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chr15:63,099,535-67,736,023

Best TWAS P=1.69e-13 · Best GWAS P=5.38e-18 conditioned to 3.4e-12

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DENND4A	0.06	0.05	enet	18	0.05	7.1e-07	6.8	6.2	5.3e-10	0.06	0.03	0.97	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SLC24A1	0.05	0.03	lasso	7	0.03	3.0e-04	6.7	6.1	9.1e-10	0.04	0.03	0.96	FALSE
3	CommonMind	Brain Pre-frontal Cortex	TIPIN	0.21	0.22	lasso	11	0.22	5.3e-26	-5.4	-5.3	1.2e-07	0.02	1.00	0.00	FALSE
4	GTEx	Adipose Subcutaneous	TIPIN	0.34	0.38	lasso	9	0.38	2.7e-32	-5.3	-5.4	5.2e-08	0.01	1.00	0.00	FALSE
5	GTEx	Adipose Subcutaneous	RPL9P25	0.15	0.04	lasso	7	0.06	6.0e-06	-4.4	-5.4	5.5e-08	-0.01	0.58	0.02	FALSE
6	GTEx	Artery Aorta	TIPIN	0.44	0.38	lasso	9	0.40	8.8e-24	-5.3	-5.6	2.5e-08	0.01	1.00	0.00	FALSE
7	GTEx	Artery Tibial	DENND4A	0.05	0.01	enet	8	0.02	8.3e-03	5.7	6.3	2.3e-10	0.04	0.04	0.90	FALSE
8	GTEx	Brain Caudate basal ganglia	TIPIN	0.44	0.34	enet	8	0.34	1.5e-10	-5.3	-5.3	9.4e-08	0.03	0.99	0.00	FALSE
9	GTEx	Brain Cerebellar Hemisphere	TIPIN	0.27	0.23	lasso	10	0.20	5.7e-06	-5.4	-5.3	1.2e-07	0.01	0.54	0.03	FALSE
10	GTEx	Brain Cerebellar Hemisphere	IGDCC4	0.19	0.12	lasso	7	0.10	1.2e-03	6.6	-6.2	7.4e-10	-0.05	0.04	0.92	FALSE
11	GTEx	Brain Cerebellum	TIPIN	0.32	0.15	lasso	7	0.14	8.3e-05	-5.3	-5.3	1.4e-07	0.01	0.76	0.01	FALSE
12	GTEx	Brain Frontal Cortex BA9	TIPIN	0.28	0.28	lasso	7	0.26	1.4e-07	-5.3	-5.3	1.2e-07	0.01	0.86	0.01	FALSE
13	GTEx	Brain Hippocampus	TIPIN	0.36	0.18	enet	37	0.18	5.8e-05	-5.3	-6.0	2.1e-09	0.04	0.39	0.21	FALSE
14	GTEx	Brain Hypothalamus	TIPIN	0.41	0.34	lasso	9	0.35	3.8e-09	-5.3	-5.2	1.7e-07	0.01	0.96	0.00	FALSE
15	GTEx	Brain Nucleus accumbens basal ganglia	DENND4A	0.16	0.09	lasso	4	0.06	8.8e-03	5.5	5.6	1.9e-08	0.02	0.08	0.36	FALSE
16	GTEx	Breast Mammary Tissue	TIPIN	0.35	0.30	enet	29	0.33	2.3e-17	-5.3	-6.1	1.1e-09	-0.01	1.00	0.00	FALSE
17	GTEx	Breast Mammary Tissue (Male)	TIPIN	0.44	0.10	lasso	24	0.16	1.4e-04	-5.3	-7.4	1.7e-13	-0.18	0.18	0.38	TRUE
18	GTEx	Cells Transformed fibroblasts	TIPIN	0.11	0.02	lasso	4	0.02	1.0e-02	-4.4	-5.7	1.3e-08	0.02	0.23	0.03	FALSE
19	GTEx	Cells Transformed fibroblasts	DENND4A	0.08	0.06	lasso	2	0.04	3.3e-04	6.6	-6.6	3.0e-11	-0.06	0.03	0.96	FALSE
20	GTEx	Colon Sigmoid	TIPIN	0.53	0.40	lasso	6	0.38	2.0e-14	-5.4	-5.6	2.8e-08	0.04	1.00	0.00	FALSE
21	GTEx	Colon Transverse	TIPIN	0.18	0.04	lasso	9	0.11	5.4e-06	-4.4	-5.7	9.7e-09	0.01	0.42	0.07	FALSE
22	GTEx	Esophagus Muscularis	TIPIN	0.41	0.31	lasso	13	0.37	8.6e-24	-5.3	-5.9	4.8e-09	0.01	1.00	0.00	FALSE
23	GTEx	Heart Left Ventricle	TIPIN	0.39	0.40	lasso	10	0.46	1.3e-26	-5.4	-5.8	7.5e-09	0.01	1.00	0.00	FALSE
24	GTEx	Lung	TIPIN	0.25	0.18	enet	24	0.18	1.8e-13	-5.3	-5.7	1.2e-08	-0.01	1.00	0.00	FALSE
25	GTEx	Muscle Skeletal	TIPIN	0.16	0.10	lasso	6	0.14	3.9e-13	-5.3	-5.9	4.7e-09	0.02	1.00	0.00	FALSE
26	GTEx	Nerve Tibial	TIPIN	0.48	0.52	lasso	5	0.53	1.6e-43	-5.3	-5.3	1.2e-07	0.02	1.00	0.00	FALSE
27	GTEx	Pancreas	TIPIN	0.45	0.41	enet	29	0.41	1.1e-18	-5.3	-5.6	2.5e-08	0.02	1.00	0.00	FALSE
28	GTEx	Pituitary	TIPIN	0.61	0.56	lasso	11	0.56	1.2e-16	-5.3	-5.4	7.3e-08	0.01	1.00	0.00	FALSE
29	GTEx	Prostate	TIPIN	0.36	0.26	lasso	10	0.23	1.8e-06	-5.3	-5.3	1.0e-07	0.01	0.68	0.02	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	TIPIN	0.40	0.39	lasso	5	0.39	5.7e-23	-5.4	-5.3	9.6e-08	0.03	1.00	0.00	FALSE
31	GTEx	Skin Sun Exposed Lower leg	TIPIN	0.31	0.35	lasso	10	0.36	1.2e-30	-5.4	-5.5	4.6e-08	0.02	1.00	0.00	FALSE
32	GTEx	Spleen	RPL9P25	0.30	0.16	lasso	4	0.10	1.8e-03	-4.4	-5.2	1.7e-07	-0.06	0.09	0.09	FALSE
33	GTEx	Stomach	TIPIN	0.43	0.22	lasso	15	0.22	8.2e-11	-5.3	-5.2	1.5e-07	0.03	1.00	0.00	FALSE
34	GTEx	Testis	TIPIN	0.37	0.35	enet	13	0.38	1.2e-17	-5.3	-5.3	1.4e-07	0.02	1.00	0.00	FALSE
35	GTEx	Thyroid	TIPIN	0.49	0.60	lasso	14	0.60	4.1e-57	-5.3	-5.4	6.8e-08	0.01	1.00	0.00	FALSE
36	GTEx	Uterus	TIPIN	0.44	0.35	lasso	14	0.31	3.5e-07	-5.3	-5.4	7.1e-08	0.01	0.58	0.02	FALSE
37	GTEx	Vagina	TIPIN	0.31	0.29	enet	26	0.25	1.7e-06	-5.3	-5.5	2.9e-08	0.03	0.71	0.02	FALSE
38	GTEx	Whole Blood	ANKDD1A	0.14	0.07	enet	33	0.06	4.6e-06	2.3	6.3	2.4e-10	0.07	0.96	0.02	TRUE
39	METSIM	Adipose	TIPIN	0.16	0.16	blup	524	0.16	1.7e-23	-5.3	-6.0	1.9e-09	-0.05	1.00	0.00	FALSE
40	NTR	Blood	USP3	0.02	0.02	enet	4	0.02	5.4e-07	6.6	6.7	2.2e-11	-0.02	0.00	1.00	TRUE
41	The Cancer Genome Atlas	Breast Invasive Carcinoma	DENND4A	0.01	0.01	blup	68	0.01	7.5e-03	6.0	-6.3	3.4e-10	-0.04	0.02	0.28	FALSE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	DPP8	0.08	0.02	lasso	4	0.05	6.1e-10	5.5	-5.6	2.2e-08	-0.01	0.16	0.84	FALSE
43	The Cancer Genome Atlas	Glioblastoma Multiforme	TIPIN	0.39	0.17	enet	15	0.22	1.9e-07	-5.3	-6.2	7.3e-10	-0.02	0.01	0.98	FALSE
44	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DENND4A	0.04	0.01	blup	68	0.01	8.0e-03	-3.0	-5.5	3.8e-08	-0.05	0.04	0.09	FALSE
45	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PTPLAD1	0.05	0.01	enet	10	0.02	4.3e-03	-3.0	-5.4	5.9e-08	-0.03	0.04	0.17	FALSE
46	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAP2K1	0.13	0.12	blup	55	0.12	3.1e-13	-5.4	-5.3	1.3e-07	0.03	0.01	0.99	FALSE
47	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TIPIN	0.15	0.18	lasso	8	0.18	2.7e-10	-5.3	-5.1	2.7e-07	0.02	0.01	0.99	FALSE
48	The Cancer Genome Atlas	Lung Adenocarcinoma	SMAD3	0.06	0.06	lasso	2	0.06	2.5e-07	5.4	5.2	2.3e-07	0.02	0.90	0.04	TRUE
49	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	DENND4A	0.04	0.02	blup	67	0.02	1.3e-02	5.5	-6.7	2.4e-11	-0.05	0.02	0.58	TRUE
50	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	DPP8	0.07	0.03	blup	53	0.01	5.4e-02	-2.9	-5.2	2.0e-07	-0.05	0.01	0.25	FALSE
51	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TIPIN	0.40	0.39	lasso	9	0.39	9.9e-17	-5.3	-5.3	1.4e-07	0.01	0.01	0.99	FALSE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	DPP8	0.08	0.08	lasso	4	0.07	1.6e-07	5.5	-5.2	2.4e-07	-0.01	0.72	0.27	FALSE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	TIPIN	0.33	0.36	lasso	10	0.36	1.3e-38	-5.2	-5.4	8.0e-08	0.02	0.01	0.99	FALSE
54	The Cancer Genome Atlas	Rectum Adenocarcinoma	DENND4A	0.17	0.08	blup	68	0.07	1.0e-02	5.5	-5.3	1.5e-07	-0.05	0.04	0.56	FALSE
55	The Cancer Genome Atlas	Testicular Germ Cell Tumors	DENND4A	0.09	0.05	lasso	4	0.03	3.3e-02	6.6	-6.6	5.6e-11	-0.06	0.02	0.63	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	TIPIN	0.46	0.50	lasso	6	0.53	7.8e-60	-5.3	-5.5	3.2e-08	0.02	0.01	0.99	FALSE