Best TWAS P=4.19e-14 · Best GWAS P=1.05e-14 conditioned to 2.07e-10
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RRAS2 | 0.11 | 0.02 | lasso | 3 | 0.02 | 9.0e-03 | -5.8 | 6.1 | 9.4e-10 | -0.04 | 0.45 | 0.15 | FALSE |
| 2 | GTEx | Artery Aorta | RRAS2 | 0.06 | 0.06 | enet | 10 | 0.03 | 5.6e-03 | 5.2 | 5.7 | 9.6e-09 | 0.21 | 0.17 | 0.14 | FALSE |
| 3 | GTEx | Brain Cerebellum | COPB1 | 0.16 | 0.09 | lasso | 8 | 0.06 | 9.3e-03 | 7.0 | -6.6 | 5.0e-11 | -0.22 | 0.19 | 0.24 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | RRAS2 | 0.09 | 0.11 | lasso | 9 | 0.10 | 8.1e-08 | -5.7 | 5.5 | 4.5e-08 | 0.05 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Heart Atrial Appendage | PDE3B | 0.17 | 0.05 | lasso | 9 | 0.04 | 5.3e-03 | -5.0 | -6.0 | 1.7e-09 | -0.15 | 0.16 | 0.12 | FALSE |
| 6 | GTEx | Lung | RRAS2 | 0.05 | 0.03 | lasso | 1 | 0.05 | 2.2e-04 | -5.7 | 5.7 | 1.1e-08 | 0.14 | 0.41 | 0.04 | FALSE |
| 7 | GTEx | Testis | RRAS2 | 0.18 | 0.13 | enet | 19 | 0.15 | 2.7e-07 | -5.7 | 7.6 | 4.2e-14 | 0.20 | 0.27 | 0.73 | TRUE |
| 8 | NTR | Blood | SPON1 | 0.05 | 0.02 | blup | 507 | 0.04 | 2.4e-13 | 5.2 | -5.3 | 1.1e-07 | -0.03 | 0.90 | 0.10 | FALSE |
| 9 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | PDE3B | 0.11 | 0.04 | blup | 64 | 0.06 | 9.7e-04 | -4.0 | -5.7 | 1.3e-08 | -0.15 | 0.08 | 0.83 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RRAS2 | 0.05 | 0.01 | blup | 11 | 0.02 | 1.3e-03 | -5.7 | 6.5 | 8.8e-11 | 0.24 | 0.00 | 0.88 | FALSE |