Best TWAS P=9.52e-33 · Best GWAS P=3.16e-48 conditioned to 0
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | ADAMTS17 | 0.14 | 0.00 | enet | 19 | 0.02 | 5.0e-03 | 10.74 | -10.0 | 1.2e-23 | -0.06 | 0.23 | 0.03 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | CTD-3076O17.1 | 0.22 | 0.05 | lasso | 6 | 0.04 | 2.9e-04 | -5.34 | -7.8 | 5.4e-15 | -0.09 | 0.81 | 0.01 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | ADAMTS17 | 0.20 | 0.00 | enet | 20 | 0.05 | 2.2e-03 | -8.01 | -10.1 | 8.7e-24 | 0.05 | 0.10 | 0.26 | TRUE |
| 4 | GTEx | Adipose Visceral Omentum | CTD-3076O17.1 | 0.21 | 0.00 | lasso | 6 | 0.00 | 6.2e-01 | -7.59 | -11.9 | 9.5e-33 | -0.08 | 0.10 | 0.20 | TRUE |
| 5 | GTEx | Brain Putamen basal ganglia | LYSMD4 | 0.32 | 0.03 | enet | 15 | 0.11 | 1.2e-03 | -0.63 | -5.2 | 2.4e-07 | 0.02 | 0.07 | 0.13 | TRUE |
| 6 | GTEx | Breast Mammary Tissue (Female) | CTD-3076O17.1 | 0.29 | -0.01 | lasso | 5 | 0.00 | 3.2e-01 | -7.76 | -6.8 | 1.4e-11 | -0.05 | 0.07 | 0.05 | TRUE |
| 7 | GTEx | Breast Mammary Tissue (Female) | CTD-2054N24.2 | 0.09 | 0.00 | enet | 12 | 0.15 | 2.8e-05 | 0.79 | -6.3 | 2.8e-10 | -0.05 | 0.09 | 0.13 | TRUE |
| 8 | GTEx | Colon Sigmoid | CTD-3076O17.1 | 0.25 | 0.15 | lasso | 5 | 0.09 | 3.5e-04 | -7.74 | -7.3 | 3.3e-13 | -0.09 | 0.23 | 0.05 | FALSE |
| 9 | GTEx | Esophagus Gastroesophageal Junction | LYSMD4 | 0.20 | 0.15 | enet | 11 | 0.16 | 2.9e-06 | -3.06 | -5.2 | 1.6e-07 | 0.01 | 0.28 | 0.04 | TRUE |
| 10 | GTEx | Esophagus Mucosa | CTD-3076O17.1 | 0.28 | 0.10 | lasso | 6 | 0.11 | 4.7e-08 | -7.63 | -6.5 | 6.7e-11 | -0.09 | 1.00 | 0.00 | TRUE |
| 11 | GTEx | Esophagus Muscularis | CTD-3076O17.1 | 0.28 | 0.11 | lasso | 6 | 0.10 | 6.2e-07 | -7.74 | -6.4 | 1.8e-10 | -0.09 | 0.96 | 0.00 | FALSE |
| 12 | GTEx | Heart Atrial Appendage | ADAMTS17 | 0.22 | 0.00 | lasso | 4 | 0.09 | 9.6e-05 | -5.92 | -8.8 | 2.1e-18 | -0.05 | 0.10 | 0.18 | TRUE |
| 13 | GTEx | Heart Atrial Appendage | CTD-3076O17.1 | 0.25 | 0.11 | enet | 24 | 0.17 | 3.8e-08 | -5.97 | -7.9 | 4.0e-15 | -0.05 | 0.71 | 0.02 | TRUE |
| 14 | GTEx | Lung | CTD-3076O17.1 | 0.15 | 0.09 | enet | 13 | 0.09 | 2.8e-07 | -7.63 | -7.8 | 4.2e-15 | -0.10 | 1.00 | 0.00 | FALSE |
| 15 | GTEx | Pancreas | CTD-3076O17.1 | 0.24 | 0.11 | enet | 6 | 0.11 | 2.7e-05 | -7.41 | -7.8 | 7.7e-15 | -0.09 | 0.53 | 0.02 | FALSE |
| 16 | GTEx | Skin Sun Exposed Lower leg | CTD-3076O17.1 | 0.15 | 0.10 | enet | 18 | 0.12 | 1.5e-10 | -7.63 | -5.5 | 3.0e-08 | -0.11 | 1.00 | 0.00 | FALSE |
| 17 | GTEx | Testis | ADAMTS17 | 0.30 | 0.24 | lasso | 2 | 0.22 | 6.7e-10 | -7.61 | -7.7 | 1.8e-14 | -0.10 | 1.00 | 0.00 | FALSE |
| 18 | GTEx | Testis | TARSL2 | 0.20 | 0.00 | enet | 26 | 0.10 | 2.6e-05 | 1.97 | -5.8 | 6.6e-09 | -0.01 | 0.10 | 0.22 | TRUE |
| 19 | GTEx | Testis | CTD-3076O17.1 | 0.45 | 0.17 | enet | 19 | 0.14 | 1.0e-06 | -7.61 | -7.1 | 9.7e-13 | -0.08 | 0.90 | 0.00 | FALSE |
| 20 | YFS | Blood | IGF1R | 0.14 | 0.09 | enet | 25 | 0.12 | 6.8e-36 | 7.12 | -6.9 | 4.4e-12 | 0.02 | 1.00 | 0.00 | TRUE |
| 21 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LRRK1 | 0.07 | 0.05 | lasso | 3 | 0.04 | 1.3e-05 | -5.98 | -6.5 | 1.0e-10 | -0.02 | 0.00 | 1.00 | TRUE |
| 22 | The Cancer Genome Atlas | Lung Adenocarcinoma | IGF1R | 0.07 | 0.05 | enet | 18 | 0.03 | 1.4e-04 | -2.52 | 5.3 | 1.1e-07 | -0.31 | 0.52 | 0.04 | TRUE |