Hub : Genes

ZRANB1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 NTR Blood 0.0401 0.0119 9.8e-06 0.009 0.015 0.005 0.016 0.010 3.5e-04 1.2e-05 9.7e-03 3.8e-06 2.6e-04
2 ROSMAP Brain Pre-frontal Cortex 0.0868 0.0262 9.3e-05 0.072 0.037 0.060 0.055 0.064 1.3e-09 1.5e-05 3.1e-08 1.2e-07 1.3e-08
3 YFS Blood 0.4028 0.0344 0.0e+00 0.436 0.416 0.451 0.403 0.444 2.7e-159 1.7e-149 1.5e-166 1.3e-143 2.4e-163
4 TCGA Thyroid Carcinoma 0.0330 0.0190 8.6e-03 -0.001 0.007 0.001 NA 0.001 3.7e-01 6.0e-02 2.3e-01 NA 2.4e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.9 3.0 6.6 -2.6 -1.6 0.3 1.7
Bipolar Disorder or Schizophrenia 0.3 0.8 1.9 -1.4 -0.4 -0.8 0.7
Depressed Affect (Nagel 2018) 5.9 12.4 22.3 1.8 -3.8 4.7 3.1
Depression (Nagel 2018) 1.7 2.6 5.7 1.8 -1.0 2.4 0.4
Intelligence (Savage-Jansen 2018) 0.6 1.9 5.4 -2.3 -0.9 -0.7 0.8
Neuroticism (Nagel 2018) 2.0 4.7 7.4 1.5 -2.3 2.7 2.0
Schizophrenia (2018) 0.3 0.6 1.5 0.3 0.7 -1.2 -0.5
Schizophrenia vs Biploar Disorder 0.9 1.2 2.2 1.5 0.7 -0.0 -1.4
Worry (Nagel 2018) 0.4 0.9 3.2 1.8 0.2 0.5 -0.1
Alzheimer’s Disease (in mother) 1.7 1.9 3.1 1.3 1.8 0.3 -1.7
Alzheimer’s Disease (in father) 1.6 1.8 2.8 1.3 1.3 0.9 -1.7
Alzheimer’s Disease (including proxy) 1.6 2.3 4.2 1.1 2.0 0.4 -1.9
Crohns Disease (2017) 0.4 0.9 1.8 -0.5 -0.9 -0.8 1.3
Irritable Bowel Disease (IBD) 0.1 0.3 1.1 0.0 -0.4 0.0 1.0
Ulcerative Colitis (UC) 0.2 0.3 0.9 0.6 0.3 1.0 0.1
Major Depression (MDD) 1.7 2.0 5.3 0.1 -2.3 1.3 1.0
Reaction Time 0.3 0.5 1.7 -0.2 1.3 -0.4 -0.3
Verbal and Numeric Reasoning (VNR) 0.4 1.1 2.0 -1.4 -0.3 -1.4 0.3
Breast Cancer 0.8 2.0 3.9 -1.8 0.4 -2.0 -0.9
Ovarian Cancer 1.7 2.3 5.1 -2.3 -0.3 -2.0 -0.0
Prostate Cancer 2.0 2.8 8.2 1.0 0.7 1.2 -2.9
Age at First Birth 1.0 1.5 3.8 -1.4 -0.1 -2.0 -0.5
Bipolar Disorder (2011) 7.9 7.7 16.7 -4.1 -1.8 -2.8 1.7
Body Mass Index (BMI) (2010) 1.8 2.5 4.7 1.0 1.1 -1.8 -2.2
Coronary Artery Disease (CAD) 1.9 2.3 4.5 -0.3 -1.6 1.3 2.1
Crohns Disease (2012) 0.4 0.6 1.2 -0.4 -1.1 -0.1 1.1
Mean Putamen Volume 0.1 0.2 0.4 -0.5 -0.0 -0.6 0.2
Fasting Glucose 0.2 0.2 0.5 -0.7 0.5 -0.1 0.4
HbA1C 0.6 0.6 1.0 -0.4 -1.0 0.7 0.9
HDL Cholesterol 0.2 0.4 0.8 -0.5 0.5 0.5 0.9
LDL Cholesterol 0.1 0.2 0.4 0.3 -0.4 -0.6 0.3
Lupus 2.3 3.5 8.0 0.5 -2.0 2.8 1.2
Neuroticism (2016) 0.3 0.5 1.7 1.3 -0.3 0.2 0.1
Primary Biliary Cirrhosis 1.3 1.8 4.1 1.7 0.2 2.0 -0.5
Rheumatoid Arthritis 0.5 0.7 1.8 -0.9 -0.1 0.3 1.3
Schizophrenia (2014) 0.4 0.9 2.9 -0.9 0.0 -1.7 0.1
Triglycerides 0.3 0.5 0.7 0.8 0.8 -0.6 -0.7
Type 2 Diabetes (T2D) (2012) 1.1 1.3 3.3 -0.4 -1.2 0.5 1.8
Ulcerative Colitis 0.2 0.3 0.7 -0.2 -0.2 0.8 0.6
Blood Eosinophil Count 1.5 11.7 28.7 -0.8 -5.4 1.7 3.8
Blood Platelet Count 0.4 4.3 7.9 2.8 2.4 1.2 -1.4
Blood Red Count 0.6 5.6 14.8 -1.4 -3.9 2.3 0.4
Blood White Count 2.6 19.6 26.5 -4.4 -5.2 3.3 4.7
Heel T-Score 1.2 9.9 17.9 1.8 3.4 -2.6 -4.2
BMI 0.4 2.2 3.5 -1.4 -1.3 -1.3 -1.9
Height 1.1 21.9 39.8 -4.0 -6.3 -1.9 5.3
Waist Hip Ratio (WHR) 1.1 4.9 11.0 3.3 0.2 2.5 1.5
Systolic Blood Pressure 1.6 8.2 13.3 3.6 2.8 -0.9 -3.3
Smoking Status 0.6 1.5 2.9 -0.5 -1.7 1.5 0.8
Allergy or Eczema 2.1 5.4 14.2 0.2 2.0 -3.8 -1.9
Cardiovascular Disease 0.5 1.8 4.9 2.2 0.5 0.7 -1.2
Hypothyroidism (self reported) 0.1 0.2 0.5 0.2 -0.7 0.6 0.1
Respiratory disease 0.2 0.4 1.0 1.0 0.8 0.2 -0.1
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.4 -0.4 -0.4 -0.4 -0.6
Lung FEV1/FVC ratio 0.1 0.7 2.4 1.6 0.1 -0.0 -0.7
Lung FVC 0.6 3.2 9.0 1.4 3.0 -0.0 -1.3
Neuroticism 0.8 1.8 4.9 2.2 -0.1 1.6 0.1
Chronotype (morning person) 2.1 4.9 14.1 -1.9 1.3 -3.8 -0.6
Hair Pigment 0.1 2.7 6.9 -0.7 0.6 -2.6 -1.7
Tanning 0.0 0.3 0.8 0.9 0.4 0.5 -0.0
Hand grip strength (left) 0.3 0.7 1.4 -0.7 -0.8 -0.4 1.2
Number of treatments/medications taken 0.4 0.6 1.6 0.9 -0.4 1.2 -0.1
Average weekly spirits intake 2.7 3.3 5.3 -1.1 -2.2 2.3 1.4
Sensitivity / hurt feelings 0.5 0.8 1.8 0.7 -0.8 0.5 1.4
Frequency of depressed mood in last 2 weeks 1.7 2.4 6.3 1.5 -0.6 2.5 0.7
Hearing difficulty/problems: Yes 3.3 5.1 8.8 -0.6 -3.0 2.8 1.9
Relative age of first facial hair 1.2 2.4 3.9 -1.4 2.0 -0.9 -1.8
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 1.1 -0.9 -0.9 1.1 0.6
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.4 0.0 0.6 -0.3 -0.0
Ever had hysterectomy (womb removed) 1.0 1.1 3.2 0.3 -0.8 1.8 0.6
Systolic blood pressure, automated reading 0.2 0.5 1.2 0.6 0.3 -1.1 -0.7
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 0.8 -0.9 -0.6 -0.3 0.6
Angina 1.2 1.6 2.2 0.1 -1.5 1.4 1.5
Medication for hormone replacement therapy 0.8 0.9 1.8 0.4 1.3 0.7 -1.1
Vitamin and mineral supplements 1.0 1.4 2.5 1.6 -0.8 1.6 -0.2
Supplements: Zinc 1.5 1.6 4.7 0.4 1.2 -0.3 -2.2
Medication: Co-codamol 1.5 1.8 3.5 1.6 -0.8 1.9 -0.6
Medication: Metformin 0.7 0.9 1.3 -1.1 -1.1 0.5 1.0
Diabetes (father) 1.8 2.2 6.4 1.2 0.8 2.5 -0.5
Diabetes (mother) 0.2 0.3 0.7 -0.5 -0.2 -0.4 0.9
Severe depression (siblings) 0.7 0.8 2.0 1.4 0.8 0.4 -0.7
Pack years adult smoking proportion 2.3 3.5 6.6 -0.3 -2.1 1.7 2.6
Impedance of leg (right) 1.3 6.2 11.3 3.4 3.1 1.5 -1.2
Leg fat-free mass (left) 2.4 12.7 29.7 -3.4 -5.5 -1.2 2.8
Trunk fat percentage 0.1 0.6 1.0 -0.5 -0.7 -1.0 -0.7
Hand grip strength (right) 0.6 1.8 3.6 -1.2 -1.4 -0.3 1.9
Townsend deprivation index at recruitment 0.5 0.7 1.4 1.2 0.9 0.7 -0.6
Current tobacco smoking 0.9 1.5 3.2 1.3 -0.8 1.8 0.6
Average weekly fortified wine intake 4.2 4.9 6.8 -2.6 -2.5 0.1 2.5
Maternal smoking around birth 1.3 1.9 5.9 0.1 -1.2 2.4 0.2
Fed-up feelings 1.6 2.9 5.5 1.6 -1.4 2.3 1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.6 2.1 4.4 1.9 -0.0 2.1 -0.5
Relative age voice broke 0.4 0.6 1.5 -1.2 0.6 -0.8 -0.2
Taking other prescription medications 0.4 0.6 1.1 0.0 -0.8 1.1 0.7
Age when periods started (menarche) 2.8 6.6 13.8 -3.7 -0.1 -3.5 0.8
Bilateral oophorectomy (both ovaries removed) 1.8 2.1 4.3 1.2 0.5 2.1 -1.6
Heel bone mineral density (BMD) T-score, automated (left) 1.9 4.4 7.0 2.2 2.6 -1.5 -2.0
Tinnitus: Yes, but not now, but have in the past 1.3 1.4 2.8 1.1 0.6 1.1 -1.7
Qualifications: CSEs or equivalent 2.5 3.3 7.1 2.7 1.1 2.0 -0.8
Serious illness, injury or assault to yourself 0.5 0.6 1.8 0.5 -0.4 1.4 0.2
High blood pressure 0.8 2.3 8.1 2.8 0.1 1.0 -0.3
Hayfever, allergic rhinitis or eczema 1.4 3.0 7.1 0.5 1.5 -2.7 -1.6
Multivitamins +/- minerals 2.0 2.5 5.9 -1.7 1.1 -2.4 -0.3
Stomach or abdominal pain in last month 0.1 0.1 0.2 -0.4 -0.1 0.5 0.2
Supplements: Glucosamine 0.8 1.0 2.0 -1.4 1.0 -0.9 -0.6
Diverticular disease/diverticulitis (self-reported) 1.4 1.6 3.3 -1.4 -1.2 0.2 1.8
Medication: Atenolol 0.2 0.2 0.5 0.4 -0.3 -0.5 -0.7
Medication: Levothyroxine sodium 0.1 0.2 0.5 0.2 -0.7 0.5 0.3
Sitting height 2.3 16.5 32.6 -3.0 -5.7 2.0 4.5
Chronic bronchitis/emphysema (father) 0.3 0.3 0.7 0.2 -0.7 0.0 0.8
High blood pressure (mother) 0.2 0.3 0.7 0.8 -0.2 0.7 0.1
Body mass index (BMI) 0.2 1.0 2.0 -1.0 -1.4 -0.8 -0.5
Impedance of leg (left) 1.4 6.8 12.1 3.2 3.5 1.4 -1.7
Leg predicted mass (left) 2.4 12.6 29.8 -3.3 -5.5 -1.1 2.9
Trunk fat mass 0.4 1.8 4.7 -1.3 -2.2 -0.9 0.3
Waist circumference 0.3 1.3 3.4 -0.9 -1.8 -0.6 0.6
Number of incorrect matches in round 1.2 2.0 4.9 -1.4 0.8 -2.2 -0.6
Past tobacco smoking 0.1 0.2 0.4 0.2 -0.2 0.5 0.6
Alcohol usually taken with meals 1.4 2.2 8.5 -0.3 0.6 -2.9 -0.1
Nervous feelings 0.6 1.2 2.8 1.7 0.9 -0.7 -0.7
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.4 1.2 0.7 0.3 0.6
Hearing difficulty/problems with background noise 3.0 4.8 9.1 1.3 -2.5 3.0 1.4
Hair/balding pattern: Pattern 2 0.3 0.4 1.3 0.0 0.2 0.4 1.2
Had menopause 0.8 1.1 3.4 -0.3 1.8 -0.8 -0.4
Had other major operations 1.0 1.3 4.0 -2.0 -0.6 -0.8 0.2
Forced vital capacity (FVC) 0.2 0.7 1.2 0.4 -0.8 0.9 1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.1 2.6 1.2 1.6 -1.6 -1.3
Ever unenthusiastic/disinterested for a whole week 2.3 2.8 4.4 -0.6 -2.0 2.1 1.7
Qualifications: None of the above 0.9 1.9 4.5 2.1 -0.3 1.8 -0.2
Financial difficulties in last 2 years 2.5 3.4 5.0 -1.9 -1.8 1.3 2.2
Mouth/teeth dental problems 0.1 0.2 0.5 0.4 -0.1 0.4 -0.7
Heart attack 0.9 1.1 1.8 -1.3 -1.2 0.0 1.1
Allergy 0.8 1.8 3.3 -0.7 -1.3 1.8 1.2
Pain all over the body in last month 1.2 1.3 3.1 0.8 -0.7 1.7 1.0
Diabetes (self-reported) 0.1 0.1 0.4 -0.1 -0.6 0.3 0.1
Hayfever/allergic rhinitis (self-reported) 2.7 3.6 5.0 1.3 1.6 -2.2 -2.2
Medication: Ramipril 0.5 0.6 1.5 0.6 1.2 -0.6 -0.6
Medication: Simvastatin 1.0 1.5 2.6 0.4 -1.2 1.6 1.4
Fluid intelligence score 0.9 1.9 5.9 -1.3 0.0 -2.4 -0.0
Illnesses of siblings 0.1 0.2 0.4 -0.1 0.5 -0.4 -0.6
Neuroticism score 0.9 1.8 5.6 2.4 0.6 1.2 -0.2
Weight 1.3 6.2 16.1 -2.3 -4.0 -0.9 1.6
Impedance of arm (right) 0.7 3.2 6.6 2.6 2.3 0.5 -0.7
Arm fat percentage (right) 0.1 0.6 1.4 0.4 -0.2 -0.9 -1.2
Trunk fat-free mass 2.4 13.7 29.9 -3.6 -5.5 -0.6 3.4
Hip circumference 0.7 2.8 5.1 -2.0 -2.2 -1.4 0.3
Time employed in main current job 0.7 0.8 1.4 0.4 1.2 -0.8 -0.9
Alcohol intake versus 10 years previously 0.3 0.5 1.3 1.1 -0.3 0.6 -0.6
Father’s age at death 2.5 3.3 5.3 -1.2 2.2 -2.3 -1.3
Worrier / anxious feelings 0.7 1.3 2.7 1.6 1.1 -0.3 -1.1
Frequency of tiredness / lethargy in last 2 weeks 5.4 8.8 21.8 2.6 -2.2 4.7 1.3
Falls in the last year 1.2 1.6 3.6 -0.3 1.4 -0.9 -1.9
Hair/balding pattern: Pattern 3 0.8 1.2 4.0 0.4 0.9 -2.0 -0.3
Number of live births 0.8 1.1 1.6 -1.0 -1.3 0.6 1.1
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 0.9 0.9 -0.3 0.3 0.3
Pulse rate 0.2 0.4 1.0 0.2 -0.6 1.0 0.2
Happiness 1.8 2.1 3.7 1.1 -1.8 1.9 0.6
Noisy workplace 1.4 1.7 4.2 -1.1 -0.1 -2.0 -1.1
Qualifications: A levels/AS levels or equivalent 0.6 1.4 2.9 -1.7 0.5 -1.0 1.1
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.4 -0.6 -0.6 -0.1 0.0
Mouth/teeth dental problems: Dentures 0.7 1.3 4.6 -0.4 -0.1 -0.5 2.1
Asthma 0.3 0.5 1.1 1.0 0.1 0.7 0.7
Medication: Ibuprofen (e.g. Nurofen) 2.0 2.5 4.7 0.5 -1.9 2.2 1.3
Medication: Cholesterol lowering 0.3 0.5 1.0 1.0 0.2 0.9 0.0
Depression (self-reported) 0.1 0.1 0.2 0.1 0.3 0.1 -0.5
Medication: Lansoprazole 0.0 0.0 0.1 0.3 -0.0 -0.0 -0.2
Prospective memory result 0.5 0.6 1.3 -0.2 1.2 -0.9 -0.4
Lung cancer (father) 0.5 0.5 2.0 -1.4 -0.5 -0.0 0.0
Illnesses of mother 0.7 0.9 1.5 0.1 -1.2 0.9 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.1 0.3 0.3 -0.2 0.5 0.2
Pulse wave Arterial Stiffness index 0.4 0.5 1.4 -0.1 0.5 -0.4 -1.2
Impedance of arm (left) 0.4 1.9 4.4 2.1 1.5 1.0 -0.3
Arm fat mass (right) 0.3 1.4 4.3 -0.9 -2.1 -0.7 0.0
Trunk predicted mass 2.4 14.0 30.7 -3.6 -5.5 -0.6 3.5
Standing height 1.6 15.7 32.3 -3.2 -5.7 -0.6 4.4
Length of working week for main job 1.3 1.4 2.8 0.7 1.6 -0.2 -1.7
Exposure to tobacco smoke at home 0.3 0.4 1.0 0.7 -0.1 -0.1 1.0
Breastfed as a baby 3.2 4.0 6.9 -2.6 -2.2 -0.0 2.1
Tense / ‘highly strung’ 0.4 0.6 1.1 1.1 -0.1 1.0 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 1.4 0.6 1.2 -0.2 -1.2
Hair/balding pattern: Pattern 4 4.2 10.1 31.5 5.6 2.7 -0.4 -1.2
Birth weight of first child 0.6 1.0 2.7 -1.6 -1.0 -0.3 0.5
Peak expiratory flow (PEF) 0.1 0.2 0.4 0.7 -0.4 0.4 0.3
Pulse wave reflection index 1.1 1.3 2.0 -0.2 1.3 -1.3 -1.4
Ever highly irritable/argumentative for 2 days 1.9 2.2 5.2 -1.4 -1.1 2.3 0.8
Loud music exposure frequency 2.5 2.7 4.3 -1.3 -2.1 1.2 1.8
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.3 -0.0 0.3 0.1 0.5
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 2.0 0.5 0.8 -0.1 -1.4
Blood clot in the leg (DVT) 0.1 0.1 0.3 0.5 -0.3 0.3 -0.3
Medication: Paracetamol 1.5 2.5 5.8 2.4 0.5 1.6 -1.2
Headache pain in last month 1.0 1.7 3.8 1.7 0.2 1.9 -0.6
Medication for cholesterol, blood pressure or diabetes 0.6 0.9 1.4 -0.8 1.0 -1.2 -0.8
Glaucoma (self-reported) 0.3 0.4 1.0 -0.5 -1.0 -0.1 0.5
Gout (self-reported) 0.4 0.5 1.2 0.2 1.1 -0.2 -0.9
Hypothyroidism/myxoedema (self-reported) 0.0 0.0 0.1 -0.1 -0.3 -0.0 0.2
Medication: Amlodipine 0.4 0.5 1.1 0.6 -0.7 0.4 1.0
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.4 0.0 -0.2 0.2 1.2
Birth weight 0.4 0.9 1.9 -1.4 -1.1 -0.5 -0.1
Chronic bronchitis/emphysema (mother) 1.5 1.8 3.8 -0.8 -1.9 -0.2 1.6
High blood pressure (siblings) 0.5 0.7 1.1 1.1 1.0 -0.6 -0.5
Forced vital capacity (FVC), Best measure 0.3 1.0 2.1 0.1 -0.8 1.4 1.1
Body fat percentage 0.1 0.6 1.3 -0.1 -0.3 -0.9 -1.1
Leg fat percentage (right) 0.2 0.7 2.0 0.9 0.1 -0.2 -1.4
Arm fat-free mass (right) 2.6 13.5 30.7 -3.8 -5.5 -0.6 2.9
Exposure to tobacco smoke outside home 0.7 0.9 2.1 1.4 0.4 1.1 -0.4
Comparative body size at age 10 3.3 9.2 15.5 -0.3 2.7 -3.9 -3.7
Number of full brothers 0.5 0.7 1.5 0.4 -1.0 1.2 -0.3
Worry too long after embarrassment 0.3 0.5 0.9 0.7 1.0 -0.3 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.2 -0.3 -0.4 0.3 0.2
Wheeze or whistling in the chest in last year 0.1 0.2 0.4 -0.0 -0.6 0.6 -0.3
Number of children fathered 2.2 2.5 4.8 -2.2 -1.6 1.2 1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.3 -0.5 -0.1 -0.5 0.6
Age at first live birth 1.0 1.8 5.1 -1.4 0.4 -2.2 -0.1
Pulse wave peak to peak time 0.9 1.0 2.7 -0.4 -1.0 0.4 1.6
Health satisfaction 1.6 2.1 4.3 -0.2 -2.1 1.6 1.3
Shortness of breath walking on level ground 1.5 1.8 4.0 0.8 -1.1 2.0 1.2
Qualifications: College or University degree 1.3 4.0 10.0 -2.4 0.4 -3.2 0.2
Eye problems/disorders: None of the above 0.7 0.8 1.2 1.1 0.9 0.1 -1.1
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.9 0.1 -0.4 -0.9 0.1
Emphysema/chronic bronchitis 0.4 0.4 0.8 -0.4 -0.5 0.7 0.9
Medication for pain relief, constipation, heartburn 2.6 4.4 10.0 -2.1 1.6 -3.2 -0.8
Neck or shoulder pain in last month 1.8 2.6 8.5 0.1 -1.2 2.9 0.7
Medication: Blood pressure 0.3 0.6 1.0 1.0 -0.8 0.6 0.6
Angina (self-reported) 0.8 1.1 1.7 0.1 -1.3 1.0 1.3
Migraine (self-reported) 0.9 1.1 2.7 1.6 -0.1 1.2 0.5
Medication: Ibuprofen 1.5 1.8 3.4 0.4 -1.8 1.8 0.6
Medication: Allopurinol 0.3 0.3 0.5 0.5 0.7 0.7 -0.4
Medication: Omeprazole 0.1 0.1 0.5 0.7 -0.2 -0.3 0.0
Medication: Seretide 50 evohaler 1.1 1.3 3.5 1.9 0.7 1.0 0.2
Mean time to correctly identify matches 0.7 1.4 4.2 0.2 2.0 -1.0 -0.6
Heart disease (mother) 0.3 0.4 0.8 -0.5 0.6 -0.9 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 1.8 1.1 0.9 -0.2 -1.3
Whole body fat mass 0.4 1.6 4.5 -1.2 -2.1 -0.7 0.2
Leg fat mass (right) 0.2 0.9 2.7 -0.5 -1.6 -0.7 -0.3
Arm predicted mass (right) 2.4 12.2 27.1 -3.8 -5.2 -0.7 2.6
Pulse rate, automated reading 0.0 0.1 0.1 -0.3 -0.4 -0.2 -0.4
Alcohol intake frequency. 0.7 1.6 4.8 2.2 0.5 0.9 -0.7
Comparative height size at age 10 1.9 10.5 23.7 -0.4 -4.9 1.4 4.0
Number of full sisters 0.8 1.0 3.1 -1.8 -0.9 -0.2 -0.0
Suffer from ‘nerves’ 1.7 2.7 7.1 2.7 0.0 1.9 -0.7
Overall health rating 2.8 6.0 12.8 1.3 -2.7 3.6 1.4
Chest pain or discomfort 3.1 4.4 10.6 1.1 -1.8 3.2 1.7
Had major operations 1.1 1.3 3.6 -0.4 -0.7 1.9 0.9
Age at last live birth 0.2 0.3 0.7 -0.6 0.3 -0.8 -0.1
Family relationship satisfaction 0.3 0.3 1.1 0.4 -1.0 0.2 0.0
Leg pain on walking 0.4 0.4 1.1 -1.1 -0.4 0.3 0.7
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 2.3 1.0 0.0 1.5 0.3
Commuting to job workplace: Car/motor vehicle 1.0 1.1 2.2 0.8 0.0 1.3 -1.5
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 4.1 2.0 0.4 0.5 0.0
Medication: Aspirin 1.1 1.5 2.7 0.5 -1.2 1.6 1.2
Supplements: Vitamin C 0.1 0.1 0.2 0.1 -0.1 0.4 0.3
Knee pain experienced in last month 0.4 0.7 1.2 -0.4 -1.1 1.1 0.4
Hypertension (Self-reported) 1.0 2.9 9.7 3.1 0.6 0.6 -1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 3.3 0.0 -1.4 1.8 1.0
Illnesses of father: Heart disease 1.2 1.6 4.9 2.2 0.8 0.7 -0.7
Illnesses of siblings: Diabetes 0.1 0.1 0.2 -0.5 -0.2 -0.0 -0.5
Smoking status: Previous 1.0 1.5 3.0 -1.5 0.3 -1.7 -0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.1 0.3 -0.2 -0.5 0.1 -0.1
Whole body fat-free mass 2.5 14.4 32.1 -3.7 -5.7 -0.9 3.3
Leg fat-free mass (right) 2.5 13.1 30.2 -3.6 -5.5 -1.1 2.8
Arm fat percentage (left) 0.1 0.4 0.8 0.1 -0.7 -0.6 -0.9
Average weekly red wine intake 0.1 0.1 0.2 0.5 0.1 0.3 0.4
Handedness (chirality/laterality): Left-handed 1.5 1.8 4.9 0.1 1.4 -2.2 -0.7
Mood swings 1.9 3.4 6.3 1.9 -0.9 2.5 1.7
Loneliness, isolation 2.4 3.3 5.5 0.9 -2.1 2.3 1.6
Long-standing illness, disability or infirmity 1.1 1.7 4.6 1.2 -0.9 2.2 0.1
Ever had bowel cancer screening 0.9 1.0 2.5 -0.8 -1.6 -0.1 1.0
Diabetes diagnosed by doctor 0.1 0.2 0.4 -0.5 -0.6 0.2 0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.7 -0.5 -0.9 0.1 0.4
Friendships satisfaction 2.9 3.7 5.8 -2.3 -2.4 -1.2 1.4
Qualifications: nursing, teaching 0.2 0.3 0.6 0.6 0.8 0.0 0.2
Commuting to job workplace: Walk 0.5 0.6 1.4 0.5 1.2 -0.5 -0.7
Eye problems/disorders: Cataract 0.9 1.0 2.2 -1.5 -0.4 -0.8 1.0
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 2.6 0.0 1.0 -0.5 -1.6
Medication for cholesterol 0.4 0.6 1.9 -1.4 -0.3 -0.6 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.7 2.0 5.1 1.6 -0.4 2.3 -0.1
Back pain experienced in last month 1.1 1.6 3.9 0.2 -1.5 2.0 0.5
Mineral and other dietary supplements 2.6 3.5 7.5 2.7 -0.4 2.5 0.4
Breast cancer (self-reported) 0.4 0.5 1.5 0.3 1.2 -0.0 -0.7
Asthma (self-reported) 0.2 0.4 0.8 0.9 0.0 0.6 0.5
Osteoporosis (self-reported) 0.1 0.1 0.3 0.1 -0.5 0.5 0.2
Osteoarthritis (self-reported) 0.1 0.2 0.5 0.3 0.4 -0.0 -0.7
Medication: Aspirin 1.3 1.7 3.4 0.3 -1.4 1.8 1.2
Medication: Gliclazide 0.3 0.3 0.7 -0.9 -0.7 -0.1 -0.1
Illnesses of father: None of the above (group 1) 1.6 2.0 4.8 -2.2 -0.1 -1.8 -0.4
Smoking status: Current 1.0 1.6 3.6 1.4 -0.8 1.9 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 2.3 -1.5 0.4 -1.2 0.1
Whole body water mass 2.4 13.6 30.2 -3.7 -5.5 -1.0 3.1
Leg predicted mass (right) 2.4 12.7 29.5 -3.5 -5.4 -1.2 2.8
Arm fat mass (left) 0.4 1.6 5.1 -1.1 -2.2 -0.6 0.1
Number of self-reported non-cancer illnesses 0.3 0.5 1.1 1.1 0.1 0.3 -0.9
Average weekly champagne plus white wine intake 0.8 1.2 1.9 -0.3 1.4 -1.4 -0.9
Miserableness 3.9 6.8 14.9 1.8 -2.3 3.9 2.0
Guilty feelings 1.4 2.1 5.5 1.3 0.5 2.3 -0.8
Wears glasses or contact lenses 0.6 0.7 1.6 -0.7 -0.7 -0.3 1.3
Ever taken oral contraceptive pill 0.5 0.6 1.0 0.9 0.6 0.3 -1.0
Hearing aid user 3.3 3.7 7.2 -2.3 -1.5 -0.2 2.7
Mother’s age at death 0.5 0.6 1.2 -0.1 1.1 -0.7 -0.8
Financial situation satisfaction 2.6 3.2 6.5 -1.9 -2.6 0.7 1.5
Tinnitus: Yes, now most or all of the time 2.3 2.7 8.3 2.9 -0.2 1.5 0.4
Commuting to job workplace: Public transport 1.7 2.0 3.5 -1.2 -0.7 -1.6 1.9
Eye problems/disorders: Glaucoma 3.0 3.5 6.7 -1.8 -2.6 -0.1 2.1
Medication: Blood pressure 0.4 0.8 2.5 1.6 -0.1 0.3 0.6
Pain type(s) experienced in last month: Hip pain 0.8 1.0 2.3 -0.6 -1.0 1.5 0.7
Supplements: Fish oil (including cod liver oil) 1.6 2.1 3.9 -1.8 0.8 -2.0 -0.7
High cholesterol (Self-reported) 0.7 1.3 2.1 -0.5 -1.2 1.2 1.5
Medication: Bendroflumethiazide 0.4 0.5 1.8 1.3 0.2 0.6 -0.1
Medication: Paracetamol 1.3 2.0 4.2 2.1 0.1 1.5 -1.1
Medication: Lisinopril 0.3 0.4 0.8 -0.4 -0.9 -0.4 0.7
Medication: Atorvastatin 0.2 0.3 0.7 0.4 -0.2 0.5 0.8
Illnesses of father: High blood pressure 0.8 1.0 1.9 1.4 0.8 0.5 -1.1
Alcohol drinker status: Never 0.5 0.6 1.3 1.1 0.6 0.8 -0.4
Ever smoked 0.4 0.7 1.4 0.5 0.6 -1.0 -1.2
Basal metabolic rate 2.1 11.8 27.6 -3.3 -5.3 -1.0 2.7
Leg fat percentage (left) 0.2 0.6 2.1 0.5 0.0 -0.4 -1.4
Arm fat-free mass (left) 1.8 9.1 22.3 -3.0 -4.7 -0.8 2.2
Number of operations (self-reported) 0.3 0.5 1.6 -1.3 -0.2 0.3 0.1
Average weekly beer plus cider intake 0.5 0.7 1.3 0.4 0.4 1.1 -1.0
Irritability 0.0 0.1 0.1 -0.4 -0.2 -0.1 0.2
Risk taking 0.3 0.4 0.8 -0.5 -0.8 0.9 0.3
Ever had prostate specific antigen (PSA) test 0.7 0.9 1.3 -1.2 -0.6 -0.7 1.1
Fractured/broken bones in last 5 years 1.1 1.5 3.5 -1.9 -1.1 0.9 0.7
Age started oral contraceptive pill 1.4 1.8 4.2 -2.0 -0.3 -1.7 -0.1
Diastolic blood pressure, automated reading 0.4 1.4 2.4 1.5 -0.4 0.8 -1.6
Ever depressed for a whole week 2.7 3.3 5.8 -0.0 -2.2 2.4 1.6
Unable to work because of sickness or disability 2.3 2.9 6.3 -0.8 -1.8 1.2 2.5
Commuting to job workplace: Cycle 0.6 0.7 1.5 -1.1 0.2 -1.2 0.1
Myopia 1.1 1.6 2.4 1.5 1.5 -0.6 -1.2
Vascular/heart problems diagnosed by doctor 0.6 1.7 5.6 -2.4 0.1 -1.2 -0.1
Cholesterol lowering medication 0.3 0.5 1.2 -0.2 -0.7 0.2 1.1
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.3 1.2 0.2 -0.0 -0.5
Pain experienced in last month 0.4 0.7 2.2 -0.0 0.7 -1.5 -0.2
Supplements: Calcium 1.3 1.4 2.3 0.1 -1.0 1.5 1.5
Basal cell carcinoma (self-reported) 1.3 1.6 4.2 -0.5 1.1 -0.8 -2.0
Heart attack/myocardial infarction (self-reported) 0.9 1.2 1.6 -1.3 -1.2 0.1 1.2
Deep venous thrombosis (DVT) (self-reported) 0.3 0.3 0.8 0.9 -0.3 0.6 -0.3
Heart disease (siblings) 0.2 0.2 0.6 -0.1 -0.8 0.5 0.2
Alcohol drinker status: Previous 0.5 0.6 1.9 -0.1 1.4 -0.7 -0.0
Pack years of smoking 1.2 1.7 3.8 -0.3 -1.4 1.0 1.9
Impedance of whole body 0.9 4.3 7.6 2.8 2.6 1.2 -1.1
Leg fat mass (left) 0.3 1.1 3.2 -0.8 -1.8 -0.8 -0.3
Arm predicted mass (left) 1.9 9.9 23.0 -3.2 -4.8 -0.8 2.4