TWAS hub - GGACT

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.2118	0.0812	5.1e-03	0.016	NA	0.127	NA	-0.007	8.5e-02	NA	2.6e-05	NA	7.1e-01
2	GTEx	Artery Tibial	0.1797	0.0619	3.1e-03	0.046	NA	0.061	NA	0.086	1.6e-04	NA	1.6e-05	NA	3.0e-07
3	GTEx	Brain Frontal Cortex BA9	0.3382	0.1027	5.6e-03	0.042	NA	0.131	NA	0.045	2.9e-02	NA	2.5e-04	NA	2.4e-02
4	GTEx	Cells Transformed fibroblasts	0.2580	0.0650	4.5e-06	0.055	NA	0.194	NA	0.200	5.6e-05	NA	1.8e-14	NA	5.5e-15
5	GTEx	Colon Sigmoid	0.2290	0.0940	3.6e-03	-0.006	NA	-0.005	NA	0.000	5.9e-01	NA	5.3e-01	NA	3.3e-01
6	GTEx	Muscle Skeletal	0.0764	0.0317	9.3e-03	0.034	NA	0.016	NA	0.023	2.5e-04	NA	9.5e-03	NA	2.3e-03
7	GTEx	Pancreas	0.2530	0.0740	1.7e-04	0.029	NA	0.115	NA	0.113	2.2e-02	NA	1.4e-05	NA	1.8e-05
8	GTEx	Skin Not Sun Exposed Suprapubic	0.1210	0.0470	5.5e-03	0.040	NA	0.072	NA	0.086	2.8e-03	NA	8.5e-05	NA	2.0e-05
9	GTEx	Skin Sun Exposed Lower leg	0.2220	0.0640	1.1e-04	0.062	NA	0.169	NA	0.149	7.6e-06	NA	5.8e-14	NA	2.2e-12
10	GTEx	Stomach	0.2100	0.0780	4.1e-03	0.009	NA	-0.005	NA	0.006	1.2e-01	NA	6.4e-01	NA	1.5e-01
11	GTEx	Testis	0.2590	0.0610	1.8e-06	0.159	NA	0.227	NA	0.259	1.5e-07	NA	2.0e-10	NA	7.2e-12
12	METSIM	Adipose	0.0947	0.0247	4.2e-09	0.028	0.073	0.073	0.06	0.083	4.1e-05	4.8e-11	4.1e-11	2.3e-09	1.8e-12

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Hair/balding pattern: Pattern 2	5.1	6.5	18.7	-4.1	-2.0	2.0	-0.9	-1.2	0.7	-4.3	-1.8	-2.7	-3.7	-2.0	-1.9
Hair/balding pattern: Pattern 3	3.8	5.7	23.1	3.4	1.4	-1.9	0.1	1.3	-2.0	4.8	1.0	2.2	3.7	1.1	1.6
Ever smoked	3.8	6.7	20.7	-3.2	-1.6	-0.6	-1.2	-0.7	-1.2	-4.5	-3.5	-2.1	-3.4	-3.6	-1.5
Smoking status: Previous	3.5	5.3	17.4	-3.2	-1.5	0.1	-1.0	-0.5	-0.2	-4.2	-3.0	-1.8	-3.1	-2.9	-1.5
Myopia	3.2	4.6	18.9	2.5	0.9	-1.4	-0.2	0.2	-1.2	4.3	2.3	1.4	3.8	1.9	0.6
Qualifications: College or University degree	3.1	9.8	27.1	3.6	1.1	1.8	1.8	1.7	2.4	5.2	4.1	2.4	3.9	4.4	2.0
Ulcerative Colitis	3.0	4.4	5.9	-2.3	-2.0	-0.9	-2.2	-2.4	-2.2	-1.8	-2.1	-2.0	-2.3	-2.3	-2.4
Past tobacco smoking	3.0	5.4	20.7	2.9	1.0	-0.2	0.6	0.1	0.8	4.5	3.4	1.4	3.0	3.3	0.9
Medication: Bendroflumethiazide	2.8	4.3	8.5	2.7	2.6	1.0	2.7	2.5	1.4	0.9	0.9	2.9	1.1	1.3	2.6
Relative age voice broke	2.7	4.1	10.3	-3.2	-2.6	-1.0	-2.2	-2.2	-0.6	-1.7	-1.6	-2.0	-1.9	-1.7	-2.3
Alcohol usually taken with meals	2.7	4.3	14.1	1.7	0.7	0.5	0.8	0.8	1.4	3.8	2.9	1.1	3.1	3.2	1.2
Guilty feelings	2.6	4.0	11.6	3.4	1.9	-1.4	1.1	1.3	-0.5	2.6	1.7	2.0	2.7	1.8	1.8
Fed-up feelings	2.3	4.1	7.4	2.6	2.3	1.0	2.0	2.6	-0.4	2.7	1.0	2.4	2.0	1.0	2.5
Smoking Status	2.2	5.3	17.9	-2.3	-0.0	-0.6	-0.4	-0.1	-2.7	-4.2	-3.4	-1.8	-2.6	-3.4	-0.4
Mouth/teeth dental problems: Dentures	2.1	3.6	8.4	-1.9	-1.0	-1.0	-1.7	-1.4	-2.9	-1.6	-2.7	-1.1	-1.9	-2.7	-1.5
Mouth/teeth dental problems: Mouth ulcers	2.1	3.4	5.7	2.1	1.5	1.9	1.6	1.2	1.6	2.1	2.2	1.8	1.7	2.4	1.5
Illnesses of father: High blood pressure	2.0	2.5	8.8	0.9	-0.0	1.2	0.9	0.4	3.0	1.3	2.3	2.0	0.4	2.5	0.5
Schizophrenia (2018)	1.9	4.0	6.6	2.0	2.3	0.1	2.5	2.6	1.8	1.0	1.8	2.3	1.5	2.2	2.4
Relative age of first facial hair	1.9	3.9	7.8	-1.9	-2.7	-0.2	-2.8	-2.8	-1.6	-1.3	-1.2	-2.2	-1.2	-1.2	-2.6
Number of children fathered	1.9	2.1	7.5	-0.2	-0.6	-0.9	-1.5	-1.7	-2.7	-0.7	-1.6	-1.4	-1.2	-1.7	-1.5
Chest pain or discomfort	1.9	2.7	10.7	-0.5	-1.4	-1.9	-2.2	-1.3	-3.3	0.2	-1.6	-1.5	0.3	-1.7	-1.4
Eye problems/disorders: None of the above	1.8	2.0	5.6	-1.8	-1.1	0.1	-0.9	-1.9	0.1	-1.7	-0.3	-2.0	-2.4	-0.7	-1.7
Qualifications: O levels/GCSEs or equivalent	1.7	2.7	6.2	2.2	0.7	0.1	0.7	0.4	1.2	2.3	2.5	1.6	2.1	2.5	0.8
Heart disease (mother)	1.7	2.0	5.0	-1.6	-1.6	-2.1	-1.7	-2.2	-1.0	0.5	-0.0	-1.4	-0.2	-0.6	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.0	9.2	-0.9	0.0	-1.3	-0.9	-0.7	-3.0	-1.5	-1.8	-0.2	-1.1	-1.9	-0.6
Medication: Paracetamol	1.7	2.6	6.7	2.5	1.7	0.2	1.5	1.7	-0.3	1.8	0.3	2.6	1.4	0.6	2.0
Pack years adult smoking proportion	1.6	2.4	5.0	-1.2	-1.9	-0.7	-1.8	-1.5	-1.0	-1.1	-1.5	-2.2	-1.8	-1.3	-1.9
Health satisfaction	1.6	2.0	5.9	1.8	0.8	-2.1	0.3	0.6	-0.4	2.4	1.1	0.9	2.4	0.9	1.1
Leg pain on walking	1.5	1.8	4.9	-0.7	-0.3	-1.4	-1.3	-1.1	-2.2	-1.3	-1.8	-1.0	-1.0	-2.0	-0.8
Commuting to job workplace: Cycle	1.5	1.8	4.7	1.8	0.1	2.2	0.8	1.0	1.9	0.6	1.3	1.0	1.1	1.9	0.7
Diabetes (mother)	1.4	1.8	6.6	-0.8	-0.6	-1.1	-1.1	-0.5	-2.6	-1.3	-2.0	-0.4	-1.1	-2.1	-0.7
Stomach or abdominal pain in last month	1.4	1.8	6.5	-0.3	-0.6	-0.8	-0.7	-0.3	-1.6	-0.9	-2.5	0.1	-2.0	-2.3	-0.7
High blood pressure (mother)	1.4	1.9	5.8	0.5	-0.3	1.7	0.5	0.4	2.0	1.0	2.4	1.4	0.9	2.4	-0.1
Qualifications: A levels/AS levels or equivalent	1.4	3.1	10.5	1.4	-0.2	0.4	0.2	-0.3	2.0	3.2	2.7	1.1	2.0	2.8	0.3
Comparative body size at age 10	1.4	3.8	11.4	1.0	0.5	1.8	1.1	0.2	2.1	2.3	3.3	0.8	2.5	3.4	1.1
Average weekly red wine intake	1.4	2.0	7.3	1.3	0.9	-0.6	0.6	0.2	0.4	1.8	1.9	1.4	2.7	1.9	1.1
Alcohol drinker status: Never	1.4	1.7	3.1	-0.2	-0.7	-1.8	-1.3	-1.5	-1.7	0.1	-1.5	-0.9	-1.4	-1.6	-1.3
Major Depression (MDD)	1.3	1.6	4.6	-1.6	-0.7	-0.8	-1.5	-1.0	-2.1	-0.9	-1.0	-1.5	-0.3	-1.3	-1.2
Hypothyroidism (self reported)	1.3	2.9	6.3	2.4	1.8	2.5	1.5	1.0	0.2	1.3	1.9	1.5	1.9	1.6	1.5
Sensitivity / hurt feelings	1.3	2.2	7.2	-1.3	-0.2	-2.2	-1.0	-1.0	-2.7	-0.9	-1.7	-0.9	-1.2	-2.0	-0.9
Townsend deprivation index at recruitment	1.3	1.8	6.5	0.4	1.7	-1.0	0.8	0.8	-2.6	-1.5	-1.6	1.2	-0.8	-1.3	1.0
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.2	5.9	2.4	1.9	-1.1	1.5	1.6	-0.3	1.4	0.8	1.3	1.3	0.9	1.9
Tense / ‘highly strung’	1.3	2.1	6.0	1.9	1.4	0.4	0.8	0.7	-1.5	2.4	1.4	1.6	1.8	1.3	1.1
Illnesses of father: None of the above (group 1)	1.3	1.6	5.5	1.9	1.1	-0.4	0.7	1.3	-0.6	2.3	0.6	0.6	1.9	0.7	1.3
Pack years of smoking	1.3	1.9	4.8	-1.1	-1.6	-0.6	-1.6	-1.2	-0.9	-1.0	-1.3	-2.2	-1.4	-1.1	-1.6
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	3.6	-1.9	-1.4	-1.5	-1.2	-0.9	-0.6	-0.9	-1.1	-0.2	-0.8	-1.2	-1.0
Number of live births	1.2	1.7	5.1	-0.7	0.4	-1.9	-0.2	-0.1	-1.5	-0.7	-2.2	0.5	-1.8	-2.3	-0.2
Standing height	1.2	12.4	27.2	3.4	2.1	-0.6	2.5	1.5	3.0	4.9	5.1	2.9	4.7	5.2	2.7
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	4.7	-1.7	-2.2	0.6	-1.8	-1.4	-0.0	-1.0	-0.8	-1.1	-0.4	-0.7	-1.5
Illnesses of siblings: Diabetes	1.2	1.4	5.2	-2.3	-1.3	-1.5	-1.0	-1.1	0.5	-1.4	-0.3	-1.2	-0.8	-0.6	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.7	1.0	1.2	1.9	1.4	1.5	0.8	0.1	0.8	1.2	0.5	1.0	1.1
Commuting to job workplace: Walk	1.2	1.3	4.4	0.9	1.2	0.1	1.1	0.8	0.0	2.1	1.5	0.9	1.2	1.3	1.1
Age started oral contraceptive pill	1.2	1.4	6.0	-0.4	-0.4	0.3	0.3	-0.0	2.4	1.6	1.8	0.0	1.3	1.8	0.2
Bipolar Disorder or Schizophrenia	1.1	2.7	6.7	1.3	2.2	-0.8	2.3	2.4	1.3	-0.3	0.2	2.6	-0.1	1.0	2.1
Schizophrenia (2014)	1.1	2.4	4.4	2.0	1.8	0.2	1.7	2.0	0.6	1.4	1.3	2.1	1.2	1.6	1.6
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.6	1.5	1.2	0.3	1.5	1.9	0.8	1.3	0.6	1.3	1.0	0.7	1.8
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	3.0	1.7	1.3	-1.1	1.1	1.3	0.1	0.8	0.3	1.5	1.6	0.4	1.7
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.2	1.0	0.1	0.5	0.7	0.6	1.8	0.6	1.4	1.6	1.4	1.6	0.9
Age at first live birth	1.1	1.9	5.2	-0.1	-0.5	1.9	0.4	0.6	2.3	1.3	2.0	-0.4	1.8	2.1	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.3	1.6	0.1	0.7	0.6	0.4	1.6	1.8	1.1	0.7	1.5	1.3	0.8
Average weekly beer plus cider intake	1.1	1.6	4.2	-0.1	0.9	1.2	1.1	1.5	0.3	-2.0	-1.6	0.5	-2.0	-1.3	0.5
Fractured/broken bones in last 5 years	1.1	1.5	3.2	-1.8	-1.4	-0.9	-1.1	-1.7	-0.2	-1.3	-0.4	-1.5	-1.1	-0.6	-1.4
Maternal smoking around birth	1.0	1.5	4.5	-0.5	0.5	-1.1	0.0	-0.3	-1.0	-1.4	-2.1	-0.4	-2.0	-2.1	-0.3
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	3.9	0.0	1.1	-2.0	0.5	0.4	-1.2	-1.0	-1.6	0.2	-0.9	-1.4	0.4
Mouth/teeth dental problems	1.0	1.6	6.3	0.7	1.0	-0.1	1.5	1.0	2.5	1.0	1.7	0.6	0.1	1.6	0.9
Diabetes (self-reported)	1.0	1.5	4.2	-1.1	-1.5	0.0	-1.6	-1.3	-1.6	-0.4	-1.2	-2.1	-0.1	-1.3	-1.0
Worrier / anxious feelings	1.0	1.9	4.0	-1.7	-0.7	-1.5	-1.1	-0.7	-2.0	-0.7	-1.9	-0.4	-1.5	-1.9	-1.0
Prospective memory result	1.0	1.3	3.5	1.0	-0.4	-0.0	-0.5	-1.3	0.4	1.7	1.9	0.7	1.7	1.3	-0.4
Pulse wave Arterial Stiffness index	1.0	1.2	3.1	1.5	0.9	-0.4	0.8	0.1	0.6	1.4	1.6	1.2	1.0	1.8	0.8
Leg fat-free mass (right)	1.0	5.2	11.6	2.0	0.9	-0.9	1.8	0.8	3.4	2.4	3.0	2.5	2.6	3.1	1.9
Breast cancer (self-reported)	1.0	1.2	3.8	-1.5	0.3	0.6	0.2	-0.2	-0.5	-1.6	-1.5	-0.8	-2.0	-1.6	-0.1
Leg predicted mass (right)	1.0	5.2	12.2	2.0	0.9	-0.9	1.8	0.8	3.5	2.4	3.0	2.5	2.5	3.2	1.9
Average weekly champagne plus white wine intake	1.0	1.3	4.4	-0.1	0.1	1.9	0.8	0.4	1.7	0.5	2.1	0.7	0.4	1.8	0.1
Age at First Birth	0.9	1.2	4.2	0.4	0.1	0.1	0.6	0.3	1.7	1.4	2.1	0.9	0.9	1.9	0.2
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.5	-1.0	-0.3	-0.7	-0.7	-0.4	-1.4	-1.6	-1.3	-0.6	-1.0	-1.6	-0.7
Diabetes (father)	0.9	1.1	3.4	-1.1	-1.8	1.4	-1.0	-0.8	1.2	-1.2	-0.4	-0.6	-1.0	-0.4	-1.1
Leg fat-free mass (left)	0.9	4.5	10.3	1.8	0.7	-1.1	1.6	0.6	3.2	2.3	2.9	2.4	2.4	3.0	1.6
Leg predicted mass (left)	0.9	4.8	10.6	1.8	0.7	-1.1	1.6	0.6	3.3	2.3	3.0	2.4	2.5	3.1	1.7
Pain all over the body in last month	0.9	1.0	2.2	0.6	1.1	-1.3	0.7	0.3	0.8	1.0	1.3	0.1	1.5	1.0	0.9
Trunk fat-free mass	0.9	5.2	11.9	2.0	1.0	-0.2	1.9	0.8	3.5	2.3	3.0	2.8	2.3	3.3	1.8
Happiness	0.9	1.1	4.0	0.4	0.3	-2.0	-0.4	0.7	-1.8	1.4	-1.3	0.4	0.7	-1.2	0.3
Trunk predicted mass	0.9	5.3	11.6	2.0	1.1	-0.3	1.9	0.8	3.4	2.4	3.0	2.8	2.4	3.4	1.8
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.5	0.5	1.5	-0.6	1.1	1.5	-0.6	-0.9	-1.1	1.6	-0.6	-0.9	1.2
Medication: Blood pressure	0.9	1.8	2.9	1.0	1.7	0.2	1.5	1.3	0.7	1.3	1.4	1.7	1.4	1.2	1.7
Depressed Affect (Nagel 2018)	0.8	1.6	3.5	1.5	1.6	0.7	1.0	1.9	-1.7	0.7	0.0	1.2	1.3	-0.1	1.7
Depression (Nagel 2018)	0.8	1.2	2.4	1.3	0.9	-0.0	1.2	1.5	1.2	1.3	0.7	1.2	0.7	0.7	1.6
Alzheimer’s Disease (including proxy)	0.8	1.2	3.9	-0.5	-1.6	-0.7	-1.6	-1.4	-0.7	-0.1	-0.3	-2.0	-0.2	-0.5	-1.4
Lupus	0.8	1.2	4.3	-0.3	0.5	-1.3	0.2	0.0	-0.1	-2.1	-1.7	0.7	-1.1	-1.6	0.2
Systolic blood pressure, automated reading	0.8	2.3	7.1	-1.0	-0.5	-1.2	-1.3	-0.9	-2.7	-1.7	-2.1	-0.6	-1.2	-2.3	-1.0
Supplements: Zinc	0.8	0.9	2.6	0.4	0.3	0.2	0.4	-1.0	1.6	0.7	1.5	1.3	0.1	1.6	-0.2
Medication: Co-codamol	0.8	0.9	1.9	1.3	1.3	-0.6	0.7	0.8	-1.4	0.3	-0.0	0.9	1.3	0.0	1.3
Time employed in main current job	0.8	1.0	3.1	-1.4	-0.6	0.2	-0.6	-1.0	0.1	-0.9	-1.0	-0.5	-1.8	-1.1	-1.2
High blood pressure (siblings)	0.8	1.2	3.2	1.1	-0.2	-0.3	-0.1	-0.5	0.0	1.7	1.5	1.2	1.6	1.8	0.0
Emphysema/chronic bronchitis	0.8	0.9	5.6	1.1	-0.5	-1.4	-0.6	-0.1	-0.7	1.0	0.3	0.2	2.4	0.4	0.4
Arm predicted mass (right)	0.8	3.9	10.7	1.5	0.9	-0.4	1.8	0.8	3.3	1.7	2.4	2.4	1.9	2.7	1.8
Family relationship satisfaction	0.8	1.0	3.8	1.5	0.3	-0.2	0.1	0.7	-0.7	1.7	0.6	0.7	1.9	0.7	0.6
Whole body fat-free mass	0.8	4.9	11.8	1.9	0.9	-0.7	1.8	0.7	3.4	2.2	2.8	2.7	2.3	3.1	1.7
Mood swings	0.8	1.5	7.9	-0.6	0.3	-0.7	-0.6	-0.2	-2.8	-0.5	-1.9	-0.3	-1.2	-1.9	-0.3
Osteoporosis (self-reported)	0.8	1.0	2.4	1.3	0.9	-0.3	0.6	1.0	-0.1	1.5	1.0	1.3	1.2	1.1	0.7
Whole body water mass	0.8	4.8	11.8	1.8	0.8	-0.6	1.8	0.7	3.4	2.3	2.8	2.6	2.3	3.1	1.7
Miserableness	0.8	1.5	4.1	1.4	1.0	2.0	0.9	1.5	-0.8	0.6	0.2	2.0	0.8	0.4	1.3
Basal metabolic rate	0.8	4.7	11.0	1.9	0.9	-1.0	1.8	0.9	3.3	2.1	2.7	2.6	2.3	2.9	1.8
Basal cell carcinoma (self-reported)	0.8	0.9	3.3	0.3	0.8	0.1	1.3	0.7	1.8	-1.6	0.4	0.8	-1.0	0.6	0.7
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.3	0.9	1.4	-0.5	1.0	1.3	-0.7	0.5	0.1	1.1	1.4	0.0	1.5
Bipolar Disorder (2018)	0.7	1.1	3.4	-0.4	0.5	-1.0	0.2	0.3	-0.4	-1.7	-1.8	0.9	-1.8	-1.2	0.1
Alzheimer’s Disease (in mother)	0.7	0.8	4.7	-0.2	-1.1	-0.2	-1.2	-0.6	-0.4	-0.1	0.5	-2.2	1.0	0.2	-0.8
Irritable Bowel Disease (IBD)	0.7	1.7	3.6	-1.9	-0.6	-0.3	-0.9	-1.4	-1.1	-1.3	-1.1	-1.5	-1.6	-1.5	-1.4
Ulcerative Colitis (UC)	0.7	1.3	3.8	-1.9	-0.6	-0.3	-0.8	-1.0	-1.1	-0.9	-1.2	-0.7	-1.5	-1.5	-1.2
Reaction Time	0.7	1.3	3.9	-1.2	-2.0	-0.9	-1.9	-0.8	-0.8	0.8	-0.5	-1.3	0.8	-0.4	-1.2
Height	0.7	12.8	25.5	2.8	2.9	-1.5	3.1	2.1	3.2	4.3	4.9	2.5	5.0	5.0	3.5
Respiratory disease	0.7	1.6	6.0	-1.0	-0.8	-2.5	-1.1	-1.0	-1.3	-0.6	-1.3	-1.6	-0.5	-1.5	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	2.7	1.3	0.8	-0.3	1.0	1.4	1.1	1.0	0.2	1.6	0.5	0.7	1.1
Medication: Atenolol	0.7	0.8	2.2	0.9	1.0	-0.6	0.8	1.1	-0.0	0.9	0.7	0.5	1.5	0.4	1.4
Had menopause	0.7	0.9	2.0	-1.1	-1.2	-1.3	-1.2	-1.2	0.2	0.1	0.2	-1.4	0.9	-0.1	-0.7
Father’s age at death	0.7	0.9	3.0	1.0	0.2	1.7	0.4	0.1	0.7	0.4	1.6	-0.4	0.5	1.7	0.1
Hair/balding pattern: Pattern 4	0.7	1.7	6.7	0.2	-0.4	2.6	0.7	0.3	2.5	-1.4	1.5	0.2	-0.4	1.5	0.0
Pulse wave reflection index	0.7	0.8	2.0	0.1	-1.0	0.9	-0.7	-1.0	0.4	0.9	1.3	-0.8	1.0	1.4	-0.8
Medication: Paracetamol	0.7	1.2	3.4	1.6	0.8	0.8	0.6	1.4	-0.6	1.5	-0.3	1.8	1.0	0.0	1.2
Medication: Ventolin 100micrograms inhaler	0.7	0.9	3.1	-0.2	-0.6	-1.8	-0.7	-0.9	-0.8	-1.5	-0.8	-1.2	-0.3	-0.9	-0.6
Chronic bronchitis/emphysema (mother)	0.7	0.9	2.7	-0.5	-0.4	0.0	-0.8	-0.0	-1.6	-1.2	-1.7	-0.2	-0.4	-1.4	-0.5
Number of full brothers	0.7	0.9	2.2	-1.3	-0.7	-0.3	-0.6	-0.4	0.0	-1.5	-1.4	-0.2	-1.2	-1.3	-0.5
Angina (self-reported)	0.7	0.9	2.8	0.4	0.5	-1.7	-0.4	0.8	-1.7	0.9	-0.6	0.5	1.4	-0.6	0.5
Medication: Seretide 50 evohaler	0.7	0.8	2.4	1.5	1.1	-1.3	0.6	0.4	-0.7	-0.0	0.6	0.9	1.0	0.6	0.8
Alcohol intake frequency.	0.7	1.6	4.7	-0.1	-0.8	-1.1	-1.0	-0.8	-1.1	-1.3	-2.2	-0.7	-1.5	-2.1	-0.7
Hearing aid user	0.7	0.8	3.0	1.2	0.5	-1.0	0.2	0.8	-0.1	1.6	0.5	-0.1	1.7	0.4	0.8
Arm fat-free mass (left)	0.7	3.5	9.2	1.4	0.7	-0.6	1.6	0.9	3.0	1.7	2.2	2.1	2.1	2.5	1.7
Schizophrenia vs Biploar Disorder	0.6	0.8	1.7	1.3	1.1	-0.2	0.8	0.2	0.5	0.9	1.3	0.4	1.2	1.2	0.0
Ovarian Cancer	0.6	0.8	3.1	-0.6	-1.0	-0.0	-1.3	-0.6	-1.8	0.1	-0.7	-1.1	0.6	-0.9	-0.7
HbA1C	0.6	0.6	1.5	0.6	0.7	-0.9	0.3	1.2	-0.4	0.2	-1.2	0.6	0.6	-0.9	1.1
Waist Hip Ratio (WHR)	0.6	2.7	9.7	-0.9	0.1	-0.2	-0.1	0.6	-1.5	-1.6	-3.1	-0.4	-2.8	-2.9	-0.4
Neuroticism	0.6	1.3	6.7	-0.6	0.9	-1.3	-0.0	0.5	-2.6	0.4	-1.5	0.4	-0.5	-1.8	0.3
Average weekly spirits intake	0.6	0.8	2.2	0.8	1.5	-0.8	0.9	0.7	-0.7	-1.0	-0.9	0.3	-0.9	-0.8	0.7
Angina	0.6	0.7	2.8	0.3	0.3	-1.7	-0.5	0.5	-1.6	0.7	-0.5	0.4	1.2	-0.5	0.3
Current tobacco smoking	0.6	1.0	6.7	-0.0	0.3	-0.6	-0.4	-0.5	-2.6	-0.7	-1.1	-0.7	-0.3	-1.3	0.0
Medication: Levothyroxine sodium	0.6	1.1	4.2	1.0	1.3	2.0	0.8	0.6	-0.6	0.6	1.3	0.5	1.0	1.0	0.8
Chronic bronchitis/emphysema (father)	0.6	0.8	2.1	0.1	0.7	-0.5	0.2	0.1	-0.6	-1.5	-1.2	1.1	-1.3	-1.2	0.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	3.3	-0.9	-0.7	-1.8	-0.8	-0.3	-0.7	0.2	-0.8	-0.7	-0.1	-1.0	-0.6
Qualifications: None of the above	0.6	1.2	3.1	-1.0	-0.3	-0.3	-0.7	-0.6	-1.4	-1.3	-1.5	-1.1	-1.4	-1.8	-0.8
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	4.6	-0.4	-0.4	-2.1	-0.5	-1.0	-0.5	-0.5	0.8	-0.5	0.4	0.7	-0.6
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	6.4	1.2	0.7	2.0	1.0	-0.3	1.4	1.5	2.5	1.3	0.4	2.4	0.2
Lung cancer (father)	0.6	0.7	1.9	0.6	1.2	0.3	1.3	0.4	1.2	-0.8	-0.0	1.4	-0.1	0.2	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	3.1	0.5	1.0	-0.6	0.4	0.8	-1.8	-0.6	-1.3	0.9	-0.4	-1.2	0.7
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	4.0	1.2	0.9	1.4	0.3	0.5	-0.9	1.0	1.5	-0.0	2.0	0.9	0.7
Arm fat-free mass (right)	0.6	3.1	9.6	1.4	0.6	-0.6	1.5	0.6	3.1	1.6	2.0	2.2	1.7	2.3	1.5
Wheeze or whistling in the chest in last year	0.6	1.1	8.3	-0.2	0.3	-2.9	0.0	0.2	-0.9	-0.4	-1.4	0.2	-0.5	-1.0	0.4
Pulse wave peak to peak time	0.6	0.7	1.8	-1.2	-0.7	0.3	-0.6	-0.0	-0.3	-1.1	-1.2	-0.9	-0.6	-1.4	-0.5
Neck or shoulder pain in last month	0.6	0.9	5.2	1.0	-0.1	-0.5	-0.7	-0.1	-1.3	2.3	0.3	0.7	1.1	-0.1	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.7	-0.9	-1.2	0.4	-1.3	0.1	-0.9	0.7	-1.0	-0.9	0.3	-1.0	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	4.6	0.3	-0.3	0.8	0.7	0.9	2.1	0.2	1.8	0.2	0.9	1.9	0.4
Loneliness, isolation	0.6	0.8	4.0	1.2	-0.2	-0.9	-0.5	0.2	-1.0	2.0	0.3	0.2	1.2	0.3	-0.0
Qualifications: nursing, teaching	0.6	0.9	3.3	0.3	-0.6	1.5	-0.3	-0.3	0.3	1.8	1.2	0.6	0.5	1.4	-0.4
Eye problems/disorders: Glaucoma	0.6	0.8	2.7	0.8	0.4	0.3	0.6	1.1	0.7	0.3	0.7	1.1	1.7	0.7	1.1
Ever had prostate specific antigen (PSA) test	0.6	0.7	3.8	0.4	0.7	-1.9	-0.1	0.1	-1.5	-0.3	-0.8	0.4	0.2	-0.8	0.3
Arm predicted mass (left)	0.6	3.3	9.1	1.4	0.6	-0.7	1.5	0.7	3.0	1.6	2.2	2.3	1.9	2.5	1.6
Alzheimer’s Disease (in father)	0.5	0.5	0.9	-0.5	-0.9	-1.0	-0.8	-0.9	0.1	0.1	-0.7	-0.6	-0.8	-0.6	-0.9
Verbal and Numeric Reasoning (VNR)	0.5	1.3	3.1	-1.0	-0.6	0.5	-0.9	-0.8	-1.2	-1.1	-1.8	0.2	-1.5	-1.7	-1.0
Breast Cancer	0.5	1.3	4.5	-0.5	-0.4	-1.5	-1.1	-1.4	-2.1	-0.3	-0.9	-0.5	-1.4	-1.0	-1.3
Primary Biliary Cirrhosis	0.5	0.8	1.5	-0.7	-0.7	-1.1	-0.9	-0.8	-0.9	-0.5	-0.9	-1.0	-0.8	-1.2	-0.9
Hand grip strength (left)	0.5	1.2	2.9	1.3	1.2	1.0	1.6	0.4	1.5	0.0	0.8	1.7	-0.5	1.1	0.8
Ever used hormone-replacement therapy (HRT)	0.5	0.7	2.2	0.3	-0.4	0.3	-1.1	-0.6	-1.5	1.3	0.3	-0.5	1.1	-0.0	-0.5
Ever had hysterectomy (womb removed)	0.5	0.5	3.2	0.2	0.3	0.9	0.7	0.5	1.8	-0.5	0.3	0.7	0.0	0.6	0.6
Medication for hormone replacement therapy	0.5	0.6	2.3	1.5	-0.0	0.7	-0.0	0.9	0.1	1.1	-0.1	0.5	1.1	0.2	0.6
Vitamin and mineral supplements	0.5	0.7	2.0	-0.8	-1.2	1.4	-0.9	-0.9	-0.5	-0.3	-0.1	-0.6	-0.7	-0.1	-1.3
Taking other prescription medications	0.5	0.7	4.6	0.5	1.2	-0.7	-0.0	0.1	-2.1	0.2	-0.8	0.2	0.2	-1.0	0.4
Age when periods started (menarche)	0.5	1.1	5.7	-0.4	-0.2	-2.4	-0.9	-1.5	-1.2	-0.4	-0.4	-0.7	-0.7	-0.9	-1.0
Qualifications: CSEs or equivalent	0.5	0.7	2.3	-0.2	0.3	1.1	0.9	0.9	1.1	-1.5	-0.5	0.5	-0.8	-0.3	0.7
Supplements: Glucosamine	0.5	0.6	3.2	0.1	0.3	0.2	0.1	0.6	0.5	1.8	0.9	0.6	1.3	0.8	0.3
Nervous feelings	0.5	0.9	2.2	0.6	0.9	0.4	1.3	1.3	1.5	0.6	0.5	1.4	-0.6	0.5	0.7
Forced vital capacity (FVC)	0.5	1.7	6.0	1.0	0.8	1.6	1.0	-0.5	1.3	1.1	2.4	0.9	0.2	2.4	0.2
Financial difficulties in last 2 years	0.5	0.7	3.1	-0.7	-0.4	-0.9	-0.3	-0.3	0.1	-1.8	-1.3	-0.2	-0.8	-1.1	-0.1
Heart attack	0.5	0.7	1.7	0.8	1.1	-0.7	0.7	1.0	-0.8	0.2	-0.0	0.8	1.3	-0.2	1.3
Allergy	0.5	1.2	6.4	-0.8	0.2	2.5	0.9	0.5	2.1	-0.3	0.8	-0.2	-0.6	1.0	0.2
Illnesses of siblings	0.5	0.7	1.8	0.0	0.4	1.3	0.2	0.3	-0.7	-1.1	-1.2	-0.8	-1.0	-1.0	0.1
Neuroticism score	0.5	1.0	3.0	1.1	1.2	0.3	0.5	1.2	-1.7	1.4	-0.1	1.4	0.7	-0.2	0.8
Medication: Lansoprazole	0.5	0.6	2.2	0.3	0.4	-0.2	0.2	0.7	-1.0	-0.4	-1.5	0.6	-0.6	-1.2	0.5
Length of working week for main job	0.5	0.6	2.1	-0.8	-0.8	-0.7	-0.1	-1.0	1.4	0.4	0.4	-0.7	-0.9	0.4	-0.6
Breastfed as a baby	0.5	0.7	2.1	-0.6	-0.8	-0.3	-0.5	-0.8	0.5	-0.5	1.0	-1.4	1.1	0.9	-0.4
Loud music exposure frequency	0.5	0.5	1.4	-1.2	-0.5	-0.8	-0.4	-0.9	0.4	-1.2	-0.2	-0.6	-0.7	-0.5	-0.7
Shortness of breath walking on level ground	0.5	0.6	2.3	0.3	0.7	-1.5	0.0	0.2	-1.2	-0.2	-1.2	-0.0	-0.3	-1.1	0.3
Medication: Blood pressure	0.5	0.9	2.4	0.9	0.3	1.0	0.6	0.9	0.7	0.7	1.0	1.0	1.5	1.0	0.9
Medication: Allopurinol	0.5	0.7	2.2	-1.0	-0.4	0.2	-0.6	-0.7	-0.8	-0.6	-0.9	-0.1	-1.5	-0.9	-1.1
Comparative height size at age 10	0.5	2.8	7.0	1.6	0.7	0.2	1.0	0.4	1.8	2.4	2.6	1.5	1.8	2.6	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.1	0.5	0.8	1.0	1.0	0.7	0.8	-0.5	-0.0	1.1	-0.0	0.3	1.0
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.7	0.7	-0.2	1.3	0.2	0.8	0.5	1.1	0.9	0.2	0.8	0.9	0.2
Commuting to job workplace: Public transport	0.5	0.6	2.3	0.4	0.9	-1.5	0.6	0.1	-0.3	-0.8	-0.8	0.5	-1.1	-0.5	0.2
High cholesterol (Self-reported)	0.5	0.9	1.8	1.3	1.2	0.5	1.3	0.8	0.7	-0.1	1.0	0.8	0.5	0.8	1.2
Number of operations (self-reported)	0.5	0.7	2.0	1.0	1.4	-0.6	0.6	0.6	-0.8	0.3	-0.5	1.0	0.7	-0.4	1.2
Diastolic blood pressure, automated reading	0.5	1.4	3.9	-0.6	-0.9	-0.1	-1.3	-1.5	-2.0	-1.5	-1.2	-0.4	-0.9	-1.4	-1.1
Unable to work because of sickness or disability	0.5	0.6	2.5	-0.2	-0.2	-1.5	-0.3	0.1	-0.3	-1.1	-1.6	0.1	-0.4	-1.2	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	3.1	-0.3	-0.1	0.9	0.4	0.6	1.8	0.8	0.6	1.1	0.3	0.8	0.4
Prostate Cancer	0.4	0.5	2.1	-1.2	0.2	-1.4	-0.1	0.2	-0.7	-0.3	-0.9	-0.2	-0.6	-1.1	-0.0
Body Mass Index (BMI) (2010)	0.4	0.6	5.2	0.0	0.0	-2.3	-0.1	0.7	0.1	-0.2	-0.4	-0.2	1.0	-0.5	0.5
Fasting Glucose	0.4	0.5	3.5	-0.7	-0.3	-1.9	-0.4	-0.2	-0.1	0.6	-0.5	-0.3	-0.3	-0.8	-0.3
Heel T-Score	0.4	3.4	11.2	1.4	0.0	2.8	0.8	-0.4	3.0	0.4	3.3	0.7	0.3	3.1	-0.1
Cardiovascular Disease	0.4	1.3	3.1	0.3	1.4	0.9	1.8	1.5	1.2	-0.8	0.4	1.7	-0.1	0.5	1.4
Number of treatments/medications taken	0.4	0.8	2.0	0.6	1.4	-0.6	0.8	1.2	-0.3	0.2	-0.3	1.3	0.9	-0.4	1.3
Impedance of leg (right)	0.4	2.0	6.5	-1.2	-0.6	0.5	-1.2	-0.5	-2.5	-1.3	-1.6	-1.8	-1.2	-1.7	-1.2
Hand grip strength (right)	0.4	1.2	2.8	1.0	1.3	0.2	1.5	-0.3	1.7	0.1	1.2	1.6	-0.4	1.5	0.7
Average weekly fortified wine intake	0.4	0.5	3.3	-0.0	-0.0	-1.8	-0.6	-0.6	-1.0	0.5	-0.1	-0.5	0.4	-0.2	-0.3
Serious illness, injury or assault to yourself	0.4	0.5	4.5	-0.1	0.0	-2.1	-0.2	-0.4	-0.3	-0.6	-0.5	-0.6	0.5	-0.5	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.7	0.1	-0.9	0.6	-0.7	-1.5	0.3	-0.1	1.6	-1.0	-0.1	1.2	-1.1
Weight	0.4	2.1	4.6	1.1	0.5	-2.0	1.0	0.7	2.1	1.3	1.5	1.4	2.0	1.5	1.4
Hip circumference	0.4	1.6	4.7	0.8	-0.3	-1.3	0.5	0.6	1.9	1.4	1.5	0.6	2.2	1.5	1.0
Pulse rate	0.4	0.6	1.4	-0.3	-0.7	-0.8	-0.8	-0.2	-1.0	-0.4	-1.1	0.4	-1.2	-1.1	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.4	0.1	-0.6	-1.0	-0.3	-1.2	0.9	-0.1	0.2	0.4	-0.6	0.3	-0.8
Illnesses of mother	0.4	0.5	1.5	0.8	1.2	0.2	0.9	0.7	-0.5	0.2	-0.7	0.2	-0.7	-0.6	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	4.1	0.5	0.1	2.0	0.4	-0.9	1.2	0.5	1.7	0.7	0.2	1.8	-0.2
Blood clot in the leg (DVT)	0.4	0.5	1.6	-0.2	0.8	-0.6	0.5	0.8	-0.3	-0.2	-1.2	0.2	-0.2	-1.2	0.9
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.6	-0.7	-0.3	-1.3	-0.7	-0.5	-1.1	0.3	-0.8	-0.7	-0.7	-0.8	-0.7
Gout (self-reported)	0.4	0.5	1.7	-0.1	0.5	0.8	0.1	0.3	-1.2	-1.3	-0.8	0.5	-0.6	-0.8	0.0
Medication for pain relief, constipation, heartburn	0.4	0.7	2.0	-0.1	-0.1	-1.2	0.1	-1.1	0.8	-1.2	0.5	-1.1	-1.4	0.5	-0.7
Mean time to correctly identify matches	0.4	0.8	1.7	-1.1	-1.0	-1.2	-1.3	-0.4	-1.1	0.7	-0.6	-0.5	0.8	-0.7	-0.6
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	2.6	0.0	0.9	1.6	0.6	0.9	-0.8	0.3	-0.0	-0.1	-0.3	-0.3	0.3
Knee pain experienced in last month	0.4	0.6	3.0	-0.4	-0.5	-0.3	-0.1	0.9	0.1	-1.7	-0.9	-0.4	0.5	-1.0	0.4
Diabetes diagnosed by doctor	0.4	0.7	2.8	-0.3	-0.7	-0.1	-1.0	-0.5	-1.7	0.2	-1.0	-1.0	0.2	-1.1	-0.4
Eye problems/disorders: Cataract	0.4	0.5	1.1	0.4	0.9	-0.3	0.5	1.0	-0.7	0.5	-0.7	1.1	0.5	-0.5	0.9
Medication for cholesterol	0.4	0.6	1.5	-0.8	-0.6	-0.5	-0.7	-1.0	-0.5	-0.9	-0.4	-1.2	-0.9	-0.6	-1.1
Asthma (self-reported)	0.4	0.9	4.3	0.1	-0.2	-2.1	-0.8	-0.8	-1.7	-0.0	-0.7	-0.7	-0.3	-0.9	-0.4
Smoking status: Current	0.4	0.6	5.0	0.2	0.5	-0.3	-0.1	0.0	-2.2	-0.6	-0.9	-0.2	0.0	-1.0	0.4
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.7	0.9	0.1	-0.1	0.1	0.1	0.4	0.6	1.0	0.3	1.3	0.9	0.3
Medication: Atorvastatin	0.4	0.5	1.3	0.6	0.9	0.1	0.5	0.7	-0.7	0.5	0.5	0.7	1.2	0.6	0.7
Supplements: Calcium	0.4	0.4	1.2	0.5	1.1	-0.8	0.9	0.5	-0.1	0.2	0.3	0.8	0.3	0.3	1.0
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.5	-0.3	0.8	-0.7	0.5	0.5	-0.2	-0.6	-1.1	0.2	-0.4	-1.2	0.8
Bipolar Disorder (2011)	0.3	0.3	1.4	0.1	0.0	0.0	0.7	0.9	0.0	-0.6	0.0	1.2	0.3	-0.1	0.0
Coronary Artery Disease (CAD)	0.3	0.4	1.9	0.2	0.5	-0.8	-0.1	-1.4	-0.6	-0.6	-0.1	0.0	-1.0	0.5	0.0
BMI	0.3	1.9	4.7	-1.3	-2.1	-0.6	-1.3	-1.1	1.3	-2.2	-1.1	-0.9	-1.3	-1.3	-1.3
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.5	0.1	-0.1	-0.5	-0.3	0.6	-0.9	1.2	-0.5	0.6	0.5	-0.4	0.2
Medication: Metformin	0.3	0.4	1.3	0.0	0.8	-0.1	0.4	-0.1	-0.5	-0.6	-0.9	0.4	-1.1	-0.7	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.1	0.5	-0.7	0.7	-0.4	-1.2	0.5	-0.0	1.4	-0.7	0.1	1.2	-0.8
Impedance of leg (left)	0.3	1.7	6.1	-0.8	-0.2	0.4	-0.8	0.2	-2.5	-1.4	-1.7	-1.7	-1.0	-1.8	-0.7
Number of incorrect matches in round	0.3	0.5	1.9	-0.2	-0.5	-1.4	-0.4	0.0	-0.3	-1.0	-0.8	-1.2	-0.2	-0.7	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.6	0.5	0.9	-1.3	0.4	0.5	-1.0	0.2	-0.3	1.2	0.2	-0.4	0.7
Noisy workplace	0.3	0.4	1.7	0.6	-0.7	0.1	-0.3	-0.5	0.9	1.3	0.6	-0.2	0.5	0.3	-0.2
Asthma	0.3	0.6	3.5	0.2	-0.0	-1.9	-0.5	-0.6	-1.3	0.0	-0.6	-0.5	-0.2	-0.7	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	3.0	0.3	-0.0	-1.7	-0.1	0.4	0.2	0.4	-0.2	0.7	0.9	0.1	0.3
Birth weight of first child	0.3	0.5	1.4	-0.8	-0.3	-0.2	-0.1	-1.2	0.7	-0.0	1.1	-0.6	-0.4	0.8	-0.7
Forced vital capacity (FVC), Best measure	0.3	1.1	3.2	0.3	-0.1	1.6	0.3	-1.3	1.2	0.4	1.8	0.6	-0.1	1.8	-0.4
Leg fat percentage (right)	0.3	1.0	3.4	-0.5	-0.0	-1.8	-0.2	0.3	-0.7	-1.4	-1.7	-0.2	-0.3	-1.8	0.2
Exposure to tobacco smoke outside home	0.3	0.5	2.4	0.9	0.9	-0.7	0.2	0.1	-1.5	0.5	-0.6	-0.1	-0.5	-0.5	0.1
Medication: Ibuprofen	0.3	0.4	2.2	0.4	0.3	-1.5	0.3	0.7	0.5	0.5	-0.1	0.7	0.7	0.2	0.6
Suffer from ‘nerves’	0.3	0.4	1.2	-0.6	0.6	1.1	0.6	0.3	-0.2	-0.7	0.0	0.9	-1.0	-0.1	0.1
Medication: Aspirin	0.3	0.4	1.5	-0.8	-0.2	-0.8	-0.6	-0.3	-1.2	0.1	-0.5	-0.5	0.8	-0.6	-0.1
Supplements: Vitamin C	0.3	0.3	1.2	0.3	0.2	-1.1	0.2	-0.3	0.5	0.7	0.6	0.2	0.8	0.6	0.3
Long-standing illness, disability or infirmity	0.3	0.4	2.0	0.2	-0.6	-1.4	-0.7	-0.1	-0.8	-0.2	-0.4	-0.5	0.8	-0.6	-0.2
Ever had bowel cancer screening	0.3	0.3	1.2	0.3	1.1	-1.1	0.4	0.0	-0.6	0.2	0.3	0.6	0.4	0.1	0.5
Friendships satisfaction	0.3	0.4	0.8	-0.0	-0.9	-0.7	-0.8	-0.2	-0.4	0.8	-0.9	0.4	-0.0	-0.4	-0.5
Medication: Aspirin	0.3	0.4	1.0	-1.0	-0.0	-1.0	-0.4	0.1	-1.0	-0.0	-0.8	-0.2	0.6	-0.8	0.2
Medication: Gliclazide	0.3	0.3	1.0	-0.9	-0.4	-1.0	-0.3	-0.3	0.0	-0.1	-0.7	-0.2	-0.7	-0.5	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	3.7	-0.3	-0.1	1.9	-0.3	-1.0	-0.1	-0.3	0.3	-0.3	-0.8	0.2	-0.7
Number of self-reported non-cancer illnesses	0.3	0.4	2.8	0.0	0.4	-0.3	-0.3	0.0	-1.7	-0.9	-0.4	-0.4	0.8	-0.7	0.3
Wears glasses or contact lenses	0.3	0.4	0.8	-0.9	-0.6	-0.4	-0.9	-0.5	-0.8	0.8	-0.6	-0.4	0.4	-0.6	-0.5
Mother’s age at death	0.3	0.4	3.1	-0.1	-0.4	1.8	0.1	0.7	0.6	0.1	-0.1	0.3	0.3	0.2	0.3
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.1	-0.1	-0.9	1.1	-0.6	-0.9	0.2	0.1	-0.2	-0.3	-0.8	-0.3	-0.7
Supplements: Fish oil (including cod liver oil)	0.3	0.5	1.8	0.0	-0.0	-0.1	-0.1	-0.3	0.2	1.3	1.2	0.0	0.8	1.2	-0.1
Leg fat percentage (left)	0.3	1.2	3.5	-0.3	0.3	-1.8	0.1	0.8	-0.8	-1.5	-1.8	-0.1	-0.2	-1.9	0.6
Irritability	0.3	0.5	2.8	0.9	0.2	1.0	-0.3	-0.0	-1.7	0.8	-0.1	0.0	0.6	-0.2	-0.0
Ever depressed for a whole week	0.3	0.4	1.5	-0.5	-0.4	0.3	-0.0	1.2	0.6	0.8	-0.7	0.1	0.6	-0.7	0.4
Cholesterol lowering medication	0.3	0.4	1.0	0.4	0.7	-1.0	0.3	0.4	-1.0	0.3	-0.4	0.7	0.6	-0.4	0.8
Neuroticism (Nagel 2018)	0.2	0.5	3.5	0.4	0.7	-0.3	0.1	0.5	-1.9	0.1	-0.7	0.6	-0.0	-0.7	0.4
Crohns Disease (2012)	0.2	0.3	0.9	0.8	0.9	-0.1	0.4	-0.6	0.0	0.6	0.7	-0.2	-0.2	0.6	-0.1
Mean Putamen Volume	0.2	0.2	1.1	0.6	0.1	1.1	0.3	0.6	0.2	0.2	0.5	-0.2	0.3	0.6	0.1
LDL Cholesterol	0.2	0.3	1.2	0.6	0.8	0.3	0.1	0.3	-1.1	-0.7	-0.3	0.2	0.3	-0.3	0.2
Blood Eosinophil Count	0.2	1.3	6.5	-1.3	-1.0	-2.5	-0.7	-1.1	1.1	-0.2	0.1	-1.7	0.5	-0.1	-0.5
Allergy or Eczema	0.2	0.6	5.0	0.8	0.3	-2.2	-0.0	0.2	-1.0	-0.3	-0.0	0.2	0.4	-0.1	0.2
Lung FVC	0.2	1.0	2.6	-0.6	-0.5	1.6	-0.7	-1.6	-0.1	-1.2	0.2	-0.7	-1.3	0.1	-1.4
Hearing difficulty/problems: Yes	0.2	0.3	1.1	0.7	-0.1	1.0	-0.3	0.0	-0.9	0.4	-0.3	-0.7	0.7	-0.2	0.1
Severe depression (siblings)	0.2	0.2	0.8	-0.1	-0.3	-0.9	-0.3	-0.8	-0.6	0.2	0.2	0.4	-0.7	0.2	-0.6
Trunk fat percentage	0.2	0.7	6.6	-0.3	-0.5	-2.6	-0.4	0.3	0.1	-0.1	-0.4	-0.3	0.8	-0.8	0.3
Hayfever, allergic rhinitis or eczema	0.2	0.5	2.8	0.5	-0.3	-1.7	-0.6	-0.2	-1.2	-0.1	-0.4	0.2	0.1	-0.4	-0.3
Sitting height	0.2	1.4	3.5	0.9	0.3	0.0	0.5	0.1	0.9	1.5	1.9	1.1	1.9	1.8	0.7
Trunk fat mass	0.2	0.8	6.2	0.3	-0.1	-2.5	0.1	0.5	0.9	0.5	0.4	0.5	1.3	0.1	0.7
Had other major operations	0.2	0.3	1.1	0.6	0.5	0.3	0.1	-0.4	-0.8	1.0	0.6	-0.1	0.0	0.4	-0.0
Medication: Ramipril	0.2	0.3	0.8	-0.3	0.1	-0.7	-0.4	0.1	-0.9	-0.4	-0.7	0.3	0.0	-0.9	-0.1
Medication: Simvastatin	0.2	0.2	0.8	0.2	0.5	-0.6	0.6	0.3	0.4	-0.7	-0.2	0.4	0.3	-0.3	0.9
Arm fat percentage (right)	0.2	0.9	5.5	-0.7	-0.7	-2.3	-0.6	0.1	-0.1	-0.9	-1.1	-0.3	0.0	-1.4	-0.1
Alcohol intake versus 10 years previously	0.2	0.4	1.1	-0.9	-1.0	-0.4	-0.6	-0.7	0.7	-0.4	0.3	-0.7	-0.1	0.0	-0.7
Medication: Cholesterol lowering	0.2	0.3	1.3	-0.0	0.2	1.0	0.5	0.1	0.8	-1.1	0.4	-0.0	0.0	0.2	0.4
Arm fat mass (right)	0.2	0.6	4.9	-0.1	-0.3	-2.2	0.1	0.5	1.1	-0.2	-0.2	0.4	0.7	-0.4	0.6
Exposure to tobacco smoke at home	0.2	0.2	2.1	1.4	0.5	0.3	0.4	0.1	0.0	0.2	0.2	0.4	0.0	0.4	0.1
Peak expiratory flow (PEF)	0.2	0.4	1.2	0.7	0.3	0.6	0.5	-0.3	0.1	0.8	1.1	1.1	-0.2	1.0	0.1
Headache pain in last month	0.2	0.4	1.0	0.1	-0.2	0.7	-0.4	-0.8	0.0	1.0	0.6	0.4	-0.8	0.4	-0.9
Medication: Amlodipine	0.2	0.3	1.8	-0.0	-0.2	1.3	0.3	0.0	1.0	-0.5	0.6	0.1	-0.1	0.6	-0.1
Birth weight	0.2	0.4	1.0	-0.9	-1.0	0.7	-0.4	-0.7	0.7	-0.5	0.4	-0.4	-0.6	0.4	-0.7
Body fat percentage	0.2	0.9	6.0	-0.5	-0.4	-2.5	-0.4	0.3	-0.4	-0.7	-1.0	-0.4	0.2	-1.3	0.2
Worry too long after embarrassment	0.2	0.3	1.8	0.3	-0.2	-1.3	-0.2	0.4	-0.5	0.9	-0.6	0.3	0.3	-0.6	0.1
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.6	-0.2	0.5	0.3	0.5	0.6	-0.5	-0.8	-0.4	0.2	0.1	-0.4	0.6
Migraine (self-reported)	0.2	0.3	1.0	-0.1	0.4	-0.5	0.2	-1.0	0.4	-0.6	0.5	-0.0	-1.0	0.4	-0.5
Medication: Omeprazole	0.2	0.3	1.3	-0.7	-0.4	0.7	-0.0	-0.0	1.2	0.0	0.1	1.0	-0.2	0.3	-0.1
Whole body fat mass	0.2	0.7	6.2	0.1	-0.2	-2.5	0.1	0.5	0.7	0.0	-0.2	0.4	0.8	-0.3	0.6
Pulse rate, automated reading	0.2	0.7	3.3	0.1	-0.3	0.7	-0.6	0.3	-1.8	-0.2	-1.2	-0.2	-0.6	-1.5	-0.3
Number of full sisters	0.2	0.2	1.2	-0.7	-0.6	0.0	-0.2	-0.4	-0.4	-1.1	-0.5	-0.2	-0.4	-0.4	-0.2
Age at last live birth	0.2	0.2	1.2	-0.3	-0.5	0.1	0.1	0.1	1.1	0.4	0.4	-0.1	0.7	0.6	0.2
Commuting to job workplace: Car/motor vehicle	0.2	0.3	1.2	-0.4	-0.4	1.1	0.1	0.7	0.8	-0.0	-0.3	-0.0	-0.5	-0.3	0.1
Illnesses of father: Heart disease	0.2	0.2	1.0	-0.9	-0.2	0.0	0.1	-0.4	0.6	-1.0	0.3	0.0	-0.6	0.2	-0.3
Arm fat percentage (left)	0.2	0.7	5.4	-0.4	-0.5	-2.3	-0.3	0.3	0.0	-0.7	-0.9	-0.1	0.2	-1.2	0.2
Mineral and other dietary supplements	0.2	0.3	1.0	0.3	0.1	0.6	0.3	0.3	-0.3	-1.0	-0.8	0.1	-0.6	-0.6	0.4
Financial situation satisfaction	0.2	0.2	2.3	0.2	0.2	-1.5	0.0	-0.1	0.5	0.2	-0.0	-0.1	0.3	0.0	0.2
Medication: Lisinopril	0.2	0.2	0.9	0.1	0.3	0.6	0.5	0.2	0.3	0.4	1.0	0.2	0.1	0.6	0.1
Risk taking	0.2	0.3	0.8	-0.4	-0.9	0.0	-0.7	-0.7	-0.3	-0.3	-0.3	-0.8	0.3	-0.0	-0.5
Heart disease (siblings)	0.2	0.2	0.7	-0.4	0.1	-0.9	0.4	0.3	0.8	-0.0	0.4	0.3	0.3	0.2	0.4
Alcohol drinker status: Previous	0.2	0.2	1.3	0.4	0.3	0.8	0.0	-0.5	-0.6	-1.1	-0.1	-0.2	-0.1	-0.1	-0.1
Leg fat mass (left)	0.2	0.6	4.2	0.2	0.2	-2.0	0.4	0.7	0.6	-0.4	-0.5	0.5	0.6	-0.5	0.9
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.9	-0.2	-0.4	0.9	-0.3	0.1	0.4	-0.2	-1.0	0.9	-0.5	-0.7	-0.1
Worry (Nagel 2018)	0.1	0.3	0.9	-0.7	-0.7	1.0	-0.5	-0.5	-0.2	0.8	0.4	0.1	-0.1	0.3	-0.6
Crohns Disease (2017)	0.1	0.1	0.4	-0.0	0.5	0.6	0.4	0.1	0.3	-0.6	0.1	-0.4	-0.2	-0.1	0.2
HDL Cholesterol	0.1	0.2	1.3	-0.3	-0.0	0.7	-0.1	0.2	0.0	-0.1	-1.1	0.1	-0.2	-0.6	0.1
Neuroticism (2016)	0.1	0.2	1.3	-0.5	0.2	-1.1	-0.0	-0.1	-0.0	0.7	0.0	0.0	-0.1	0.1	-0.2
Rheumatoid Arthritis	0.1	0.2	0.4	-0.3	-0.3	-0.2	-0.3	-0.1	-0.6	0.5	-0.7	0.4	-0.1	-0.6	-0.1
Triglycerides	0.1	0.2	0.5	0.6	0.3	0.2	0.4	0.6	0.1	0.3	0.7	-0.1	0.3	0.5	0.3
Blood Platelet Count	0.1	1.4	6.4	-1.1	-0.9	-0.5	-0.4	0.1	0.1	-2.5	-1.8	-0.4	-1.4	-1.5	-0.6
Blood White Count	0.1	1.0	2.8	0.8	0.9	-1.1	0.5	0.9	-1.1	-0.9	-1.6	0.3	-0.9	-1.7	0.5
Systolic Blood Pressure	0.1	0.5	1.4	0.4	0.6	-0.4	0.3	1.0	-1.2	0.1	-0.6	1.0	0.3	-0.5	0.7
Type 2 Diabetes (T2D) (2018)	0.1	0.3	0.9	0.6	-0.3	-0.2	-0.1	-0.2	0.3	0.7	0.7	-0.3	0.9	0.7	0.2
Lung FEV1/FVC ratio	0.1	0.5	1.5	0.9	-0.3	0.6	0.1	0.4	0.9	1.2	0.4	0.7	1.0	0.3	0.5
Chronotype (morning person)	0.1	0.1	0.6	0.0	-0.2	-0.7	-0.5	-0.8	-0.2	-0.1	-0.4	0.0	0.1	-0.3	-0.2
Hair Pigment	0.1	3.1	8.7	-1.8	0.1	-1.9	-0.2	-1.1	-1.4	-2.9	-2.0	-1.1	-2.6	-2.4	-0.7
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.7	-0.4	-0.0	-0.1	-0.0	-0.3	0.4	-0.8	-0.0	-0.4	-0.2	0.1	-0.0
High blood pressure	0.1	0.3	1.2	0.1	0.5	0.5	0.5	0.5	0.0	-0.6	0.5	0.6	1.1	0.3	0.8
Multivitamins +/- minerals	0.1	0.2	0.6	0.3	0.8	-0.1	0.5	0.4	0.1	-0.6	-0.3	0.2	0.0	-0.4	0.6
Body mass index (BMI)	0.1	0.6	3.2	-0.5	-0.5	-1.8	-0.1	0.2	0.8	-0.9	-0.9	0.1	-0.1	-1.0	0.2
Waist circumference	0.1	0.5	3.1	-0.4	-0.4	-1.8	-0.1	0.5	0.5	-0.3	-1.0	0.2	-0.1	-1.1	0.3
Hearing difficulty/problems with background noise	0.1	0.2	0.7	0.1	-0.3	-0.4	-0.4	-0.5	-0.6	-0.5	-0.7	-0.6	0.3	-0.8	-0.0
Fluid intelligence score	0.1	0.3	1.2	0.4	0.1	1.1	0.0	-0.0	0.3	0.9	-0.1	1.0	-0.2	0.1	-0.3
Impedance of arm (right)	0.1	0.4	1.6	0.3	0.1	-0.4	-0.4	0.4	-1.3	0.6	0.6	-0.8	1.1	0.2	-0.1
Falls in the last year	0.1	0.1	1.2	0.1	-0.0	1.1	0.1	0.1	-0.0	-0.3	0.3	-0.4	0.2	0.2	0.0
Depression (self-reported)	0.1	0.1	0.8	-0.1	0.2	-0.7	0.0	0.1	-0.1	-0.9	-0.3	0.5	-0.2	-0.3	-0.1
Impedance of arm (left)	0.1	0.6	2.2	0.6	0.5	-0.7	-0.1	0.6	-1.0	1.1	0.9	-0.6	1.5	0.5	0.2
Glaucoma (self-reported)	0.1	0.2	1.1	-0.1	-0.5	0.2	-0.5	-0.2	-0.0	-0.1	0.5	0.0	1.0	0.3	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.4	0.6	0.1	-0.1	-0.2	-0.3	-0.6	-0.5	-0.4	0.5	-0.6	-0.5	-0.2
Leg fat mass (right)	0.1	0.6	4.2	0.1	0.1	-2.1	0.3	0.5	0.5	-0.3	-0.5	0.5	0.5	-0.5	0.8
Overall health rating	0.1	0.3	1.5	0.6	-0.0	-1.2	-0.1	0.3	-0.7	0.1	-0.6	-0.1	0.8	-0.4	0.4
Had major operations	0.1	0.2	1.0	0.5	1.0	-0.1	0.5	-0.2	0.2	-0.3	0.1	0.4	0.0	0.1	0.4
Hypertension (Self-reported)	0.1	0.4	1.1	0.1	0.5	0.7	0.6	0.5	0.3	-0.3	0.7	0.8	1.0	0.6	0.8
Back pain experienced in last month	0.1	0.1	0.4	0.5	-0.0	-0.3	0.0	0.3	-0.3	0.2	-0.6	0.5	0.4	-0.2	0.5
Osteoarthritis (self-reported)	0.1	0.1	0.4	-0.6	-0.5	0.0	-0.3	-0.2	0.5	-0.4	-0.2	-0.2	-0.2	-0.1	-0.4
Arm fat mass (left)	0.1	0.6	4.8	-0.1	-0.2	-2.2	0.1	0.5	0.9	-0.2	-0.3	0.4	0.7	-0.5	0.6
Ever taken oral contraceptive pill	0.1	0.1	0.4	0.6	-0.6	-0.2	-0.2	0.3	0.4	-0.3	-0.3	0.2	-0.4	-0.1	-0.3
Vascular/heart problems diagnosed by doctor	0.1	0.2	1.0	0.2	-0.4	-0.2	-0.4	-0.4	0.1	0.5	-0.4	-0.3	-1.0	-0.1	-0.7
Pain experienced in last month	0.1	0.2	1.0	-0.4	-0.0	1.0	0.3	-0.1	0.6	0.1	0.2	-0.2	-0.6	0.6	-0.2
Impedance of whole body	0.1	0.5	3.4	-0.2	0.0	0.0	-0.5	0.4	-1.9	0.0	-0.2	-1.3	0.3	-0.5	-0.3
Blood Red Count	0.0	0.2	1.2	0.3	0.1	-0.6	-0.1	-0.1	-0.4	-0.1	-0.0	-0.1	-1.1	-0.2	-0.5
Tanning	0.0	0.3	1.6	-1.3	-0.1	-0.3	0.1	-0.0	0.6	-0.7	0.6	-0.9	-0.5	0.4	-0.4

Hub : Genes

GGACT

Models

Trait associations