Best TWAS P=5.42e-09 · Best GWAS P=3.13e-08 conditioned to 0.00409
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Coronary | TMTC4 | 0.22 | 0.12 | enet | 17 | 0.12 | 9.1e-05 | -4.8 | -5.2 | 2.6e-07 | -0.25 | 0.10 | 0.76 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Female) | TMTC4 | 0.26 | 0.09 | lasso | 6 | 0.09 | 9.5e-04 | -3.9 | -5.1 | 2.7e-07 | -0.21 | 0.08 | 0.24 | FALSE |
| 3 | GTEx | Esophagus Mucosa | TMTC4 | 0.20 | 0.11 | enet | 21 | 0.15 | 4.3e-10 | -5.2 | -5.8 | 6.0e-09 | -0.51 | 0.05 | 0.95 | FALSE |
| 4 | GTEx | Heart Atrial Appendage | TMTC4 | 0.23 | 0.12 | enet | 20 | 0.14 | 5.1e-07 | -3.8 | -5.8 | 8.3e-09 | -0.38 | 0.28 | 0.71 | FALSE |
| 5 | GTEx | Testis | GGACT | 0.26 | 0.16 | lasso | 6 | 0.26 | 7.2e-12 | 5.1 | 5.2 | 1.8e-07 | 0.78 | 0.02 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | A2LD1 | 0.10 | 0.15 | enet | 9 | 0.15 | 6.1e-17 | 5.3 | 5.5 | 4.6e-08 | 0.90 | 0.02 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Stomach Adenocarcinoma | TMTC4 | 0.07 | 0.00 | blup | 75 | 0.03 | 5.9e-03 | -3.9 | -5.8 | 5.4e-09 | -0.53 | 0.03 | 0.46 | TRUE |