Best TWAS P=1.44e-09 · Best GWAS P=2.8e-09 conditioned to 0.322
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2 | GTEx | Cells Transformed fibroblasts | THUMPD1 | 0.13 | 0.16 | enet | 16 | 0.16 | 4.2e-12 | -5.8 | -6.0 | 1.4e-09 | 0.92 | 0.02 | 0.98 | TRUE |
| 6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | THUMPD1 | 0.04 | 0.04 | blup | 30 | 0.03 | 2.3e-03 | -5.8 | -6.0 | 2.2e-09 | 0.92 | 0.01 | 0.86 | FALSE |
| 3 | GTEx | Testis | AC004381.6 | 0.18 | 0.10 | lasso | 7 | 0.08 | 1.8e-04 | -5.8 | -5.9 | 4.3e-09 | 0.93 | 0.02 | 0.95 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | ACSM3 | 0.06 | 0.04 | blup | 43 | 0.03 | 5.9e-04 | -5.8 | 5.8 | 5.4e-09 | -0.90 | 0.01 | 0.96 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ACSM3 | 0.06 | 0.06 | lasso | 13 | 0.05 | 2.8e-06 | -5.8 | 5.8 | 8.1e-09 | -0.94 | 0.01 | 0.99 | FALSE |
| 1 | GTEx | Adipose Subcutaneous | ERI2 | 0.06 | 0.02 | enet | 3 | 0.01 | 3.3e-02 | -5.8 | -5.7 | 1.5e-08 | 0.87 | 0.03 | 0.92 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | THUMPD1 | 0.08 | 0.12 | enet | 24 | 0.12 | 3.0e-15 | -5.7 | 5.6 | 2.6e-08 | -0.93 | 0.02 | 0.98 | FALSE |
| 4 | METSIM | Adipose | ACSM1 | 0.05 | 0.05 | lasso | 5 | 0.06 | 9.5e-09 | -5.7 | -5.5 | 5.0e-08 | 0.87 | 0.03 | 0.97 | FALSE |