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chr2:15,703-988,346

Best TWAS P=1.08e-15 · Best GWAS P=3.03e-14 conditioned to 0.000347

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
12	GTEx	Heart Left Ventricle	SH3YL1	0.14	0.11	enet	16	0.10	8.2e-06	6.7	8.0	1.1e-15	-0.59	0.36	0.55	TRUE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SH3YL1	0.16	0.04	blup	67	0.06	5.6e-07	6.7	-8.0	1.5e-15	0.71	0.04	0.96	FALSE
31	The Cancer Genome Atlas	Esophageal Carcinoma	SH3YL1	0.16	0.02	blup	67	0.08	1.9e-03	6.7	-8.0	1.9e-15	0.51	0.10	0.33	FALSE
40	The Cancer Genome Atlas	Soft Tissue Sarcoma	SH3YL1	0.07	0.04	enet	9	0.05	1.0e-03	-7.2	7.5	4.9e-14	-0.87	0.04	0.63	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	FAM150B	0.06	0.01	bslmm	381	0.03	9.9e-05	-7.2	-7.3	2.7e-13	0.71	0.01	0.96	FALSE
5	GTEx	Cells Transformed fibroblasts	SH3YL1	0.16	0.09	lasso	7	0.10	3.3e-08	-7.6	7.2	8.9e-13	-0.93	0.01	0.99	FALSE
15	GTEx	Nerve Tibial	SH3YL1	0.33	0.23	enet	35	0.25	5.6e-18	6.7	6.9	5.6e-12	-0.49	0.67	0.33	FALSE
3	GTEx	Adipose Visceral Omentum	SH3YL1	0.15	0.03	lasso	4	0.01	6.5e-02	4.8	6.9	6.0e-12	-0.53	0.08	0.55	FALSE
10	GTEx	Esophagus Muscularis	SH3YL1	0.30	0.23	enet	50	0.28	4.6e-17	6.7	6.9	6.5e-12	-0.56	0.67	0.33	FALSE
6	GTEx	Colon Sigmoid	SH3YL1	0.20	0.14	lasso	3	0.14	1.3e-05	6.7	6.8	1.0e-11	-0.46	0.10	0.76	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	FAM150B	0.07	0.07	lasso	2	0.06	5.8e-07	6.7	-6.8	1.1e-11	0.48	0.71	0.29	FALSE
21	GTEx	Whole Blood	SH3YL1	0.21	0.17	lasso	6	0.18	2.6e-16	6.8	-6.8	1.3e-11	0.47	0.67	0.33	FALSE
2	GTEx	Adipose Subcutaneous	SH3YL1	0.08	0.10	lasso	1	0.08	4.1e-07	6.7	6.8	1.5e-11	-0.47	0.67	0.33	FALSE
18	GTEx	Skin Sun Exposed Lower leg	SH3YL1	0.42	0.44	lasso	5	0.45	3.3e-41	6.7	-6.7	1.6e-11	0.46	0.66	0.34	FALSE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SH3YL1	0.24	0.25	lasso	4	0.25	8.1e-28	6.7	-6.7	1.6e-11	0.48	0.71	0.29	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	SH3YL1	0.47	0.53	lasso	2	0.53	2.1e-33	6.7	-6.7	1.7e-11	0.47	0.67	0.33	FALSE
16	GTEx	Pancreas	SH3YL1	0.48	0.43	lasso	11	0.41	6.9e-19	6.8	-6.7	2.3e-11	0.46	0.66	0.34	FALSE
19	GTEx	Stomach	SH3YL1	0.33	0.21	lasso	6	0.20	3.8e-10	6.7	-6.7	2.6e-11	0.54	0.69	0.31	FALSE
20	GTEx	Thyroid	SH3YL1	0.29	0.32	lasso	4	0.31	2.9e-24	6.8	-6.7	2.9e-11	0.45	0.66	0.34	FALSE
38	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SH3YL1	0.21	0.18	lasso	1	0.15	9.6e-07	6.7	-6.7	2.9e-11	0.47	0.68	0.31	FALSE
4	GTEx	Artery Tibial	SH3YL1	0.10	0.02	lasso	3	0.01	2.9e-02	6.7	6.6	3.2e-11	-0.63	0.06	0.91	FALSE
9	GTEx	Esophagus Mucosa	SH3YL1	0.60	0.67	lasso	4	0.66	9.2e-58	6.8	-6.6	3.7e-11	0.44	0.64	0.36	FALSE
30	The Cancer Genome Atlas	Colon Adenocarcinoma	SH3YL1	0.32	0.34	lasso	6	0.35	2.8e-21	6.8	-6.6	4.2e-11	0.45	0.68	0.32	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	ACP1	0.03	0.04	lasso	2	0.02	4.7e-04	6.7	-6.6	4.6e-11	0.46	0.48	0.22	FALSE
14	GTEx	Muscle Skeletal	SH3YL1	0.12	0.10	lasso	3	0.09	4.1e-09	6.7	6.6	5.2e-11	-0.47	0.67	0.33	FALSE
7	GTEx	Colon Transverse	SH3YL1	0.36	0.25	lasso	7	0.26	1.2e-12	6.6	-6.5	6.1e-11	0.48	0.67	0.33	FALSE
11	GTEx	Heart Atrial Appendage	SH3YL1	0.27	0.23	lasso	6	0.22	2.1e-10	6.7	6.5	9.3e-11	-0.45	0.67	0.33	FALSE
42	The Cancer Genome Atlas	Thyroid Carcinoma	SH3YL1	0.54	0.56	lasso	4	0.57	1.1e-67	6.8	-6.4	1.8e-10	0.43	0.64	0.36	FALSE
39	The Cancer Genome Atlas	Rectum Adenocarcinoma	SH3YL1	0.51	0.29	blup	67	0.38	6.8e-10	6.8	-6.4	1.9e-10	0.21	0.66	0.30	FALSE
23	NTR	Blood	SH3YL1	0.12	0.17	lasso	5	0.16	6.2e-51	6.7	-6.3	2.1e-10	0.40	0.69	0.31	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	SH3YL1	0.19	0.31	lasso	5	0.32	2.5e-66	6.6	-6.2	6.5e-10	0.38	0.70	0.30	FALSE
41	The Cancer Genome Atlas	Stomach Adenocarcinoma	SH3YL1	0.19	0.21	enet	12	0.23	2.1e-16	6.6	-6.0	2.6e-09	0.33	0.70	0.30	FALSE
36	The Cancer Genome Atlas	Lung Adenocarcinoma	SH3YL1	0.17	0.24	enet	15	0.24	5.8e-28	6.8	-5.9	3.3e-09	0.35	0.67	0.33	FALSE
27	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SH3YL1	0.25	0.15	blup	67	0.18	2.8e-15	6.8	-5.8	4.9e-09	0.16	0.70	0.30	FALSE
26	YFS	Blood	SH3YL1	0.48	0.40	enet	100	0.46	3.2e-171	6.7	-5.7	9.3e-09	0.34	0.68	0.32	FALSE
43	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	SH3YL1	0.16	0.14	lasso	2	0.09	1.8e-03	6.6	-5.7	1.4e-08	0.33	0.13	0.10	FALSE
1	CommonMind	Brain Pre-frontal Cortex	SH3YL1	0.11	0.12	lasso	2	0.13	5.8e-16	-7.6	5.5	3.4e-08	-0.91	0.01	0.99	FALSE
34	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SH3YL1	0.20	0.05	blup	67	0.09	9.5e-06	6.7	-5.5	3.4e-08	0.58	0.28	0.54	FALSE
8	GTEx	Esophagus Gastroesophageal Junction	SH3YL1	0.21	0.09	lasso	7	0.14	1.3e-05	4.2	5.5	3.7e-08	-0.42	0.24	0.55	FALSE
13	GTEx	Lung	SH3YL1	0.09	0.08	lasso	5	0.05	8.5e-05	6.7	-5.5	4.5e-08	0.37	0.61	0.27	FALSE
29	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SH3YL1	0.32	0.27	enet	14	0.28	6.6e-14	6.7	-5.5	4.8e-08	0.25	0.69	0.31	FALSE
37	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SH3YL1	0.11	0.10	lasso	5	0.10	4.5e-11	6.8	-5.5	5.0e-08	0.28	0.69	0.31	FALSE
22	METSIM	Adipose	SH3YL1	0.03	0.02	lasso	3	0.02	9.5e-04	4.2	5.3	1.2e-07	-0.34	0.37	0.33	FALSE