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chr1:91,848,784-94,716,440

Best TWAS P=8.21e-28 · Best GWAS P=1.21e-23 conditioned to 0.506

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
22	GTEx	Cells Transformed fibroblasts	EVI5	0.18	0.11	enet	28	0.20	5.9e-15	-9.71	-10.9	8.2e-28	0.83	0.09	0.91	TRUE
10	GTEx	Artery Aorta	FNBP1L	0.13	0.03	lasso	1	0.00	1.9e-01	6.16	6.2	7.5e-10	-0.10	0.16	0.08	TRUE
31	GTEx	Lung	EVI5	0.11	0.08	lasso	11	0.13	7.0e-10	-9.61	-10.8	2.7e-27	0.86	0.02	0.98	FALSE
42	GTEx	Whole Blood	EVI5	0.03	0.01	lasso	2	0.01	6.8e-02	-9.98	-10.8	3.1e-27	0.96	0.02	0.96	FALSE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	EVI5	0.03	0.03	lasso	4	0.04	3.6e-09	-9.45	-10.8	4.2e-27	0.89	0.04	0.96	FALSE
52	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EVI5	0.08	0.04	blup	96	0.06	8.6e-08	-9.30	-10.7	1.7e-26	0.88	0.03	0.97	FALSE
26	GTEx	Esophagus Gastroesophageal Junction	EVI5	0.22	0.10	lasso	7	0.06	2.3e-03	-9.37	-10.6	2.2e-26	0.84	0.04	0.96	FALSE
56	The Cancer Genome Atlas	Brain Lower Grade Glioma	EVI5	0.18	0.16	lasso	7	0.15	2.0e-16	-9.98	-10.6	2.2e-26	0.98	0.01	0.99	FALSE
3	CommonMind	Brain Pre-frontal Cortex	FAM69A	0.10	0.13	lasso	4	0.14	1.2e-16	-9.53	-10.6	2.8e-26	0.76	0.40	0.60	FALSE
49	The Cancer Genome Atlas	Colon Adenocarcinoma	EVI5	0.07	0.04	blup	93	0.03	4.7e-03	-9.53	-10.6	3.7e-26	0.79	0.08	0.57	FALSE
61	The Cancer Genome Atlas	Prostate Adenocarcinoma	EVI5	0.06	0.10	blup	94	0.10	1.7e-10	-10.00	-10.6	4.4e-26	0.92	0.01	0.99	FALSE
60	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EVI5	0.10	0.06	blup	94	0.08	2.9e-04	-10.00	-10.5	5.6e-26	0.92	0.02	0.96	FALSE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EVI5	0.07	0.05	blup	96	0.06	2.5e-07	-9.45	-10.5	6.1e-26	0.80	0.13	0.87	FALSE
27	GTEx	Esophagus Mucosa	EVI5	0.12	0.19	lasso	4	0.19	6.0e-13	-9.37	-10.5	1.0e-25	0.83	0.04	0.96	FALSE
58	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EVI5	0.04	0.04	blup	93	0.03	4.8e-04	-9.37	-10.4	2.6e-25	0.85	0.08	0.89	FALSE
30	GTEx	Heart Left Ventricle	EVI5	0.07	0.11	lasso	5	0.08	7.7e-05	-9.99	-10.4	2.7e-25	0.99	0.02	0.98	FALSE
2	CommonMind	Brain Pre-frontal Cortex	EVI5	0.03	0.01	blup	335	0.02	1.3e-03	-9.98	-10.3	5.1e-25	0.92	0.02	0.96	FALSE
57	The Cancer Genome Atlas	Lung Adenocarcinoma	EVI5	0.05	0.07	lasso	5	0.07	5.6e-09	-9.45	-10.3	1.1e-24	0.80	0.12	0.88	FALSE
20	GTEx	Breast Mammary Tissue	EVI5	0.07	0.06	lasso	4	0.07	2.3e-04	-9.98	-10.2	1.9e-24	0.99	0.02	0.98	FALSE
33	GTEx	Nerve Tibial	EVI5	0.17	0.13	enet	25	0.18	4.5e-13	-9.30	-10.2	1.9e-24	0.84	0.09	0.91	FALSE
18	GTEx	Brain Cortex	EVI5	0.25	0.33	lasso	13	0.30	4.1e-09	-9.98	-10.1	3.8e-24	0.99	0.02	0.98	FALSE
59	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	EVI5	0.05	0.02	blup	96	0.03	2.3e-03	-9.56	-10.1	3.8e-24	0.83	0.08	0.73	FALSE
29	GTEx	Heart Atrial Appendage	EVI5	0.09	0.06	lasso	7	0.05	4.2e-03	-9.98	-10.1	8.0e-24	1.00	0.02	0.95	FALSE
5	GTEx	Adipose Subcutaneous	EVI5	0.09	0.07	lasso	3	0.09	1.2e-07	-9.52	-10.0	1.0e-23	0.66	0.28	0.72	FALSE
25	GTEx	Colon Transverse	EVI5	0.21	0.08	lasso	9	0.14	4.2e-07	-7.28	-10.0	1.4e-23	0.77	0.03	0.97	FALSE
24	GTEx	Colon Sigmoid	EVI5	0.13	0.16	lasso	3	0.12	7.0e-05	-9.99	-10.0	1.6e-23	1.00	0.02	0.98	FALSE
19	GTEx	Brain Hypothalamus	EVI5	0.16	0.12	lasso	13	0.05	2.1e-02	-9.98	-10.0	1.8e-23	1.00	0.02	0.86	FALSE
41	GTEx	Uterus	EVI5	0.23	0.12	enet	27	0.16	4.3e-04	-9.98	-9.9	3.4e-23	0.90	0.04	0.87	FALSE
4	CommonMind	Brain Pre-frontal Cortex	RPAP2	0.20	0.06	enet	29	0.16	8.6e-19	-8.89	-9.8	7.3e-23	0.69	0.15	0.85	FALSE
28	GTEx	Esophagus Muscularis	EVI5	0.16	0.23	lasso	5	0.23	4.9e-14	-9.37	-9.8	8.5e-23	0.70	0.24	0.76	FALSE
36	GTEx	Skin Not Sun Exposed Suprapubic	EVI5	0.07	0.05	lasso	6	0.08	2.2e-05	-9.31	-9.7	2.0e-22	0.72	0.06	0.93	FALSE
53	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FAM69A	0.05	0.03	blup	62	0.05	4.4e-06	-9.46	-9.7	2.7e-22	0.53	0.02	0.98	FALSE
12	GTEx	Artery Coronary	EVI5	0.09	0.10	lasso	2	0.07	3.1e-03	-9.53	-9.5	1.7e-21	0.64	0.08	0.61	FALSE
55	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EVI5	0.04	0.02	blup	96	0.04	1.4e-03	-6.25	-9.5	2.1e-21	0.85	0.03	0.66	FALSE
9	GTEx	Adipose Visceral Omentum	EVI5	0.13	0.08	lasso	2	0.07	2.3e-04	-9.37	-9.3	8.9e-21	0.64	0.29	0.46	FALSE
14	GTEx	Artery Tibial	EVI5	0.08	0.08	lasso	10	0.12	9.5e-10	-9.01	-9.2	3.0e-20	0.88	0.13	0.87	FALSE
51	The Cancer Genome Atlas	Glioblastoma Multiforme	EVI5	0.14	0.04	blup	93	0.06	8.9e-03	-6.29	-9.2	3.1e-20	0.88	0.03	0.74	FALSE
16	GTEx	Brain Caudate basal ganglia	EVI5	0.10	0.00	enet	19	0.01	1.7e-01	-9.98	-8.9	6.3e-19	0.82	0.04	0.67	FALSE
21	GTEx	Breast Mammary Tissue (Male)	EVI5	0.17	0.03	lasso	10	0.08	5.9e-03	-9.01	-8.8	2.2e-18	0.82	0.04	0.56	FALSE
63	The Cancer Genome Atlas	Thyroid Carcinoma	EVI5	0.05	0.01	blup	94	0.03	5.7e-04	-9.56	8.7	2.5e-18	-0.44	0.18	0.47	FALSE
62	The Cancer Genome Atlas	Stomach Adenocarcinoma	EVI5	0.14	0.07	lasso	3	0.08	3.4e-06	-9.45	-8.7	3.2e-18	0.61	0.32	0.66	FALSE
46	ROSMAP	Brain Pre-frontal Cortex	FAM69A	0.10	0.13	lasso	4	0.15	2.4e-19	-5.67	-8.5	1.7e-17	0.70	0.95	0.05	FALSE
38	GTEx	Stomach	EVI5	0.12	0.13	lasso	6	0.14	4.7e-07	-9.37	-8.5	2.5e-17	0.52	0.32	0.68	FALSE
37	GTEx	Spleen	EVI5	0.21	0.15	enet	22	0.25	3.3e-07	-9.86	-8.4	3.7e-17	0.79	0.04	0.94	FALSE
39	GTEx	Thyroid	RPAP2	0.04	0.03	enet	15	0.03	4.2e-03	6.18	-8.3	6.7e-17	0.47	0.22	0.20	FALSE
8	GTEx	Adipose Subcutaneous	FAM69A	0.08	0.06	lasso	7	0.04	3.8e-04	-7.28	8.1	5.2e-16	-0.80	0.03	0.96	FALSE
13	GTEx	Artery Coronary	FAM69A	0.25	0.25	lasso	2	0.26	3.4e-09	-7.28	7.8	6.9e-15	-0.68	0.31	0.61	FALSE
34	GTEx	Nerve Tibial	FAM69A	0.17	0.03	enet	19	0.05	1.4e-04	-7.13	7.6	3.1e-14	-0.64	0.51	0.42	FALSE
47	YFS	Blood	FAM69A	0.28	0.09	enet	29	0.13	4.9e-40	6.10	7.6	3.3e-14	-0.42	1.00	0.00	FALSE
44	METSIM	Adipose	FAM69A	0.03	0.03	bslmm	293	0.02	1.8e-03	-9.56	7.5	4.3e-14	-0.61	0.32	0.52	FALSE
40	GTEx	Thyroid	FAM69A	0.43	0.18	enet	41	0.20	5.5e-15	6.10	7.5	5.6e-14	-0.44	1.00	0.00	FALSE
7	GTEx	Adipose Subcutaneous	RPAP2	0.12	0.02	lasso	8	0.04	3.1e-04	4.44	-7.5	8.5e-14	0.46	0.56	0.06	FALSE
43	METSIM	Adipose	EVI5	0.14	0.10	enet	35	0.11	1.0e-15	-9.30	-7.4	1.0e-13	0.61	0.33	0.67	FALSE
50	The Cancer Genome Atlas	Colon Adenocarcinoma	FAM69A	0.05	0.01	enet	7	0.02	3.6e-02	-5.84	-7.4	1.2e-13	0.47	0.02	0.75	FALSE
23	GTEx	Cells Transformed fibroblasts	FAM69A	0.24	0.19	lasso	7	0.17	4.9e-13	-7.28	7.4	1.4e-13	-0.62	1.00	0.00	FALSE
32	GTEx	Lung	RPAP2	0.08	0.04	enet	27	0.06	1.0e-05	5.25	-7.0	1.8e-12	0.61	0.37	0.45	FALSE
35	GTEx	Pancreas	FAM69A	0.10	0.08	enet	12	0.04	1.1e-02	-9.52	-6.9	5.0e-12	0.51	0.19	0.28	FALSE
11	GTEx	Artery Aorta	FAM69A	0.34	0.22	lasso	7	0.27	3.9e-15	-7.13	6.5	8.8e-11	-0.69	0.98	0.02	FALSE
6	GTEx	Adipose Subcutaneous	CCDC18	0.06	0.00	lasso	6	0.01	2.1e-02	0.62	-6.0	2.4e-09	0.48	0.06	0.77	FALSE
64	The Cancer Genome Atlas	Thyroid Carcinoma	FAM69A	0.25	0.06	lasso	4	0.05	1.2e-05	6.10	5.9	3.7e-09	-0.26	0.80	0.01	FALSE
45	NTR	Blood	RPAP2	0.01	0.01	enet	16	0.00	9.5e-03	7.59	-5.7	1.0e-08	0.18	0.46	0.02	FALSE
1	CommonMind	Brain Pre-frontal Cortex	BTBD8	0.06	0.00	bslmm	441	0.02	1.3e-03	4.59	-5.7	1.5e-08	0.02	0.05	0.03	FALSE
17	GTEx	Brain Cerebellar Hemisphere	TMED5	0.37	0.06	enet	21	0.11	1.1e-03	5.08	-5.3	1.4e-07	0.27	0.28	0.21	FALSE
15	GTEx	Artery Tibial	FAM69A	0.35	0.34	enet	36	0.36	3.6e-29	-7.28	5.2	1.7e-07	-0.51	1.00	0.00	FALSE