Best TWAS P=6.4e-44 · Best GWAS P=3.89e-50 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | KLHL7 | 0.18 | 0.10 | lasso | 6 | 0.07 | 7.3e-05 | 2.47 | 6.9 | 4.1e-12 | -0.21 | 0.27 | 0.14 | TRUE |
2 | GTEx | Brain Hippocampus | FAM221A | 0.40 | 0.37 | enet | 24 | 0.38 | 6.0e-10 | 4.26 | 5.5 | 3.0e-08 | -0.35 | 0.83 | 0.03 | FALSE |
3 | GTEx | Cells EBV-transformed lymphocytes | CCDC126 | 0.52 | 0.39 | enet | 26 | 0.40 | 3.0e-14 | -7.98 | -7.2 | 6.4e-13 | 0.30 | 1.00 | 0.00 | TRUE |
4 | GTEx | Esophagus Gastroesophageal Junction | FAM221A | 0.15 | 0.16 | lasso | 4 | 0.13 | 1.6e-05 | 4.19 | -5.2 | 2.4e-07 | 0.33 | 0.32 | 0.03 | FALSE |
5 | GTEx | Esophagus Mucosa | CCDC126 | 0.12 | 0.03 | lasso | 7 | 0.01 | 4.3e-02 | -10.73 | 10.8 | 4.4e-27 | -0.66 | 0.07 | 0.68 | TRUE |
6 | GTEx | Muscle Skeletal | AK3P3 | 0.05 | 0.00 | enet | 14 | 0.00 | 9.9e-02 | 5.90 | 5.8 | 6.4e-09 | -0.15 | 0.11 | 0.07 | TRUE |
7 | GTEx | Nerve Tibial | FAM221A | 0.13 | 0.06 | enet | 24 | 0.08 | 3.2e-06 | 4.22 | -5.7 | 1.0e-08 | 0.31 | 0.84 | 0.01 | TRUE |
8 | GTEx | Prostate | NUPL2 | 0.21 | 0.12 | enet | 15 | 0.17 | 4.7e-05 | -0.77 | -7.0 | 2.4e-12 | 0.25 | 0.10 | 0.06 | FALSE |
9 | YFS | Blood | CCDC126 | 0.05 | 0.04 | enet | 10 | 0.05 | 1.6e-15 | -7.96 | -6.9 | 6.4e-12 | 0.42 | 1.00 | 0.00 | FALSE |
10 | YFS | Blood | TRA2A | 0.07 | 0.04 | lasso | 9 | 0.05 | 3.9e-16 | -11.67 | 6.6 | 5.5e-11 | -0.28 | 1.00 | 0.00 | FALSE |
11 | The Cancer Genome Atlas | Esophageal Carcinoma | TRA2A | 0.18 | 0.02 | blup | 40 | 0.05 | 1.2e-02 | -13.23 | -13.9 | 6.4e-44 | 0.64 | 0.01 | 0.48 | TRUE |
12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | GPNMB | 0.03 | 0.02 | enet | 25 | 0.02 | 1.4e-03 | -1.66 | 5.2 | 2.0e-07 | -0.14 | 0.06 | 0.18 | TRUE |
13 | The Cancer Genome Atlas | Soft Tissue Sarcoma | RPS2P32 | 0.08 | 0.02 | blup | 27 | 0.02 | 3.1e-02 | -7.34 | 9.0 | 1.7e-19 | -0.70 | 0.02 | 0.43 | TRUE |
14 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C7orf46 | 0.19 | 0.08 | blup | 52 | 0.09 | 3.4e-04 | -4.74 | -5.2 | 2.4e-07 | 0.20 | 0.02 | 0.10 | FALSE |