Hub : Genes

IGF1R

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0910 0.0350 0.0055 0.040 0.018 0.023 0.031 0.020 1.2e-05 2.6e-03 6.8e-04 8.9e-05 1.4e-03
2 GTEx Esophagus Muscularis 0.2150 0.0670 0.0020 0.033 NA -0.003 NA 0.027 4.1e-03 NA 5.4e-01 NA 8.7e-03
3 GTEx Heart Left Ventricle 0.2368 0.0705 0.0015 0.006 NA 0.029 NA 0.008 1.5e-01 NA 1.0e-02 NA 1.2e-01
4 YFS Blood 0.1360 0.0211 0.0000 0.094 0.092 0.116 0.109 0.115 3.1e-29 1.4e-28 6.8e-36 1.4e-33 1.3e-35
5 TCGA Lung Adenocarcinoma 0.0713 0.0308 0.0052 0.045 0.010 0.031 NA 0.029 4.7e-06 1.9e-02 1.4e-04 NA 2.0e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.4 0.7 2.5 1.6 0.3 -0.7 -0.1 0.6
Bipolar Disorder or Schizophrenia 0.3 0.7 1.6 -0.5 0.0 -0.2 1.3 1.2
Depressed Affect (Nagel 2018) 0.6 1.3 2.8 -0.8 0.7 -1.7 1.6 -0.4
Depression (Nagel 2018) 0.3 0.4 1.3 -0.0 0.7 1.1 0.4 -0.1
Intelligence (Savage-Jansen 2018) 1.3 3.9 10.3 -1.8 -0.3 -2.0 1.3 3.2
Neuroticism (Nagel 2018) 0.1 0.3 1.0 -0.5 -0.6 -0.4 1.0 -0.1
Schizophrenia (2018) 0.8 1.6 3.5 -1.9 -0.2 0.3 1.6 1.2
Schizophrenia vs Biploar Disorder 2.1 2.7 10.7 -3.3 -0.1 0.4 1.6 0.1
Worry (Nagel 2018) 0.1 0.2 0.9 -0.2 0.2 0.2 0.9 -0.3
Alzheimer’s Disease (in mother) 0.4 0.5 1.4 1.2 -0.7 0.0 -0.8 0.3
Alzheimer’s Disease (in father) 0.1 0.2 0.5 -0.1 0.7 0.5 0.0 -0.1
Alzheimer’s Disease (including proxy) 0.7 1.0 3.1 1.8 0.2 0.2 -1.4 0.1
Crohns Disease (2017) 0.2 0.5 0.9 1.0 0.5 -0.9 0.4 -0.5
Irritable Bowel Disease (IBD) 0.3 0.6 1.1 1.1 0.7 0.5 0.4 -1.1
Ulcerative Colitis (UC) 0.3 0.6 1.3 0.4 0.0 1.0 0.8 -1.1
Major Depression (MDD) 1.6 1.9 3.6 1.9 1.4 -0.4 -1.1 -1.7
Reaction Time 0.6 1.2 3.1 1.5 0.7 0.3 -1.8 -0.1
Verbal and Numeric Reasoning (VNR) 1.6 3.9 11.6 -3.4 -0.8 -1.6 0.7 2.0
Breast Cancer 0.9 2.1 5.8 1.8 0.6 2.4 -0.0 -0.9
Ovarian Cancer 0.5 0.7 1.4 1.2 0.0 1.2 0.7 -0.2
Prostate Cancer 1.9 2.7 6.0 1.0 2.4 -2.1 -1.4 -0.5
Age at First Birth 2.3 3.3 7.3 -1.3 -1.3 2.2 2.7 1.0
Bipolar Disorder (2011) 1.3 1.3 5.5 0.8 2.4 0.2 0.4 0.3
Body Mass Index (BMI) (2010) 0.5 0.7 1.8 -0.2 -0.6 0.1 1.3 -1.2
Coronary Artery Disease (CAD) 0.8 0.9 1.9 -1.1 0.8 -1.4 0.8 -0.5
Crohns Disease (2012) 0.7 1.1 2.4 -1.1 1.2 -1.6 0.7 0.2
Mean Putamen Volume 2.9 3.3 9.4 -2.1 0.4 -0.6 3.1 -1.5
Fasting Glucose 1.6 1.9 4.2 -1.2 2.0 -1.2 0.2 -1.5
HbA1C 0.9 1.0 1.5 -1.2 -0.4 -0.9 0.8 1.2
HDL Cholesterol 0.8 1.3 3.2 1.3 1.8 -0.3 -1.1 0.4
LDL Cholesterol 1.5 2.4 5.4 1.3 0.9 -1.5 -2.3 -1.4
Lupus 0.4 0.7 1.7 -0.6 0.3 1.1 1.3 -0.1
Neuroticism (2016) 1.2 1.7 3.4 1.3 1.8 -0.4 0.1 -1.8
Primary Biliary Cirrhosis 0.6 0.8 1.8 -1.0 1.4 -0.9 0.4 -0.6
Rheumatoid Arthritis 0.7 1.0 1.8 -1.1 1.2 -1.3 0.2 0.6
Schizophrenia (2014) 0.6 1.2 2.3 -1.5 -0.5 0.5 1.4 1.2
Triglycerides 1.2 2.0 5.1 2.3 0.4 -0.1 -1.6 -1.4
Type 2 Diabetes (T2D) (2012) 0.9 1.0 3.2 1.0 0.5 0.8 0.2 -1.8
Ulcerative Colitis 0.7 1.1 4.3 0.8 0.5 2.1 -0.1 0.1
Blood Eosinophil Count 0.1 0.9 1.9 -0.4 0.8 -1.4 1.1 -0.7
Blood Platelet Count 0.1 1.5 4.8 1.1 2.2 -0.6 -0.8 -0.7
Blood Red Count 0.5 4.6 14.9 0.7 -0.3 2.5 3.9 -1.1
Blood White Count 1.0 7.4 16.6 -2.3 1.7 -0.8 4.1 -3.4
Heel T-Score 0.5 3.8 6.9 2.6 0.8 -0.7 -2.2 -2.5
BMI 1.0 5.9 14.6 -1.1 -0.4 -3.5 3.8 1.0
Height 1.9 35.9 75.3 4.4 4.0 -2.5 -8.7 7.9
Waist Hip Ratio (WHR) 2.6 11.7 30.7 2.8 2.6 2.1 -5.5 -3.0
Systolic Blood Pressure 0.5 2.7 7.8 0.3 1.8 0.8 1.2 -2.8
Smoking Status 1.8 4.3 12.5 0.6 3.5 -1.3 0.4 -2.6
Allergy or Eczema 0.7 1.7 3.2 1.2 0.9 1.8 -0.8 -1.6
Cardiovascular Disease 0.7 2.4 6.4 -2.5 1.2 -0.3 1.3 -1.6
Hypothyroidism (self reported) 0.4 0.8 2.1 -1.5 1.3 0.4 0.4 0.2
Respiratory disease 0.5 1.2 2.1 1.1 1.4 -1.1 -0.4 -1.2
Type 2 Diabetes (T2D) (2018) 0.5 1.0 2.4 1.3 -0.6 1.6 -0.7 0.1
Lung FEV1/FVC ratio 0.2 1.3 4.5 0.2 1.0 -2.1 -0.6 -0.7
Lung FVC 1.9 9.9 24.7 -2.9 -3.4 0.6 5.0 2.0
Neuroticism 0.1 0.3 0.8 0.5 0.6 -0.9 0.1 -0.6
Chronotype (morning person) 0.4 1.0 1.4 1.1 -1.2 1.1 -0.5 -0.8
Hair Pigment 0.0 1.0 3.4 -0.0 -0.6 1.9 0.3 -1.0
Tanning 0.1 1.7 4.3 -0.6 2.1 1.5 -0.2 -1.3
Hand grip strength (left) 1.2 3.3 13.6 1.3 3.7 -0.0 -1.1 0.2
Number of treatments/medications taken 0.3 0.5 1.5 0.9 0.5 -0.3 -0.2 -1.2
Average weekly spirits intake 0.5 0.6 1.8 0.7 1.3 -0.6 0.1 -0.6
Sensitivity / hurt feelings 0.3 0.5 1.2 -0.1 -0.6 0.4 -1.1 -0.9
Frequency of depressed mood in last 2 weeks 0.2 0.2 0.6 0.5 0.3 0.8 0.3 0.2
Hearing difficulty/problems: Yes 1.4 2.1 3.0 1.4 1.3 0.8 -1.7 -1.7
Relative age of first facial hair 0.9 1.9 5.0 1.6 -0.3 2.2 -1.3 -0.2
Other serious medical condition/disability diagnosed by doctor 1.3 1.7 5.3 0.9 1.2 0.2 -2.3 -0.9
Ever used hormone-replacement therapy (HRT) 0.6 0.8 1.9 -0.6 0.2 1.4 0.8 1.0
Ever had hysterectomy (womb removed) 1.2 1.4 4.2 -0.3 1.6 -2.1 0.1 0.3
Systolic blood pressure, automated reading 0.4 1.1 3.5 0.2 -0.1 -0.1 1.9 -1.3
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 2.1 0.5 -1.3 -1.4 -0.3 -0.4
Angina 0.4 0.6 2.0 -0.2 1.4 -0.3 -0.8 -0.0
Medication for hormone replacement therapy 0.8 0.9 1.4 0.9 0.6 1.2 -1.1 -0.8
Vitamin and mineral supplements 1.5 2.0 4.5 -1.2 -0.2 -2.1 2.0 -0.3
Supplements: Zinc 0.3 0.3 0.7 0.2 -0.1 -0.6 0.8 -0.8
Medication: Co-codamol 1.3 1.5 4.2 -1.2 2.0 0.1 0.6 -1.3
Medication: Metformin 0.6 0.8 3.0 1.7 -0.3 0.8 -0.6 -0.5
Diabetes (father) 0.7 0.9 2.1 -1.4 -0.2 -0.3 1.1 -1.1
Diabetes (mother) 0.5 0.6 1.7 0.4 0.6 0.2 -1.3 -0.7
Severe depression (siblings) 0.6 0.7 2.9 0.4 0.5 0.3 1.7 0.3
Pack years adult smoking proportion 1.1 1.6 3.0 1.7 1.5 -1.0 0.5 -1.2
Impedance of leg (right) 1.2 5.8 14.8 1.4 2.3 0.8 -3.9 -2.5
Leg fat-free mass (left) 0.8 4.2 13.3 0.4 0.3 -2.7 -0.2 3.6
Trunk fat percentage 0.6 2.3 7.7 -0.7 -0.2 -2.8 1.6 0.7
Hand grip strength (right) 1.2 3.2 11.2 1.7 3.3 -0.1 -1.2 0.6
Townsend deprivation index at recruitment 0.4 0.5 1.1 -0.3 1.0 -0.7 0.6 -0.7
Current tobacco smoking 1.3 2.2 3.9 -0.3 2.0 0.5 1.7 -2.0
Average weekly fortified wine intake 1.9 2.3 4.9 -1.7 -2.2 0.7 -0.2 1.7
Maternal smoking around birth 2.5 3.7 8.8 0.4 2.6 -3.0 -0.5 -1.6
Fed-up feelings 0.2 0.4 1.6 0.1 -0.4 -0.5 1.2 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.4 4.0 0.8 0.7 2.0 -0.2 -1.4
Relative age voice broke 1.7 2.5 4.6 1.4 1.7 1.6 -2.1 -0.8
Taking other prescription medications 0.3 0.5 1.1 0.6 1.1 -0.1 0.9 -0.6
Age when periods started (menarche) 0.4 0.9 1.2 1.1 -0.9 0.7 -1.1 0.9
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 5.3 -0.1 2.3 0.5 1.0 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.7 5.0 2.2 0.6 -1.8 -2.2 -0.3
Tinnitus: Yes, but not now, but have in the past 1.3 1.4 2.6 1.3 -1.1 -0.2 -1.6 1.1
Qualifications: CSEs or equivalent 0.2 0.2 0.6 0.0 -0.8 -0.7 -0.2 -0.1
Serious illness, injury or assault to yourself 0.2 0.3 0.4 0.4 0.5 -0.5 -0.6 0.6
High blood pressure 0.3 0.8 2.3 -1.5 0.4 -0.2 1.2 -0.2
Hayfever, allergic rhinitis or eczema 0.4 0.8 1.2 1.1 0.3 1.1 -1.1 -0.6
Multivitamins +/- minerals 1.7 2.1 4.6 1.8 0.6 1.5 -2.1 -0.3
Stomach or abdominal pain in last month 1.3 1.6 3.8 1.9 0.9 -1.2 -0.9 -1.0
Supplements: Glucosamine 1.6 2.1 7.7 -1.3 -0.5 2.8 -0.7 0.4
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.2 -0.2 -0.4 0.4 -0.3 0.1
Medication: Atenolol 0.2 0.3 0.6 -0.8 0.4 -0.8 -0.0 0.3
Medication: Levothyroxine sodium 0.4 0.7 1.1 -1.0 0.9 0.6 0.5 -0.9
Sitting height 1.4 10.0 37.3 -0.6 0.4 -2.2 -2.7 6.1
Chronic bronchitis/emphysema (father) 0.2 0.3 0.8 0.9 0.1 -0.0 0.4 0.6
High blood pressure (mother) 0.3 0.4 1.2 0.8 0.2 -1.1 -0.3 -0.0
Body mass index (BMI) 1.0 4.1 14.2 -0.8 -0.4 -2.3 3.8 0.1
Impedance of leg (left) 1.0 5.0 9.5 0.5 2.6 0.3 -3.1 -2.9
Leg predicted mass (left) 0.8 4.3 13.8 0.4 0.2 -2.7 -0.2 3.7
Trunk fat mass 0.6 2.5 9.1 -0.4 0.5 -3.0 1.1 1.3
Waist circumference 0.4 1.5 4.7 -0.4 0.3 -2.2 1.4 0.8
Number of incorrect matches in round 1.1 1.8 4.3 2.1 -0.5 0.8 -2.0 0.4
Past tobacco smoking 1.0 1.8 3.7 -1.4 -1.9 0.9 0.4 1.5
Alcohol usually taken with meals 1.3 2.2 4.3 -1.2 -1.4 2.1 1.0 1.4
Nervous feelings 0.1 0.2 0.7 -0.2 -0.9 0.5 0.3 -0.2
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 5.0 0.7 0.4 2.2 -0.1 -0.1
Hearing difficulty/problems with background noise 1.7 2.7 6.9 -0.4 2.6 0.2 -0.7 -2.5
Hair/balding pattern: Pattern 2 1.1 1.4 3.8 0.4 0.8 0.5 -1.5 -2.0
Had menopause 0.7 0.9 1.7 -0.3 -1.0 1.3 0.1 1.3
Had other major operations 1.8 2.2 4.8 2.1 2.2 0.4 0.1 -1.3
Forced vital capacity (FVC) 0.5 2.1 5.6 -2.0 -0.5 0.4 0.5 2.4
Heel bone mineral density (BMD) T-score, automated (right) 1.3 2.9 7.2 2.2 0.5 -0.8 -2.7 -1.2
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 5.3 -0.3 0.1 -0.2 2.3 -0.3
Qualifications: None of the above 0.5 1.0 3.1 0.0 -0.7 -1.8 1.1 -0.3
Financial difficulties in last 2 years 0.4 0.5 1.0 1.0 -0.0 -0.5 -0.9 -0.6
Mouth/teeth dental problems 1.4 2.1 6.8 -2.6 -0.3 -1.0 1.6 0.2
Heart attack 0.5 0.6 1.6 -0.2 0.7 -1.3 0.8 -0.7
Allergy 0.2 0.4 0.8 -0.7 -0.8 0.1 0.9 0.3
Pain all over the body in last month 0.4 0.5 1.3 -0.0 0.8 -0.4 -0.3 -1.2
Diabetes (self-reported) 0.6 1.0 2.7 1.2 -0.3 1.6 -0.6 -0.3
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.2 0.1 -0.2 0.8 -1.1 0.8
Medication: Ramipril 0.7 1.0 3.0 1.0 0.3 -1.7 -0.7 -0.4
Medication: Simvastatin 0.7 1.1 3.4 -0.2 1.4 0.1 0.0 -1.8
Fluid intelligence score 1.0 2.0 5.2 -2.3 0.5 -1.4 0.5 1.6
Illnesses of siblings 0.6 0.8 1.7 -1.3 0.8 0.3 1.2 0.1
Neuroticism score 0.0 0.1 0.2 0.4 0.2 -0.4 0.0 -0.2
Weight 0.7 3.4 9.5 0.1 0.8 -3.1 0.7 2.5
Impedance of arm (right) 1.1 5.2 16.2 0.6 -2.4 0.2 -4.0 1.9
Arm fat percentage (right) 0.7 2.8 7.0 -0.9 -1.0 -2.6 2.1 0.8
Trunk fat-free mass 0.8 4.8 10.0 1.2 2.2 -2.1 -1.8 3.2
Hip circumference 1.6 6.7 13.7 -1.4 -1.1 -3.7 2.6 3.1
Time employed in main current job 0.3 0.4 1.3 1.1 0.3 0.6 -0.2 -0.5
Alcohol intake versus 10 years previously 0.1 0.2 0.6 -0.4 -0.2 -0.3 0.8 -0.1
Father’s age at death 2.5 3.4 5.6 -1.9 -1.9 0.5 1.9 2.4
Worrier / anxious feelings 0.1 0.3 1.3 1.1 0.1 -0.1 0.2 -0.1
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.2 2.0 1.4 1.4 0.6 -0.9 -1.1
Falls in the last year 0.3 0.4 0.7 0.8 0.5 0.1 -0.5 -0.8
Hair/balding pattern: Pattern 3 0.1 0.1 0.4 0.1 0.6 0.1 -0.5 -0.2
Number of live births 2.2 3.1 8.8 2.5 0.5 -0.4 -3.0 0.2
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 3.9 -1.7 -0.3 -0.0 0.1 2.0
Pulse rate 0.7 1.2 3.1 1.8 0.1 -1.1 -0.9 -0.8
Happiness 0.1 0.2 0.4 0.6 0.5 0.3 -0.1 -0.2
Noisy workplace 2.1 2.6 6.0 -0.7 2.4 -0.5 0.4 -2.4
Qualifications: A levels/AS levels or equivalent 0.5 1.0 1.9 0.2 -1.2 -0.2 -1.3 1.4
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 2.4 -0.5 0.6 -0.6 -1.0 -1.6
Mouth/teeth dental problems: Dentures 1.1 1.8 4.0 2.0 -0.0 -0.4 -1.8 1.3
Asthma 0.6 1.2 2.1 1.0 1.4 -1.4 -0.3 -0.9
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 2.4 0.5 0.5 -1.6 -0.1 -0.9
Medication: Cholesterol lowering 2.9 4.5 9.9 2.0 3.1 0.4 -1.4 -2.6
Depression (self-reported) 1.0 1.2 4.9 -0.3 0.6 0.5 2.2 0.5
Medication: Lansoprazole 1.3 1.5 5.5 0.8 2.3 0.3 -0.6 -1.0
Prospective memory result 1.1 1.4 4.8 0.5 -2.2 0.2 -0.1 1.4
Lung cancer (father) 1.0 1.2 3.0 -1.3 0.1 -0.5 1.0 1.7
Illnesses of mother 0.8 1.0 3.6 -1.0 -0.5 1.9 0.3 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.5 1.0 -0.8 -0.0 0.3 -0.7 1.0
Pulse wave Arterial Stiffness index 0.2 0.3 0.5 -0.5 0.7 0.5 0.4 0.5
Impedance of arm (left) 1.3 6.1 16.6 0.9 -3.0 0.5 -4.1 2.0
Arm fat mass (right) 0.7 2.7 8.3 -0.4 -0.3 -2.9 1.6 1.5
Trunk predicted mass 0.9 5.0 10.3 1.3 2.2 -2.2 -1.9 3.2
Standing height 1.9 18.4 47.9 2.2 2.7 -1.9 -6.9 5.3
Length of working week for main job 2.3 2.6 5.6 -0.3 1.9 -1.9 0.6 -2.4
Exposure to tobacco smoke at home 1.5 1.7 6.8 -0.0 -0.8 -2.6 0.3 1.0
Breastfed as a baby 1.0 1.2 4.0 2.0 -1.0 0.1 -1.0 0.1
Tense / ‘highly strung’ 0.2 0.3 0.5 0.7 0.4 0.5 -0.4 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 2.2 -0.5 0.1 0.7 1.5 -0.1
Hair/balding pattern: Pattern 4 0.5 1.2 1.9 1.3 1.4 1.3 -0.6 0.3
Birth weight of first child 1.7 3.1 7.6 0.5 -0.5 0.0 -2.8 2.7
Peak expiratory flow (PEF) 1.4 3.2 6.8 -2.4 -1.1 0.9 2.6 1.1
Pulse wave reflection index 0.7 0.8 3.1 -1.8 0.5 0.7 0.5 -0.4
Ever highly irritable/argumentative for 2 days 2.0 2.4 6.1 1.0 1.2 0.5 1.8 -2.5
Loud music exposure frequency 1.3 1.5 4.7 2.2 -0.6 0.7 -0.5 -1.3
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 2.1 1.5 0.3 -0.1 -1.5 0.9
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 2.3 1.5 -0.0 0.4 -0.9 -0.7
Blood clot in the leg (DVT) 0.6 0.8 2.5 -0.9 0.6 0.1 -1.6 0.6
Medication: Paracetamol 2.7 4.4 14.7 1.2 0.6 -2.0 -1.3 -3.8
Headache pain in last month 0.3 0.5 1.4 0.3 0.2 -1.2 -0.5 0.7
Medication for cholesterol, blood pressure or diabetes 1.6 2.7 7.1 -0.5 -2.4 -0.5 -0.2 2.7
Glaucoma (self-reported) 1.8 2.1 4.0 1.5 2.0 -0.9 -1.8 -0.1
Gout (self-reported) 2.1 2.9 5.6 -1.2 2.4 -1.0 1.8 -1.8
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 2.8 -1.7 1.6 0.8 0.8 -0.4
Medication: Amlodipine 0.6 0.9 1.5 1.0 -1.2 -1.2 -0.3 0.6
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.2 -0.1 -0.8 -1.1 0.8 0.5
Birth weight 4.3 9.2 24.7 2.1 -1.9 0.8 -3.5 5.0
Chronic bronchitis/emphysema (mother) 0.9 1.0 3.7 0.2 -0.0 -1.9 0.3 1.1
High blood pressure (siblings) 0.3 0.4 1.5 -0.5 -0.6 -1.2 -0.0 0.0
Forced vital capacity (FVC), Best measure 0.3 1.1 2.7 -1.5 -0.1 0.8 -0.1 1.6
Body fat percentage 0.6 2.5 7.8 -0.7 0.0 -2.8 2.0 0.2
Leg fat percentage (right) 0.6 2.3 6.2 -0.1 0.8 -1.9 2.5 -1.1
Arm fat-free mass (right) 0.6 3.1 5.4 0.8 2.3 -2.3 -0.5 1.9
Exposure to tobacco smoke outside home 1.1 1.4 6.1 -1.0 0.3 -2.5 0.3 0.0
Comparative body size at age 10 0.6 1.6 4.4 -0.3 -0.9 -2.1 1.4 0.9
Number of full brothers 0.4 0.6 1.7 0.3 0.5 -1.3 0.6 0.6
Worry too long after embarrassment 0.5 0.8 2.6 0.4 -1.6 -0.5 -0.8 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 2.0 1.1 0.7 1.4 -0.1 0.8
Wheeze or whistling in the chest in last year 1.0 1.9 5.7 0.2 1.5 -2.4 0.5 -1.0
Number of children fathered 1.7 1.9 4.2 -1.5 2.0 -1.6 0.9 0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 2.7 -1.2 0.0 -1.6 0.9 1.2
Age at first live birth 0.8 1.5 3.1 1.8 -1.1 1.7 0.4 -0.1
Pulse wave peak to peak time 0.2 0.3 0.4 0.4 -0.7 -0.6 -0.6 0.2
Health satisfaction 0.6 0.7 1.5 1.1 0.1 0.3 -0.9 -1.2
Shortness of breath walking on level ground 0.7 0.8 2.7 0.5 0.3 -1.1 0.0 -1.6
Qualifications: College or University degree 0.6 1.8 4.7 -1.1 -2.2 0.7 0.4 1.6
Eye problems/disorders: None of the above 1.6 1.8 3.5 -1.5 -0.6 -1.4 1.9 0.9
Mouth/teeth dental problems: Loose teeth 1.0 1.2 3.2 0.7 1.5 -0.5 -0.2 -1.8
Emphysema/chronic bronchitis 0.4 0.5 1.5 0.7 1.2 0.0 -0.6 0.3
Medication for pain relief, constipation, heartburn 1.7 2.9 9.0 -0.7 -1.0 1.7 1.1 3.0
Neck or shoulder pain in last month 0.9 1.3 2.2 1.0 1.2 -0.1 -1.4 -1.5
Medication: Blood pressure 0.5 0.8 2.0 -0.3 1.1 0.0 1.0 -1.4
Angina (self-reported) 0.4 0.5 1.9 -0.1 1.4 -0.3 -0.7 -0.3
Migraine (self-reported) 0.5 0.6 1.9 0.4 1.4 -0.0 -0.9 -0.1
Medication: Ibuprofen 0.9 1.0 4.1 0.5 0.3 -2.0 -0.2 -0.9
Medication: Allopurinol 0.9 1.2 3.1 -0.4 1.8 -0.6 1.4 -0.7
Medication: Omeprazole 0.2 0.2 0.8 0.9 -0.1 0.4 -0.3 0.1
Medication: Seretide 50 evohaler 0.3 0.3 0.8 0.0 -0.3 -0.9 0.7 -0.3
Mean time to correctly identify matches 0.3 0.6 1.6 1.3 0.2 0.2 -0.8 0.7
Heart disease (mother) 1.1 1.3 2.8 0.7 1.2 -1.7 -1.3 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 2.3 1.3 1.1 -0.0 -0.2 -1.5
Whole body fat mass 0.7 2.9 10.6 -0.3 0.7 -3.3 1.4 1.1
Leg fat mass (right) 0.7 2.7 7.8 -0.1 1.2 -2.8 2.0 -0.0
Arm predicted mass (right) 0.7 3.4 5.8 1.2 2.4 -2.4 -0.5 2.0
Pulse rate, automated reading 0.3 1.1 3.1 0.5 -0.1 1.8 0.6 -1.2
Alcohol intake frequency. 0.6 1.4 4.7 0.5 -2.2 0.2 -0.0 1.4
Comparative height size at age 10 0.7 3.8 9.6 -0.4 1.5 -0.1 -2.6 3.1
Number of full sisters 0.8 1.0 3.2 0.4 -1.8 -1.1 -0.3 -0.5
Suffer from ‘nerves’ 0.5 0.7 1.1 -0.4 -0.8 0.9 1.0 -1.0
Overall health rating 0.2 0.4 0.9 -0.2 -0.6 -0.9 -0.3 -0.7
Chest pain or discomfort 1.1 1.6 3.3 1.3 0.4 -1.8 -1.5 -0.5
Had major operations 1.1 1.3 2.9 1.0 1.4 0.8 -1.7 0.4
Age at last live birth 1.0 1.4 5.0 2.2 0.1 1.1 -0.8 0.0
Family relationship satisfaction 0.4 0.5 1.0 -0.7 1.0 0.8 0.8 0.1
Leg pain on walking 0.6 0.8 2.1 0.7 0.2 1.0 -0.2 -1.4
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.4 0.4 1.2 -1.0 0.2 -0.3
Commuting to job workplace: Car/motor vehicle 0.8 0.9 2.2 -1.3 1.5 -0.3 0.6 -0.2
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 1.0 -0.5 -0.0 1.0 0.4 0.4
Medication: Aspirin 0.4 0.5 1.3 -0.6 0.4 -0.4 -0.8 -1.2
Supplements: Vitamin C 0.9 1.0 2.7 -1.6 0.4 1.3 0.2 0.7
Knee pain experienced in last month 0.5 0.8 1.6 -0.5 -1.3 -0.0 1.2 -0.8
Hypertension (Self-reported) 0.5 1.5 3.8 -1.8 0.4 -0.2 1.9 -0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.9 2.2 0.3 1.2 0.7 0.3 -1.5
Illnesses of father: Heart disease 0.8 1.0 2.2 1.0 0.0 -1.5 -1.4 -0.2
Illnesses of siblings: Diabetes 0.5 0.6 1.6 1.2 0.3 -0.3 0.3 -1.3
Smoking status: Previous 1.5 2.2 4.4 1.4 2.1 -1.2 -1.1 -1.5
Forced expiratory volume in 1-second (FEV1), predicted 1.4 3.0 6.5 1.5 2.2 0.4 -2.6 1.1
Whole body fat-free mass 0.7 4.2 10.5 0.8 1.7 -2.5 -1.0 3.2
Leg fat-free mass (right) 0.8 4.4 14.1 0.0 0.1 -2.8 0.1 3.8
Arm fat percentage (left) 0.7 2.9 6.0 -0.9 -1.4 -2.4 2.2 0.9
Average weekly red wine intake 0.6 0.9 2.3 -1.5 -0.4 0.8 -0.2 -1.3
Handedness (chirality/laterality): Left-handed 0.8 0.9 3.2 -0.7 -0.5 -0.2 1.8 0.8
Mood swings 0.2 0.3 0.7 0.8 -0.2 0.8 0.5 0.1
Loneliness, isolation 0.2 0.3 1.0 0.4 -0.4 -0.4 -1.0 0.3
Long-standing illness, disability or infirmity 0.1 0.1 0.3 0.1 -0.5 -0.0 -0.4 -0.4
Ever had bowel cancer screening 0.5 0.6 2.1 -0.0 0.3 1.5 -0.1 0.7
Diabetes diagnosed by doctor 0.5 0.8 1.8 1.4 -0.7 1.2 -0.1 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 1.6 1.7 3.4 0.6 1.0 -1.8 -1.6 -1.1
Friendships satisfaction 0.4 0.5 1.3 -1.1 -0.0 -0.8 0.6 -0.3
Qualifications: nursing, teaching 0.5 0.7 2.3 0.6 -0.6 -1.5 0.4 0.7
Commuting to job workplace: Walk 0.9 1.0 2.2 -1.3 -1.5 0.7 0.6 0.3
Eye problems/disorders: Cataract 0.7 0.8 2.7 0.6 -0.4 1.6 -0.8 0.3
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 3.7 0.1 0.2 1.9 0.1 -0.1
Medication for cholesterol 0.5 0.7 1.8 1.4 -0.5 0.9 -0.0 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.5 1.0 -0.1 -0.6 -1.2 0.0
Back pain experienced in last month 0.3 0.5 1.2 -0.2 -1.0 -1.1 0.1 0.5
Mineral and other dietary supplements 2.2 2.9 5.9 -1.3 1.7 -2.4 1.9 -0.8
Breast cancer (self-reported) 1.5 1.8 3.7 -0.6 -1.2 -1.8 -0.6 1.9
Asthma (self-reported) 0.5 0.9 1.6 1.1 1.1 -1.3 -0.4 -0.8
Osteoporosis (self-reported) 1.7 2.0 3.8 1.4 -2.0 0.6 -1.8 0.9
Osteoarthritis (self-reported) 1.2 1.6 3.8 -0.1 -1.6 2.0 -1.0 -0.7
Medication: Aspirin 0.2 0.3 0.9 -0.5 0.2 -0.3 -0.6 -1.0
Medication: Gliclazide 0.4 0.4 0.8 0.8 -0.2 0.9 -0.8 -0.4
Illnesses of father: None of the above (group 1) 0.4 0.5 1.0 0.5 1.0 0.7 0.2 -0.9
Smoking status: Current 1.1 1.8 3.7 -0.2 1.9 0.1 1.6 -1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 3.5 -1.2 -1.9 0.3 1.3 1.8
Whole body water mass 0.7 4.1 9.9 0.8 1.7 -2.5 -0.9 3.2
Leg predicted mass (right) 0.8 4.3 13.9 0.0 0.2 -2.7 0.1 3.7
Arm fat mass (left) 0.6 2.5 7.0 -0.6 -0.5 -2.6 1.8 1.3
Number of self-reported non-cancer illnesses 0.4 0.8 1.3 0.5 1.2 1.0 -1.0 -0.7
Average weekly champagne plus white wine intake 0.4 0.6 1.1 -1.0 0.6 0.4 1.0 0.6
Miserableness 0.6 1.0 3.1 -0.4 0.9 -1.1 1.8 0.3
Guilty feelings 0.3 0.4 0.8 0.6 -0.6 0.1 -0.8 0.9
Wears glasses or contact lenses 0.2 0.2 0.4 -0.4 0.7 -0.1 0.3 0.6
Ever taken oral contraceptive pill 2.9 3.2 6.8 -2.2 0.7 -2.6 1.8 -0.8
Hearing aid user 0.5 0.5 1.0 -0.3 0.4 0.6 1.0 -1.0
Mother’s age at death 0.3 0.3 0.8 -0.4 0.1 0.8 -0.9 0.3
Financial situation satisfaction 1.1 1.3 3.8 1.3 -0.4 0.4 -0.9 -2.0
Tinnitus: Yes, now most or all of the time 1.1 1.3 2.8 0.3 1.0 -1.5 0.4 -1.7
Commuting to job workplace: Public transport 1.2 1.4 2.7 -0.5 -1.6 0.0 1.6 1.3
Eye problems/disorders: Glaucoma 1.7 2.0 4.2 1.2 2.1 -1.1 -0.9 -1.5
Medication: Blood pressure 0.6 1.1 3.6 -1.9 0.4 -1.3 0.2 0.1
Pain type(s) experienced in last month: Hip pain 1.4 1.7 4.4 -2.1 0.9 -1.2 1.3 -0.5
Supplements: Fish oil (including cod liver oil) 1.9 2.5 5.7 1.3 -0.7 2.2 -2.4 0.1
High cholesterol (Self-reported) 1.1 1.9 5.6 0.0 1.8 0.5 -0.5 -2.4
Medication: Bendroflumethiazide 0.7 1.0 2.4 -1.1 1.6 -0.1 0.3 -1.2
Medication: Paracetamol 1.9 2.9 9.5 1.0 -0.4 -1.8 -0.9 -3.1
Medication: Lisinopril 0.5 0.6 1.3 0.9 1.2 -0.3 0.6 -0.7
Medication: Atorvastatin 2.3 2.8 4.2 1.8 -1.5 -2.0 -2.0 0.5
Illnesses of father: High blood pressure 0.2 0.2 1.0 -0.3 0.0 -0.1 -0.1 -1.0
Alcohol drinker status: Never 0.2 0.2 0.8 -0.2 -0.9 0.3 0.2 0.2
Ever smoked 0.4 0.7 1.4 0.9 1.1 -0.2 0.1 -1.2
Basal metabolic rate 0.7 4.1 9.7 0.5 1.4 -2.9 -0.5 3.1
Leg fat percentage (left) 1.0 3.5 9.2 -0.6 1.0 -2.3 3.0 -1.3
Arm fat-free mass (left) 0.6 3.0 6.7 0.4 2.6 -2.4 -0.3 1.6
Number of operations (self-reported) 3.2 4.8 12.8 3.6 2.0 1.4 -2.2 0.2
Average weekly beer plus cider intake 1.4 2.0 3.4 0.2 1.7 1.8 0.3 -1.8
Irritability 0.2 0.4 0.8 0.9 -0.1 -0.2 0.6 -0.9
Risk taking 1.0 1.5 5.4 -0.7 2.3 -0.8 -0.8 0.5
Ever had prostate specific antigen (PSA) test 0.4 0.4 0.8 -0.7 -0.7 -0.9 0.6 -0.0
Fractured/broken bones in last 5 years 0.6 0.8 2.2 0.3 0.9 1.5 -0.8 0.4
Age started oral contraceptive pill 2.1 2.6 6.8 -1.2 -2.1 0.3 0.5 2.6
Diastolic blood pressure, automated reading 0.5 1.6 4.3 -1.7 -0.7 0.3 2.1 -0.6
Ever depressed for a whole week 0.7 0.8 2.0 0.6 1.4 0.1 1.1 -0.9
Unable to work because of sickness or disability 0.5 0.7 1.4 -0.4 -1.2 1.1 0.8 -0.4
Commuting to job workplace: Cycle 0.7 0.9 3.5 0.2 -0.7 -1.9 0.5 -0.2
Myopia 3.4 4.9 9.9 -2.0 0.6 -1.2 3.1 3.0
Vascular/heart problems diagnosed by doctor 0.4 1.0 1.6 1.3 -1.1 0.0 -1.1 1.0
Cholesterol lowering medication 1.1 1.6 3.6 -1.8 -0.9 -1.9 0.5 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.9 0.7 0.3 0.9 0.1 -0.3
Pain experienced in last month 0.2 0.4 1.3 -0.3 0.1 0.5 0.4 1.1
Supplements: Calcium 1.3 1.4 5.2 0.2 -1.0 2.3 0.3 0.8
Basal cell carcinoma (self-reported) 0.7 0.9 1.8 -1.3 0.8 -0.7 -0.7 -1.0
Heart attack/myocardial infarction (self-reported) 0.6 0.8 2.1 0.0 0.7 -1.4 0.9 -0.7
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 2.4 -1.0 0.3 0.2 -1.6 0.9
Heart disease (siblings) 0.4 0.4 1.2 1.1 0.2 -0.1 -1.0 0.1
Alcohol drinker status: Previous 1.6 1.8 3.2 1.5 -1.2 1.3 -0.9 1.8
Pack years of smoking 1.0 1.4 2.7 1.6 1.3 -1.4 0.2 -0.7
Impedance of whole body 0.7 3.5 15.9 0.9 -0.6 0.7 -4.0 -0.2
Leg fat mass (left) 0.9 3.4 9.5 -0.4 1.4 -3.1 2.3 -0.1
Arm predicted mass (left) 0.6 3.0 6.1 0.4 2.5 -2.4 -0.3 1.7