Best TWAS P=2.56e-14 · Best GWAS P=3.25e-15 conditioned to 3.26e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | IFT88 | 0.27 | 0.33 | lasso | 11 | 0.34 | 1.4e-42 | 5.3 | 5.3 | 1.1e-07 | 0.61 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | IFT88 | 0.25 | 0.18 | lasso | 6 | 0.18 | 2.9e-14 | 5.3 | 5.1 | 2.7e-07 | 0.60 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Artery Aorta | IFT88 | 0.25 | 0.23 | enet | 16 | 0.22 | 2.3e-12 | 5.3 | 5.4 | 6.7e-08 | 0.62 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Artery Tibial | IFT88 | 0.27 | 0.17 | enet | 40 | 0.19 | 1.4e-14 | 5.5 | 5.2 | 2.2e-07 | 0.53 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Brain Cerebellum | IFT88 | 0.29 | 0.24 | lasso | 1 | 0.22 | 3.3e-07 | 5.5 | 5.5 | 4.0e-08 | 0.62 | 0.75 | 0.12 | FALSE |
| 6 | GTEx | Cells EBV-transformed lymphocytes | CRYL1 | 0.27 | 0.00 | lasso | 11 | 0.00 | 3.4e-01 | -5.5 | -7.5 | 6.8e-14 | -0.57 | 0.04 | 0.46 | FALSE |
| 7 | GTEx | Esophagus Gastroesophageal Junction | IFT88 | 0.42 | 0.20 | lasso | 8 | 0.23 | 5.7e-09 | 5.3 | 5.4 | 6.9e-08 | 0.60 | 0.99 | 0.00 | FALSE |
| 8 | GTEx | Esophagus Muscularis | IFT88 | 0.38 | 0.26 | lasso | 4 | 0.25 | 1.4e-15 | 5.5 | 5.5 | 3.3e-08 | 0.61 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Heart Atrial Appendage | IFT88 | 0.36 | 0.28 | lasso | 4 | 0.28 | 4.7e-13 | 5.5 | 5.4 | 7.2e-08 | 0.60 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Heart Left Ventricle | IFT88 | 0.27 | 0.27 | lasso | 7 | 0.26 | 2.3e-14 | 5.3 | 5.3 | 9.9e-08 | 0.63 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Skin Not Sun Exposed Suprapubic | IFT88 | 0.12 | 0.08 | lasso | 5 | 0.05 | 1.4e-03 | 5.5 | 5.5 | 3.6e-08 | 0.63 | 0.37 | 0.15 | FALSE |
| 12 | GTEx | Skin Sun Exposed Lower leg | IFT88 | 0.10 | 0.06 | lasso | 4 | 0.06 | 1.7e-05 | 5.5 | 5.5 | 4.5e-08 | 0.63 | 0.95 | 0.02 | FALSE |
| 13 | METSIM | Adipose | IFT88 | 0.11 | 0.07 | bslmm | 543 | 0.07 | 3.9e-10 | 5.3 | 6.1 | 1.0e-09 | 0.56 | 1.00 | 0.00 | FALSE |
| 14 | YFS | Blood | IL17D | 0.02 | 0.02 | blup | 482 | 0.01 | 1.8e-04 | -5.5 | -7.6 | 2.6e-14 | -0.43 | 0.64 | 0.13 | TRUE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IFT88 | 0.06 | 0.04 | blup | 86 | 0.03 | 1.4e-07 | 4.3 | 5.7 | 1.4e-08 | 0.48 | 0.84 | 0.15 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IFT88 | 0.04 | 0.03 | blup | 83 | 0.03 | 2.2e-04 | 5.4 | 7.3 | 2.1e-13 | 0.58 | 0.03 | 0.91 | FALSE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | IFT88 | 0.11 | 0.10 | blup | 86 | 0.09 | 3.5e-10 | 5.5 | 7.2 | 5.4e-13 | 0.64 | 0.03 | 0.97 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | IFT88 | 0.05 | 0.00 | blup | 85 | 0.02 | 2.1e-03 | 4.7 | 7.3 | 2.2e-13 | 0.51 | 0.02 | 0.49 | FALSE |