Hub : Genes

IGF1R

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0910	0.0350	0.0055	0.040	0.018	0.023	0.031	0.020	1.2e-05	2.6e-03	6.8e-04	8.9e-05	1.4e-03
2	GTEx	Esophagus Muscularis	0.2150	0.0670	0.0020	0.033	NA	-0.003	NA	0.027	4.1e-03	NA	5.4e-01	NA	8.7e-03
3	GTEx	Heart Left Ventricle	0.2368	0.0705	0.0015	0.006	NA	0.029	NA	0.008	1.5e-01	NA	1.0e-02	NA	1.2e-01
4	YFS	Blood	0.1360	0.0211	0.0000	0.094	0.092	0.116	0.109	0.115	3.1e-29	1.4e-28	6.8e-36	1.4e-33	1.3e-35
5	TCGA	Lung Adenocarcinoma	0.0713	0.0308	0.0052	0.045	0.010	0.031	NA	0.029	4.7e-06	1.9e-02	1.4e-04	NA	2.0e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.4	0.7	2.5	1.6	0.3	-0.7	-0.1	0.6
Bipolar Disorder or Schizophrenia	0.3	0.7	1.6	-0.5	0.0	-0.2	1.3	1.2
Depressed Affect (Nagel 2018)	0.6	1.3	2.8	-0.8	0.7	-1.7	1.6	-0.4
Depression (Nagel 2018)	0.3	0.4	1.3	-0.0	0.7	1.1	0.4	-0.1
Intelligence (Savage-Jansen 2018)	1.3	3.9	10.3	-1.8	-0.3	-2.0	1.3	3.2
Neuroticism (Nagel 2018)	0.1	0.3	1.0	-0.5	-0.6	-0.4	1.0	-0.1
Schizophrenia (2018)	0.8	1.6	3.5	-1.9	-0.2	0.3	1.6	1.2
Schizophrenia vs Biploar Disorder	2.1	2.7	10.7	-3.3	-0.1	0.4	1.6	0.1
Worry (Nagel 2018)	0.1	0.2	0.9	-0.2	0.2	0.2	0.9	-0.3
Alzheimer’s Disease (in mother)	0.4	0.5	1.4	1.2	-0.7	0.0	-0.8	0.3
Alzheimer’s Disease (in father)	0.1	0.2	0.5	-0.1	0.7	0.5	0.0	-0.1
Alzheimer’s Disease (including proxy)	0.7	1.0	3.1	1.8	0.2	0.2	-1.4	0.1
Crohns Disease (2017)	0.2	0.5	0.9	1.0	0.5	-0.9	0.4	-0.5
Irritable Bowel Disease (IBD)	0.3	0.6	1.1	1.1	0.7	0.5	0.4	-1.1
Ulcerative Colitis (UC)	0.3	0.6	1.3	0.4	0.0	1.0	0.8	-1.1
Major Depression (MDD)	1.6	1.9	3.6	1.9	1.4	-0.4	-1.1	-1.7
Reaction Time	0.6	1.2	3.1	1.5	0.7	0.3	-1.8	-0.1
Verbal and Numeric Reasoning (VNR)	1.6	3.9	11.6	-3.4	-0.8	-1.6	0.7	2.0
Breast Cancer	0.9	2.1	5.8	1.8	0.6	2.4	-0.0	-0.9
Ovarian Cancer	0.5	0.7	1.4	1.2	0.0	1.2	0.7	-0.2
Prostate Cancer	1.9	2.7	6.0	1.0	2.4	-2.1	-1.4	-0.5
Age at First Birth	2.3	3.3	7.3	-1.3	-1.3	2.2	2.7	1.0
Bipolar Disorder (2011)	1.3	1.3	5.5	0.8	2.4	0.2	0.4	0.3
Body Mass Index (BMI) (2010)	0.5	0.7	1.8	-0.2	-0.6	0.1	1.3	-1.2
Coronary Artery Disease (CAD)	0.8	0.9	1.9	-1.1	0.8	-1.4	0.8	-0.5
Crohns Disease (2012)	0.7	1.1	2.4	-1.1	1.2	-1.6	0.7	0.2
Mean Putamen Volume	2.9	3.3	9.4	-2.1	0.4	-0.6	3.1	-1.5
Fasting Glucose	1.6	1.9	4.2	-1.2	2.0	-1.2	0.2	-1.5
HbA1C	0.9	1.0	1.5	-1.2	-0.4	-0.9	0.8	1.2
HDL Cholesterol	0.8	1.3	3.2	1.3	1.8	-0.3	-1.1	0.4
LDL Cholesterol	1.5	2.4	5.4	1.3	0.9	-1.5	-2.3	-1.4
Lupus	0.4	0.7	1.7	-0.6	0.3	1.1	1.3	-0.1
Neuroticism (2016)	1.2	1.7	3.4	1.3	1.8	-0.4	0.1	-1.8
Primary Biliary Cirrhosis	0.6	0.8	1.8	-1.0	1.4	-0.9	0.4	-0.6
Rheumatoid Arthritis	0.7	1.0	1.8	-1.1	1.2	-1.3	0.2	0.6
Schizophrenia (2014)	0.6	1.2	2.3	-1.5	-0.5	0.5	1.4	1.2
Triglycerides	1.2	2.0	5.1	2.3	0.4	-0.1	-1.6	-1.4
Type 2 Diabetes (T2D) (2012)	0.9	1.0	3.2	1.0	0.5	0.8	0.2	-1.8
Ulcerative Colitis	0.7	1.1	4.3	0.8	0.5	2.1	-0.1	0.1
Blood Eosinophil Count	0.1	0.9	1.9	-0.4	0.8	-1.4	1.1	-0.7
Blood Platelet Count	0.1	1.5	4.8	1.1	2.2	-0.6	-0.8	-0.7
Blood Red Count	0.5	4.6	14.9	0.7	-0.3	2.5	3.9	-1.1
Blood White Count	1.0	7.4	16.6	-2.3	1.7	-0.8	4.1	-3.4
Heel T-Score	0.5	3.8	6.9	2.6	0.8	-0.7	-2.2	-2.5
BMI	1.0	5.9	14.6	-1.1	-0.4	-3.5	3.8	1.0
Height	1.9	35.9	75.3	4.4	4.0	-2.5	-8.7	7.9
Waist Hip Ratio (WHR)	2.6	11.7	30.7	2.8	2.6	2.1	-5.5	-3.0
Systolic Blood Pressure	0.5	2.7	7.8	0.3	1.8	0.8	1.2	-2.8
Smoking Status	1.8	4.3	12.5	0.6	3.5	-1.3	0.4	-2.6
Allergy or Eczema	0.7	1.7	3.2	1.2	0.9	1.8	-0.8	-1.6
Cardiovascular Disease	0.7	2.4	6.4	-2.5	1.2	-0.3	1.3	-1.6
Hypothyroidism (self reported)	0.4	0.8	2.1	-1.5	1.3	0.4	0.4	0.2
Respiratory disease	0.5	1.2	2.1	1.1	1.4	-1.1	-0.4	-1.2
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.4	1.3	-0.6	1.6	-0.7	0.1
Lung FEV1/FVC ratio	0.2	1.3	4.5	0.2	1.0	-2.1	-0.6	-0.7
Lung FVC	1.9	9.9	24.7	-2.9	-3.4	0.6	5.0	2.0
Neuroticism	0.1	0.3	0.8	0.5	0.6	-0.9	0.1	-0.6
Chronotype (morning person)	0.4	1.0	1.4	1.1	-1.2	1.1	-0.5	-0.8
Hair Pigment	0.0	1.0	3.4	-0.0	-0.6	1.9	0.3	-1.0
Tanning	0.1	1.7	4.3	-0.6	2.1	1.5	-0.2	-1.3
Hand grip strength (left)	1.2	3.3	13.6	1.3	3.7	-0.0	-1.1	0.2
Number of treatments/medications taken	0.3	0.5	1.5	0.9	0.5	-0.3	-0.2	-1.2
Average weekly spirits intake	0.5	0.6	1.8	0.7	1.3	-0.6	0.1	-0.6
Sensitivity / hurt feelings	0.3	0.5	1.2	-0.1	-0.6	0.4	-1.1	-0.9
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.6	0.5	0.3	0.8	0.3	0.2
Hearing difficulty/problems: Yes	1.4	2.1	3.0	1.4	1.3	0.8	-1.7	-1.7
Relative age of first facial hair	0.9	1.9	5.0	1.6	-0.3	2.2	-1.3	-0.2
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	5.3	0.9	1.2	0.2	-2.3	-0.9
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.9	-0.6	0.2	1.4	0.8	1.0
Ever had hysterectomy (womb removed)	1.2	1.4	4.2	-0.3	1.6	-2.1	0.1	0.3
Systolic blood pressure, automated reading	0.4	1.1	3.5	0.2	-0.1	-0.1	1.9	-1.3
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.1	0.5	-1.3	-1.4	-0.3	-0.4
Angina	0.4	0.6	2.0	-0.2	1.4	-0.3	-0.8	-0.0
Medication for hormone replacement therapy	0.8	0.9	1.4	0.9	0.6	1.2	-1.1	-0.8
Vitamin and mineral supplements	1.5	2.0	4.5	-1.2	-0.2	-2.1	2.0	-0.3
Supplements: Zinc	0.3	0.3	0.7	0.2	-0.1	-0.6	0.8	-0.8
Medication: Co-codamol	1.3	1.5	4.2	-1.2	2.0	0.1	0.6	-1.3
Medication: Metformin	0.6	0.8	3.0	1.7	-0.3	0.8	-0.6	-0.5
Diabetes (father)	0.7	0.9	2.1	-1.4	-0.2	-0.3	1.1	-1.1
Diabetes (mother)	0.5	0.6	1.7	0.4	0.6	0.2	-1.3	-0.7
Severe depression (siblings)	0.6	0.7	2.9	0.4	0.5	0.3	1.7	0.3
Pack years adult smoking proportion	1.1	1.6	3.0	1.7	1.5	-1.0	0.5	-1.2
Impedance of leg (right)	1.2	5.8	14.8	1.4	2.3	0.8	-3.9	-2.5
Leg fat-free mass (left)	0.8	4.2	13.3	0.4	0.3	-2.7	-0.2	3.6
Trunk fat percentage	0.6	2.3	7.7	-0.7	-0.2	-2.8	1.6	0.7
Hand grip strength (right)	1.2	3.2	11.2	1.7	3.3	-0.1	-1.2	0.6
Townsend deprivation index at recruitment	0.4	0.5	1.1	-0.3	1.0	-0.7	0.6	-0.7
Current tobacco smoking	1.3	2.2	3.9	-0.3	2.0	0.5	1.7	-2.0
Average weekly fortified wine intake	1.9	2.3	4.9	-1.7	-2.2	0.7	-0.2	1.7
Maternal smoking around birth	2.5	3.7	8.8	0.4	2.6	-3.0	-0.5	-1.6
Fed-up feelings	0.2	0.4	1.6	0.1	-0.4	-0.5	1.2	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	4.0	0.8	0.7	2.0	-0.2	-1.4
Relative age voice broke	1.7	2.5	4.6	1.4	1.7	1.6	-2.1	-0.8
Taking other prescription medications	0.3	0.5	1.1	0.6	1.1	-0.1	0.9	-0.6
Age when periods started (menarche)	0.4	0.9	1.2	1.1	-0.9	0.7	-1.1	0.9
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	5.3	-0.1	2.3	0.5	1.0	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	5.0	2.2	0.6	-1.8	-2.2	-0.3
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	2.6	1.3	-1.1	-0.2	-1.6	1.1
Qualifications: CSEs or equivalent	0.2	0.2	0.6	0.0	-0.8	-0.7	-0.2	-0.1
Serious illness, injury or assault to yourself	0.2	0.3	0.4	0.4	0.5	-0.5	-0.6	0.6
High blood pressure	0.3	0.8	2.3	-1.5	0.4	-0.2	1.2	-0.2
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.2	1.1	0.3	1.1	-1.1	-0.6
Multivitamins +/- minerals	1.7	2.1	4.6	1.8	0.6	1.5	-2.1	-0.3
Stomach or abdominal pain in last month	1.3	1.6	3.8	1.9	0.9	-1.2	-0.9	-1.0
Supplements: Glucosamine	1.6	2.1	7.7	-1.3	-0.5	2.8	-0.7	0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	-0.2	-0.4	0.4	-0.3	0.1
Medication: Atenolol	0.2	0.3	0.6	-0.8	0.4	-0.8	-0.0	0.3
Medication: Levothyroxine sodium	0.4	0.7	1.1	-1.0	0.9	0.6	0.5	-0.9
Sitting height	1.4	10.0	37.3	-0.6	0.4	-2.2	-2.7	6.1
Chronic bronchitis/emphysema (father)	0.2	0.3	0.8	0.9	0.1	-0.0	0.4	0.6
High blood pressure (mother)	0.3	0.4	1.2	0.8	0.2	-1.1	-0.3	-0.0
Body mass index (BMI)	1.0	4.1	14.2	-0.8	-0.4	-2.3	3.8	0.1
Impedance of leg (left)	1.0	5.0	9.5	0.5	2.6	0.3	-3.1	-2.9
Leg predicted mass (left)	0.8	4.3	13.8	0.4	0.2	-2.7	-0.2	3.7
Trunk fat mass	0.6	2.5	9.1	-0.4	0.5	-3.0	1.1	1.3
Waist circumference	0.4	1.5	4.7	-0.4	0.3	-2.2	1.4	0.8
Number of incorrect matches in round	1.1	1.8	4.3	2.1	-0.5	0.8	-2.0	0.4
Past tobacco smoking	1.0	1.8	3.7	-1.4	-1.9	0.9	0.4	1.5
Alcohol usually taken with meals	1.3	2.2	4.3	-1.2	-1.4	2.1	1.0	1.4
Nervous feelings	0.1	0.2	0.7	-0.2	-0.9	0.5	0.3	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	5.0	0.7	0.4	2.2	-0.1	-0.1
Hearing difficulty/problems with background noise	1.7	2.7	6.9	-0.4	2.6	0.2	-0.7	-2.5
Hair/balding pattern: Pattern 2	1.1	1.4	3.8	0.4	0.8	0.5	-1.5	-2.0
Had menopause	0.7	0.9	1.7	-0.3	-1.0	1.3	0.1	1.3
Had other major operations	1.8	2.2	4.8	2.1	2.2	0.4	0.1	-1.3
Forced vital capacity (FVC)	0.5	2.1	5.6	-2.0	-0.5	0.4	0.5	2.4
Heel bone mineral density (BMD) T-score, automated (right)	1.3	2.9	7.2	2.2	0.5	-0.8	-2.7	-1.2
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	5.3	-0.3	0.1	-0.2	2.3	-0.3
Qualifications: None of the above	0.5	1.0	3.1	0.0	-0.7	-1.8	1.1	-0.3
Financial difficulties in last 2 years	0.4	0.5	1.0	1.0	-0.0	-0.5	-0.9	-0.6
Mouth/teeth dental problems	1.4	2.1	6.8	-2.6	-0.3	-1.0	1.6	0.2
Heart attack	0.5	0.6	1.6	-0.2	0.7	-1.3	0.8	-0.7
Allergy	0.2	0.4	0.8	-0.7	-0.8	0.1	0.9	0.3
Pain all over the body in last month	0.4	0.5	1.3	-0.0	0.8	-0.4	-0.3	-1.2
Diabetes (self-reported)	0.6	1.0	2.7	1.2	-0.3	1.6	-0.6	-0.3
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.2	0.1	-0.2	0.8	-1.1	0.8
Medication: Ramipril	0.7	1.0	3.0	1.0	0.3	-1.7	-0.7	-0.4
Medication: Simvastatin	0.7	1.1	3.4	-0.2	1.4	0.1	0.0	-1.8
Fluid intelligence score	1.0	2.0	5.2	-2.3	0.5	-1.4	0.5	1.6
Illnesses of siblings	0.6	0.8	1.7	-1.3	0.8	0.3	1.2	0.1
Neuroticism score	0.0	0.1	0.2	0.4	0.2	-0.4	0.0	-0.2
Weight	0.7	3.4	9.5	0.1	0.8	-3.1	0.7	2.5
Impedance of arm (right)	1.1	5.2	16.2	0.6	-2.4	0.2	-4.0	1.9
Arm fat percentage (right)	0.7	2.8	7.0	-0.9	-1.0	-2.6	2.1	0.8
Trunk fat-free mass	0.8	4.8	10.0	1.2	2.2	-2.1	-1.8	3.2
Hip circumference	1.6	6.7	13.7	-1.4	-1.1	-3.7	2.6	3.1
Time employed in main current job	0.3	0.4	1.3	1.1	0.3	0.6	-0.2	-0.5
Alcohol intake versus 10 years previously	0.1	0.2	0.6	-0.4	-0.2	-0.3	0.8	-0.1
Father’s age at death	2.5	3.4	5.6	-1.9	-1.9	0.5	1.9	2.4
Worrier / anxious feelings	0.1	0.3	1.3	1.1	0.1	-0.1	0.2	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	2.0	1.4	1.4	0.6	-0.9	-1.1
Falls in the last year	0.3	0.4	0.7	0.8	0.5	0.1	-0.5	-0.8
Hair/balding pattern: Pattern 3	0.1	0.1	0.4	0.1	0.6	0.1	-0.5	-0.2
Number of live births	2.2	3.1	8.8	2.5	0.5	-0.4	-3.0	0.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	3.9	-1.7	-0.3	-0.0	0.1	2.0
Pulse rate	0.7	1.2	3.1	1.8	0.1	-1.1	-0.9	-0.8
Happiness	0.1	0.2	0.4	0.6	0.5	0.3	-0.1	-0.2
Noisy workplace	2.1	2.6	6.0	-0.7	2.4	-0.5	0.4	-2.4
Qualifications: A levels/AS levels or equivalent	0.5	1.0	1.9	0.2	-1.2	-0.2	-1.3	1.4
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.4	-0.5	0.6	-0.6	-1.0	-1.6
Mouth/teeth dental problems: Dentures	1.1	1.8	4.0	2.0	-0.0	-0.4	-1.8	1.3
Asthma	0.6	1.2	2.1	1.0	1.4	-1.4	-0.3	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.4	0.5	0.5	-1.6	-0.1	-0.9
Medication: Cholesterol lowering	2.9	4.5	9.9	2.0	3.1	0.4	-1.4	-2.6
Depression (self-reported)	1.0	1.2	4.9	-0.3	0.6	0.5	2.2	0.5
Medication: Lansoprazole	1.3	1.5	5.5	0.8	2.3	0.3	-0.6	-1.0
Prospective memory result	1.1	1.4	4.8	0.5	-2.2	0.2	-0.1	1.4
Lung cancer (father)	1.0	1.2	3.0	-1.3	0.1	-0.5	1.0	1.7
Illnesses of mother	0.8	1.0	3.6	-1.0	-0.5	1.9	0.3	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.5	1.0	-0.8	-0.0	0.3	-0.7	1.0
Pulse wave Arterial Stiffness index	0.2	0.3	0.5	-0.5	0.7	0.5	0.4	0.5
Impedance of arm (left)	1.3	6.1	16.6	0.9	-3.0	0.5	-4.1	2.0
Arm fat mass (right)	0.7	2.7	8.3	-0.4	-0.3	-2.9	1.6	1.5
Trunk predicted mass	0.9	5.0	10.3	1.3	2.2	-2.2	-1.9	3.2
Standing height	1.9	18.4	47.9	2.2	2.7	-1.9	-6.9	5.3
Length of working week for main job	2.3	2.6	5.6	-0.3	1.9	-1.9	0.6	-2.4
Exposure to tobacco smoke at home	1.5	1.7	6.8	-0.0	-0.8	-2.6	0.3	1.0
Breastfed as a baby	1.0	1.2	4.0	2.0	-1.0	0.1	-1.0	0.1
Tense / ‘highly strung’	0.2	0.3	0.5	0.7	0.4	0.5	-0.4	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	2.2	-0.5	0.1	0.7	1.5	-0.1
Hair/balding pattern: Pattern 4	0.5	1.2	1.9	1.3	1.4	1.3	-0.6	0.3
Birth weight of first child	1.7	3.1	7.6	0.5	-0.5	0.0	-2.8	2.7
Peak expiratory flow (PEF)	1.4	3.2	6.8	-2.4	-1.1	0.9	2.6	1.1
Pulse wave reflection index	0.7	0.8	3.1	-1.8	0.5	0.7	0.5	-0.4
Ever highly irritable/argumentative for 2 days	2.0	2.4	6.1	1.0	1.2	0.5	1.8	-2.5
Loud music exposure frequency	1.3	1.5	4.7	2.2	-0.6	0.7	-0.5	-1.3
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.1	1.5	0.3	-0.1	-1.5	0.9
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.3	1.5	-0.0	0.4	-0.9	-0.7
Blood clot in the leg (DVT)	0.6	0.8	2.5	-0.9	0.6	0.1	-1.6	0.6
Medication: Paracetamol	2.7	4.4	14.7	1.2	0.6	-2.0	-1.3	-3.8
Headache pain in last month	0.3	0.5	1.4	0.3	0.2	-1.2	-0.5	0.7
Medication for cholesterol, blood pressure or diabetes	1.6	2.7	7.1	-0.5	-2.4	-0.5	-0.2	2.7
Glaucoma (self-reported)	1.8	2.1	4.0	1.5	2.0	-0.9	-1.8	-0.1
Gout (self-reported)	2.1	2.9	5.6	-1.2	2.4	-1.0	1.8	-1.8
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	2.8	-1.7	1.6	0.8	0.8	-0.4
Medication: Amlodipine	0.6	0.9	1.5	1.0	-1.2	-1.2	-0.3	0.6
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.2	-0.1	-0.8	-1.1	0.8	0.5
Birth weight	4.3	9.2	24.7	2.1	-1.9	0.8	-3.5	5.0
Chronic bronchitis/emphysema (mother)	0.9	1.0	3.7	0.2	-0.0	-1.9	0.3	1.1
High blood pressure (siblings)	0.3	0.4	1.5	-0.5	-0.6	-1.2	-0.0	0.0
Forced vital capacity (FVC), Best measure	0.3	1.1	2.7	-1.5	-0.1	0.8	-0.1	1.6
Body fat percentage	0.6	2.5	7.8	-0.7	0.0	-2.8	2.0	0.2
Leg fat percentage (right)	0.6	2.3	6.2	-0.1	0.8	-1.9	2.5	-1.1
Arm fat-free mass (right)	0.6	3.1	5.4	0.8	2.3	-2.3	-0.5	1.9
Exposure to tobacco smoke outside home	1.1	1.4	6.1	-1.0	0.3	-2.5	0.3	0.0
Comparative body size at age 10	0.6	1.6	4.4	-0.3	-0.9	-2.1	1.4	0.9
Number of full brothers	0.4	0.6	1.7	0.3	0.5	-1.3	0.6	0.6
Worry too long after embarrassment	0.5	0.8	2.6	0.4	-1.6	-0.5	-0.8	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.0	1.1	0.7	1.4	-0.1	0.8
Wheeze or whistling in the chest in last year	1.0	1.9	5.7	0.2	1.5	-2.4	0.5	-1.0
Number of children fathered	1.7	1.9	4.2	-1.5	2.0	-1.6	0.9	0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.7	-1.2	0.0	-1.6	0.9	1.2
Age at first live birth	0.8	1.5	3.1	1.8	-1.1	1.7	0.4	-0.1
Pulse wave peak to peak time	0.2	0.3	0.4	0.4	-0.7	-0.6	-0.6	0.2
Health satisfaction	0.6	0.7	1.5	1.1	0.1	0.3	-0.9	-1.2
Shortness of breath walking on level ground	0.7	0.8	2.7	0.5	0.3	-1.1	0.0	-1.6
Qualifications: College or University degree	0.6	1.8	4.7	-1.1	-2.2	0.7	0.4	1.6
Eye problems/disorders: None of the above	1.6	1.8	3.5	-1.5	-0.6	-1.4	1.9	0.9
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.2	0.7	1.5	-0.5	-0.2	-1.8
Emphysema/chronic bronchitis	0.4	0.5	1.5	0.7	1.2	0.0	-0.6	0.3
Medication for pain relief, constipation, heartburn	1.7	2.9	9.0	-0.7	-1.0	1.7	1.1	3.0
Neck or shoulder pain in last month	0.9	1.3	2.2	1.0	1.2	-0.1	-1.4	-1.5
Medication: Blood pressure	0.5	0.8	2.0	-0.3	1.1	0.0	1.0	-1.4
Angina (self-reported)	0.4	0.5	1.9	-0.1	1.4	-0.3	-0.7	-0.3
Migraine (self-reported)	0.5	0.6	1.9	0.4	1.4	-0.0	-0.9	-0.1
Medication: Ibuprofen	0.9	1.0	4.1	0.5	0.3	-2.0	-0.2	-0.9
Medication: Allopurinol	0.9	1.2	3.1	-0.4	1.8	-0.6	1.4	-0.7
Medication: Omeprazole	0.2	0.2	0.8	0.9	-0.1	0.4	-0.3	0.1
Medication: Seretide 50 evohaler	0.3	0.3	0.8	0.0	-0.3	-0.9	0.7	-0.3
Mean time to correctly identify matches	0.3	0.6	1.6	1.3	0.2	0.2	-0.8	0.7
Heart disease (mother)	1.1	1.3	2.8	0.7	1.2	-1.7	-1.3	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.3	1.3	1.1	-0.0	-0.2	-1.5
Whole body fat mass	0.7	2.9	10.6	-0.3	0.7	-3.3	1.4	1.1
Leg fat mass (right)	0.7	2.7	7.8	-0.1	1.2	-2.8	2.0	-0.0
Arm predicted mass (right)	0.7	3.4	5.8	1.2	2.4	-2.4	-0.5	2.0
Pulse rate, automated reading	0.3	1.1	3.1	0.5	-0.1	1.8	0.6	-1.2
Alcohol intake frequency.	0.6	1.4	4.7	0.5	-2.2	0.2	-0.0	1.4
Comparative height size at age 10	0.7	3.8	9.6	-0.4	1.5	-0.1	-2.6	3.1
Number of full sisters	0.8	1.0	3.2	0.4	-1.8	-1.1	-0.3	-0.5
Suffer from ‘nerves’	0.5	0.7	1.1	-0.4	-0.8	0.9	1.0	-1.0
Overall health rating	0.2	0.4	0.9	-0.2	-0.6	-0.9	-0.3	-0.7
Chest pain or discomfort	1.1	1.6	3.3	1.3	0.4	-1.8	-1.5	-0.5
Had major operations	1.1	1.3	2.9	1.0	1.4	0.8	-1.7	0.4
Age at last live birth	1.0	1.4	5.0	2.2	0.1	1.1	-0.8	0.0
Family relationship satisfaction	0.4	0.5	1.0	-0.7	1.0	0.8	0.8	0.1
Leg pain on walking	0.6	0.8	2.1	0.7	0.2	1.0	-0.2	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.4	0.4	1.2	-1.0	0.2	-0.3
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.2	-1.3	1.5	-0.3	0.6	-0.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.0	-0.5	-0.0	1.0	0.4	0.4
Medication: Aspirin	0.4	0.5	1.3	-0.6	0.4	-0.4	-0.8	-1.2
Supplements: Vitamin C	0.9	1.0	2.7	-1.6	0.4	1.3	0.2	0.7
Knee pain experienced in last month	0.5	0.8	1.6	-0.5	-1.3	-0.0	1.2	-0.8
Hypertension (Self-reported)	0.5	1.5	3.8	-1.8	0.4	-0.2	1.9	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	2.2	0.3	1.2	0.7	0.3	-1.5
Illnesses of father: Heart disease	0.8	1.0	2.2	1.0	0.0	-1.5	-1.4	-0.2
Illnesses of siblings: Diabetes	0.5	0.6	1.6	1.2	0.3	-0.3	0.3	-1.3
Smoking status: Previous	1.5	2.2	4.4	1.4	2.1	-1.2	-1.1	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.4	3.0	6.5	1.5	2.2	0.4	-2.6	1.1
Whole body fat-free mass	0.7	4.2	10.5	0.8	1.7	-2.5	-1.0	3.2
Leg fat-free mass (right)	0.8	4.4	14.1	0.0	0.1	-2.8	0.1	3.8
Arm fat percentage (left)	0.7	2.9	6.0	-0.9	-1.4	-2.4	2.2	0.9
Average weekly red wine intake	0.6	0.9	2.3	-1.5	-0.4	0.8	-0.2	-1.3
Handedness (chirality/laterality): Left-handed	0.8	0.9	3.2	-0.7	-0.5	-0.2	1.8	0.8
Mood swings	0.2	0.3	0.7	0.8	-0.2	0.8	0.5	0.1
Loneliness, isolation	0.2	0.3	1.0	0.4	-0.4	-0.4	-1.0	0.3
Long-standing illness, disability or infirmity	0.1	0.1	0.3	0.1	-0.5	-0.0	-0.4	-0.4
Ever had bowel cancer screening	0.5	0.6	2.1	-0.0	0.3	1.5	-0.1	0.7
Diabetes diagnosed by doctor	0.5	0.8	1.8	1.4	-0.7	1.2	-0.1	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	3.4	0.6	1.0	-1.8	-1.6	-1.1
Friendships satisfaction	0.4	0.5	1.3	-1.1	-0.0	-0.8	0.6	-0.3
Qualifications: nursing, teaching	0.5	0.7	2.3	0.6	-0.6	-1.5	0.4	0.7
Commuting to job workplace: Walk	0.9	1.0	2.2	-1.3	-1.5	0.7	0.6	0.3
Eye problems/disorders: Cataract	0.7	0.8	2.7	0.6	-0.4	1.6	-0.8	0.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	3.7	0.1	0.2	1.9	0.1	-0.1
Medication for cholesterol	0.5	0.7	1.8	1.4	-0.5	0.9	-0.0	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.5	1.0	-0.1	-0.6	-1.2	0.0
Back pain experienced in last month	0.3	0.5	1.2	-0.2	-1.0	-1.1	0.1	0.5
Mineral and other dietary supplements	2.2	2.9	5.9	-1.3	1.7	-2.4	1.9	-0.8
Breast cancer (self-reported)	1.5	1.8	3.7	-0.6	-1.2	-1.8	-0.6	1.9
Asthma (self-reported)	0.5	0.9	1.6	1.1	1.1	-1.3	-0.4	-0.8
Osteoporosis (self-reported)	1.7	2.0	3.8	1.4	-2.0	0.6	-1.8	0.9
Osteoarthritis (self-reported)	1.2	1.6	3.8	-0.1	-1.6	2.0	-1.0	-0.7
Medication: Aspirin	0.2	0.3	0.9	-0.5	0.2	-0.3	-0.6	-1.0
Medication: Gliclazide	0.4	0.4	0.8	0.8	-0.2	0.9	-0.8	-0.4
Illnesses of father: None of the above (group 1)	0.4	0.5	1.0	0.5	1.0	0.7	0.2	-0.9
Smoking status: Current	1.1	1.8	3.7	-0.2	1.9	0.1	1.6	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	3.5	-1.2	-1.9	0.3	1.3	1.8
Whole body water mass	0.7	4.1	9.9	0.8	1.7	-2.5	-0.9	3.2
Leg predicted mass (right)	0.8	4.3	13.9	0.0	0.2	-2.7	0.1	3.7
Arm fat mass (left)	0.6	2.5	7.0	-0.6	-0.5	-2.6	1.8	1.3
Number of self-reported non-cancer illnesses	0.4	0.8	1.3	0.5	1.2	1.0	-1.0	-0.7
Average weekly champagne plus white wine intake	0.4	0.6	1.1	-1.0	0.6	0.4	1.0	0.6
Miserableness	0.6	1.0	3.1	-0.4	0.9	-1.1	1.8	0.3
Guilty feelings	0.3	0.4	0.8	0.6	-0.6	0.1	-0.8	0.9
Wears glasses or contact lenses	0.2	0.2	0.4	-0.4	0.7	-0.1	0.3	0.6
Ever taken oral contraceptive pill	2.9	3.2	6.8	-2.2	0.7	-2.6	1.8	-0.8
Hearing aid user	0.5	0.5	1.0	-0.3	0.4	0.6	1.0	-1.0
Mother’s age at death	0.3	0.3	0.8	-0.4	0.1	0.8	-0.9	0.3
Financial situation satisfaction	1.1	1.3	3.8	1.3	-0.4	0.4	-0.9	-2.0
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.8	0.3	1.0	-1.5	0.4	-1.7
Commuting to job workplace: Public transport	1.2	1.4	2.7	-0.5	-1.6	0.0	1.6	1.3
Eye problems/disorders: Glaucoma	1.7	2.0	4.2	1.2	2.1	-1.1	-0.9	-1.5
Medication: Blood pressure	0.6	1.1	3.6	-1.9	0.4	-1.3	0.2	0.1
Pain type(s) experienced in last month: Hip pain	1.4	1.7	4.4	-2.1	0.9	-1.2	1.3	-0.5
Supplements: Fish oil (including cod liver oil)	1.9	2.5	5.7	1.3	-0.7	2.2	-2.4	0.1
High cholesterol (Self-reported)	1.1	1.9	5.6	0.0	1.8	0.5	-0.5	-2.4
Medication: Bendroflumethiazide	0.7	1.0	2.4	-1.1	1.6	-0.1	0.3	-1.2
Medication: Paracetamol	1.9	2.9	9.5	1.0	-0.4	-1.8	-0.9	-3.1
Medication: Lisinopril	0.5	0.6	1.3	0.9	1.2	-0.3	0.6	-0.7
Medication: Atorvastatin	2.3	2.8	4.2	1.8	-1.5	-2.0	-2.0	0.5
Illnesses of father: High blood pressure	0.2	0.2	1.0	-0.3	0.0	-0.1	-0.1	-1.0
Alcohol drinker status: Never	0.2	0.2	0.8	-0.2	-0.9	0.3	0.2	0.2
Ever smoked	0.4	0.7	1.4	0.9	1.1	-0.2	0.1	-1.2
Basal metabolic rate	0.7	4.1	9.7	0.5	1.4	-2.9	-0.5	3.1
Leg fat percentage (left)	1.0	3.5	9.2	-0.6	1.0	-2.3	3.0	-1.3
Arm fat-free mass (left)	0.6	3.0	6.7	0.4	2.6	-2.4	-0.3	1.6
Number of operations (self-reported)	3.2	4.8	12.8	3.6	2.0	1.4	-2.2	0.2
Average weekly beer plus cider intake	1.4	2.0	3.4	0.2	1.7	1.8	0.3	-1.8
Irritability	0.2	0.4	0.8	0.9	-0.1	-0.2	0.6	-0.9
Risk taking	1.0	1.5	5.4	-0.7	2.3	-0.8	-0.8	0.5
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.8	-0.7	-0.7	-0.9	0.6	-0.0
Fractured/broken bones in last 5 years	0.6	0.8	2.2	0.3	0.9	1.5	-0.8	0.4
Age started oral contraceptive pill	2.1	2.6	6.8	-1.2	-2.1	0.3	0.5	2.6
Diastolic blood pressure, automated reading	0.5	1.6	4.3	-1.7	-0.7	0.3	2.1	-0.6
Ever depressed for a whole week	0.7	0.8	2.0	0.6	1.4	0.1	1.1	-0.9
Unable to work because of sickness or disability	0.5	0.7	1.4	-0.4	-1.2	1.1	0.8	-0.4
Commuting to job workplace: Cycle	0.7	0.9	3.5	0.2	-0.7	-1.9	0.5	-0.2
Myopia	3.4	4.9	9.9	-2.0	0.6	-1.2	3.1	3.0
Vascular/heart problems diagnosed by doctor	0.4	1.0	1.6	1.3	-1.1	0.0	-1.1	1.0
Cholesterol lowering medication	1.1	1.6	3.6	-1.8	-0.9	-1.9	0.5	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.9	0.7	0.3	0.9	0.1	-0.3
Pain experienced in last month	0.2	0.4	1.3	-0.3	0.1	0.5	0.4	1.1
Supplements: Calcium	1.3	1.4	5.2	0.2	-1.0	2.3	0.3	0.8
Basal cell carcinoma (self-reported)	0.7	0.9	1.8	-1.3	0.8	-0.7	-0.7	-1.0
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.1	0.0	0.7	-1.4	0.9	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.4	-1.0	0.3	0.2	-1.6	0.9
Heart disease (siblings)	0.4	0.4	1.2	1.1	0.2	-0.1	-1.0	0.1
Alcohol drinker status: Previous	1.6	1.8	3.2	1.5	-1.2	1.3	-0.9	1.8
Pack years of smoking	1.0	1.4	2.7	1.6	1.3	-1.4	0.2	-0.7
Impedance of whole body	0.7	3.5	15.9	0.9	-0.6	0.7	-4.0	-0.2
Leg fat mass (left)	0.9	3.4	9.5	-0.4	1.4	-3.1	2.3	-0.1
Arm predicted mass (left)	0.6	3.0	6.1	0.4	2.5	-2.4	-0.3	1.7