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chr15:88,317,958-92,120,170

Best TWAS P=3.13e-39 · Best GWAS P=2.82e-99 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
27	The Cancer Genome Atlas	Colon Adenocarcinoma	HAPLN3	0.14	0.04	lasso	4	0.08	1.7e-05	2.561	-13.1	3.1e-39	0.43	0.05	0.58	TRUE
35	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	MFGE8	0.18	0.01	lasso	4	0.04	9.9e-03	7.662	-10.6	2.4e-26	-0.01	0.04	0.05	TRUE
1	GTEx	Brain Cortex	HAPLN3	0.40	-0.01	lasso	5	-0.01	6.0e-01	-4.060	-8.9	5.8e-19	-0.04	0.05	0.09	TRUE
12	GTEx	Testis	FANCI	0.19	0.04	enet	21	0.09	1.3e-04	-4.253	-8.5	2.0e-17	-0.08	0.21	0.04	TRUE
14	GTEx	Whole Blood	MFGE8	0.12	0.14	lasso	4	0.13	9.3e-12	-6.911	-7.4	1.3e-13	-0.01	1.00	0.00	TRUE
7	GTEx	Lung	MFGE8	0.12	0.04	lasso	5	0.06	1.4e-05	-8.187	7.2	4.4e-13	-0.03	0.78	0.01	TRUE
9	GTEx	Nerve Tibial	MFGE8	0.21	0.07	enet	17	0.12	1.0e-08	-4.982	7.2	6.0e-13	0.01	0.98	0.00	TRUE
16	METSIM	Adipose	POLG	0.04	0.02	blup	469	0.03	4.9e-05	-4.280	-7.2	6.0e-13	-0.08	0.96	0.00	TRUE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C15orf42	0.02	0.01	lasso	2	0.02	9.7e-04	7.065	7.1	9.6e-13	-0.01	0.00	0.95	TRUE
34	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C15orf42	0.09	0.08	lasso	1	0.08	3.2e-04	6.932	6.9	4.1e-12	-0.03	0.01	0.91	TRUE
11	GTEx	Stomach	MRPS11	0.35	-0.01	lasso	11	0.01	1.1e-01	-6.447	-6.7	1.5e-11	0.01	0.07	0.06	TRUE
3	GTEx	Colon Transverse	MFGE8	0.17	0.05	lasso	2	0.05	3.0e-03	-6.519	6.6	3.6e-11	-0.01	0.23	0.09	TRUE
17	NTR	Blood	IQGAP1	0.03	0.04	enet	10	0.04	1.5e-12	6.247	6.5	7.9e-11	0.06	0.02	0.98	TRUE
6	GTEx	Heart Left Ventricle	MFGE8	0.11	0.03	lasso	6	0.05	1.8e-03	-5.929	6.4	1.4e-10	0.03	0.11	0.04	TRUE
20	YFS	Blood	DET1	0.17	0.20	lasso	4	0.20	1.4e-62	-6.364	-6.4	1.4e-10	0.02	1.00	0.00	TRUE
10	GTEx	Skin Sun Exposed Lower leg	CRTC3	0.10	0.08	lasso	3	0.05	7.5e-05	6.082	-6.2	6.0e-10	-0.07	0.04	0.96	TRUE
2	GTEx	Cells Transformed fibroblasts	IQGAP1	0.13	0.06	enet	19	0.11	9.2e-09	4.769	6.2	7.7e-10	0.05	0.06	0.92	TRUE
22	YFS	Blood	IQGAP1	0.18	0.17	enet	46	0.20	5.8e-65	4.361	5.8	8.2e-09	0.06	1.00	0.00	TRUE
21	YFS	Blood	FURIN	0.11	0.03	enet	37	0.06	8.3e-19	2.448	5.5	4.2e-08	0.08	1.00	0.00	TRUE
13	GTEx	Testis	ISG20	0.39	0.23	enet	41	0.26	4.0e-12	4.945	-5.4	8.3e-08	0.00	0.99	0.00	TRUE
18	NTR	Blood	ZNF710	0.02	0.00	bslmm	443	0.01	1.5e-04	-4.120	-5.3	1.4e-07	0.05	0.14	0.02	TRUE
26	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	IQGAP1	0.15	0.09	lasso	4	0.12	1.9e-06	6.029	5.3	1.4e-07	0.07	0.01	0.98	TRUE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	DET1	0.02	0.02	blup	48	0.01	8.6e-04	5.086	-5.2	1.5e-07	0.01	0.07	0.84	TRUE
30	The Cancer Genome Atlas	Brain Lower Grade Glioma	C15orf42	0.07	0.07	lasso	5	0.06	9.0e-08	6.623	6.6	4.5e-11	-0.02	0.02	0.98	FALSE
4	GTEx	Esophagus Gastroesophageal Junction	ZNF774	0.16	0.16	lasso	2	0.11	7.8e-05	6.288	6.4	1.7e-10	0.05	0.02	0.96	FALSE
24	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IQGAP1	0.04	0.03	lasso	4	0.02	6.5e-03	6.247	6.3	2.3e-10	0.06	0.02	0.87	FALSE
33	The Cancer Genome Atlas	Lung Adenocarcinoma	IQGAP1	0.06	0.04	blup	94	0.03	5.8e-05	5.303	6.3	3.1e-10	0.07	0.06	0.94	FALSE
23	YFS	Blood	MRPS11	0.03	0.00	bslmm	436	0.01	9.6e-05	0.096	-6.2	4.4e-10	0.07	0.13	0.05	FALSE
19	YFS	Blood	BLM	0.41	0.35	enet	13	0.36	2.7e-122	5.917	6.1	1.4e-09	-0.01	0.15	0.85	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF774	0.06	0.06	lasso	3	0.04	1.2e-05	6.288	-6.1	1.4e-09	-0.05	0.00	1.00	FALSE
36	The Cancer Genome Atlas	Stomach Adenocarcinoma	IQGAP1	0.12	0.07	lasso	4	0.07	1.4e-05	6.423	5.9	3.0e-09	0.04	0.01	0.99	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	CRTC3	0.03	0.01	blup	78	0.01	4.2e-02	4.881	-5.9	3.4e-09	-0.04	0.02	0.59	FALSE
8	GTEx	Lung	ZNF774	0.06	0.09	enet	6	0.03	1.5e-03	6.288	5.8	5.9e-09	0.04	0.02	0.98	FALSE
15	METSIM	Adipose	IQGAP1	0.11	0.08	enet	32	0.12	3.9e-17	6.423	5.8	7.5e-09	0.04	0.02	0.98	FALSE
5	GTEx	Esophagus Mucosa	CRTC3	0.08	0.07	enet	7	0.04	6.1e-04	5.996	-5.7	9.7e-09	-0.04	0.04	0.96	FALSE
29	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IQGAP1	0.07	0.06	blup	94	0.07	9.5e-09	6.361	5.1	3.0e-07	0.04	0.01	0.99	FALSE