Best TWAS P=4.06e-45 · Best GWAS P=5.33e-84 conditioned to 3.76e-46
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue (Male) | MRPL42 | 0.21 | -0.01 | lasso | 2 | -0.01 | 6.0e-01 | 11.2 | -11.0 | 6.2e-28 | -0.47 | 0.05 | 0.05 | TRUE |
| 2 | GTEx | Muscle Skeletal | MRPL42 | 0.07 | 0.02 | lasso | 3 | 0.04 | 1.5e-04 | -6.9 | -6.8 | 1.2e-11 | -0.16 | 0.70 | 0.01 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | UBE2N | 0.09 | 0.07 | lasso | 2 | 0.06 | 1.6e-05 | 6.4 | 5.7 | 1.4e-08 | 0.17 | 0.91 | 0.00 | FALSE |
| 4 | GTEx | Testis | MRPL42 | 0.35 | 0.17 | lasso | 3 | 0.24 | 3.3e-11 | -4.5 | -6.2 | 6.5e-10 | -0.14 | 1.00 | 0.00 | FALSE |
| 5 | NTR | Blood | SOCS2 | 0.04 | 0.02 | bslmm | 454 | 0.02 | 6.5e-08 | 13.0 | 10.2 | 1.3e-24 | -0.22 | 1.00 | 0.00 | TRUE |
| 6 | YFS | Blood | SOCS2 | 0.06 | 0.04 | bslmm | 444 | 0.04 | 1.7e-12 | 12.9 | 14.1 | 4.1e-45 | 0.07 | 1.00 | 0.00 | TRUE |
| 7 | YFS | Blood | UBE2N | 0.02 | 0.00 | bslmm | 424 | 0.01 | 3.6e-03 | 16.9 | 6.9 | 4.9e-12 | 0.38 | 0.06 | 0.31 | TRUE |
| 8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MRPL42 | 0.05 | 0.02 | blup | 49 | 0.03 | 5.1e-04 | 6.3 | 6.5 | 1.1e-10 | 0.15 | 0.05 | 0.33 | TRUE |
| 9 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | MRPL42 | 0.11 | 0.06 | lasso | 2 | 0.09 | 7.1e-07 | -4.5 | 5.2 | 1.5e-07 | 0.15 | 0.27 | 0.63 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MRPL42 | 0.07 | 0.03 | blup | 49 | 0.03 | 1.4e-04 | -4.5 | 7.1 | 1.5e-12 | 0.21 | 0.52 | 0.30 | FALSE |
| 11 | The Cancer Genome Atlas | Stomach Adenocarcinoma | MRPL42 | 0.12 | 0.01 | blup | 49 | 0.04 | 4.0e-04 | -4.5 | 5.9 | 4.5e-09 | 0.18 | 0.02 | 0.17 | FALSE |