.1
Commuting to job workplace: Car/motor vehicle	2.2	2.5	6.4	-0.7	2.1	1.8	0.2	-0.7	2.5
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	4.8	-2.0	2.2	-0.8	-1.3	-1.4	-0.6
Medication: Aspirin	0.8	1.1	3.0	1.2	1.4	-0.0	-1.7	0.2	0.1
Supplements: Vitamin C	0.9	1.1	2.8	0.2	0.7	1.7	1.3	-1.2	-0.4
Knee pain experienced in last month	0.6	1.0	4.4	1.2	2.1	-0.2	0.1	0.1	0.1
Hypertension (Self-reported)	1.0	2.9	10.0	0.4	-0.9	-1.4	-1.8	3.2	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.1	-0.4	0.1	1.8	-1.6	-0.6	1.0
Illnesses of father: Heart disease	0.4	0.6	1.3	1.1	0.9	-0.5	-0.0	-0.2	1.0
Illnesses of siblings: Diabetes	1.9	2.4	9.2	-1.7	-1.1	-3.0	-0.2	0.6	-0.7
Smoking status: Previous	1.3	2.0	7.7	-1.1	-2.8	-1.3	0.9	0.1	0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	9.0	-2.1	-0.9	0.7	-0.0	-3.0	0.1
Whole body fat-free mass	0.7	3.9	11.0	-0.9	-0.6	2.0	-1.6	-3.3	2.0
Leg fat-free mass (right)	0.5	2.4	6.2	-0.9	-0.4	1.7	-1.0	-2.5	1.9
Arm fat percentage (left)	0.4	1.7	5.6	0.6	0.4	-1.7	1.0	2.4	0.6
Average weekly red wine intake	1.1	1.6	4.9	0.1	-2.2	0.4	1.1	0.5	1.8
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.3	-0.2	-0.4	0.4	-1.1	-1.5	-1.0
Mood swings	0.3	0.6	1.4	0.3	1.0	-1.1	-0.3	1.2	-0.2
Loneliness, isolation	0.7	1.0	3.0	0.3	1.6	-0.3	-1.7	-0.1	0.1
Long-standing illness, disability or infirmity	0.3	0.5	1.8	1.3	-0.4	-0.6	-0.2	0.8	0.1
Ever had bowel cancer screening	1.1	1.3	5.5	-1.4	-0.1	-0.6	-0.3	-2.3	-0.1
Diabetes diagnosed by doctor	0.4	0.7	1.3	-0.7	1.0	0.1	-1.2	-0.9	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.3	-0.9	-0.8	1.1	-0.6	-1.1	-0.0
Friendships satisfaction	1.3	1.6	3.3	-0.8	1.0	1.1	-0.8	-1.6	1.8
Qualifications: nursing, teaching	0.2	0.4	1.2	-0.1	0.4	-0.7	0.5	-0.4	-1.1
Commuting to job workplace: Walk	1.1	1.2	3.0	0.8	-1.7	-0.1	0.7	1.6	-0.1
Eye problems/disorders: Cataract	1.4	1.6	4.1	-2.0	0.9	0.2	-0.5	-1.9	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.1	-1.5	-0.3	-1.2	-1.8	0.9	0.3
Medication for cholesterol	0.8	1.3	4.0	-1.1	-0.2	0.6	2.0	-1.1	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.8	3.5	1.4	-1.2	-0.9	-1.6	1.9	0.7
Back pain experienced in last month	0.6	0.8	2.6	-0.5	-1.2	-0.4	-0.2	1.6	0.8
Mineral and other dietary supplements	0.7	0.9	2.0	-0.6	0.4	-0.9	-1.4	1.2	-1.0
Breast cancer (self-reported)	1.5	1.8	4.0	-1.8	-1.2	-2.0	0.2	0.1	-1.5
Asthma (self-reported)	0.6	1.2	3.7	0.4	-1.9	0.9	-0.7	0.6	1.2
Osteoporosis (self-reported)	0.4	0.5	1.0	0.1	0.1	1.0	1.0	0.9	-0.0
Osteoarthritis (self-reported)	0.7	0.9	2.2	1.3	1.1	-0.3	-0.3	1.5	-0.2
Medication: Aspirin	0.8	1.1	3.5	1.2	1.0	-0.2	-1.9	0.5	0.2
Medication: Gliclazide	0.8	0.9	1.9	1.2	-0.1	1.0	-0.7	-0.5	1.4
Illnesses of father: None of the above (group 1)	0.5	0.6	1.6	1.3	-0.4	0.5	-0.1	-1.0	-0.7
Smoking status: Current	0.5	0.8	3.0	-0.1	0.3	-0.9	-1.7	-0.6	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.0	10.2	0.8	-0.9	0.2	-2.2	-1.1	-3.2
Whole body water mass	0.7	3.9	10.9	-0.8	-0.7	2.1	-1.5	-3.3	2.1
Leg predicted mass (right)	0.4	2.4	6.6	-0.9	-0.3	1.7	-1.0	-2.6	1.7
Arm fat mass (left)	0.1	0.4	1.2	-0.1	0.3	-0.8	0.1	0.8	1.1
Number of self-reported non-cancer illnesses	0.5	0.9	1.9	-0.5	1.4	0.7	-1.4	0.0	-1.0
Average weekly champagne plus white wine intake	0.5	0.7	3.3	-1.8	-0.0	0.3	-0.7	-0.2	-0.3
Miserableness	0.2	0.3	0.7	0.7	0.8	-0.2	0.3	0.2	-0.5
Guilty feelings	0.6	0.9	1.9	1.2	0.1	-1.4	0.4	1.3	0.3
Wears glasses or contact lenses	0.5	0.6	1.1	0.9	1.0	1.0	0.5	0.6	0.1
Ever taken oral contraceptive pill	1.7	1.9	6.8	-2.6	-0.3	-0.3	-0.2	-1.9	-0.9
Hearing aid user	0.8	0.9	1.8	-1.3	0.9	-0.9	-0.4	1.3	0.1
Mother’s age at death	0.8	1.0	3.3	0.0	-0.0	1.8	0.9	0.2	1.4
Financial situation satisfaction	0.8	1.0	2.7	-0.0	-0.5	-1.5	-1.6	0.7	0.1
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.8	1.4	-0.5	0.4	0.3	0.6	-0.2
Commuting to job workplace: Public transport	0.8	0.9	2.5	0.1	-1.6	-0.4	0.7	-0.5	-1.5
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	-0.5	-0.2	-0.5	-0.7	-0.4	-0.1
Medication: Blood pressure	1.3	2.5	5.0	0.8	-0.4	-1.2	-1.8	2.1	-2.2
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.4	-0.2	1.5	-0.5	-0.0	-0.6	0.0
Supplements: Fish oil (including cod liver oil)	1.1	1.5	4.3	0.8	0.7	0.9	-0.0	-2.1	1.6
High cholesterol (Self-reported)	0.7	1.2	3.2	1.2	-0.1	-0.3	-1.2	1.8	-1.1
Medication: Bendroflumethiazide	1.6	2.4	6.3	2.5	-0.2	-0.4	0.1	2.5	-1.1
Medication: Paracetamol	0.5	0.8	2.3	-0.0	1.4	0.0	-1.5	-0.2	-0.7
Medication: Lisinopril	0.8	1.0	4.1	0.5	0.5	-0.7	-1.0	2.0	0.0
Medication: Atorvastatin	0.7	0.9	4.8	-0.4	-0.4	-0.1	-0.5	0.2	-2.2
Illnesses of father: High blood pressure	2.1	2.6	6.6	-0.2	-0.4	-2.6	0.2	1.9	-2.2
Alcohol drinker status: Never	1.3	1.5	8.4	0.2	0.2	0.2	0.8	-0.1	-2.9
Ever smoked	0.7	1.1	3.0	-0.5	-1.4	-1.7	-0.1	-0.6	1.1
Basal metabolic rate	0.6	3.1	8.4	-0.9	-0.4	1.7	-1.4	-2.9	2.2
Leg fat percentage (left)	0.3	1.0	3.3	0.6	0.0	-1.8	0.2	1.6	-0.0
Arm fat-free mass (left)	0.7	3.5	9.8	-0.6	-0.9	1.8	-1.5	-3.1	2.2
Number of operations (self-reported)	0.6	0.9	2.6	1.3	0.1	-0.8	0.4	1.6	-0.5
Average weekly beer plus cider intake	0.3	0.5	0.8	0.8	0.3	-0.9	-0.9	-0.5	-0.5
Irritability	0.8	1.4	3.5	-1.6	0.4	-1.9	-0.4	-0.4	-1.4
Risk taking	1.7	2.5	8.2	0.2	-1.0	-0.9	0.8	2.0	2.9
Ever had prostate specific antigen (PSA) test	0.7	0.8	3.1	-0.7	0.4	-0.1	1.8	-0.7	-0.8
Fractured/broken bones in last 5 years	1.0	1.3	4.6	1.0	-0.7	-0.5	1.2	2.1	0.5
Age started oral contraceptive pill	2.3	2.9	9.2	-0.8	1.4	-0.4	1.2	-2.1	-3.0
Diastolic blood pressure, automated reading	0.2	0.8	2.7	-0.4	-0.8	0.7	0.6	-1.6	0.4
Ever depressed for a whole week	0.5	0.6	1.4	0.6	0.8	1.2	1.0	0.3	-0.2
Unable to work because of sickness or disability	1.3	1.7	2.6	1.4	-1.6	1.3	-0.9	1.2	1.3
Commuting to job workplace: Cycle	0.1	0.1	0.8	0.1	-0.1	0.1	-0.2	-0.9	0.2
Myopia	0.3	0.4	0.9	0.6	-1.0	-0.8	0.6	0.6	-0.2
Vascular/heart problems diagnosed by doctor	1.2	3.2	9.9	-0.7	-0.3	1.7	1.8	-3.1	1.6
Cholesterol lowering medication	1.4	2.1	7.2	2.2	0.2	-0.1	-2.7	-0.1	-0.7
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	9.4	-0.9	0.3	-0.6	-3.1	-0.8	-0.6
Pain experienced in last month	0.4	0.6	1.9	-0.6	-0.2	0.6	0.4	-1.4	-0.8
Supplements: Calcium	0.3	0.3	0.8	-0.4	-0.9	-0.1	0.8	0.2	0.1
Basal cell carcinoma (self-reported)	0.8	1.0	2.5	-1.0	-1.6	-0.5	-0.9	-0.9	-0.6
Heart attack/myocardial infarction (self-reported)	0.9	1.2	4.2	0.3	1.2	-0.2	-0.9	2.0	-0.6
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	4.3	0.8	2.1	1.4	-0.4	-0.9	-0.4
Heart disease (siblings)	0.8	0.9	2.9	-0.2	0.6	-0.1	-1.3	1.7	-0.8
Alcohol drinker status: Previous	1.5	1.7	3.6	-0.0	-0.3	1.5	-1.9	0.9	-1.8
Pack years of smoking	0.7	1.0	3.0	1.7	-0.7	-0.7	0.3	1.3	-0.5
Impedance of whole body	0.2	1.2	3.5	-1.9	0.8	-0.0	1.3	-1.1	0.1
Leg fat mass (left)	0.1	0.3	1.1	0.2	0.2	-1.1	-0.3	0.4	0.6
Arm predicted mass (left)	0.7	3.8	9.6	-0.8	-1.0	1.9	-1.9	-3.1	2.1