Best TWAS P=1.26e-12 · Best GWAS P=1.38e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | CFDP1 | 0.20 | 0.09 | lasso | 4 | 0.08 | 5.2e-05 | -4.4 | -5.7 | 1.4e-08 | 0.08 | 0.55 | 0.02 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | ZFP1 | 0.38 | 0.21 | lasso | 5 | 0.21 | 5.6e-11 | -6.9 | 6.9 | 5.3e-12 | -0.94 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Adrenal Gland | TMEM170A | 0.11 | 0.06 | enet | 4 | 0.04 | 1.7e-02 | -5.5 | 5.4 | 5.5e-08 | -0.08 | 0.27 | 0.05 | FALSE |
| 4 | GTEx | Adrenal Gland | ZFP1 | 0.53 | 0.28 | enet | 30 | 0.30 | 1.7e-11 | -6.9 | 6.8 | 1.0e-11 | -0.82 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Artery Aorta | BCAR1 | 0.18 | 0.13 | lasso | 3 | 0.11 | 9.8e-07 | -5.5 | 5.7 | 1.5e-08 | -0.06 | 0.98 | 0.02 | FALSE |
| 6 | GTEx | Artery Aorta | ZFP1 | 0.28 | 0.14 | enet | 13 | 0.19 | 1.0e-10 | -6.8 | 6.7 | 1.9e-11 | -0.90 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Brain Cortex | CFDP1 | 0.18 | 0.07 | lasso | 3 | 0.08 | 3.4e-03 | -4.8 | -5.3 | 1.4e-07 | -0.02 | 0.16 | 0.05 | FALSE |
| 8 | GTEx | Breast Mammary Tissue | ZFP1 | 0.21 | 0.18 | lasso | 2 | 0.17 | 7.0e-09 | -6.9 | 7.1 | 1.3e-12 | -0.95 | 0.00 | 1.00 | TRUE |
| 9 | GTEx | Breast Mammary Tissue (Male) | ZFP1 | 0.23 | 0.24 | lasso | 3 | 0.22 | 7.8e-06 | -6.3 | 6.3 | 3.3e-10 | -0.79 | 0.02 | 0.90 | FALSE |
| 10 | GTEx | Cells Transformed fibroblasts | CFDP1 | 0.17 | 0.20 | enet | 10 | 0.24 | 9.9e-18 | -5.4 | -5.7 | 1.5e-08 | 0.04 | 0.98 | 0.02 | FALSE |
| 11 | GTEx | Esophagus Gastroesophageal Junction | CFDP1 | 0.31 | 0.17 | lasso | 4 | 0.16 | 3.0e-06 | -5.1 | -5.2 | 1.7e-07 | -0.04 | 0.89 | 0.01 | FALSE |
| 12 | GTEx | Esophagus Gastroesophageal Junction | ZFP1 | 0.35 | 0.16 | lasso | 3 | 0.14 | 7.7e-06 | -6.9 | 5.6 | 1.8e-08 | -0.92 | 0.00 | 0.99 | FALSE |
| 13 | GTEx | Esophagus Muscularis | ZFP1 | 0.30 | 0.23 | lasso | 4 | 0.26 | 3.8e-16 | -6.9 | 5.4 | 5.3e-08 | -0.91 | 0.00 | 1.00 | FALSE |
| 14 | GTEx | Heart Atrial Appendage | ZFP1 | 0.23 | 0.15 | lasso | 2 | 0.14 | 9.1e-07 | -6.9 | 6.9 | 6.2e-12 | -0.97 | 0.00 | 0.99 | FALSE |
| 15 | GTEx | Heart Left Ventricle | ZFP1 | 0.37 | 0.20 | lasso | 8 | 0.19 | 1.4e-10 | -6.8 | 6.5 | 7.6e-11 | -0.90 | 0.00 | 1.00 | FALSE |
| 16 | GTEx | Muscle Skeletal | ZFP1 | 0.27 | 0.08 | enet | 31 | 0.11 | 3.1e-11 | -6.9 | 5.7 | 1.4e-08 | -0.80 | 0.00 | 1.00 | FALSE |
| 17 | GTEx | Nerve Tibial | CFDP1 | 0.16 | 0.14 | lasso | 3 | 0.12 | 1.6e-08 | -4.9 | -5.4 | 5.7e-08 | -0.01 | 1.00 | 0.00 | FALSE |
| 18 | GTEx | Nerve Tibial | ZFP1 | 0.41 | 0.23 | enet | 17 | 0.25 | 8.6e-18 | -6.9 | 6.0 | 2.7e-09 | -0.92 | 0.00 | 1.00 | FALSE |
| 19 | GTEx | Skin Not Sun Exposed Suprapubic | ZFP1 | 0.33 | 0.15 | lasso | 10 | 0.16 | 2.8e-09 | -6.8 | 6.3 | 2.3e-10 | -0.94 | 0.00 | 1.00 | FALSE |
| 20 | GTEx | Skin Sun Exposed Lower leg | CFDP1 | 0.17 | 0.13 | enet | 25 | 0.11 | 2.8e-09 | -4.9 | -6.0 | 1.5e-09 | 0.11 | 1.00 | 0.00 | FALSE |
| 21 | GTEx | Testis | ZFP1 | 0.17 | 0.14 | lasso | 3 | 0.12 | 4.5e-06 | -7.1 | 7.1 | 1.3e-12 | -0.99 | 0.00 | 1.00 | FALSE |
| 22 | GTEx | Thyroid | ZFP1 | 0.27 | 0.16 | enet | 17 | 0.18 | 1.3e-13 | -6.9 | 6.7 | 2.6e-11 | -0.92 | 0.00 | 1.00 | FALSE |
| 23 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CFDP1 | 0.04 | 0.03 | enet | 10 | 0.03 | 5.2e-07 | -4.9 | -5.6 | 2.6e-08 | -0.03 | 0.26 | 0.73 | FALSE |
| 24 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZFP1 | 0.08 | 0.10 | lasso | 3 | 0.10 | 2.5e-20 | -6.8 | 7.0 | 2.9e-12 | -0.97 | 0.00 | 1.00 | FALSE |
| 25 | The Cancer Genome Atlas | Colon Adenocarcinoma | ZFP1 | 0.22 | 0.09 | lasso | 6 | 0.12 | 3.3e-07 | -6.8 | 6.0 | 1.6e-09 | -0.84 | 0.01 | 0.99 | FALSE |
| 26 | The Cancer Genome Atlas | Esophageal Carcinoma | ZFP1 | 0.19 | 0.01 | blup | 63 | 0.06 | 6.9e-03 | -4.7 | 6.4 | 1.2e-10 | -0.58 | 0.01 | 0.54 | FALSE |
| 27 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CFDP1 | 0.02 | 0.02 | lasso | 4 | 0.02 | 1.9e-03 | -5.8 | -5.8 | 7.5e-09 | 0.02 | 0.02 | 0.92 | FALSE |
| 28 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ZFP1 | 0.21 | 0.12 | lasso | 5 | 0.18 | 2.1e-20 | -6.8 | 5.6 | 1.8e-08 | -0.86 | 0.00 | 1.00 | FALSE |
| 29 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | TMEM170A | 0.08 | 0.10 | blup | 36 | 0.13 | 9.1e-08 | -4.2 | -6.1 | 1.2e-09 | 0.06 | 0.01 | 0.99 | TRUE |
| 30 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CFDP1 | 0.04 | 0.02 | lasso | 6 | 0.03 | 4.0e-04 | -4.4 | -5.3 | 9.0e-08 | 0.00 | 0.03 | 0.96 | FALSE |
| 31 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZFP1 | 0.15 | 0.12 | lasso | 6 | 0.13 | 2.7e-14 | -6.5 | 6.6 | 3.2e-11 | -0.86 | 0.06 | 0.94 | FALSE |
| 32 | The Cancer Genome Atlas | Lung Adenocarcinoma | CFDP1 | 0.05 | 0.02 | enet | 11 | 0.04 | 2.0e-05 | -5.1 | -5.3 | 1.4e-07 | -0.05 | 0.20 | 0.41 | FALSE |
| 33 | The Cancer Genome Atlas | Lung Adenocarcinoma | ZFP1 | 0.20 | 0.07 | enet | 11 | 0.14 | 1.3e-16 | -6.9 | 6.0 | 2.1e-09 | -0.83 | 0.00 | 1.00 | FALSE |
| 34 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZFP1 | 0.10 | 0.09 | blup | 63 | 0.08 | 2.2e-08 | -6.9 | 6.1 | 1.4e-09 | -0.88 | 0.00 | 1.00 | FALSE |
| 35 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CHST6 | 0.20 | 0.08 | enet | 10 | 0.10 | 2.2e-04 | -4.8 | 5.4 | 5.6e-08 | -0.14 | 0.01 | 0.92 | FALSE |
| 36 | The Cancer Genome Atlas | Thyroid Carcinoma | ZFP1 | 0.25 | 0.16 | blup | 63 | 0.16 | 1.5e-15 | -6.9 | 5.8 | 6.4e-09 | -0.78 | 0.00 | 1.00 | FALSE |
| 37 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | ZFP1 | 0.32 | -0.01 | blup | 63 | 0.01 | 1.6e-01 | -6.5 | 5.5 | 3.3e-08 | -0.75 | 0.01 | 0.59 | FALSE |