Hub : Genes

ZRANB1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0401	0.0119	9.8e-06	0.009	0.015	0.005	0.016	0.010	3.5e-04	1.2e-05	9.7e-03	3.8e-06	2.6e-04
2	ROSMAP	Brain Pre-frontal Cortex	0.0868	0.0262	9.3e-05	0.072	0.037	0.060	0.055	0.064	1.3e-09	1.5e-05	3.1e-08	1.2e-07	1.3e-08
3	YFS	Blood	0.4028	0.0344	0.0e+00	0.436	0.416	0.451	0.403	0.444	2.7e-159	1.7e-149	1.5e-166	1.3e-143	2.4e-163
4	TCGA	Thyroid Carcinoma	0.0330	0.0190	8.6e-03	-0.001	0.007	0.001	NA	0.001	3.7e-01	6.0e-02	2.3e-01	NA	2.4e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.9	3.0	6.6	-2.6	-1.6	0.3	1.7
Bipolar Disorder or Schizophrenia	0.3	0.8	1.9	-1.4	-0.4	-0.8	0.7
Depressed Affect (Nagel 2018)	5.9	12.4	22.3	1.8	-3.8	4.7	3.1
Depression (Nagel 2018)	1.7	2.6	5.7	1.8	-1.0	2.4	0.4
Intelligence (Savage-Jansen 2018)	0.6	1.9	5.4	-2.3	-0.9	-0.7	0.8
Neuroticism (Nagel 2018)	2.0	4.7	7.4	1.5	-2.3	2.7	2.0
Schizophrenia (2018)	0.3	0.6	1.5	0.3	0.7	-1.2	-0.5
Schizophrenia vs Biploar Disorder	0.9	1.2	2.2	1.5	0.7	-0.0	-1.4
Worry (Nagel 2018)	0.4	0.9	3.2	1.8	0.2	0.5	-0.1
Alzheimer’s Disease (in mother)	1.7	1.9	3.1	1.3	1.8	0.3	-1.7
Alzheimer’s Disease (in father)	1.6	1.8	2.8	1.3	1.3	0.9	-1.7
Alzheimer’s Disease (including proxy)	1.6	2.3	4.2	1.1	2.0	0.4	-1.9
Crohns Disease (2017)	0.4	0.9	1.8	-0.5	-0.9	-0.8	1.3
Irritable Bowel Disease (IBD)	0.1	0.3	1.1	0.0	-0.4	0.0	1.0
Ulcerative Colitis (UC)	0.2	0.3	0.9	0.6	0.3	1.0	0.1
Major Depression (MDD)	1.7	2.0	5.3	0.1	-2.3	1.3	1.0
Reaction Time	0.3	0.5	1.7	-0.2	1.3	-0.4	-0.3
Verbal and Numeric Reasoning (VNR)	0.4	1.1	2.0	-1.4	-0.3	-1.4	0.3
Breast Cancer	0.8	2.0	3.9	-1.8	0.4	-2.0	-0.9
Ovarian Cancer	1.7	2.3	5.1	-2.3	-0.3	-2.0	-0.0
Prostate Cancer	2.0	2.8	8.2	1.0	0.7	1.2	-2.9
Age at First Birth	1.0	1.5	3.8	-1.4	-0.1	-2.0	-0.5
Bipolar Disorder (2011)	7.9	7.7	16.7	-4.1	-1.8	-2.8	1.7
Body Mass Index (BMI) (2010)	1.8	2.5	4.7	1.0	1.1	-1.8	-2.2
Coronary Artery Disease (CAD)	1.9	2.3	4.5	-0.3	-1.6	1.3	2.1
Crohns Disease (2012)	0.4	0.6	1.2	-0.4	-1.1	-0.1	1.1
Mean Putamen Volume	0.1	0.2	0.4	-0.5	-0.0	-0.6	0.2
Fasting Glucose	0.2	0.2	0.5	-0.7	0.5	-0.1	0.4
HbA1C	0.6	0.6	1.0	-0.4	-1.0	0.7	0.9
HDL Cholesterol	0.2	0.4	0.8	-0.5	0.5	0.5	0.9
LDL Cholesterol	0.1	0.2	0.4	0.3	-0.4	-0.6	0.3
Lupus	2.3	3.5	8.0	0.5	-2.0	2.8	1.2
Neuroticism (2016)	0.3	0.5	1.7	1.3	-0.3	0.2	0.1
Primary Biliary Cirrhosis	1.3	1.8	4.1	1.7	0.2	2.0	-0.5
Rheumatoid Arthritis	0.5	0.7	1.8	-0.9	-0.1	0.3	1.3
Schizophrenia (2014)	0.4	0.9	2.9	-0.9	0.0	-1.7	0.1
Triglycerides	0.3	0.5	0.7	0.8	0.8	-0.6	-0.7
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.3	-0.4	-1.2	0.5	1.8
Ulcerative Colitis	0.2	0.3	0.7	-0.2	-0.2	0.8	0.6
Blood Eosinophil Count	1.5	11.7	28.7	-0.8	-5.4	1.7	3.8
Blood Platelet Count	0.4	4.3	7.9	2.8	2.4	1.2	-1.4
Blood Red Count	0.6	5.6	14.8	-1.4	-3.9	2.3	0.4
Blood White Count	2.6	19.6	26.5	-4.4	-5.2	3.3	4.7
Heel T-Score	1.2	9.9	17.9	1.8	3.4	-2.6	-4.2
BMI	0.4	2.2	3.5	-1.4	-1.3	-1.3	-1.9
Height	1.1	21.9	39.8	-4.0	-6.3	-1.9	5.3
Waist Hip Ratio (WHR)	1.1	4.9	11.0	3.3	0.2	2.5	1.5
Systolic Blood Pressure	1.6	8.2	13.3	3.6	2.8	-0.9	-3.3
Smoking Status	0.6	1.5	2.9	-0.5	-1.7	1.5	0.8
Allergy or Eczema	2.1	5.4	14.2	0.2	2.0	-3.8	-1.9
Cardiovascular Disease	0.5	1.8	4.9	2.2	0.5	0.7	-1.2
Hypothyroidism (self reported)	0.1	0.2	0.5	0.2	-0.7	0.6	0.1
Respiratory disease	0.2	0.4	1.0	1.0	0.8	0.2	-0.1
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	-0.4	-0.4	-0.4	-0.6
Lung FEV1/FVC ratio	0.1	0.7	2.4	1.6	0.1	-0.0	-0.7
Lung FVC	0.6	3.2	9.0	1.4	3.0	-0.0	-1.3
Neuroticism	0.8	1.8	4.9	2.2	-0.1	1.6	0.1
Chronotype (morning person)	2.1	4.9	14.1	-1.9	1.3	-3.8	-0.6
Hair Pigment	0.1	2.7	6.9	-0.7	0.6	-2.6	-1.7
Tanning	0.0	0.3	0.8	0.9	0.4	0.5	-0.0
Hand grip strength (left)	0.3	0.7	1.4	-0.7	-0.8	-0.4	1.2
Number of treatments/medications taken	0.4	0.6	1.6	0.9	-0.4	1.2	-0.1
Average weekly spirits intake	2.7	3.3	5.3	-1.1	-2.2	2.3	1.4
Sensitivity / hurt feelings	0.5	0.8	1.8	0.7	-0.8	0.5	1.4
Frequency of depressed mood in last 2 weeks	1.7	2.4	6.3	1.5	-0.6	2.5	0.7
Hearing difficulty/problems: Yes	3.3	5.1	8.8	-0.6	-3.0	2.8	1.9
Relative age of first facial hair	1.2	2.4	3.9	-1.4	2.0	-0.9	-1.8
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.1	-0.9	-0.9	1.1	0.6
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.4	0.0	0.6	-0.3	-0.0
Ever had hysterectomy (womb removed)	1.0	1.1	3.2	0.3	-0.8	1.8	0.6
Systolic blood pressure, automated reading	0.2	0.5	1.2	0.6	0.3	-1.1	-0.7
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.8	-0.9	-0.6	-0.3	0.6
Angina	1.2	1.6	2.2	0.1	-1.5	1.4	1.5
Medication for hormone replacement therapy	0.8	0.9	1.8	0.4	1.3	0.7	-1.1
Vitamin and mineral supplements	1.0	1.4	2.5	1.6	-0.8	1.6	-0.2
Supplements: Zinc	1.5	1.6	4.7	0.4	1.2	-0.3	-2.2
Medication: Co-codamol	1.5	1.8	3.5	1.6	-0.8	1.9	-0.6
Medication: Metformin	0.7	0.9	1.3	-1.1	-1.1	0.5	1.0
Diabetes (father)	1.8	2.2	6.4	1.2	0.8	2.5	-0.5
Diabetes (mother)	0.2	0.3	0.7	-0.5	-0.2	-0.4	0.9
Severe depression (siblings)	0.7	0.8	2.0	1.4	0.8	0.4	-0.7
Pack years adult smoking proportion	2.3	3.5	6.6	-0.3	-2.1	1.7	2.6
Impedance of leg (right)	1.3	6.2	11.3	3.4	3.1	1.5	-1.2
Leg fat-free mass (left)	2.4	12.7	29.7	-3.4	-5.5	-1.2	2.8
Trunk fat percentage	0.1	0.6	1.0	-0.5	-0.7	-1.0	-0.7
Hand grip strength (right)	0.6	1.8	3.6	-1.2	-1.4	-0.3	1.9
Townsend deprivation index at recruitment	0.5	0.7	1.4	1.2	0.9	0.7	-0.6
Current tobacco smoking	0.9	1.5	3.2	1.3	-0.8	1.8	0.6
Average weekly fortified wine intake	4.2	4.9	6.8	-2.6	-2.5	0.1	2.5
Maternal smoking around birth	1.3	1.9	5.9	0.1	-1.2	2.4	0.2
Fed-up feelings	1.6	2.9	5.5	1.6	-1.4	2.3	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	4.4	1.9	-0.0	2.1	-0.5
Relative age voice broke	0.4	0.6	1.5	-1.2	0.6	-0.8	-0.2
Taking other prescription medications	0.4	0.6	1.1	0.0	-0.8	1.1	0.7
Age when periods started (menarche)	2.8	6.6	13.8	-3.7	-0.1	-3.5	0.8
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	4.3	1.2	0.5	2.1	-1.6
Heel bone mineral density (BMD) T-score, automated (left)	1.9	4.4	7.0	2.2	2.6	-1.5	-2.0
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	2.8	1.1	0.6	1.1	-1.7
Qualifications: CSEs or equivalent	2.5	3.3	7.1	2.7	1.1	2.0	-0.8
Serious illness, injury or assault to yourself	0.5	0.6	1.8	0.5	-0.4	1.4	0.2
High blood pressure	0.8	2.3	8.1	2.8	0.1	1.0	-0.3
Hayfever, allergic rhinitis or eczema	1.4	3.0	7.1	0.5	1.5	-2.7	-1.6
Multivitamins +/- minerals	2.0	2.5	5.9	-1.7	1.1	-2.4	-0.3
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.4	-0.1	0.5	0.2
Supplements: Glucosamine	0.8	1.0	2.0	-1.4	1.0	-0.9	-0.6
Diverticular disease/diverticulitis (self-reported)	1.4	1.6	3.3	-1.4	-1.2	0.2	1.8
Medication: Atenolol	0.2	0.2	0.5	0.4	-0.3	-0.5	-0.7
Medication: Levothyroxine sodium	0.1	0.2	0.5	0.2	-0.7	0.5	0.3
Sitting height	2.3	16.5	32.6	-3.0	-5.7	2.0	4.5
Chronic bronchitis/emphysema (father)	0.3	0.3	0.7	0.2	-0.7	0.0	0.8
High blood pressure (mother)	0.2	0.3	0.7	0.8	-0.2	0.7	0.1
Body mass index (BMI)	0.2	1.0	2.0	-1.0	-1.4	-0.8	-0.5
Impedance of leg (left)	1.4	6.8	12.1	3.2	3.5	1.4	-1.7
Leg predicted mass (left)	2.4	12.6	29.8	-3.3	-5.5	-1.1	2.9
Trunk fat mass	0.4	1.8	4.7	-1.3	-2.2	-0.9	0.3
Waist circumference	0.3	1.3	3.4	-0.9	-1.8	-0.6	0.6
Number of incorrect matches in round	1.2	2.0	4.9	-1.4	0.8	-2.2	-0.6
Past tobacco smoking	0.1	0.2	0.4	0.2	-0.2	0.5	0.6
Alcohol usually taken with meals	1.4	2.2	8.5	-0.3	0.6	-2.9	-0.1
Nervous feelings	0.6	1.2	2.8	1.7	0.9	-0.7	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.4	1.2	0.7	0.3	0.6
Hearing difficulty/problems with background noise	3.0	4.8	9.1	1.3	-2.5	3.0	1.4
Hair/balding pattern: Pattern 2	0.3	0.4	1.3	0.0	0.2	0.4	1.2
Had menopause	0.8	1.1	3.4	-0.3	1.8	-0.8	-0.4
Had other major operations	1.0	1.3	4.0	-2.0	-0.6	-0.8	0.2
Forced vital capacity (FVC)	0.2	0.7	1.2	0.4	-0.8	0.9	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	2.6	1.2	1.6	-1.6	-1.3
Ever unenthusiastic/disinterested for a whole week	2.3	2.8	4.4	-0.6	-2.0	2.1	1.7
Qualifications: None of the above	0.9	1.9	4.5	2.1	-0.3	1.8	-0.2
Financial difficulties in last 2 years	2.5	3.4	5.0	-1.9	-1.8	1.3	2.2
Mouth/teeth dental problems	0.1	0.2	0.5	0.4	-0.1	0.4	-0.7
Heart attack	0.9	1.1	1.8	-1.3	-1.2	0.0	1.1
Allergy	0.8	1.8	3.3	-0.7	-1.3	1.8	1.2
Pain all over the body in last month	1.2	1.3	3.1	0.8	-0.7	1.7	1.0
Diabetes (self-reported)	0.1	0.1	0.4	-0.1	-0.6	0.3	0.1
Hayfever/allergic rhinitis (self-reported)	2.7	3.6	5.0	1.3	1.6	-2.2	-2.2
Medication: Ramipril	0.5	0.6	1.5	0.6	1.2	-0.6	-0.6
Medication: Simvastatin	1.0	1.5	2.6	0.4	-1.2	1.6	1.4
Fluid intelligence score	0.9	1.9	5.9	-1.3	0.0	-2.4	-0.0
Illnesses of siblings	0.1	0.2	0.4	-0.1	0.5	-0.4	-0.6
Neuroticism score	0.9	1.8	5.6	2.4	0.6	1.2	-0.2
Weight	1.3	6.2	16.1	-2.3	-4.0	-0.9	1.6
Impedance of arm (right)	0.7	3.2	6.6	2.6	2.3	0.5	-0.7
Arm fat percentage (right)	0.1	0.6	1.4	0.4	-0.2	-0.9	-1.2
Trunk fat-free mass	2.4	13.7	29.9	-3.6	-5.5	-0.6	3.4
Hip circumference	0.7	2.8	5.1	-2.0	-2.2	-1.4	0.3
Time employed in main current job	0.7	0.8	1.4	0.4	1.2	-0.8	-0.9
Alcohol intake versus 10 years previously	0.3	0.5	1.3	1.1	-0.3	0.6	-0.6
Father’s age at death	2.5	3.3	5.3	-1.2	2.2	-2.3	-1.3
Worrier / anxious feelings	0.7	1.3	2.7	1.6	1.1	-0.3	-1.1
Frequency of tiredness / lethargy in last 2 weeks	5.4	8.8	21.8	2.6	-2.2	4.7	1.3
Falls in the last year	1.2	1.6	3.6	-0.3	1.4	-0.9	-1.9
Hair/balding pattern: Pattern 3	0.8	1.2	4.0	0.4	0.9	-2.0	-0.3
Number of live births	0.8	1.1	1.6	-1.0	-1.3	0.6	1.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.9	0.9	-0.3	0.3	0.3
Pulse rate	0.2	0.4	1.0	0.2	-0.6	1.0	0.2
Happiness	1.8	2.1	3.7	1.1	-1.8	1.9	0.6
Noisy workplace	1.4	1.7	4.2	-1.1	-0.1	-2.0	-1.1
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.9	-1.7	0.5	-1.0	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	-0.6	-0.6	-0.1	0.0
Mouth/teeth dental problems: Dentures	0.7	1.3	4.6	-0.4	-0.1	-0.5	2.1
Asthma	0.3	0.5	1.1	1.0	0.1	0.7	0.7
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.5	4.7	0.5	-1.9	2.2	1.3
Medication: Cholesterol lowering	0.3	0.5	1.0	1.0	0.2	0.9	0.0
Depression (self-reported)	0.1	0.1	0.2	0.1	0.3	0.1	-0.5
Medication: Lansoprazole	0.0	0.0	0.1	0.3	-0.0	-0.0	-0.2
Prospective memory result	0.5	0.6	1.3	-0.2	1.2	-0.9	-0.4
Lung cancer (father)	0.5	0.5	2.0	-1.4	-0.5	-0.0	0.0
Illnesses of mother	0.7	0.9	1.5	0.1	-1.2	0.9	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.3	0.3	-0.2	0.5	0.2
Pulse wave Arterial Stiffness index	0.4	0.5	1.4	-0.1	0.5	-0.4	-1.2
Impedance of arm (left)	0.4	1.9	4.4	2.1	1.5	1.0	-0.3
Arm fat mass (right)	0.3	1.4	4.3	-0.9	-2.1	-0.7	0.0
Trunk predicted mass	2.4	14.0	30.7	-3.6	-5.5	-0.6	3.5
Standing height	1.6	15.7	32.3	-3.2	-5.7	-0.6	4.4
Length of working week for main job	1.3	1.4	2.8	0.7	1.6	-0.2	-1.7
Exposure to tobacco smoke at home	0.3	0.4	1.0	0.7	-0.1	-0.1	1.0
Breastfed as a baby	3.2	4.0	6.9	-2.6	-2.2	-0.0	2.1
Tense / ‘highly strung’	0.4	0.6	1.1	1.1	-0.1	1.0	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.4	0.6	1.2	-0.2	-1.2
Hair/balding pattern: Pattern 4	4.2	10.1	31.5	5.6	2.7	-0.4	-1.2
Birth weight of first child	0.6	1.0	2.7	-1.6	-1.0	-0.3	0.5
Peak expiratory flow (PEF)	0.1	0.2	0.4	0.7	-0.4	0.4	0.3
Pulse wave reflection index	1.1	1.3	2.0	-0.2	1.3	-1.3	-1.4
Ever highly irritable/argumentative for 2 days	1.9	2.2	5.2	-1.4	-1.1	2.3	0.8
Loud music exposure frequency	2.5	2.7	4.3	-1.3	-2.1	1.2	1.8
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.3	-0.0	0.3	0.1	0.5
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.0	0.5	0.8	-0.1	-1.4
Blood clot in the leg (DVT)	0.1	0.1	0.3	0.5	-0.3	0.3	-0.3
Medication: Paracetamol	1.5	2.5	5.8	2.4	0.5	1.6	-1.2
Headache pain in last month	1.0	1.7	3.8	1.7	0.2	1.9	-0.6
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	1.4	-0.8	1.0	-1.2	-0.8
Glaucoma (self-reported)	0.3	0.4	1.0	-0.5	-1.0	-0.1	0.5
Gout (self-reported)	0.4	0.5	1.2	0.2	1.1	-0.2	-0.9
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.1	-0.1	-0.3	-0.0	0.2
Medication: Amlodipine	0.4	0.5	1.1	0.6	-0.7	0.4	1.0
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.4	0.0	-0.2	0.2	1.2
Birth weight	0.4	0.9	1.9	-1.4	-1.1	-0.5	-0.1
Chronic bronchitis/emphysema (mother)	1.5	1.8	3.8	-0.8	-1.9	-0.2	1.6
High blood pressure (siblings)	0.5	0.7	1.1	1.1	1.0	-0.6	-0.5
Forced vital capacity (FVC), Best measure	0.3	1.0	2.1	0.1	-0.8	1.4	1.1
Body fat percentage	0.1	0.6	1.3	-0.1	-0.3	-0.9	-1.1
Leg fat percentage (right)	0.2	0.7	2.0	0.9	0.1	-0.2	-1.4
Arm fat-free mass (right)	2.6	13.5	30.7	-3.8	-5.5	-0.6	2.9
Exposure to tobacco smoke outside home	0.7	0.9	2.1	1.4	0.4	1.1	-0.4
Comparative body size at age 10	3.3	9.2	15.5	-0.3	2.7	-3.9	-3.7
Number of full brothers	0.5	0.7	1.5	0.4	-1.0	1.2	-0.3
Worry too long after embarrassment	0.3	0.5	0.9	0.7	1.0	-0.3	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.3	-0.4	0.3	0.2
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	-0.0	-0.6	0.6	-0.3
Number of children fathered	2.2	2.5	4.8	-2.2	-1.6	1.2	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.3	-0.5	-0.1	-0.5	0.6
Age at first live birth	1.0	1.8	5.1	-1.4	0.4	-2.2	-0.1
Pulse wave peak to peak time	0.9	1.0	2.7	-0.4	-1.0	0.4	1.6
Health satisfaction	1.6	2.1	4.3	-0.2	-2.1	1.6	1.3
Shortness of breath walking on level ground	1.5	1.8	4.0	0.8	-1.1	2.0	1.2
Qualifications: College or University degree	1.3	4.0	10.0	-2.4	0.4	-3.2	0.2
Eye problems/disorders: None of the above	0.7	0.8	1.2	1.1	0.9	0.1	-1.1
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.9	0.1	-0.4	-0.9	0.1
Emphysema/chronic bronchitis	0.4	0.4	0.8	-0.4	-0.5	0.7	0.9
Medication for pain relief, constipation, heartburn	2.6	4.4	10.0	-2.1	1.6	-3.2	-0.8
Neck or shoulder pain in last month	1.8	2.6	8.5	0.1	-1.2	2.9	0.7
Medication: Blood pressure	0.3	0.6	1.0	1.0	-0.8	0.6	0.6
Angina (self-reported)	0.8	1.1	1.7	0.1	-1.3	1.0	1.3
Migraine (self-reported)	0.9	1.1	2.7	1.6	-0.1	1.2	0.5
Medication: Ibuprofen	1.5	1.8	3.4	0.4	-1.8	1.8	0.6
Medication: Allopurinol	0.3	0.3	0.5	0.5	0.7	0.7	-0.4
Medication: Omeprazole	0.1	0.1	0.5	0.7	-0.2	-0.3	0.0
Medication: Seretide 50 evohaler	1.1	1.3	3.5	1.9	0.7	1.0	0.2
Mean time to correctly identify matches	0.7	1.4	4.2	0.2	2.0	-1.0	-0.6
Heart disease (mother)	0.3	0.4	0.8	-0.5	0.6	-0.9	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.8	1.1	0.9	-0.2	-1.3
Whole body fat mass	0.4	1.6	4.5	-1.2	-2.1	-0.7	0.2
Leg fat mass (right)	0.2	0.9	2.7	-0.5	-1.6	-0.7	-0.3
Arm predicted mass (right)	2.4	12.2	27.1	-3.8	-5.2	-0.7	2.6
Pulse rate, automated reading	0.0	0.1	0.1	-0.3	-0.4	-0.2	-0.4
Alcohol intake frequency.	0.7	1.6	4.8	2.2	0.5	0.9	-0.7
Comparative height size at age 10	1.9	10.5	23.7	-0.4	-4.9	1.4	4.0
Number of full sisters	0.8	1.0	3.1	-1.8	-0.9	-0.2	-0.0
Suffer from ‘nerves’	1.7	2.7	7.1	2.7	0.0	1.9	-0.7
Overall health rating	2.8	6.0	12.8	1.3	-2.7	3.6	1.4
Chest pain or discomfort	3.1	4.4	10.6	1.1	-1.8	3.2	1.7
Had major operations	1.1	1.3	3.6	-0.4	-0.7	1.9	0.9
Age at last live birth	0.2	0.3	0.7	-0.6	0.3	-0.8	-0.1
Family relationship satisfaction	0.3	0.3	1.1	0.4	-1.0	0.2	0.0
Leg pain on walking	0.4	0.4	1.1	-1.1	-0.4	0.3	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.3	1.0	0.0	1.5	0.3
Commuting to job workplace: Car/motor vehicle	1.0	1.1	2.2	0.8	0.0	1.3	-1.5
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	4.1	2.0	0.4	0.5	0.0
Medication: Aspirin	1.1	1.5	2.7	0.5	-1.2	1.6	1.2
Supplements: Vitamin C	0.1	0.1	0.2	0.1	-0.1	0.4	0.3
Knee pain experienced in last month	0.4	0.7	1.2	-0.4	-1.1	1.1	0.4
Hypertension (Self-reported)	1.0	2.9	9.7	3.1	0.6	0.6	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	3.3	0.0	-1.4	1.8	1.0
Illnesses of father: Heart disease	1.2	1.6	4.9	2.2	0.8	0.7	-0.7
Illnesses of siblings: Diabetes	0.1	0.1	0.2	-0.5	-0.2	-0.0	-0.5
Smoking status: Previous	1.0	1.5	3.0	-1.5	0.3	-1.7	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.3	-0.2	-0.5	0.1	-0.1
Whole body fat-free mass	2.5	14.4	32.1	-3.7	-5.7	-0.9	3.3
Leg fat-free mass (right)	2.5	13.1	30.2	-3.6	-5.5	-1.1	2.8
Arm fat percentage (left)	0.1	0.4	0.8	0.1	-0.7	-0.6	-0.9
Average weekly red wine intake	0.1	0.1	0.2	0.5	0.1	0.3	0.4
Handedness (chirality/laterality): Left-handed	1.5	1.8	4.9	0.1	1.4	-2.2	-0.7
Mood swings	1.9	3.4	6.3	1.9	-0.9	2.5	1.7
Loneliness, isolation	2.4	3.3	5.5	0.9	-2.1	2.3	1.6
Long-standing illness, disability or infirmity	1.1	1.7	4.6	1.2	-0.9	2.2	0.1
Ever had bowel cancer screening	0.9	1.0	2.5	-0.8	-1.6	-0.1	1.0
Diabetes diagnosed by doctor	0.1	0.2	0.4	-0.5	-0.6	0.2	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.7	-0.5	-0.9	0.1	0.4
Friendships satisfaction	2.9	3.7	5.8	-2.3	-2.4	-1.2	1.4
Qualifications: nursing, teaching	0.2	0.3	0.6	0.6	0.8	0.0	0.2
Commuting to job workplace: Walk	0.5	0.6	1.4	0.5	1.2	-0.5	-0.7
Eye problems/disorders: Cataract	0.9	1.0	2.2	-1.5	-0.4	-0.8	1.0
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.6	0.0	1.0	-0.5	-1.6
Medication for cholesterol	0.4	0.6	1.9	-1.4	-0.3	-0.6	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	5.1	1.6	-0.4	2.3	-0.1
Back pain experienced in last month	1.1	1.6	3.9	0.2	-1.5	2.0	0.5
Mineral and other dietary supplements	2.6	3.5	7.5	2.7	-0.4	2.5	0.4
Breast cancer (self-reported)	0.4	0.5	1.5	0.3	1.2	-0.0	-0.7
Asthma (self-reported)	0.2	0.4	0.8	0.9	0.0	0.6	0.5
Osteoporosis (self-reported)	0.1	0.1	0.3	0.1	-0.5	0.5	0.2
Osteoarthritis (self-reported)	0.1	0.2	0.5	0.3	0.4	-0.0	-0.7
Medication: Aspirin	1.3	1.7	3.4	0.3	-1.4	1.8	1.2
Medication: Gliclazide	0.3	0.3	0.7	-0.9	-0.7	-0.1	-0.1
Illnesses of father: None of the above (group 1)	1.6	2.0	4.8	-2.2	-0.1	-1.8	-0.4
Smoking status: Current	1.0	1.6	3.6	1.4	-0.8	1.9	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.3	-1.5	0.4	-1.2	0.1
Whole body water mass	2.4	13.6	30.2	-3.7	-5.5	-1.0	3.1
Leg predicted mass (right)	2.4	12.7	29.5	-3.5	-5.4	-1.2	2.8
Arm fat mass (left)	0.4	1.6	5.1	-1.1	-2.2	-0.6	0.1
Number of self-reported non-cancer illnesses	0.3	0.5	1.1	1.1	0.1	0.3	-0.9
Average weekly champagne plus white wine intake	0.8	1.2	1.9	-0.3	1.4	-1.4	-0.9
Miserableness	3.9	6.8	14.9	1.8	-2.3	3.9	2.0
Guilty feelings	1.4	2.1	5.5	1.3	0.5	2.3	-0.8
Wears glasses or contact lenses	0.6	0.7	1.6	-0.7	-0.7	-0.3	1.3
Ever taken oral contraceptive pill	0.5	0.6	1.0	0.9	0.6	0.3	-1.0
Hearing aid user	3.3	3.7	7.2	-2.3	-1.5	-0.2	2.7
Mother’s age at death	0.5	0.6	1.2	-0.1	1.1	-0.7	-0.8
Financial situation satisfaction	2.6	3.2	6.5	-1.9	-2.6	0.7	1.5
Tinnitus: Yes, now most or all of the time	2.3	2.7	8.3	2.9	-0.2	1.5	0.4
Commuting to job workplace: Public transport	1.7	2.0	3.5	-1.2	-0.7	-1.6	1.9
Eye problems/disorders: Glaucoma	3.0	3.5	6.7	-1.8	-2.6	-0.1	2.1
Medication: Blood pressure	0.4	0.8	2.5	1.6	-0.1	0.3	0.6
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.3	-0.6	-1.0	1.5	0.7
Supplements: Fish oil (including cod liver oil)	1.6	2.1	3.9	-1.8	0.8	-2.0	-0.7
High cholesterol (Self-reported)	0.7	1.3	2.1	-0.5	-1.2	1.2	1.5
Medication: Bendroflumethiazide	0.4	0.5	1.8	1.3	0.2	0.6	-0.1
Medication: Paracetamol	1.3	2.0	4.2	2.1	0.1	1.5	-1.1
Medication: Lisinopril	0.3	0.4	0.8	-0.4	-0.9	-0.4	0.7
Medication: Atorvastatin	0.2	0.3	0.7	0.4	-0.2	0.5	0.8
Illnesses of father: High blood pressure	0.8	1.0	1.9	1.4	0.8	0.5	-1.1
Alcohol drinker status: Never	0.5	0.6	1.3	1.1	0.6	0.8	-0.4
Ever smoked	0.4	0.7	1.4	0.5	0.6	-1.0	-1.2
Basal metabolic rate	2.1	11.8	27.6	-3.3	-5.3	-1.0	2.7
Leg fat percentage (left)	0.2	0.6	2.1	0.5	0.0	-0.4	-1.4
Arm fat-free mass (left)	1.8	9.1	22.3	-3.0	-4.7	-0.8	2.2
Number of operations (self-reported)	0.3	0.5	1.6	-1.3	-0.2	0.3	0.1
Average weekly beer plus cider intake	0.5	0.7	1.3	0.4	0.4	1.1	-1.0
Irritability	0.0	0.1	0.1	-0.4	-0.2	-0.1	0.2
Risk taking	0.3	0.4	0.8	-0.5	-0.8	0.9	0.3
Ever had prostate specific antigen (PSA) test	0.7	0.9	1.3	-1.2	-0.6	-0.7	1.1
Fractured/broken bones in last 5 years	1.1	1.5	3.5	-1.9	-1.1	0.9	0.7
Age started oral contraceptive pill	1.4	1.8	4.2	-2.0	-0.3	-1.7	-0.1
Diastolic blood pressure, automated reading	0.4	1.4	2.4	1.5	-0.4	0.8	-1.6
Ever depressed for a whole week	2.7	3.3	5.8	-0.0	-2.2	2.4	1.6
Unable to work because of sickness or disability	2.3	2.9	6.3	-0.8	-1.8	1.2	2.5
Commuting to job workplace: Cycle	0.6	0.7	1.5	-1.1	0.2	-1.2	0.1
Myopia	1.1	1.6	2.4	1.5	1.5	-0.6	-1.2
Vascular/heart problems diagnosed by doctor	0.6	1.7	5.6	-2.4	0.1	-1.2	-0.1
Cholesterol lowering medication	0.3	0.5	1.2	-0.2	-0.7	0.2	1.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.3	1.2	0.2	-0.0	-0.5
Pain experienced in last month	0.4	0.7	2.2	-0.0	0.7	-1.5	-0.2
Supplements: Calcium	1.3	1.4	2.3	0.1	-1.0	1.5	1.5
Basal cell carcinoma (self-reported)	1.3	1.6	4.2	-0.5	1.1	-0.8	-2.0
Heart attack/myocardial infarction (self-reported)	0.9	1.2	1.6	-1.3	-1.2	0.1	1.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.8	0.9	-0.3	0.6	-0.3
Heart disease (siblings)	0.2	0.2	0.6	-0.1	-0.8	0.5	0.2
Alcohol drinker status: Previous	0.5	0.6	1.9	-0.1	1.4	-0.7	-0.0
Pack years of smoking	1.2	1.7	3.8	-0.3	-1.4	1.0	1.9
Impedance of whole body	0.9	4.3	7.6	2.8	2.6	1.2	-1.1
Leg fat mass (left)	0.3	1.1	3.2	-0.8	-1.8	-0.8	-0.3
Arm predicted mass (left)	1.9	9.9	23.0	-3.2	-4.8	-0.8	2.4