Best TWAS P=2.28e-21 · Best GWAS P=3.98e-24 conditioned to 2.78e-10
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TNFAIP8L3 | 0.12 | 0.07 | blup | 462 | 0.09 | 1.2e-10 | -9.2 | -9.5 | 2.3e-21 | 0.28 | 0.96 | 0.03 | TRUE |
| 2 | GTEx | Brain Putamen basal ganglia | LYSMD2 | 0.18 | 0.04 | lasso | 4 | 0.01 | 1.4e-01 | -6.6 | -6.2 | 4.5e-10 | 0.65 | 0.07 | 0.24 | FALSE |
| 3 | GTEx | Lung | SPPL2A | 0.08 | 0.08 | lasso | 4 | 0.07 | 6.0e-06 | 5.0 | 5.2 | 1.9e-07 | -0.12 | 0.77 | 0.01 | FALSE |
| 4 | GTEx | Muscle Skeletal | AP4E1 | 0.17 | 0.08 | lasso | 9 | 0.11 | 9.1e-11 | -7.4 | -5.5 | 4.3e-08 | 0.19 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Nerve Tibial | GLDN | 0.10 | 0.06 | lasso | 4 | 0.04 | 4.7e-04 | -9.2 | 8.8 | 2.0e-18 | -0.46 | 0.56 | 0.10 | TRUE |
| 6 | YFS | Blood | LYSMD2 | 0.07 | 0.00 | blup | 461 | 0.02 | 1.6e-06 | -3.3 | 5.4 | 6.0e-08 | -0.41 | 0.44 | 0.05 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | AP4E1 | 0.02 | 0.02 | lasso | 3 | 0.01 | 9.5e-04 | 5.0 | 5.3 | 1.4e-07 | -0.11 | 0.59 | 0.01 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | AP4E1 | 0.04 | 0.01 | enet | 20 | 0.02 | 2.2e-03 | 6.9 | 7.8 | 5.2e-15 | -0.23 | 0.01 | 0.84 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TNFAIP8L3 | 0.03 | 0.00 | blup | 41 | 0.01 | 8.3e-03 | 5.4 | 6.8 | 1.1e-11 | -0.28 | 0.01 | 0.31 | FALSE |
| 10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LOC100132724 | 0.03 | 0.01 | blup | 31 | 0.01 | 1.9e-02 | 6.9 | 6.7 | 2.6e-11 | -0.14 | 0.07 | 0.07 | FALSE |
| 11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | AP4E1 | 0.09 | 0.01 | enet | 8 | 0.03 | 6.5e-04 | -9.2 | 8.1 | 4.3e-16 | -0.32 | 0.00 | 0.98 | FALSE |