Best TWAS P=5.23e-19 · Best GWAS P=1.64e-28 conditioned to 5.36e-25
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CCDC53 | 0.21 | 0.15 | blup | 448 | 0.19 | 2.4e-22 | 2.24 | -6.0 | 2.7e-09 | -0.14 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | GNPTAB | 0.08 | 0.02 | enet | 13 | 0.03 | 8.2e-04 | 2.42 | -6.7 | 2.7e-11 | -0.02 | 0.20 | 0.03 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | DRAM1 | 0.12 | 0.01 | lasso | 3 | 0.00 | 3.5e-01 | -5.00 | 6.9 | 4.3e-12 | 0.03 | 0.05 | 0.05 | FALSE |
| 4 | GTEx | Adrenal Gland | CHPT1 | 0.30 | 0.09 | lasso | 14 | 0.10 | 2.1e-04 | 5.63 | -5.7 | 1.1e-08 | 0.10 | 0.25 | 0.53 | FALSE |
| 5 | GTEx | Artery Aorta | CCDC53 | 0.16 | 0.16 | enet | 12 | 0.17 | 7.0e-10 | 2.71 | -5.3 | 1.4e-07 | -0.10 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Artery Aorta | DRAM1 | 0.20 | 0.03 | lasso | 9 | 0.03 | 6.3e-03 | -5.54 | 6.0 | 2.6e-09 | -0.01 | 0.75 | 0.02 | FALSE |
| 7 | GTEx | Brain Caudate basal ganglia | CHPT1 | 0.19 | 0.01 | lasso | 5 | 0.03 | 5.6e-02 | 6.14 | -5.5 | 3.9e-08 | -0.03 | 0.12 | 0.05 | FALSE |
| 8 | GTEx | Cells Transformed fibroblasts | CCDC53 | 0.10 | 0.18 | lasso | 1 | 0.17 | 1.5e-12 | 5.73 | -5.7 | 9.9e-09 | 0.07 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Colon Transverse | CHPT1 | 0.25 | 0.04 | enet | 36 | 0.18 | 5.1e-09 | 5.68 | -5.2 | 1.6e-07 | -0.02 | 0.81 | 0.01 | FALSE |
| 10 | GTEx | Esophagus Gastroesophageal Junction | CHPT1 | 0.17 | 0.16 | enet | 24 | 0.15 | 5.7e-06 | 5.68 | -6.2 | 6.3e-10 | -0.07 | 0.38 | 0.03 | FALSE |
| 11 | GTEx | Esophagus Mucosa | GNPTAB | 0.22 | 0.00 | enet | 28 | 0.00 | 2.0e-01 | -1.10 | -5.7 | 1.4e-08 | 0.00 | 0.22 | 0.03 | FALSE |
| 12 | GTEx | Heart Left Ventricle | CCDC53 | 0.14 | 0.20 | lasso | 4 | 0.18 | 9.6e-10 | 5.76 | -5.1 | 3.0e-07 | 0.01 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Lung | CCDC53 | 0.12 | 0.10 | lasso | 3 | 0.11 | 6.8e-09 | 5.73 | -6.5 | 1.1e-10 | 0.02 | 1.00 | 0.00 | TRUE |
| 14 | GTEx | Lung | DRAM1 | 0.13 | 0.08 | lasso | 3 | 0.09 | 2.3e-07 | -5.00 | 5.7 | 1.3e-08 | 0.06 | 0.94 | 0.00 | FALSE |
| 15 | GTEx | Prostate | DRAM1 | 0.57 | 0.08 | lasso | 20 | 0.00 | 2.7e-01 | 2.20 | 7.6 | 2.2e-14 | -0.62 | 0.03 | 0.40 | FALSE |
| 16 | GTEx | Spleen | CCDC53 | 0.25 | 0.19 | lasso | 11 | 0.16 | 5.8e-05 | 5.76 | -5.9 | 3.2e-09 | 0.08 | 0.52 | 0.03 | FALSE |
| 17 | GTEx | Testis | CHPT1 | 0.17 | 0.03 | lasso | 3 | 0.04 | 5.8e-03 | 5.68 | -6.2 | 7.0e-10 | -0.06 | 0.39 | 0.04 | FALSE |
| 18 | GTEx | Thyroid | CCDC53 | 0.15 | 0.12 | lasso | 6 | 0.12 | 4.3e-09 | 5.80 | -5.5 | 4.3e-08 | 0.01 | 1.00 | 0.00 | FALSE |
| 19 | METSIM | Adipose | DRAM1 | 0.12 | 0.03 | enet | 24 | 0.08 | 1.1e-12 | 5.88 | 8.1 | 5.2e-16 | 0.03 | 1.00 | 0.00 | FALSE |
| 20 | YFS | Blood | DRAM1 | 0.33 | 0.13 | enet | 101 | 0.19 | 1.6e-58 | 6.46 | 8.9 | 5.2e-19 | -0.06 | 1.00 | 0.00 | TRUE |
| 21 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | DRAM1 | 0.15 | -0.01 | blup | 70 | 0.06 | 2.2e-03 | -0.29 | 5.9 | 3.7e-09 | -0.02 | 0.01 | 0.04 | TRUE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GNPTAB | 0.04 | 0.03 | blup | 62 | 0.04 | 9.7e-05 | 3.91 | -5.7 | 1.4e-08 | -0.05 | 0.03 | 0.88 | FALSE |
| 23 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CCDC53 | 0.04 | 0.07 | lasso | 4 | 0.06 | 2.1e-05 | 5.76 | -5.7 | 1.2e-08 | 0.07 | 0.83 | 0.01 | FALSE |
| 24 | The Cancer Genome Atlas | Thyroid Carcinoma | CCDC53 | 0.31 | 0.16 | enet | 21 | 0.18 | 6.2e-17 | 5.79 | -5.6 | 1.8e-08 | -0.05 | 1.00 | 0.00 | FALSE |