Best TWAS P=6.77e-17 · Best GWAS P=4.99e-17 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | VPS13C | 0.08 | 0.04 | lasso | 2 | 0.02 | 1.3e-02 | -6.2 | 6.2 | 4.2e-10 | -0.69 | 0.21 | 0.56 | FALSE |
2 | GTEx | Adipose Visceral Omentum | VPS13C | 0.16 | 0.06 | enet | 15 | 0.05 | 9.2e-04 | 7.0 | 5.9 | 4.8e-09 | -0.64 | 0.43 | 0.33 | FALSE |
3 | GTEx | Skin Sun Exposed Lower leg | VPS13C | 0.09 | 0.09 | lasso | 2 | 0.08 | 1.8e-07 | 6.8 | 7.0 | 3.2e-12 | -0.82 | 0.39 | 0.61 | FALSE |
4 | GTEx | Spleen | VPS13C | 0.27 | 0.19 | lasso | 7 | 0.12 | 6.6e-04 | 6.5 | 6.9 | 6.2e-12 | -0.80 | 0.32 | 0.44 | FALSE |
5 | GTEx | Whole Blood | VPS13C | 0.09 | 0.00 | enet | 35 | 0.00 | 1.9e-01 | -7.9 | 7.1 | 8.8e-13 | -0.59 | 0.11 | 0.70 | FALSE |
6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C2CD4A | 0.03 | 0.01 | blup | 59 | 0.02 | 7.2e-03 | -7.9 | -5.9 | 4.7e-09 | 0.82 | 0.02 | 0.72 | FALSE |
7 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C2CD4A | 0.09 | 0.11 | lasso | 1 | 0.08 | 9.4e-04 | -8.4 | -8.4 | 6.8e-17 | 0.99 | 0.01 | 0.89 | TRUE |
8 | The Cancer Genome Atlas | Thyroid Carcinoma | VPS13C | 0.07 | 0.03 | enet | 15 | 0.03 | 5.3e-04 | -8.4 | 6.0 | 1.8e-09 | -0.73 | 0.02 | 0.93 | FALSE |