Hub : Genes

PDE3B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Heart Atrial Appendage 0.167 0.071 9.8e-03 0.052 NA 0.019 NA 0.043 0.0023 NA 0.0480 NA 0.0053
2 TCGA Cervical Squamous Cell Carcinoma 0.112 0.052 2.3e-05 0.036 0.056 0.050 NA 0.043 0.0067 0.00096 0.0017 NA 0.0035

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.3 0.5 1.0 1.0 0.0
Bipolar Disorder or Schizophrenia 0.4 1.1 2.2 -1.5 0.0
Depressed Affect (Nagel 2018) 0.1 0.2 0.2 0.5 -0.3
Depression (Nagel 2018) 0.1 0.2 0.2 0.5 0.3
Intelligence (Savage-Jansen 2018) 0.9 2.8 3.9 -2.0 1.3
Neuroticism (Nagel 2018) 0.4 0.9 1.7 1.3 0.3
Schizophrenia (2018) 1.8 3.7 7.5 -2.7 0.0
Schizophrenia vs Biploar Disorder 4.0 5.3 10.4 -3.2 -0.5
Worry (Nagel 2018) 0.4 0.8 1.0 0.8 1.0
Alzheimer’s Disease (in mother) 0.9 1.1 1.9 1.4 0.5
Alzheimer’s Disease (in father) 1.1 1.2 1.6 -0.9 -1.3
Alzheimer’s Disease (including proxy) 0.6 0.9 1.7 1.3 -0.4
Crohns Disease (2017) 0.3 0.7 1.0 0.6 -1.0
Irritable Bowel Disease (IBD) 0.1 0.1 0.3 -0.1 -0.5
Ulcerative Colitis (UC) 0.1 0.1 0.2 -0.2 0.5
Major Depression (MDD) 1.5 1.8 2.1 1.4 -1.2
Reaction Time 0.5 0.9 1.7 -1.3 -0.3
Verbal and Numeric Reasoning (VNR) 1.1 2.6 5.0 -2.2 -0.4
Breast Cancer 0.2 0.4 0.4 0.7 0.7
Ovarian Cancer 0.1 0.2 0.3 0.5 -0.2
Prostate Cancer 1.3 1.8 3.6 -1.9 -0.1
Age at First Birth 0.0 0.0 0.1 -0.2 -0.1
Bipolar Disorder (2011) 0.5 0.5 0.9 0.9 0.2
Body Mass Index (BMI) (2010) 2.0 2.8 4.0 -2.0 1.2
Coronary Artery Disease (CAD) 0.4 0.5 0.9 -0.1 -1.0
Crohns Disease (2012) 0.5 0.8 1.3 0.4 -1.2
Mean Putamen Volume 0.0 0.0 0.0 0.2 0.1
Fasting Glucose 0.4 0.5 0.8 -0.4 0.9
HbA1C 0.1 0.1 0.1 0.3 0.3
HDL Cholesterol 0.6 1.0 1.0 -1.0 -1.0
LDL Cholesterol 1.9 3.0 4.7 1.2 -2.2
Lupus 0.1 0.2 0.2 -0.4 0.4
Neuroticism (2016) 0.8 1.1 1.7 1.3 0.7
Primary Biliary Cirrhosis 0.9 1.4 2.7 -0.1 1.6
Rheumatoid Arthritis 1.1 1.6 1.9 -1.4 1.1
Schizophrenia (2014) 1.8 4.0 7.4 -2.7 0.8
Triglycerides 1.6 2.6 4.4 2.1 0.9
Type 2 Diabetes (T2D) (2012) 1.4 1.6 3.1 -0.4 1.8
Ulcerative Colitis 0.1 0.2 0.3 0.3 0.5
Blood Eosinophil Count 0.9 6.9 7.4 -2.5 2.7
Blood Platelet Count 0.2 2.8 4.5 2.1 1.1
Blood Red Count 0.3 2.5 4.9 2.2 0.5
Blood White Count 0.3 1.9 3.0 1.0 1.7
Heel T-Score 0.0 0.1 0.1 0.3 0.2
BMI 0.1 0.7 1.1 -0.4 1.1
Height 3.4 66.3 78.3 -8.8 -7.4
Waist Hip Ratio (WHR) 1.6 7.3 14.7 3.8 -0.1
Systolic Blood Pressure 2.2 11.1 13.5 3.7 3.0
Smoking Status 0.6 1.3 1.8 0.9 -1.3
Allergy or Eczema 0.6 1.6 2.6 -1.6 0.7
Cardiovascular Disease 0.8 2.6 2.7 1.6 1.6
Hypothyroidism (self reported) 0.1 0.1 0.2 -0.4 -0.3
Respiratory disease 0.2 0.4 0.7 -0.4 -0.8
Type 2 Diabetes (T2D) (2018) 2.9 5.4 10.9 0.0 3.3
Lung FEV1/FVC ratio 1.5 7.5 12.5 1.6 -3.5
Lung FVC 0.1 0.4 0.5 0.5 -0.7
Neuroticism 0.1 0.1 0.2 0.3 0.5
Chronotype (morning person) 1.7 4.0 7.3 0.8 2.7
Hair Pigment 0.0 0.8 1.2 1.1 0.7
Tanning 0.1 0.8 0.9 -1.0 -0.9
Hand grip strength (left) 0.3 0.7 1.3 1.1 -0.2
Number of treatments/medications taken 0.8 1.5 2.0 1.0 1.4
Average weekly spirits intake 0.1 0.1 0.2 -0.2 -0.5
Sensitivity / hurt feelings 0.5 0.9 1.6 1.3 0.4
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.5 0.7 0.2
Hearing difficulty/problems: Yes 0.3 0.5 0.8 -0.9 0.4
Relative age of first facial hair 0.2 0.4 0.5 0.5 0.7
Other serious medical condition/disability diagnosed by doctor 5.2 6.7 11.7 -3.4 -1.3
Ever used hormone-replacement therapy (HRT) 0.7 0.9 1.7 0.3 -1.3
Ever had hysterectomy (womb removed) 0.8 0.9 1.6 -0.5 1.2
Systolic blood pressure, automated reading 2.3 6.8 7.8 2.4 2.8
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 1.8 0.6 1.3
Angina 0.1 0.2 0.3 0.5 -0.3
Medication for hormone replacement therapy 0.7 0.8 1.0 1.0 -0.8
Vitamin and mineral supplements 2.4 3.2 6.3 2.5 0.4
Supplements: Zinc 3.1 3.4 6.5 -2.5 -0.5
Medication: Co-codamol 2.7 3.2 5.9 0.7 2.4
Medication: Metformin 2.9 4.1 7.6 -0.7 2.8
Diabetes (father) 0.7 0.8 0.9 -1.0 0.8
Diabetes (mother) 2.4 3.1 5.3 -0.9 2.3
Severe depression (siblings) 0.6 0.6 0.7 -0.8 0.7
Pack years adult smoking proportion 2.2 3.3 5.9 0.9 2.4
Impedance of leg (right) 0.4 1.9 2.1 1.3 -1.4
Leg fat-free mass (left) 2.1 11.0 19.9 -4.5 -1.4
Trunk fat percentage 1.1 4.4 8.7 -3.0 -0.3
Hand grip strength (right) 0.4 1.1 2.2 0.2 -1.5
Townsend deprivation index at recruitment 0.2 0.3 0.5 -0.7 -0.3
Current tobacco smoking 0.2 0.4 0.7 0.4 -0.8
Average weekly fortified wine intake 0.2 0.2 0.3 -0.5 -0.4
Maternal smoking around birth 2.6 3.8 6.9 0.9 2.6
Fed-up feelings 0.0 0.1 0.1 -0.2 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.2 0.3 0.6 0.2
Relative age voice broke 0.0 0.0 0.1 -0.2 -0.0
Taking other prescription medications 0.9 1.4 2.3 1.5 0.7
Age when periods started (menarche) 1.4 3.3 6.2 2.5 -0.6
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 0.6 0.8 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 2.4 1.5 0.5
Tinnitus: Yes, but not now, but have in the past 1.0 1.0 1.3 0.9 -1.1
Qualifications: CSEs or equivalent 0.2 0.2 0.4 -0.3 0.7
Serious illness, injury or assault to yourself 1.5 1.8 3.2 -1.8 -0.6
High blood pressure 1.2 3.3 5.2 1.1 2.3
Hayfever, allergic rhinitis or eczema 0.9 1.9 3.3 -1.8 0.8
Multivitamins +/- minerals 0.7 0.9 1.6 -1.3 -0.4
Stomach or abdominal pain in last month 2.3 2.9 4.3 2.1 1.2
Supplements: Glucosamine 0.4 0.6 0.8 -0.5 -0.9
Diverticular disease/diverticulitis (self-reported) 0.0 0.0 0.0 0.0 -0.1
Medication: Atenolol 0.8 1.0 2.0 1.4 -0.2
Medication: Levothyroxine sodium 0.4 0.6 0.9 -1.0 -0.5
Sitting height 1.5 11.0 20.4 -4.5 -1.2
Chronic bronchitis/emphysema (father) 1.8 2.1 3.6 0.8 -1.9
High blood pressure (mother) 1.1 1.5 2.6 1.6 0.6
Body mass index (BMI) 0.5 2.0 2.2 -1.4 1.5
Impedance of leg (left) 0.6 3.0 3.2 1.7 -1.8
Leg predicted mass (left) 2.1 10.9 19.8 -4.4 -1.4
Trunk fat mass 1.6 7.0 13.5 -3.7 -0.8
Waist circumference 0.3 1.0 1.7 -1.3 -0.5
Number of incorrect matches in round 0.5 0.8 1.5 -0.4 1.2
Past tobacco smoking 1.3 2.3 2.3 -1.5 1.5
Alcohol usually taken with meals 1.2 2.0 2.6 1.2 -1.6
Nervous feelings 0.3 0.5 0.9 0.9 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.5 -0.7 -0.3
Hearing difficulty/problems with background noise 0.1 0.1 0.1 -0.3 -0.3
Hair/balding pattern: Pattern 2 1.1 1.4 1.6 1.1 1.3
Had menopause 0.0 0.0 0.0 -0.2 -0.2
Had other major operations 0.3 0.4 0.8 -0.2 -0.9
Forced vital capacity (FVC) 2.4 9.3 13.2 -2.3 -3.6
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.4 1.2 0.3
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.2 -0.5 -1.1
Qualifications: None of the above 2.4 5.0 9.3 3.0 0.9
Financial difficulties in last 2 years 0.1 0.1 0.3 0.5 0.1
Mouth/teeth dental problems 0.1 0.1 0.2 -0.5 -0.3
Heart attack 1.1 1.4 2.7 0.1 1.6
Allergy 1.5 3.4 4.7 2.2 -1.4
Pain all over the body in last month 0.6 0.6 0.9 0.5 -1.0
Diabetes (self-reported) 3.0 4.6 9.0 0.4 3.0
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 1.1 -1.1 0.1
Medication: Ramipril 0.8 1.0 1.7 -0.5 1.3
Medication: Simvastatin 3.2 4.7 6.9 1.6 2.6
Fluid intelligence score 0.9 1.8 1.9 -1.4 -1.3
Illnesses of siblings 0.2 0.3 0.5 -0.7 -0.3
Neuroticism score 0.3 0.6 1.2 1.1 0.4
Weight 1.9 9.2 16.4 -4.0 -1.4
Impedance of arm (right) 0.9 4.1 5.9 -1.5 -2.4
Arm fat percentage (right) 1.0 4.0 8.0 -2.8 0.3
Trunk fat-free mass 1.6 9.4 14.6 -3.8 -2.0
Hip circumference 2.3 9.8 17.0 -4.1 -1.6
Time employed in main current job 1.1 1.3 1.4 1.2 1.1
Alcohol intake versus 10 years previously 0.7 1.1 2.1 -1.5 -0.3
Father’s age at death 1.7 2.3 2.5 -1.4 -1.6
Worrier / anxious feelings 0.6 1.1 1.5 1.2 0.8
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 1.9 1.4 -0.6
Falls in the last year 0.6 0.8 1.4 -1.2 0.3
Hair/balding pattern: Pattern 3 1.9 2.8 3.3 -1.5 -1.8
Number of live births 0.2 0.3 0.6 0.7 -0.2
Forced expiratory volume in 1-second (FEV1) 2.2 7.4 12.5 -1.5 -3.5
Pulse rate 2.1 3.6 5.9 1.1 2.4
Happiness 0.3 0.4 0.6 -0.3 -0.8
Noisy workplace 0.9 1.1 2.0 0.5 1.4
Qualifications: A levels/AS levels or equivalent 1.2 2.6 3.5 -1.3 -1.9
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.6 1.1 -0.5 -1.0
Mouth/teeth dental problems: Dentures 0.1 0.2 0.4 -0.2 0.6
Asthma 0.1 0.1 0.3 -0.5 0.1
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 0.8 0.5 -0.9
Medication: Cholesterol lowering 0.8 1.3 1.6 -1.3 1.0
Depression (self-reported) 5.4 6.4 10.7 3.3 -1.5
Medication: Lansoprazole 1.8 2.1 3.4 1.8 0.8
Prospective memory result 0.5 0.7 1.2 -0.3 1.1
Lung cancer (father) 0.3 0.3 0.7 0.0 0.8
Illnesses of mother 2.0 2.5 4.5 -0.7 -2.1
Forced expiratory volume in 1-second (FEV1), Best measure 2.1 6.7 12.8 -0.7 -3.6
Pulse wave Arterial Stiffness index 0.5 0.6 0.9 0.9 -0.5
Impedance of arm (left) 0.8 3.8 6.3 -1.2 -2.5
Arm fat mass (right) 1.1 4.4 8.7 -3.0 0.1
Trunk predicted mass 1.7 9.5 14.9 -3.9 -2.0
Standing height 3.5 34.3 36.4 -6.0 -5.7
Length of working week for main job 0.5 0.5 0.9 0.4 1.0
Exposure to tobacco smoke at home 1.3 1.4 2.7 -0.3 1.6
Breastfed as a baby 0.9 1.2 1.6 0.8 1.3
Tense / ‘highly strung’ 0.5 0.8 1.2 0.7 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.9 3.8 1.9 -0.1
Hair/balding pattern: Pattern 4 0.3 0.7 1.4 -1.2 -0.3
Birth weight of first child 0.4 0.7 1.5 -1.2 -0.0
Peak expiratory flow (PEF) 1.1 2.5 4.0 -1.0 -2.0
Pulse wave reflection index 1.0 1.3 2.4 0.4 -1.6
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.3 0.5 0.5
Loud music exposure frequency 1.9 2.1 4.1 0.2 2.0
Qualifications: O levels/GCSEs or equivalent 2.1 3.3 6.3 -2.5 -0.6
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.4 -0.1 -0.6
Blood clot in the leg (DVT) 0.8 1.0 1.9 -1.4 0.3
Medication: Paracetamol 0.6 1.1 1.1 1.0 1.0
Headache pain in last month 0.9 1.6 2.9 1.7 -0.5
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 0.8 0.9 -0.4
Glaucoma (self-reported) 0.2 0.3 0.5 -0.3 0.7
Gout (self-reported) 0.7 1.0 1.5 1.2 0.7
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 1.2 -1.1 -0.9
Medication: Amlodipine 0.4 0.6 0.8 -0.6 0.9
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.3 -0.1 1.1
Birth weight 3.2 6.9 13.6 -0.4 -3.7
Chronic bronchitis/emphysema (mother) 1.7 2.0 3.8 -2.0 0.4
High blood pressure (siblings) 1.4 2.0 2.6 1.6 1.2
Forced vital capacity (FVC), Best measure 2.4 8.7 13.3 -2.0 -3.6
Body fat percentage 0.8 3.0 6.0 -2.5 0.0
Leg fat percentage (right) 0.3 1.2 1.5 -1.2 0.9
Arm fat-free mass (right) 1.0 5.2 8.6 -2.9 -1.3
Exposure to tobacco smoke outside home 1.4 1.9 3.6 0.4 1.9
Comparative body size at age 10 0.2 0.4 0.5 -0.7 -0.6
Number of full brothers 2.0 2.5 2.6 1.6 1.6
Worry too long after embarrassment 0.3 0.6 1.0 -0.4 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 0.9 1.0 0.2
Wheeze or whistling in the chest in last year 0.0 0.1 0.1 -0.2 0.3
Number of children fathered 0.0 0.0 0.0 -0.0 0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.5 -0.3 -0.7
Age at first live birth 2.1 3.8 5.3 -2.3 -1.5
Pulse wave peak to peak time 0.8 0.9 1.8 -1.3 -0.0
Health satisfaction 0.6 0.8 0.8 -0.8 0.9
Shortness of breath walking on level ground 0.6 0.7 1.4 -0.2 1.2
Qualifications: College or University degree 0.2 0.5 0.9 -0.0 -1.0
Eye problems/disorders: None of the above 0.4 0.5 0.9 0.9 0.3
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.5 -0.3 -0.7
Emphysema/chronic bronchitis 0.1 0.1 0.2 -0.4 0.1
Medication for pain relief, constipation, heartburn 1.4 2.4 3.7 -1.1 -1.9
Neck or shoulder pain in last month 0.4 0.6 0.9 1.0 0.5
Medication: Blood pressure 0.4 0.7 1.3 -1.1 0.4
Angina (self-reported) 0.1 0.1 0.2 0.5 0.0
Migraine (self-reported) 0.7 0.8 1.4 1.2 -0.5
Medication: Ibuprofen 0.8 1.0 1.2 0.9 -1.1
Medication: Allopurinol 1.2 1.6 2.2 1.1 1.5
Medication: Omeprazole 0.2 0.2 0.4 0.6 -0.3
Medication: Seretide 50 evohaler 0.8 0.9 1.7 -0.5 1.3
Mean time to correctly identify matches 0.3 0.5 0.7 -0.8 -0.5
Heart disease (mother) 0.3 0.4 0.8 0.3 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 1.4 1.0 1.2
Whole body fat mass 1.3 5.3 10.4 -3.2 -0.4
Leg fat mass (right) 0.7 2.8 5.7 -2.4 0.1
Arm predicted mass (right) 1.1 5.7 9.6 -3.1 -1.4
Pulse rate, automated reading 1.3 4.2 6.8 2.6 1.2
Alcohol intake frequency. 0.4 0.9 1.8 -0.2 1.3
Comparative height size at age 10 4.0 22.1 29.2 -5.4 -3.9
Number of full sisters 0.8 1.0 2.0 0.2 1.4
Suffer from ‘nerves’ 1.3 2.0 3.8 0.5 1.9
Overall health rating 0.2 0.4 0.8 -0.9 0.1
Chest pain or discomfort 0.3 0.4 0.5 -0.5 -0.7
Had major operations 0.8 0.9 1.6 0.5 -1.3
Age at last live birth 0.8 1.2 1.8 -0.7 -1.3
Family relationship satisfaction 0.5 0.6 1.2 -0.3 1.1
Leg pain on walking 0.3 0.3 0.5 0.7 -0.4
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 1.5 -1.0 -1.2
Commuting to job workplace: Car/motor vehicle 2.1 2.4 4.6 0.4 2.1
Illness, injury, bereavement, stress in last 2 years 0.0 0.0 0.0 -0.1 0.2
Medication: Aspirin 1.0 1.3 2.0 0.8 1.4
Supplements: Vitamin C 2.7 3.2 6.3 -2.5 0.2
Knee pain experienced in last month 0.0 0.0 0.1 -0.3 -0.0
Hypertension (Self-reported) 1.1 3.0 4.3 1.3 2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.3 1.2 -0.1
Illnesses of father: Heart disease 0.0 0.0 0.0 0.1 0.2
Illnesses of siblings: Diabetes 0.7 0.9 1.7 0.1 1.3
Smoking status: Previous 0.4 0.6 0.8 0.7 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.2 2.7 -1.7 -1.3
Whole body fat-free mass 1.9 10.6 17.6 -4.2 -1.9
Leg fat-free mass (right) 2.0 10.7 18.6 -4.3 -1.7
Arm fat percentage (left) 0.8 3.3 6.4 -2.5 0.4
Average weekly red wine intake 0.5 0.7 1.2 0.4 -1.1
Handedness (chirality/laterality): Left-handed 2.0 2.3 4.5 2.1 0.4
Mood swings 0.2 0.3 0.6 0.8 -0.2
Loneliness, isolation 0.4 0.6 1.1 1.0 0.2
Long-standing illness, disability or infirmity 0.6 1.0 1.3 -1.2 0.8
Ever had bowel cancer screening 1.1 1.3 2.3 0.5 -1.5
Diabetes diagnosed by doctor 2.6 4.2 8.4 0.2 2.9
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.7 0.3 -0.9
Friendships satisfaction 0.2 0.3 0.4 0.5 -0.6
Qualifications: nursing, teaching 2.3 3.5 4.7 -2.2 1.5
Commuting to job workplace: Walk 0.3 0.4 0.6 -0.3 -0.8
Eye problems/disorders: Cataract 0.8 0.9 1.6 -1.3 -0.5
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 1.6 1.3 1.2
Medication for cholesterol 4.8 7.3 10.1 -3.2 -2.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 0.7 0.4 -0.9
Back pain experienced in last month 0.0 0.0 0.0 -0.0 0.2
Mineral and other dietary supplements 1.0 1.4 2.2 0.7 1.5
Breast cancer (self-reported) 1.2 1.5 2.8 -0.4 -1.7
Asthma (self-reported) 0.2 0.3 0.6 -0.8 0.1
Osteoporosis (self-reported) 0.1 0.2 0.2 -0.5 -0.3
Osteoarthritis (self-reported) 0.0 0.0 0.0 -0.0 0.0
Medication: Aspirin 1.1 1.4 1.8 1.0 1.3
Medication: Gliclazide 2.6 2.9 5.5 0.6 2.3
Illnesses of father: None of the above (group 1) 0.3 0.4 0.6 -0.5 -0.8
Smoking status: Current 0.2 0.4 0.4 0.6 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.1 3.8 0.6 -1.9
Whole body water mass 1.8 10.1 17.0 -4.1 -1.8
Leg predicted mass (right) 1.9 10.2 17.7 -4.2 -1.6
Arm fat mass (left) 0.9 3.9 7.8 -2.8 0.0
Number of self-reported non-cancer illnesses 0.7 1.2 1.8 0.7 1.4
Average weekly champagne plus white wine intake 0.7 1.0 1.9 1.4 -0.2
Miserableness 0.0 0.0 0.0 -0.1 -0.1
Guilty feelings 2.2 3.3 5.6 2.4 1.0
Wears glasses or contact lenses 1.4 1.6 2.8 -1.7 -0.7
Ever taken oral contraceptive pill 0.3 0.4 0.7 -0.3 -0.8
Hearing aid user 0.3 0.4 0.6 0.8 0.3
Mother’s age at death 0.1 0.2 0.3 0.1 -0.5
Financial situation satisfaction 1.0 1.2 2.4 -1.6 0.0
Tinnitus: Yes, now most or all of the time 0.4 0.4 0.7 0.4 -0.8
Commuting to job workplace: Public transport 3.5 4.2 6.6 -1.3 -2.6
Eye problems/disorders: Glaucoma 0.1 0.2 0.3 0.3 0.5
Medication: Blood pressure 3.5 6.6 9.5 3.1 1.9
Pain type(s) experienced in last month: Hip pain 0.0 0.0 0.0 -0.0 -0.2
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.6 -0.0 -0.8
High cholesterol (Self-reported) 0.4 0.8 1.5 1.2 0.1
Medication: Bendroflumethiazide 0.3 0.5 1.0 1.0 -0.3
Medication: Paracetamol 0.8 1.2 1.3 1.1 1.1
Medication: Lisinopril 0.6 0.7 0.9 0.7 1.0
Medication: Atorvastatin 0.1 0.1 0.1 -0.2 0.4
Illnesses of father: High blood pressure 1.2 1.5 1.7 1.1 1.3
Alcohol drinker status: Never 0.2 0.3 0.5 0.2 -0.7
Ever smoked 2.1 3.7 5.2 1.5 -2.3
Basal metabolic rate 1.9 10.6 17.8 -4.2 -1.8
Leg fat percentage (left) 0.2 0.9 1.1 -1.1 0.8
Arm fat-free mass (left) 1.4 7.0 11.7 -3.4 -1.5
Number of operations (self-reported) 1.2 1.8 2.3 1.5 -1.2
Average weekly beer plus cider intake 0.1 0.2 0.4 -0.6 0.1
Irritability 0.5 0.9 1.7 -0.3 -1.3
Risk taking 0.6 0.9 1.5 1.2 -0.6
Ever had prostate specific antigen (PSA) test 1.4 1.6 1.7 -1.3 -1.2
Fractured/broken bones in last 5 years 2.1 2.7 4.0 -2.0 -1.1
Age started oral contraceptive pill 1.8 2.2 4.4 -2.1 -0.1
Diastolic blood pressure, automated reading 2.6 8.0 8.8 3.0 2.7
Ever depressed for a whole week 0.4 0.5 1.1 -1.0 -0.0
Unable to work because of sickness or disability 0.1 0.1 0.1 0.1 -0.4
Commuting to job workplace: Cycle 1.1 1.3 1.7 -1.3 1.0
Myopia 3.8 5.5 8.8 -3.0 -1.5
Vascular/heart problems diagnosed by doctor 1.9 5.1 6.9 -1.8 -2.6
Cholesterol lowering medication 6.6 9.7 12.5 3.5 2.6
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 0.6 0.8 -0.8
Pain experienced in last month 0.2 0.3 0.4 -0.6 -0.5
Supplements: Calcium 2.9 3.2 5.6 -0.8 -2.4
Basal cell carcinoma (self-reported) 0.3 0.4 0.7 -0.8 -0.1
Heart attack/myocardial infarction (self-reported) 1.0 1.3 2.6 -0.0 1.6
Deep venous thrombosis (DVT) (self-reported) 0.7 0.8 1.6 -1.3 0.2
Heart disease (siblings) 0.2 0.3 0.5 0.7 0.4
Alcohol drinker status: Previous 0.3 0.3 0.6 0.1 0.8
Pack years of smoking 2.1 3.0 5.2 0.9 2.3
Impedance of whole body 0.4 2.1 4.1 0.2 -2.0
Leg fat mass (left) 0.6 2.4 4.8 -2.2 0.0
Arm predicted mass (left) 1.4 7.4 11.6 -3.4 -1.8