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chr15:98,493,891-102,400,037

Best TWAS P=9.52e-33 · Best GWAS P=3.16e-48 conditioned to 0

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Adipose Visceral Omentum	CTD-3076O17.1	0.21	0.00	lasso	6	0.00	6.2e-01	-7.59	-11.9	9.5e-33	-0.08	0.10	0.20	TRUE
3	GTEx	Adipose Visceral Omentum	ADAMTS17	0.20	0.00	enet	20	0.05	2.2e-03	-8.01	-10.1	8.7e-24	0.05	0.10	0.26	TRUE
1	GTEx	Adipose Subcutaneous	ADAMTS17	0.14	0.00	enet	19	0.02	5.0e-03	10.74	-10.0	1.2e-23	-0.06	0.23	0.03	TRUE
12	GTEx	Heart Atrial Appendage	ADAMTS17	0.22	0.00	lasso	4	0.09	9.6e-05	-5.92	-8.8	2.1e-18	-0.05	0.10	0.18	TRUE
13	GTEx	Heart Atrial Appendage	CTD-3076O17.1	0.25	0.11	enet	24	0.17	3.8e-08	-5.97	-7.9	4.0e-15	-0.05	0.71	0.02	TRUE
20	YFS	Blood	IGF1R	0.14	0.09	enet	25	0.12	6.8e-36	7.12	-6.9	4.4e-12	0.02	1.00	0.00	TRUE
6	GTEx	Breast Mammary Tissue (Female)	CTD-3076O17.1	0.29	-0.01	lasso	5	0.00	3.2e-01	-7.76	-6.8	1.4e-11	-0.05	0.07	0.05	TRUE
10	GTEx	Esophagus Mucosa	CTD-3076O17.1	0.28	0.10	lasso	6	0.11	4.7e-08	-7.63	-6.5	6.7e-11	-0.09	1.00	0.00	TRUE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	LRRK1	0.07	0.05	lasso	3	0.04	1.3e-05	-5.98	-6.5	1.0e-10	-0.02	0.00	1.00	TRUE
7	GTEx	Breast Mammary Tissue (Female)	CTD-2054N24.2	0.09	0.00	enet	12	0.15	2.8e-05	0.79	-6.3	2.8e-10	-0.05	0.09	0.13	TRUE
18	GTEx	Testis	TARSL2	0.20	0.00	enet	26	0.10	2.6e-05	1.97	-5.8	6.6e-09	-0.01	0.10	0.22	TRUE
22	The Cancer Genome Atlas	Lung Adenocarcinoma	IGF1R	0.07	0.05	enet	18	0.03	1.4e-04	-2.52	5.3	1.1e-07	-0.31	0.52	0.04	TRUE
9	GTEx	Esophagus Gastroesophageal Junction	LYSMD4	0.20	0.15	enet	11	0.16	2.9e-06	-3.06	-5.2	1.6e-07	0.01	0.28	0.04	TRUE
5	GTEx	Brain Putamen basal ganglia	LYSMD4	0.32	0.03	enet	15	0.11	1.2e-03	-0.63	-5.2	2.4e-07	0.02	0.07	0.13	TRUE
14	GTEx	Lung	CTD-3076O17.1	0.15	0.09	enet	13	0.09	2.8e-07	-7.63	-7.8	4.2e-15	-0.10	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	CTD-3076O17.1	0.22	0.05	lasso	6	0.04	2.9e-04	-5.34	-7.8	5.4e-15	-0.09	0.81	0.01	FALSE
15	GTEx	Pancreas	CTD-3076O17.1	0.24	0.11	enet	6	0.11	2.7e-05	-7.41	-7.8	7.7e-15	-0.09	0.53	0.02	FALSE
17	GTEx	Testis	ADAMTS17	0.30	0.24	lasso	2	0.22	6.7e-10	-7.61	-7.7	1.8e-14	-0.10	1.00	0.00	FALSE
8	GTEx	Colon Sigmoid	CTD-3076O17.1	0.25	0.15	lasso	5	0.09	3.5e-04	-7.74	-7.3	3.3e-13	-0.09	0.23	0.05	FALSE
19	GTEx	Testis	CTD-3076O17.1	0.45	0.17	enet	19	0.14	1.0e-06	-7.61	-7.1	9.7e-13	-0.08	0.90	0.00	FALSE
11	GTEx	Esophagus Muscularis	CTD-3076O17.1	0.28	0.11	lasso	6	0.10	6.2e-07	-7.74	-6.4	1.8e-10	-0.09	0.96	0.00	FALSE
16	GTEx	Skin Sun Exposed Lower leg	CTD-3076O17.1	0.15	0.10	enet	18	0.12	1.5e-10	-7.63	-5.5	3.0e-08	-0.11	1.00	0.00	FALSE