Best TWAS P=3.08e-25 · Best GWAS P=5.29e-23 conditioned to 0.409
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | PLEKHA1 | 0.14 | 0.06 | lasso | 2 | 0.03 | 2.4e-03 | 8.6 | -8.8 | 1.6e-18 | 0.50 | 0.15 | 0.79 | FALSE |
2 | GTEx | Breast Mammary Tissue | PLEKHA1 | 0.30 | 0.05 | enet | 38 | 0.01 | 8.6e-02 | 8.6 | -5.5 | 3.4e-08 | 0.27 | 0.09 | 0.34 | FALSE |
3 | GTEx | Colon Sigmoid | RP11-500G22.2 | 0.54 | 0.00 | lasso | 20 | 0.08 | 1.0e-03 | 3.6 | 5.5 | 3.1e-08 | -0.11 | 0.17 | 0.05 | TRUE |
4 | GTEx | Muscle Skeletal | PLEKHA1 | 0.10 | 0.04 | lasso | 3 | 0.04 | 8.2e-05 | -9.5 | -8.9 | 3.8e-19 | 0.83 | 0.02 | 0.97 | FALSE |
5 | GTEx | Nerve Tibial | PLEKHA1 | 0.22 | 0.23 | enet | 17 | 0.19 | 1.1e-13 | 8.6 | -7.5 | 7.1e-14 | 0.41 | 0.99 | 0.01 | FALSE |
6 | GTEx | Pancreas | PLEKHA1 | 0.29 | 0.05 | lasso | 11 | 0.07 | 4.7e-04 | -6.2 | -6.8 | 1.3e-11 | 0.77 | 0.04 | 0.87 | FALSE |
7 | GTEx | Skin Sun Exposed Lower leg | PLEKHA1 | 0.16 | 0.02 | lasso | 5 | 0.01 | 4.0e-02 | -9.9 | -10.2 | 3.0e-24 | 0.96 | 0.00 | 0.99 | FALSE |
8 | METSIM | Adipose | PLEKHA1 | 0.05 | 0.03 | lasso | 4 | 0.04 | 3.6e-07 | 8.6 | -10.4 | 3.1e-25 | 0.85 | 0.01 | 0.99 | TRUE |
9 | ROSMAP | Brain Pre-frontal Cortex | PLEKHA1 | 0.06 | 0.05 | lasso | 4 | 0.05 | 1.3e-06 | -9.5 | -9.5 | 3.0e-21 | 0.65 | 0.07 | 0.93 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PLEKHA1 | 0.04 | 0.05 | lasso | 2 | 0.04 | 4.3e-05 | 8.6 | -8.6 | 6.8e-18 | 0.49 | 0.58 | 0.27 | FALSE |
11 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ARMS2 | 0.23 | 0.20 | lasso | 2 | 0.21 | 7.0e-09 | -5.3 | -5.6 | 2.1e-08 | 0.12 | 0.93 | 0.00 | FALSE |
12 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | PLEKHA1 | 0.08 | 0.06 | blup | 103 | 0.02 | 4.0e-02 | 8.6 | -8.1 | 5.8e-16 | 0.56 | 0.04 | 0.54 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ARMS2 | 0.06 | 0.04 | blup | 71 | 0.05 | 4.9e-06 | -9.5 | -7.1 | 1.3e-12 | 0.28 | 0.12 | 0.84 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | PLEKHA1 | 0.08 | 0.10 | lasso | 1 | 0.09 | 3.5e-09 | 8.6 | -8.6 | 1.2e-17 | 0.50 | 0.97 | 0.03 | FALSE |