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chr12:101,392,911-103,148,974

Best TWAS P=5.23e-19 · Best GWAS P=1.64e-28 conditioned to 5.36e-25

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	YFS	Blood	DRAM1	0.33	0.13	enet	101	0.19	1.6e-58	6.46	8.9	5.2e-19	-0.06	1.00	0.00	TRUE
13	GTEx	Lung	CCDC53	0.12	0.10	lasso	3	0.11	6.8e-09	5.73	-6.5	1.1e-10	0.02	1.00	0.00	TRUE
21	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	DRAM1	0.15	-0.01	blup	70	0.06	2.2e-03	-0.29	5.9	3.7e-09	-0.02	0.01	0.04	TRUE
19	METSIM	Adipose	DRAM1	0.12	0.03	enet	24	0.08	1.1e-12	5.88	8.1	5.2e-16	0.03	1.00	0.00	FALSE
15	GTEx	Prostate	DRAM1	0.57	0.08	lasso	20	0.00	2.7e-01	2.20	7.6	2.2e-14	-0.62	0.03	0.40	FALSE
3	GTEx	Adipose Subcutaneous	DRAM1	0.12	0.01	lasso	3	0.00	3.5e-01	-5.00	6.9	4.3e-12	0.03	0.05	0.05	FALSE
2	GTEx	Adipose Subcutaneous	GNPTAB	0.08	0.02	enet	13	0.03	8.2e-04	2.42	-6.7	2.7e-11	-0.02	0.20	0.03	FALSE
10	GTEx	Esophagus Gastroesophageal Junction	CHPT1	0.17	0.16	enet	24	0.15	5.7e-06	5.68	-6.2	6.3e-10	-0.07	0.38	0.03	FALSE
17	GTEx	Testis	CHPT1	0.17	0.03	lasso	3	0.04	5.8e-03	5.68	-6.2	7.0e-10	-0.06	0.39	0.04	FALSE
6	GTEx	Artery Aorta	DRAM1	0.20	0.03	lasso	9	0.03	6.3e-03	-5.54	6.0	2.6e-09	-0.01	0.75	0.02	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CCDC53	0.21	0.15	blup	448	0.19	2.4e-22	2.24	-6.0	2.7e-09	-0.14	1.00	0.00	FALSE
16	GTEx	Spleen	CCDC53	0.25	0.19	lasso	11	0.16	5.8e-05	5.76	-5.9	3.2e-09	0.08	0.52	0.03	FALSE
8	GTEx	Cells Transformed fibroblasts	CCDC53	0.10	0.18	lasso	1	0.17	1.5e-12	5.73	-5.7	9.9e-09	0.07	1.00	0.00	FALSE
4	GTEx	Adrenal Gland	CHPT1	0.30	0.09	lasso	14	0.10	2.1e-04	5.63	-5.7	1.1e-08	0.10	0.25	0.53	FALSE
23	The Cancer Genome Atlas	Stomach Adenocarcinoma	CCDC53	0.04	0.07	lasso	4	0.06	2.1e-05	5.76	-5.7	1.2e-08	0.07	0.83	0.01	FALSE
14	GTEx	Lung	DRAM1	0.13	0.08	lasso	3	0.09	2.3e-07	-5.00	5.7	1.3e-08	0.06	0.94	0.00	FALSE
11	GTEx	Esophagus Mucosa	GNPTAB	0.22	0.00	enet	28	0.00	2.0e-01	-1.10	-5.7	1.4e-08	0.00	0.22	0.03	FALSE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	GNPTAB	0.04	0.03	blup	62	0.04	9.7e-05	3.91	-5.7	1.4e-08	-0.05	0.03	0.88	FALSE
24	The Cancer Genome Atlas	Thyroid Carcinoma	CCDC53	0.31	0.16	enet	21	0.18	6.2e-17	5.79	-5.6	1.8e-08	-0.05	1.00	0.00	FALSE
7	GTEx	Brain Caudate basal ganglia	CHPT1	0.19	0.01	lasso	5	0.03	5.6e-02	6.14	-5.5	3.9e-08	-0.03	0.12	0.05	FALSE
18	GTEx	Thyroid	CCDC53	0.15	0.12	lasso	6	0.12	4.3e-09	5.80	-5.5	4.3e-08	0.01	1.00	0.00	FALSE
5	GTEx	Artery Aorta	CCDC53	0.16	0.16	enet	12	0.17	7.0e-10	2.71	-5.3	1.4e-07	-0.10	1.00	0.00	FALSE
9	GTEx	Colon Transverse	CHPT1	0.25	0.04	enet	36	0.18	5.1e-09	5.68	-5.2	1.6e-07	-0.02	0.81	0.01	FALSE
12	GTEx	Heart Left Ventricle	CCDC53	0.14	0.20	lasso	4	0.18	9.6e-10	5.76	-5.1	3.0e-07	0.01	1.00	0.00	FALSE