Best TWAS P=5.71e-13 · Best GWAS P=2.59e-16 conditioned to 8.81e-16
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | NLRX1 | 0.14 | 0.03 | lasso | 5 | 0.03 | 9.6e-03 | 7.1 | -7.2 | 5.7e-13 | -0.05 | 0.02 | 0.88 | TRUE |
| 6 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | OAF | 0.09 | 0.09 | enet | 3 | 0.08 | 2.1e-05 | 5.3 | -5.3 | 1.3e-07 | 0.11 | 0.00 | 0.99 | TRUE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | TREH | 0.27 | 0.18 | lasso | 3 | 0.21 | 8.6e-20 | 5.7 | 6.0 | 2.2e-09 | 0.05 | 0.01 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TREH | 0.05 | 0.05 | lasso | 2 | 0.04 | 2.7e-05 | 5.7 | 5.7 | 1.3e-08 | 0.03 | 0.01 | 0.97 | FALSE |
| 2 | GTEx | Brain Caudate basal ganglia | RP11-110I1.13 | 0.28 | 0.01 | enet | 23 | 0.03 | 3.6e-02 | -1.7 | -5.7 | 1.6e-08 | -0.02 | 0.06 | 0.28 | FALSE |
| 5 | GTEx | Pancreas | RP11-110I1.14 | 0.23 | 0.00 | enet | 15 | 0.03 | 2.5e-02 | -2.9 | 5.4 | 6.1e-08 | 0.05 | 0.08 | 0.53 | FALSE |
| 4 | GTEx | Esophagus Muscularis | OAF | 0.26 | 0.14 | lasso | 7 | 0.12 | 5.9e-08 | 5.3 | -5.3 | 1.4e-07 | 0.06 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | OAF | 0.19 | 0.14 | lasso | 3 | 0.13 | 1.1e-09 | 5.3 | -5.2 | 2.5e-07 | 0.11 | 1.00 | 0.00 | FALSE |