Best TWAS P=3.2e-16 · Best GWAS P=7.84e-22 conditioned to 8.23e-14
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | NTAN1 | 0.05 | 0.03 | lasso | 2 | 0.04 | 6.7e-04 | -6.3 | 6.4 | 1.2e-10 | -0.12 | 0.01 | 0.97 | FALSE |
| 2 | GTEx | Artery Coronary | NPIPA5 | 0.30 | 0.03 | enet | 13 | 0.07 | 3.1e-03 | -5.5 | 5.6 | 2.1e-08 | -0.02 | 0.02 | 0.78 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | PDXDC1 | 0.25 | 0.03 | enet | 20 | 0.05 | 1.1e-02 | -5.0 | 5.2 | 1.8e-07 | 0.00 | 0.02 | 0.74 | FALSE |
| 4 | GTEx | Muscle Skeletal | RRN3 | 0.18 | 0.03 | enet | 17 | 0.11 | 5.7e-11 | 1.6 | -5.3 | 1.1e-07 | 0.09 | 0.17 | 0.70 | FALSE |
| 5 | GTEx | Thyroid | RP11-65J21.3 | 0.35 | 0.32 | lasso | 2 | 0.31 | 2.6e-24 | -8.1 | -8.2 | 3.2e-16 | -0.54 | 1.00 | 0.00 | TRUE |
| 6 | NTR | Blood | NTAN1 | 0.01 | 0.00 | bslmm | 110 | 0.00 | 4.2e-02 | 4.5 | 5.9 | 2.9e-09 | -0.09 | 0.02 | 0.03 | FALSE |
| 7 | NTR | Blood | PDXDC1 | 0.12 | 0.12 | enet | 26 | 0.15 | 1.3e-46 | -6.4 | 7.2 | 7.8e-13 | -0.14 | 0.01 | 0.99 | TRUE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | NPIPA2 | 0.48 | 0.26 | bslmm | 145 | 0.47 | 2.1e-68 | 2.5 | -5.3 | 1.2e-07 | 0.06 | 1.00 | 0.00 | FALSE |