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chr15:50,301,649-52,733,671

Best TWAS P=2.28e-21 · Best GWAS P=3.98e-24 conditioned to 2.78e-10

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TNFAIP8L3	0.12	0.07	blup	462	0.09	1.2e-10	-9.2	-9.5	2.3e-21	0.28	0.96	0.03	TRUE
5	GTEx	Nerve Tibial	GLDN	0.10	0.06	lasso	4	0.04	4.7e-04	-9.2	8.8	2.0e-18	-0.46	0.56	0.10	TRUE
11	The Cancer Genome Atlas	Prostate Adenocarcinoma	AP4E1	0.09	0.01	enet	8	0.03	6.5e-04	-9.2	8.1	4.3e-16	-0.32	0.00	0.98	FALSE
8	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AP4E1	0.04	0.01	enet	20	0.02	2.2e-03	6.9	7.8	5.2e-15	-0.23	0.01	0.84	FALSE
9	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TNFAIP8L3	0.03	0.00	blup	41	0.01	8.3e-03	5.4	6.8	1.1e-11	-0.28	0.01	0.31	FALSE
10	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC100132724	0.03	0.01	blup	31	0.01	1.9e-02	6.9	6.7	2.6e-11	-0.14	0.07	0.07	FALSE
2	GTEx	Brain Putamen basal ganglia	LYSMD2	0.18	0.04	lasso	4	0.01	1.4e-01	-6.6	-6.2	4.5e-10	0.65	0.07	0.24	FALSE
4	GTEx	Muscle Skeletal	AP4E1	0.17	0.08	lasso	9	0.11	9.1e-11	-7.4	-5.5	4.3e-08	0.19	1.00	0.00	FALSE
6	YFS	Blood	LYSMD2	0.07	0.00	blup	461	0.02	1.6e-06	-3.3	5.4	6.0e-08	-0.41	0.44	0.05	FALSE
7	The Cancer Genome Atlas	Breast Invasive Carcinoma	AP4E1	0.02	0.02	lasso	3	0.01	9.5e-04	5.0	5.3	1.4e-07	-0.11	0.59	0.01	FALSE
3	GTEx	Lung	SPPL2A	0.08	0.08	lasso	4	0.07	6.0e-06	5.0	5.2	1.9e-07	-0.12	0.77	0.01	FALSE